We here aimed to investigate the impact of gender on the clinical characteristics and laboratory results of patients with coronavirus disease 2019(COVID-19)and provide clues to the pathological mechanisms underlying C...We here aimed to investigate the impact of gender on the clinical characteristics and laboratory results of patients with coronavirus disease 2019(COVID-19)and provide clues to the pathological mechanisms underlying COVID-19.A retrospective study was performed.Clinical characteristics,severity of lung infection,laboratory results,and prognoses of patients of different gender were analyzed.A total of 242 patients were finally included.The median age was 58 years(IQR:40-68),including 54(22.3%)hospital staffs.Ninety-four(38.8%)were male and 148(61.1%)were female.The proportion of patients with diabetes was significantly higher in the male group than in the female group(P=0.034).Male patients had a significantly larger proportion of severe lung infection,higher leukocyte count,neutrophil count,neutrophil-to-lymphocyte ratio,C-reactive protein,and procalcitonin than femalc.Furthermore,male patients had worse liver,cardiac,and coagulation function than their female counterparts.Male patients with COVID-19 showed more severe inflammation reaction and coagulation dysfunction than female patients.In conclusion,gender is associated with host response to SARS-CoV-2 infection.展开更多
基金supported by the National Natural Science Foundation of China(Nos.81570416,81570337)Hubei Province Health and Family Planning Scientifie Research Project(No.WJ2019M120)+3 种基金Natural Science Foundation of Hubei Province(No.2019CFB668)the Fundamental Research Fund for the Central Universities(HUST)(No.2017KFYXJJ099)the Science and Technology Project Foundation of Wuhan(No.2017060201010175)the Outstanding Young Investigator Foundation of Tongji Hospital(No.YXQN009)。
文摘We here aimed to investigate the impact of gender on the clinical characteristics and laboratory results of patients with coronavirus disease 2019(COVID-19)and provide clues to the pathological mechanisms underlying COVID-19.A retrospective study was performed.Clinical characteristics,severity of lung infection,laboratory results,and prognoses of patients of different gender were analyzed.A total of 242 patients were finally included.The median age was 58 years(IQR:40-68),including 54(22.3%)hospital staffs.Ninety-four(38.8%)were male and 148(61.1%)were female.The proportion of patients with diabetes was significantly higher in the male group than in the female group(P=0.034).Male patients had a significantly larger proportion of severe lung infection,higher leukocyte count,neutrophil count,neutrophil-to-lymphocyte ratio,C-reactive protein,and procalcitonin than femalc.Furthermore,male patients had worse liver,cardiac,and coagulation function than their female counterparts.Male patients with COVID-19 showed more severe inflammation reaction and coagulation dysfunction than female patients.In conclusion,gender is associated with host response to SARS-CoV-2 infection.
