Unlike most animals,plants fail to move bodily at will.However,movements also occur in every single part of plants out of energy and nutrients needs,spanning from milliseconds to hours on a time scale.And with the gro...Unlike most animals,plants fail to move bodily at will.However,movements also occur in every single part of plants out of energy and nutrients needs,spanning from milliseconds to hours on a time scale.And with the growing understanding of plant movement in the academic community,bionic soft robots based on plant movement principles are increasingly studied and are considered by scientists as a source of inspiration for innovative engineering solutions.In this paper,through the study of the biological morphology,microstructure,and motion mechanism of the flytrap,we developed chambered design rules,and designed and fabricated a gas-driven bionic flytrap blade,intending to investigate its feasibility of performing complex bending deformation.The experimental result shows that the bionic flytrap blade can achieve multi-dimensional bending deformation,and complete the bending and closing action within 2 s.The performance of the bionic flytrap blade fabricated is in high agreement with the real flytrap blade in terms of bending and deformation,achieving an excellent bionic design effect.In this study,the chambered design rules of the bionic flytrap blade were proposed and developed,and the possibility of its deformation was investigated.The effects of different chamber types and different flow channel design precepts on the bending deformation of the bionic flytrap blade were revealed,together with the relationship between the response time and flow rate of the bionic flytrap blade.At last,this study provides new ideas for the study of plant blade motion mechanism in a hope to expand the application fields of bionic robots,especially hope to offer solutions for plant-type robotics.展开更多
We report on emergence of an abnormal electronic polarization in twisted double bilayer WSe_(2) in antiparallel interface stacking geometry,where local centrosymmetry of atomic registries at the twist interface does n...We report on emergence of an abnormal electronic polarization in twisted double bilayer WSe_(2) in antiparallel interface stacking geometry,where local centrosymmetry of atomic registries at the twist interface does not favor the spontaneous electronic polarizations as recently observed in the parallel interface stacking geometry.The unconventional ferroelectric behaviors probed by electronic transport measurement occur at half filling insulating states at 1.5 K and gradually disappear at about 40 K.Single band Hubbard model based on the triangular moirélattice and the interlayer charge transfer controlled by insulating phase transition are proposed to interpret the formation of electronic polarization states near half filling in twisted WSe_(2) devices.Our work highlights the prominent role of many-body electronic interaction in fostering novel quantum states in moiré-structured systems.展开更多
In the present study,we aimed to confirm whether NF-κB inhibitor pyrrolidine dithiocarbamate(PDTC)could induce apoptosis of human hepatic stellate cells(HSCs)LX-2 and explore the potential pharmacological mechanism u...In the present study,we aimed to confirm whether NF-κB inhibitor pyrrolidine dithiocarbamate(PDTC)could induce apoptosis of human hepatic stellate cells(HSCs)LX-2 and explore the potential pharmacological mechanism underlying these effects.In this study,LX-2 cells were cultured in vitro,and the experiment was divided into two groups,including the control and PDTC groups.The viability of LX-2 cells was measured by CCK8 assay after the cells were exposed to PDTC.The anti-apoptotic effect of PDTC was detected by AO/EB double assay staining kit.Additionally,the activities of NF-κB,Fas/FasL,apoptosis-related proteins,as well as the cellular localization of AIF,were determined by Western blotting analysis and immunofluorescence staining respectively.After PDTC treatment for 12 and 24 h,AO/EB dual staining showed typical apoptotic changes,such as cell volume reduction,cell shrinkage,nuclear fragmentation,and so on.PDTC at 60μmol/L significantly increased the proliferation inhibition rate and decreased the secretion of collagen I,collagen III,andα-SMA in LX-2 cells.The Western blotting analysis and RT-PCR showed no significant difference in the expression of AIF between the control group and PDTC group,and the expressions of Fas and FasL were not observed in all groups(P>0.05).Further results showed that PDTC could promote the displacement of AIF from mitochondria to the nucleus,activate the apoptotic signaling in the cell nucleus,and possibly participate in the apoptosis process of LX-2 cells.In conclusion,the pharmacological mechanism of PDTC against hepatic fibrosis might be to promote the displacement of AIF from mitochondria to the nucleus,then activate the apoptotic signaling in the cell nucleus,and finally induce the apoptosis of LX-2 cells.Meanwhile,these results also revealed that the Fas/FasL-mediated apoptosis pathway was not involved in the PDTC-induced apoptosis process of LX-2 cells.展开更多
基金the National Natural Science Foundation of China,51905084the Natural Science Foundation of Heilongjiang Province,YQ2021E002.
文摘Unlike most animals,plants fail to move bodily at will.However,movements also occur in every single part of plants out of energy and nutrients needs,spanning from milliseconds to hours on a time scale.And with the growing understanding of plant movement in the academic community,bionic soft robots based on plant movement principles are increasingly studied and are considered by scientists as a source of inspiration for innovative engineering solutions.In this paper,through the study of the biological morphology,microstructure,and motion mechanism of the flytrap,we developed chambered design rules,and designed and fabricated a gas-driven bionic flytrap blade,intending to investigate its feasibility of performing complex bending deformation.The experimental result shows that the bionic flytrap blade can achieve multi-dimensional bending deformation,and complete the bending and closing action within 2 s.The performance of the bionic flytrap blade fabricated is in high agreement with the real flytrap blade in terms of bending and deformation,achieving an excellent bionic design effect.In this study,the chambered design rules of the bionic flytrap blade were proposed and developed,and the possibility of its deformation was investigated.The effects of different chamber types and different flow channel design precepts on the bending deformation of the bionic flytrap blade were revealed,together with the relationship between the response time and flow rate of the bionic flytrap blade.At last,this study provides new ideas for the study of plant blade motion mechanism in a hope to expand the application fields of bionic robots,especially hope to offer solutions for plant-type robotics.
基金supported by the National Key R&D Program of China(2020YFA 0309600)the Hong Kong Research Grants Council(AoE/P-701/20,C6025-19G,16305919 ECS26302118,16303720,16305019,16306220 and N_HKUST626/18)+1 种基金the National Natural Science Foundation of China(NSFC20SC07)the William Mong Institute of Nano Science and Technology.
文摘We report on emergence of an abnormal electronic polarization in twisted double bilayer WSe_(2) in antiparallel interface stacking geometry,where local centrosymmetry of atomic registries at the twist interface does not favor the spontaneous electronic polarizations as recently observed in the parallel interface stacking geometry.The unconventional ferroelectric behaviors probed by electronic transport measurement occur at half filling insulating states at 1.5 K and gradually disappear at about 40 K.Single band Hubbard model based on the triangular moirélattice and the interlayer charge transfer controlled by insulating phase transition are proposed to interpret the formation of electronic polarization states near half filling in twisted WSe_(2) devices.Our work highlights the prominent role of many-body electronic interaction in fostering novel quantum states in moiré-structured systems.
基金supported by the Fujian Provincial Natural Science Foundation,China(Grant No.2019J01611)the Youth Project of Fujian Provincial Health Commission,Fujian Province,China(Grant No.2017-1-94).
文摘In the present study,we aimed to confirm whether NF-κB inhibitor pyrrolidine dithiocarbamate(PDTC)could induce apoptosis of human hepatic stellate cells(HSCs)LX-2 and explore the potential pharmacological mechanism underlying these effects.In this study,LX-2 cells were cultured in vitro,and the experiment was divided into two groups,including the control and PDTC groups.The viability of LX-2 cells was measured by CCK8 assay after the cells were exposed to PDTC.The anti-apoptotic effect of PDTC was detected by AO/EB double assay staining kit.Additionally,the activities of NF-κB,Fas/FasL,apoptosis-related proteins,as well as the cellular localization of AIF,were determined by Western blotting analysis and immunofluorescence staining respectively.After PDTC treatment for 12 and 24 h,AO/EB dual staining showed typical apoptotic changes,such as cell volume reduction,cell shrinkage,nuclear fragmentation,and so on.PDTC at 60μmol/L significantly increased the proliferation inhibition rate and decreased the secretion of collagen I,collagen III,andα-SMA in LX-2 cells.The Western blotting analysis and RT-PCR showed no significant difference in the expression of AIF between the control group and PDTC group,and the expressions of Fas and FasL were not observed in all groups(P>0.05).Further results showed that PDTC could promote the displacement of AIF from mitochondria to the nucleus,activate the apoptotic signaling in the cell nucleus,and possibly participate in the apoptosis process of LX-2 cells.In conclusion,the pharmacological mechanism of PDTC against hepatic fibrosis might be to promote the displacement of AIF from mitochondria to the nucleus,then activate the apoptotic signaling in the cell nucleus,and finally induce the apoptosis of LX-2 cells.Meanwhile,these results also revealed that the Fas/FasL-mediated apoptosis pathway was not involved in the PDTC-induced apoptosis process of LX-2 cells.
