The coagulation process is a widely applied technology in water and wastewater treatment.Novel composite polyferric mag-nesium-silicate-sulfate(PFMS)coagulants were synthesized using Na_(2)SiO_(3)·9H_(2)O,Fe_(2)(...The coagulation process is a widely applied technology in water and wastewater treatment.Novel composite polyferric mag-nesium-silicate-sulfate(PFMS)coagulants were synthesized using Na_(2)SiO_(3)·9H_(2)O,Fe_(2)(SO_(4))_(3),and MgSO_(4) as raw materials in this paper.The effects of aging time,Fe:Si:Mg,and OH:M molar ratios(M represents the metal ions)on the coagulation performance of the as-pre-pared PFMS were systematically investigated to obtain optimum coagulants.The results showed that PFMS coagulant exhibited good co-agulation properties in the treatment of simulated humic acid-kaolin surface water and reactive dye wastewater.When the molar ratio was controlled at Fe:Si:Mg=2:2:1 and OH:M=0.32,the obtained PFMS presented excellent stability and a high coagulation efficiency.The removal efficiency of ultraviolet UV254 was 99.81%,and the residual turbidity of the surface water reached 0.56 NTU at a dosage of 30 mg·L^(-1).After standing the coagulant for 120 d in the laboratory,the removal efficiency of UV254 and residual turbidity of the surface wa-ter were 88.12%and 0.68 NTU,respectively,which accord with the surface water treatment requirements.In addition,the coagulation performance in the treatment of reactive dye wastewater was greatly improved by combining the advantages of magnesium and iron salts.Compared with polyferric silicate-sulfate(PFS)and polymagnesium silicate-sulfate(PMS),the PFMS coagulant played a better decolor-ization role within the pH range of 7-13.展开更多
BACKGROUND Myosteatosis,rather than low muscle mass,is the primary etiologic factor of sarcopenia in patients with type 2 diabetes mellitus(T2DM).Myosteatosis may lead to a series of metabolic dysfunctions,such as ins...BACKGROUND Myosteatosis,rather than low muscle mass,is the primary etiologic factor of sarcopenia in patients with type 2 diabetes mellitus(T2DM).Myosteatosis may lead to a series of metabolic dysfunctions,such as insulin resistance,systematic inflammation,and oxidative stress,and all these dysfunctions are closely associated with the acceleration of T2DM and atherosclerosis.AIM To investigate the association between myosteatosis and coronary artery calcification(CAC)in patients with T2DM.METHODS Patients with T2DM,who had not experienced major cardiovascular events and had undergone both abdominal and thoracic computed tomography(CT)scans,were included.The mean skeletal muscle attenuation was assessed using abdominal CT images at the L3 level.The CAC score was determined from thoracic CT images using the Agatston scoring method.Myosteatosis was diagnosed according to Martin’s criteria.Severe CAC(SCAC)was defined when the CAC score exceeded 300.Logistic regression and decision tree analyses were performed.RESULTS A total of 652 patients with T2DM were enrolled.Among them,167(25.6%)patients had SCAC.Logistic regression analysis demonstrated that myosteatosis,age,duration of diabetes,cigarette smoking,and alcohol consumption were independent risk factors of SCAC.Myosteatosis was significantly associated with an increased risk of SCAC(OR=2.381,P=0.003).The association between myosteatosis and SCAC was significant in the younger patients(OR=2.672,95%CI:1.477-4.834,P=0.002),but not the older patients(OR=1.456,95%CI:0.863-2.455,P=0.188),and was more prominent in the population with lower risks of atherosclerosis.The decision tree analyses prioritized older age as the primary variable for SCAC.In older patients,cigarette smoking was the main contributing factor for SCAC,while in younger patients,it was myosteatosis.CONCLUSION Myosteatosis is a novel risk factor for atherosclerosis in patients with T2DM,especially in the population with younger ages and fewer traditional risk factors.展开更多
BACKGROUND Metabolic dysfunction-associated fatty liver disease(MAFLD)is a severe threat to human health.Polygonum multiflorum(PM)has been proven to remedy mitochondria and relieve MAFLD,but the main pharmacodynamic i...BACKGROUND Metabolic dysfunction-associated fatty liver disease(MAFLD)is a severe threat to human health.Polygonum multiflorum(PM)has been proven to remedy mitochondria and relieve MAFLD,but the main pharmacodynamic ingredients for mitigating MAFLD remain unclear.AIM To research the active ingredients of PM adjusting mitochondria to relieve highfat diet(HFD)-induced MAFLD in rats.METHODS Fat emulsion-induced L02 adipocyte model and HFD-induced MAFLD rat model were used to investigate the anti-MAFLD ability of PM and explore their action mechanisms.The adipocyte model was also applied to evaluate the activities of PM-derived constituents in liver mitochondria from HFD-fed rats(mitochondrial pharmacology).PM-derived constituents in liver mitochondria were confirmed by ultra-high-performance liquid chromatography/mass spectrometry(mitochondrial pharmacochemistry).The abilities of PM-derived monomer and monomer groups were evaluated by the adipocyte model and MAFLD mouse model,respectively.RESULTS PM repaired mitochondrial ultrastructure and prevented oxidative stress and energy production disorder of liver mitochondria to mitigate fat emulsion-induced cellular steatosis and HFD-induced MAFLD.PM-derived constituents that entered the liver mitochondria inhibited oxidative stress damage and improved energy production against cellular steatosis.Eight chemicals were found in the liver mitochondria of PM-administrated rats.The anti-steatosis ability of one monomer and the anti-MAFLD activity of the monomer group were validated.CONCLUSION PM restored mitochondrial structure and function and alleviated MAFLD,which may be associated with the remedy of oxidative stress and energy production.The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD.Thus,PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction.Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.展开更多
The non-noble metal modified sulfated zirconia was found easy to deactivate.Herein,highly active and highly stable non-noble core-shell Ni-S_(2)O_(8)^(2−)/Al_(2)O_(3)@ZrO_(2) catalysts(Ni-SA@Z-x,x=Al content in wt%)ha...The non-noble metal modified sulfated zirconia was found easy to deactivate.Herein,highly active and highly stable non-noble core-shell Ni-S_(2)O_(8)^(2−)/Al_(2)O_(3)@ZrO_(2) catalysts(Ni-SA@Z-x,x=Al content in wt%)have been successfully prepared and investigated for n-pentane isomerization.The results showed that the core-shell Ni-SA@Z-30 provided a sustained high isopentane yield(63.1%)with little or no deactivation within 5000 min at a mild reaction pressure of 2.0 MPa,which can be attributed to the following factors:(i)carbon deposition was greatly suppressed by the large pore size and huge pore volume;(ii)the loss of sulfur entities was suppressed because the small and highly dispersed tetragonal ZrO_(2) particles can bond with the S species strongly;(iii)strong Brønsted acidity can be maintained well after the isomerization.The pore structures and acid nature of the core-shell Ni-SA@Z-x are entirely different from those of the normal structure Ni-S_(2)O_(8)^(2−)/ZrO_(2)-Al_(2)O_(3),even though the Al content and the compositions of the individual components are the same.The Al_(2)O_(3)cores endow the catalysts with high internal surface area and high mechanical strength.Meanwhile,the ZrO_(2) shell,which consists of more and smaller tetragonal ZrO_(2) particles because of the large surface area of the Al_(2)O_(3)core,promotes the formation of more stable sulfur species and stronger binding sites.展开更多
Image distortion caused by the angular misalignment of quadrupole magnets in high-energy electron radiography has been studied systematically.We propose that the distortion originates from the coupling of the electron...Image distortion caused by the angular misalignment of quadrupole magnets in high-energy electron radiography has been studied systematically.We propose that the distortion originates from the coupling of the electron motions in the transverse directions,based on a theoretical analysis and the transfer-matrix method.The relative angular rotation between the second and third magnetic quadrupoles was identified as the main contributor to image distortion.This was verified by both a beam-dynamics simulation and experiments.Different strategies to mitigate this image distortion are also explored,including magnets online tuning,higher beam energy and larger magnification factor.This study provides criteria for designing experiments and paves the way for achieving higher image precision.展开更多
The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,...The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,making the identification and quantification of specific ingredients still a challenge.Herein,we developed a quality control(QC)system for monitoring TCM pharmaceuticals based on paper spray ionization miniature mass spectrometry(mini-MS).It enabled real-time online qualitative and quantitative detection of target ingredients in herbal extracts using mini-MS without chromatographic separation for the first time.Dynamic changes of alkaloids in Aconiti Lateralis Radix Praeparata(Fuzi)during decoction were used as examples,and the scientific principle of Fuzi compatibility was also investigated.Finally,the system was verified to work stably at the hourly level for pilot-scale extraction.This mini-MS based online analytical system is expected to be further developed for QC applications in a wider range of pharmaceutical processes.展开更多
Waste heat recovery from hot steel slag was determined in a granular bed through the combination of numerical simulation and an industrial test method.First,the effective thermal conductivity of the granular bed was c...Waste heat recovery from hot steel slag was determined in a granular bed through the combination of numerical simulation and an industrial test method.First,the effective thermal conductivity of the granular bed was calculated.Then,the unsteady-state model was used to simulate the heat recovery under three different flow fields(O-type,S-type,and nonshielding type(Nontype)).Second,the simulation results were validated by in-situ industrial experiments.The two methods confirmed that the heat recovery efficiencies of the flow fields from high to low followed the order of Nontype,S-type,and O-type.Finally,heat recovery was carried out under the Nontype flow field in an industrial test.The heat recovery efficiency increased from~76%and~78%to~81%when the steel slag thickness decreased from 400 and 300 to 200 mm,corresponding to reductions in the steel slag mass from 3.96 and 2.97 to 1.98 t with a blower air volume of 14687 m^(3)/h.Therefore,the research results showed that numerical simulation can not only guide experiments on waste heat recovery but also optimize the flow field.Most importantly,the method proposed in this paper has achieved higher waste heat recovery from hot steel slag in industrial scale.展开更多
Magnetic helicity is an important concept in solar physics,with a number of theoretical statements pointing out the important role of magnetic helicity in solar flares and coronal mass ejections(CMEs).Here we construc...Magnetic helicity is an important concept in solar physics,with a number of theoretical statements pointing out the important role of magnetic helicity in solar flares and coronal mass ejections(CMEs).Here we construct a sample of 47 solar flares,which contains 18 no-CME-associated confined flares and 29 CME-associated eruptive flares.We calculate the change ratios of magnetic helicity and magnetic free energy before and after these 47 flares.Our calculations show that the change ratios of magnetic helicity and magnetic free energy show distinct different distributions in confined flares and eruptive flares.The median value of the change ratios of magnetic helicity in confined flares is-0.8%,while this number is-14.5%for eruptive flares.For the magnetic free energy,the median value of the change ratios is-4.3%for confined flares,whereas this number is-14.6%for eruptive flares.This statistical result,using observational data,is well consistent with the theoretical understandings that magnetic helicity is approximately conserved in the magnetic reconnection,as shown by confined flares,and the CMEs take away magnetic helicity from the corona,as shown by eruptive flares.展开更多
The discharge channel is a crucial diagnostic tool for identifying the properties of gas switches.However,single-view images cannot easily be used to inherently understand the discharge channel characteristics of trig...The discharge channel is a crucial diagnostic tool for identifying the properties of gas switches.However,single-view images cannot easily be used to inherently understand the discharge channel characteristics of trigger electrodes.A reconstruction method of the discharge channel in gas switches is proposed based on a multi-axis tomography technique,which uses very few projections of optical images to reconstruct the location of a multichannel discharge in annular electrodes.In this paper,an algorithm named TVM-OSEM(total variation minimization ordered subsets expectation maximization)is proposed,which can effectively remove artifact noise to improve the reconstruction accuracy of discharge channels.The method is validated against simulations of a radiator with high-density-difference boundary.The calculated discharge channel distribution from one experiment is presented.展开更多
Accurate measurement of magnetic fields is very important for understanding the formation and evolution of solar magnetic fields.Currently,there are two types of solar magnetic field measurement instruments:filter-bas...Accurate measurement of magnetic fields is very important for understanding the formation and evolution of solar magnetic fields.Currently,there are two types of solar magnetic field measurement instruments:filter-based magnetographs and Stokes polarimeters.The former gives high temporal resolution magnetograms and the latter provides more accurate measurements of magnetic fields.Calibrating the magnetograms obtained by filter-based magnetographs with those obtained by Stokes polarimeters is a good way to combine the advantages of the two types.Our previous studies have shown that,compared to the magnetograms obtained by the Spectro-Polarimeter(SP)on board Hinode,those magnetograms obtained by both the filter-based Solar Magnetic Field Telescope(SMFT)of the Huairou Solar Observing Station and by the filter-based Michelson Doppler Imager(MDI)aboard SOHO have underestimated the flux densities in their magnetograms and systematic center-to-limb variations present in the magnetograms of both instruments.Here,using a sample of 75 vector magnetograms of stable alpha sunspots,we compare the vector magnetograms obtained by the Helioseismic and Magnetic Imager(HMI)aboard Solar Dynamics Observatory(SDO)with co-temporal vector magnetograms acquired by SP/Hinode.Our analysis shows that both the longitudinal and transverse flux densities in the HMI/SDO magnetograms are very close to those in the SP/Hinode magnetograms and the systematic center-to-limb variations in the HMI/SDO magnetograms are very minor.Our study suggests that using a filter-based magnetograph to construct a low spectral resolution Stokes profile,as done by HMI/SDO,can largely remove the disadvantages of the filter-type measurements and yet still possess the advantage of high temporal resolution.展开更多
Objective:This study compared the prevalence,awareness,treatment and control of hypertension and associated factors in China and the United States(US).Methods:Adult data from nationally representative samples were der...Objective:This study compared the prevalence,awareness,treatment and control of hypertension and associated factors in China and the United States(US).Methods:Adult data from nationally representative samples were derived from the Chronic Disease and Risk Factors Surveillance in 2010 and 2013 in China and the National Health and Nutrition Examination Survey in 2010 and 2013 in the US.Multivariable logistic and Poisson regression analysis were conducted to assess associations of the four outcomes with body weight status and behavioral factors.Results:Age-standardized prevalence rates of hypertension was 35.7%(95%confidence interval[CI]:35.4%to 36.1%)in 2010 and 29.8%(95%CI:29.4%to 30.2%)in 2013 in China,and 35.3%(95%CI:33.6%to 37.1%)in 2010 and 37.9%(95%CI:36.0%to 39.7%)in 2013 in the US.Among hypertensive participants,the age-standardized rates of treatment were 18.4%(95%CI:17.9%to 1&9%)in 2010 and 23.8%(95%CI:23.1%to 24.6%)in 2013 in China and 54.5%(95%CI:50.3%to 5&7%)in 2010 and 50.9%(95%CI:46.5%to 55.3%)in 2013 in the US;the age-standardized hypertension control rates were 3.2%(95%CI:3.0%to 3.5%)and 5.7%(95%CI:5.3%to 6.0%)in 2010 and 2013 in China and 50.6%(95%CI:46.2%to 55.0%)and 55.3%(95%CI:50.3%to 60.3%)in the US.Obesity was significantly associated with prevalence,awareness and control rates in both countries.Different from the US,obesity was negatively associated with hypertension control in China.Conclusion:Hypertension prevalence in China is similar to that in the US,but the control rate in China was significantly lower.Obesity was a critical risk factor for poor hypertension control in China.展开更多
<span style="font-family:Verdana;">Purpose: </span><span style="font-family:Verdana;">To discuss the effect of “1 + 3 + 3” emergency management mode to deal with COVID-19 pandem...<span style="font-family:Verdana;">Purpose: </span><span style="font-family:Verdana;">To discuss the effect of “1 + 3 + 3” emergency management mode to deal with COVID-19 pandemic in fever outpatient service of general hospitals. Method: This paper analyzes and summarizes the problems encountered by fever outpatient service in dealing with the COVID-19 pandemic from three aspects of “One Team”, “Three-Key” Control and “Three Mosts”. Results: The application of “1 + 3 + 3” emergency management mode can effectively boost the orderliness and efficiency of fever outpatient service in dealing with COVID-19 pandemic. Conclusion: The “1 + 3 + 3” emergency management mode provides a new management mode and idea for dealing with COVID-19 pandemic,</span><span style="font-family:""> </span><span style="font-family:Verdana;">so the fever outpatient service of general hospitals can better improve the national overall anti-pandemic situation.展开更多
<strong>Objective:</strong> To explore the clinical effects of conventional surgery, ultrasound-guided microwave ablation and rotational adenomammectomy on the prognosis of benign breast nodules. <stron...<strong>Objective:</strong> To explore the clinical effects of conventional surgery, ultrasound-guided microwave ablation and rotational adenomammectomy on the prognosis of benign breast nodules. <strong>Methods:</strong> 232 cases of patients with benign breast nodules confirmed by pathological examination who received surgical treatment in the breast surgery department of our hospital from December 2016 to December 2020 were included. According to the surgical methods, they were divided into microwave ablation group (n = 48), conventional surgery group (n = 105) and rotational adenomammectomy group (n = 79). The clinical parameters were compared and analyzed between the three groups, and the postoperative pain, residual tumor, breast beauty and complication rate of the patients were evaluated. <strong>Results:</strong> Operative time, intraoperative blood loss, healing time and postoperative pain in microwave ablation group were lower than those of rotational adenomammectomy group (P < 0.05) and those of conventional surgery group (P < 0.05). Besides, those in the rotational adenomammectomy group were lower than those in the conventional surgery group (P < 0.05). The residual tumor rates in microwave ablation group and rotational adenomammectomy group were 4.17% and 3.80%, respectively. And the difference was not statistically significant (P > 0.05). Both of them were lower than 6.66% in conventional surgery group, with statistically significant differences (P < 0.05). The effective rates of breast beauty were 91.67%, 82.28% and 68.58% in the microwave ablation group, the rotational adenomammectomy group and the conventional surgery group, respectively. And the difference between groups was statistically significant (P < 0.05). The rate of postoperative complications in microwave ablation group and rotational adenomammectomy group were 4.17% and 3.80% respectively, both of which were significantly lower than 6.66% in conventional surgery group (P < 0.05). <strong>Conclusion:</strong> Microwave ablation, rotational adenomammectomy and conventional surgery are effective for the treatment of benign breast tumors. Among them, microwave ablation is the best option with many advantages of shorter operative time, less intraoperative blood loss, more beautiful breast shape, less postoperative pain, a lower residual rate after surgery, and a lower complication rate.展开更多
Objective: To explore the effect of systematic pre-job training for isolation ward nurses during the Corona Virus Disease 2019 (COVID-19) pandemic. Methods: Establish a pre-job training program for the isolation ...Objective: To explore the effect of systematic pre-job training for isolation ward nurses during the Corona Virus Disease 2019 (COVID-19) pandemic. Methods: Establish a pre-job training program for the isolation ward for COVID-19, standardize the content of theoretical and skill training, formulate training SOPs, and conduct training for the nurses using online teaching assessment, video teaching, on-site scenario simulation operation drills, as well as real-time protection guidance and supervision. 60 nurses from non-infectious departments temporarily selected by the hospital were trained;the theoretical knowledge scores, quarantine techniques, and nursing quality of nurses before and after the training were compared, and the effect of the intervention was evaluated. Results: The scores of the COVID-19 protection theory test were 81.17 ± 8.46 after the nurses were trained for 3 days. The pass rates of hand hygiene compliance tests and protective clothing putting-on and taking-off practices were 96.67% and 100%, respectively. There was no significant difference between the scores of the COVID-19 protection theory test for the nurses that were trained for 3 days and the scores for the nurses originally at the quarantine zone (81.59 ± 7.59, P > 0.05). The pass rate of hand hygiene compliance and the pass rate of protective clothing putting-on and taking-off practices were significantly improved compared with those before training (81.67% and 56.67% respectively, P < 0.001). The scores of the COVID-19 protection theory test at 30 days of training were 95.67 ± 5.89, which were significantly higher than those at 3 days of training (P < 0.001). The qualified rate of disinfection and quarantine in the first month for the trained nurses entering the isolation ward was 89.47%;compared with that for the nurses originally in the isolation wards (94.7%), there was no significant difference (P > 0.05). The comprehensive nursing ability scores of bedside nurses in the first month of training were 80.14 ± 5.63, which were lower than those of nurses originally in the isolation wards (86.88 ± 4.53, P Conclusion: Systematic pre-job training for nurses in isolation wards can help improve nurses’ knowledge of the COVID-19, self-protection awareness, and protection skills, and can quickly train nurses who are competent for work in isolation wards. It is an important guarantee of “zero infection” for medical staff, and it can quickly and effectively help medical institutions respond to the COVID-19 pandemic in an emergency.展开更多
基金supported by the National Natural Science Foundation of China (No.U1810205).
文摘The coagulation process is a widely applied technology in water and wastewater treatment.Novel composite polyferric mag-nesium-silicate-sulfate(PFMS)coagulants were synthesized using Na_(2)SiO_(3)·9H_(2)O,Fe_(2)(SO_(4))_(3),and MgSO_(4) as raw materials in this paper.The effects of aging time,Fe:Si:Mg,and OH:M molar ratios(M represents the metal ions)on the coagulation performance of the as-pre-pared PFMS were systematically investigated to obtain optimum coagulants.The results showed that PFMS coagulant exhibited good co-agulation properties in the treatment of simulated humic acid-kaolin surface water and reactive dye wastewater.When the molar ratio was controlled at Fe:Si:Mg=2:2:1 and OH:M=0.32,the obtained PFMS presented excellent stability and a high coagulation efficiency.The removal efficiency of ultraviolet UV254 was 99.81%,and the residual turbidity of the surface water reached 0.56 NTU at a dosage of 30 mg·L^(-1).After standing the coagulant for 120 d in the laboratory,the removal efficiency of UV254 and residual turbidity of the surface wa-ter were 88.12%and 0.68 NTU,respectively,which accord with the surface water treatment requirements.In addition,the coagulation performance in the treatment of reactive dye wastewater was greatly improved by combining the advantages of magnesium and iron salts.Compared with polyferric silicate-sulfate(PFS)and polymagnesium silicate-sulfate(PMS),the PFMS coagulant played a better decolor-ization role within the pH range of 7-13.
基金Supported by Research Fund for Lin He’s Academician Workstation of New Medicine and Clinical Translation in Jining Medical University,No.JYHL2021FMS11and Jining Key Research and Development Projects,No.2022YXNS009.
文摘BACKGROUND Myosteatosis,rather than low muscle mass,is the primary etiologic factor of sarcopenia in patients with type 2 diabetes mellitus(T2DM).Myosteatosis may lead to a series of metabolic dysfunctions,such as insulin resistance,systematic inflammation,and oxidative stress,and all these dysfunctions are closely associated with the acceleration of T2DM and atherosclerosis.AIM To investigate the association between myosteatosis and coronary artery calcification(CAC)in patients with T2DM.METHODS Patients with T2DM,who had not experienced major cardiovascular events and had undergone both abdominal and thoracic computed tomography(CT)scans,were included.The mean skeletal muscle attenuation was assessed using abdominal CT images at the L3 level.The CAC score was determined from thoracic CT images using the Agatston scoring method.Myosteatosis was diagnosed according to Martin’s criteria.Severe CAC(SCAC)was defined when the CAC score exceeded 300.Logistic regression and decision tree analyses were performed.RESULTS A total of 652 patients with T2DM were enrolled.Among them,167(25.6%)patients had SCAC.Logistic regression analysis demonstrated that myosteatosis,age,duration of diabetes,cigarette smoking,and alcohol consumption were independent risk factors of SCAC.Myosteatosis was significantly associated with an increased risk of SCAC(OR=2.381,P=0.003).The association between myosteatosis and SCAC was significant in the younger patients(OR=2.672,95%CI:1.477-4.834,P=0.002),but not the older patients(OR=1.456,95%CI:0.863-2.455,P=0.188),and was more prominent in the population with lower risks of atherosclerosis.The decision tree analyses prioritized older age as the primary variable for SCAC.In older patients,cigarette smoking was the main contributing factor for SCAC,while in younger patients,it was myosteatosis.CONCLUSION Myosteatosis is a novel risk factor for atherosclerosis in patients with T2DM,especially in the population with younger ages and fewer traditional risk factors.
基金financially supported by the National Natural Science Foundation of China(No.22008167,21978187,21978196)the Natural Science Foundation for Young Scientists of Shanxi Province,China(Nos.201901D211100,201901D211058,201901D211027)。
基金the National Natural Science Foundation of China,No.82060707 and 82104381the Application and Basis Research Project of Yunnan China,No.202201AW070016,202001AZ070001-006,and 2019IB009the Young and Middle-aged Academic and Technological Leader of Yunnan,No.202005AC160059.
文摘BACKGROUND Metabolic dysfunction-associated fatty liver disease(MAFLD)is a severe threat to human health.Polygonum multiflorum(PM)has been proven to remedy mitochondria and relieve MAFLD,but the main pharmacodynamic ingredients for mitigating MAFLD remain unclear.AIM To research the active ingredients of PM adjusting mitochondria to relieve highfat diet(HFD)-induced MAFLD in rats.METHODS Fat emulsion-induced L02 adipocyte model and HFD-induced MAFLD rat model were used to investigate the anti-MAFLD ability of PM and explore their action mechanisms.The adipocyte model was also applied to evaluate the activities of PM-derived constituents in liver mitochondria from HFD-fed rats(mitochondrial pharmacology).PM-derived constituents in liver mitochondria were confirmed by ultra-high-performance liquid chromatography/mass spectrometry(mitochondrial pharmacochemistry).The abilities of PM-derived monomer and monomer groups were evaluated by the adipocyte model and MAFLD mouse model,respectively.RESULTS PM repaired mitochondrial ultrastructure and prevented oxidative stress and energy production disorder of liver mitochondria to mitigate fat emulsion-induced cellular steatosis and HFD-induced MAFLD.PM-derived constituents that entered the liver mitochondria inhibited oxidative stress damage and improved energy production against cellular steatosis.Eight chemicals were found in the liver mitochondria of PM-administrated rats.The anti-steatosis ability of one monomer and the anti-MAFLD activity of the monomer group were validated.CONCLUSION PM restored mitochondrial structure and function and alleviated MAFLD,which may be associated with the remedy of oxidative stress and energy production.The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD.Thus,PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction.Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.
文摘The non-noble metal modified sulfated zirconia was found easy to deactivate.Herein,highly active and highly stable non-noble core-shell Ni-S_(2)O_(8)^(2−)/Al_(2)O_(3)@ZrO_(2) catalysts(Ni-SA@Z-x,x=Al content in wt%)have been successfully prepared and investigated for n-pentane isomerization.The results showed that the core-shell Ni-SA@Z-30 provided a sustained high isopentane yield(63.1%)with little or no deactivation within 5000 min at a mild reaction pressure of 2.0 MPa,which can be attributed to the following factors:(i)carbon deposition was greatly suppressed by the large pore size and huge pore volume;(ii)the loss of sulfur entities was suppressed because the small and highly dispersed tetragonal ZrO_(2) particles can bond with the S species strongly;(iii)strong Brønsted acidity can be maintained well after the isomerization.The pore structures and acid nature of the core-shell Ni-SA@Z-x are entirely different from those of the normal structure Ni-S_(2)O_(8)^(2−)/ZrO_(2)-Al_(2)O_(3),even though the Al content and the compositions of the individual components are the same.The Al_(2)O_(3)cores endow the catalysts with high internal surface area and high mechanical strength.Meanwhile,the ZrO_(2) shell,which consists of more and smaller tetragonal ZrO_(2) particles because of the large surface area of the Al_(2)O_(3)core,promotes the formation of more stable sulfur species and stronger binding sites.
基金supported by the National Natural Science Foundation of China(Nos.12005211,12075192).
文摘Image distortion caused by the angular misalignment of quadrupole magnets in high-energy electron radiography has been studied systematically.We propose that the distortion originates from the coupling of the electron motions in the transverse directions,based on a theoretical analysis and the transfer-matrix method.The relative angular rotation between the second and third magnetic quadrupoles was identified as the main contributor to image distortion.This was verified by both a beam-dynamics simulation and experiments.Different strategies to mitigate this image distortion are also explored,including magnets online tuning,higher beam energy and larger magnification factor.This study provides criteria for designing experiments and paves the way for achieving higher image precision.
基金supported by Ministry of Science and Technology of the People's Republic of China(Grant No.:2022YFC3502300)Beijing Natural Science Foundation(Grant No.:L222150)+2 种基金the National Natural Science Foundation of China(Grant No.:82072247)the second batch of“Ten thousand plan”National High Level Talents Special Support Plan(Grant No.:W02020052)Beijing University of Chinese Medicine(Grant Nos.:XJYS21005,JY21024,MSGZF-202001,2022-syjs-05,and 2022-syjs-10).
文摘The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,making the identification and quantification of specific ingredients still a challenge.Herein,we developed a quality control(QC)system for monitoring TCM pharmaceuticals based on paper spray ionization miniature mass spectrometry(mini-MS).It enabled real-time online qualitative and quantitative detection of target ingredients in herbal extracts using mini-MS without chromatographic separation for the first time.Dynamic changes of alkaloids in Aconiti Lateralis Radix Praeparata(Fuzi)during decoction were used as examples,and the scientific principle of Fuzi compatibility was also investigated.Finally,the system was verified to work stably at the hourly level for pilot-scale extraction.This mini-MS based online analytical system is expected to be further developed for QC applications in a wider range of pharmaceutical processes.
基金financially supported by the National Natural Science Foundation of China(No.51972019)the National Key Research and Development Program of China(No.2019YFC1905702)。
文摘Waste heat recovery from hot steel slag was determined in a granular bed through the combination of numerical simulation and an industrial test method.First,the effective thermal conductivity of the granular bed was calculated.Then,the unsteady-state model was used to simulate the heat recovery under three different flow fields(O-type,S-type,and nonshielding type(Nontype)).Second,the simulation results were validated by in-situ industrial experiments.The two methods confirmed that the heat recovery efficiencies of the flow fields from high to low followed the order of Nontype,S-type,and O-type.Finally,heat recovery was carried out under the Nontype flow field in an industrial test.The heat recovery efficiency increased from~76%and~78%to~81%when the steel slag thickness decreased from 400 and 300 to 200 mm,corresponding to reductions in the steel slag mass from 3.96 and 2.97 to 1.98 t with a blower air volume of 14687 m^(3)/h.Therefore,the research results showed that numerical simulation can not only guide experiments on waste heat recovery but also optimize the flow field.Most importantly,the method proposed in this paper has achieved higher waste heat recovery from hot steel slag in industrial scale.
基金supported by the National Key R&D Program of China(grant Nos.2022YFF0503800,2021YFA1600503 and 2021YFA1600500)the National Natural Science Foundation of China(grant Nos.12250005,12073040,11973056,12003051,11573037,12073041,11427901,11973056,12173049 and 11611530679)+5 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(grant Nos.XDA15010700,XDA15320102 and XDB09040200)by the Youth Innovation Promotion Association of CAS(2019059)the ISSI International Team on Magnetic Helicity estimations in models and observations of the solar magnetic fieldsupported by the mobility program(M-0068)of the SinoGerman Science Center,the International Space Science Institute(ISSI)in Bernthe ISSI-BJ in Beijing,through ISSI International Team project 568ISSI-BJ International Team project 55(Magnetohydrostatic Modeling of the Solar Atmosphere with New Datasets).
文摘Magnetic helicity is an important concept in solar physics,with a number of theoretical statements pointing out the important role of magnetic helicity in solar flares and coronal mass ejections(CMEs).Here we construct a sample of 47 solar flares,which contains 18 no-CME-associated confined flares and 29 CME-associated eruptive flares.We calculate the change ratios of magnetic helicity and magnetic free energy before and after these 47 flares.Our calculations show that the change ratios of magnetic helicity and magnetic free energy show distinct different distributions in confined flares and eruptive flares.The median value of the change ratios of magnetic helicity in confined flares is-0.8%,while this number is-14.5%for eruptive flares.For the magnetic free energy,the median value of the change ratios is-4.3%for confined flares,whereas this number is-14.6%for eruptive flares.This statistical result,using observational data,is well consistent with the theoretical understandings that magnetic helicity is approximately conserved in the magnetic reconnection,as shown by confined flares,and the CMEs take away magnetic helicity from the corona,as shown by eruptive flares.
基金supported by National Natural Science Foundation of China(No.11575147)the Distinguished Youth Fund(No.JQZQ021901)。
文摘The discharge channel is a crucial diagnostic tool for identifying the properties of gas switches.However,single-view images cannot easily be used to inherently understand the discharge channel characteristics of trigger electrodes.A reconstruction method of the discharge channel in gas switches is proposed based on a multi-axis tomography technique,which uses very few projections of optical images to reconstruct the location of a multichannel discharge in annular electrodes.In this paper,an algorithm named TVM-OSEM(total variation minimization ordered subsets expectation maximization)is proposed,which can effectively remove artifact noise to improve the reconstruction accuracy of discharge channels.The method is validated against simulations of a radiator with high-density-difference boundary.The calculated discharge channel distribution from one experiment is presented.
基金supported by the National Natural Science Foundation of China(NSFC,grant No.11973056)the National Key R&D Program of China(grant No.2021YFA1600500)。
文摘Accurate measurement of magnetic fields is very important for understanding the formation and evolution of solar magnetic fields.Currently,there are two types of solar magnetic field measurement instruments:filter-based magnetographs and Stokes polarimeters.The former gives high temporal resolution magnetograms and the latter provides more accurate measurements of magnetic fields.Calibrating the magnetograms obtained by filter-based magnetographs with those obtained by Stokes polarimeters is a good way to combine the advantages of the two types.Our previous studies have shown that,compared to the magnetograms obtained by the Spectro-Polarimeter(SP)on board Hinode,those magnetograms obtained by both the filter-based Solar Magnetic Field Telescope(SMFT)of the Huairou Solar Observing Station and by the filter-based Michelson Doppler Imager(MDI)aboard SOHO have underestimated the flux densities in their magnetograms and systematic center-to-limb variations present in the magnetograms of both instruments.Here,using a sample of 75 vector magnetograms of stable alpha sunspots,we compare the vector magnetograms obtained by the Helioseismic and Magnetic Imager(HMI)aboard Solar Dynamics Observatory(SDO)with co-temporal vector magnetograms acquired by SP/Hinode.Our analysis shows that both the longitudinal and transverse flux densities in the HMI/SDO magnetograms are very close to those in the SP/Hinode magnetograms and the systematic center-to-limb variations in the HMI/SDO magnetograms are very minor.Our study suggests that using a filter-based magnetograph to construct a low spectral resolution Stokes profile,as done by HMI/SDO,can largely remove the disadvantages of the filter-type measurements and yet still possess the advantage of high temporal resolution.
基金supported in part by research grants from the National Key Research and Development Program of China(Grant Number:2017YFC0907200 and 2017YFC0907201).
文摘Objective:This study compared the prevalence,awareness,treatment and control of hypertension and associated factors in China and the United States(US).Methods:Adult data from nationally representative samples were derived from the Chronic Disease and Risk Factors Surveillance in 2010 and 2013 in China and the National Health and Nutrition Examination Survey in 2010 and 2013 in the US.Multivariable logistic and Poisson regression analysis were conducted to assess associations of the four outcomes with body weight status and behavioral factors.Results:Age-standardized prevalence rates of hypertension was 35.7%(95%confidence interval[CI]:35.4%to 36.1%)in 2010 and 29.8%(95%CI:29.4%to 30.2%)in 2013 in China,and 35.3%(95%CI:33.6%to 37.1%)in 2010 and 37.9%(95%CI:36.0%to 39.7%)in 2013 in the US.Among hypertensive participants,the age-standardized rates of treatment were 18.4%(95%CI:17.9%to 1&9%)in 2010 and 23.8%(95%CI:23.1%to 24.6%)in 2013 in China and 54.5%(95%CI:50.3%to 5&7%)in 2010 and 50.9%(95%CI:46.5%to 55.3%)in 2013 in the US;the age-standardized hypertension control rates were 3.2%(95%CI:3.0%to 3.5%)and 5.7%(95%CI:5.3%to 6.0%)in 2010 and 2013 in China and 50.6%(95%CI:46.2%to 55.0%)and 55.3%(95%CI:50.3%to 60.3%)in the US.Obesity was significantly associated with prevalence,awareness and control rates in both countries.Different from the US,obesity was negatively associated with hypertension control in China.Conclusion:Hypertension prevalence in China is similar to that in the US,but the control rate in China was significantly lower.Obesity was a critical risk factor for poor hypertension control in China.
文摘<span style="font-family:Verdana;">Purpose: </span><span style="font-family:Verdana;">To discuss the effect of “1 + 3 + 3” emergency management mode to deal with COVID-19 pandemic in fever outpatient service of general hospitals. Method: This paper analyzes and summarizes the problems encountered by fever outpatient service in dealing with the COVID-19 pandemic from three aspects of “One Team”, “Three-Key” Control and “Three Mosts”. Results: The application of “1 + 3 + 3” emergency management mode can effectively boost the orderliness and efficiency of fever outpatient service in dealing with COVID-19 pandemic. Conclusion: The “1 + 3 + 3” emergency management mode provides a new management mode and idea for dealing with COVID-19 pandemic,</span><span style="font-family:""> </span><span style="font-family:Verdana;">so the fever outpatient service of general hospitals can better improve the national overall anti-pandemic situation.
文摘<strong>Objective:</strong> To explore the clinical effects of conventional surgery, ultrasound-guided microwave ablation and rotational adenomammectomy on the prognosis of benign breast nodules. <strong>Methods:</strong> 232 cases of patients with benign breast nodules confirmed by pathological examination who received surgical treatment in the breast surgery department of our hospital from December 2016 to December 2020 were included. According to the surgical methods, they were divided into microwave ablation group (n = 48), conventional surgery group (n = 105) and rotational adenomammectomy group (n = 79). The clinical parameters were compared and analyzed between the three groups, and the postoperative pain, residual tumor, breast beauty and complication rate of the patients were evaluated. <strong>Results:</strong> Operative time, intraoperative blood loss, healing time and postoperative pain in microwave ablation group were lower than those of rotational adenomammectomy group (P < 0.05) and those of conventional surgery group (P < 0.05). Besides, those in the rotational adenomammectomy group were lower than those in the conventional surgery group (P < 0.05). The residual tumor rates in microwave ablation group and rotational adenomammectomy group were 4.17% and 3.80%, respectively. And the difference was not statistically significant (P > 0.05). Both of them were lower than 6.66% in conventional surgery group, with statistically significant differences (P < 0.05). The effective rates of breast beauty were 91.67%, 82.28% and 68.58% in the microwave ablation group, the rotational adenomammectomy group and the conventional surgery group, respectively. And the difference between groups was statistically significant (P < 0.05). The rate of postoperative complications in microwave ablation group and rotational adenomammectomy group were 4.17% and 3.80% respectively, both of which were significantly lower than 6.66% in conventional surgery group (P < 0.05). <strong>Conclusion:</strong> Microwave ablation, rotational adenomammectomy and conventional surgery are effective for the treatment of benign breast tumors. Among them, microwave ablation is the best option with many advantages of shorter operative time, less intraoperative blood loss, more beautiful breast shape, less postoperative pain, a lower residual rate after surgery, and a lower complication rate.
文摘Objective: To explore the effect of systematic pre-job training for isolation ward nurses during the Corona Virus Disease 2019 (COVID-19) pandemic. Methods: Establish a pre-job training program for the isolation ward for COVID-19, standardize the content of theoretical and skill training, formulate training SOPs, and conduct training for the nurses using online teaching assessment, video teaching, on-site scenario simulation operation drills, as well as real-time protection guidance and supervision. 60 nurses from non-infectious departments temporarily selected by the hospital were trained;the theoretical knowledge scores, quarantine techniques, and nursing quality of nurses before and after the training were compared, and the effect of the intervention was evaluated. Results: The scores of the COVID-19 protection theory test were 81.17 ± 8.46 after the nurses were trained for 3 days. The pass rates of hand hygiene compliance tests and protective clothing putting-on and taking-off practices were 96.67% and 100%, respectively. There was no significant difference between the scores of the COVID-19 protection theory test for the nurses that were trained for 3 days and the scores for the nurses originally at the quarantine zone (81.59 ± 7.59, P > 0.05). The pass rate of hand hygiene compliance and the pass rate of protective clothing putting-on and taking-off practices were significantly improved compared with those before training (81.67% and 56.67% respectively, P < 0.001). The scores of the COVID-19 protection theory test at 30 days of training were 95.67 ± 5.89, which were significantly higher than those at 3 days of training (P < 0.001). The qualified rate of disinfection and quarantine in the first month for the trained nurses entering the isolation ward was 89.47%;compared with that for the nurses originally in the isolation wards (94.7%), there was no significant difference (P > 0.05). The comprehensive nursing ability scores of bedside nurses in the first month of training were 80.14 ± 5.63, which were lower than those of nurses originally in the isolation wards (86.88 ± 4.53, P Conclusion: Systematic pre-job training for nurses in isolation wards can help improve nurses’ knowledge of the COVID-19, self-protection awareness, and protection skills, and can quickly train nurses who are competent for work in isolation wards. It is an important guarantee of “zero infection” for medical staff, and it can quickly and effectively help medical institutions respond to the COVID-19 pandemic in an emergency.
