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Bone without borders-Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope
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作者 Furqan A.Shah martina jolic +7 位作者 Chiara Micheletti Omar Omar Birgitta Norlindh Lena Emanuelsson Håkan Engqvist Thomas Engstrand Anders Palmquist Peter Thomsen 《Bioactive Materials》 SCIE CSCD 2023年第1期103-114,共12页
Calcium phosphates(CaP)represent an important class of osteoconductive and osteoinductive biomaterials.As proof-of-concept,we show how a multi-component CaP formulation(monetite,beta-tricalcium phosphate,and calcium p... Calcium phosphates(CaP)represent an important class of osteoconductive and osteoinductive biomaterials.As proof-of-concept,we show how a multi-component CaP formulation(monetite,beta-tricalcium phosphate,and calcium pyrophosphate)guides osteogenesis beyond the physiological envelope.In a sheep model,hollow dome-shaped constructs were placed directly over the occipital bone.At 12 months,large amounts of bone(~75%)occupy the hollow space with strong evidence of ongoing remodelling.Features of both compact bone(osteonal/osteon-like arrangements)and spongy bone(trabeculae separated by marrow cavities)reveal insights into function/need-driven microstructural adaptation.Pores within the CaP also contain both woven bone and vascularised lamellar bone.Osteoclasts actively contribute to CaP degradation/removal.Of the constituent phases,only calcium pyrophosphate persists within osseous(cutting cones)and non-osseous(macrophages)sites.From a translational perspective,this multi-component CaP opens up exciting new avenues for osteotomy-free and minimally-invasive repair of large bone defects and augmentation of the dental alveolar ridge. 展开更多
关键词 BONE Calcium phosphate Monetite Calcium pyrophosphate Electron microscopy Raman spectroscopy
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