Background:Flat and depressed lesions are becoming increasingly recognized in the esophagus,stomach,and colon.Various techniques have been described for endoscopic mucosal resection(EMR)of these lesions.Aims:To evalua...Background:Flat and depressed lesions are becoming increasingly recognized in the esophagus,stomach,and colon.Various techniques have been described for endoscopic mucosal resection(EMR)of these lesions.Aims:To evaluate the efficacy of lift-grasp-cut EMR using a prototype dual-channel forward-viewing endoscope with an instrument elevator in one accessory channel(dual-channel elevator scope)as compared to standard dual-channel endoscopes.Methods:EMR was performed using a lift-grasp-cut technique on normal flat rectosigmoid or gastric mucosa in live porcine models after submucosal injection of 4mL of saline using a dual-channel elevator scope or a standard dual-channel endoscope.With the dual-channel elevator scope,the elevator was used to attain further lifting of the mucosa.The primary endpoint was size of the EMR specimen and the secondary endpoint was number of complications.Results:Twelve experiments were performed(six gastric and six colonic).Mean specimen diameter was 2.27 cm with the dual-channel elevator scope and 1.34 cm with the dual-channel endoscope(P=0.018).Two colonic perforations occurred with the dual-channel endoscope,vs no complications with the dual-channel elevator scope.Conclusions:The increased lift of the mucosal epithelium,through use of the dual-channel elevator scope,allows for larger EMR when using a lift-grasp-cut technique.Noting the thin nature of the porcine colonic wall,use of the elevator may also make this technique safer.展开更多
基金Amitabh Chak received research support from Olympus America,supported by NIH Grant DK02800.
文摘Background:Flat and depressed lesions are becoming increasingly recognized in the esophagus,stomach,and colon.Various techniques have been described for endoscopic mucosal resection(EMR)of these lesions.Aims:To evaluate the efficacy of lift-grasp-cut EMR using a prototype dual-channel forward-viewing endoscope with an instrument elevator in one accessory channel(dual-channel elevator scope)as compared to standard dual-channel endoscopes.Methods:EMR was performed using a lift-grasp-cut technique on normal flat rectosigmoid or gastric mucosa in live porcine models after submucosal injection of 4mL of saline using a dual-channel elevator scope or a standard dual-channel endoscope.With the dual-channel elevator scope,the elevator was used to attain further lifting of the mucosa.The primary endpoint was size of the EMR specimen and the secondary endpoint was number of complications.Results:Twelve experiments were performed(six gastric and six colonic).Mean specimen diameter was 2.27 cm with the dual-channel elevator scope and 1.34 cm with the dual-channel endoscope(P=0.018).Two colonic perforations occurred with the dual-channel endoscope,vs no complications with the dual-channel elevator scope.Conclusions:The increased lift of the mucosal epithelium,through use of the dual-channel elevator scope,allows for larger EMR when using a lift-grasp-cut technique.Noting the thin nature of the porcine colonic wall,use of the elevator may also make this technique safer.
