Human normal flora is a source of probiotics.The safety characteristics of a specific isolate determine its application in foods or drugs.The food-borne-pathogen antagonist strain Lactobacillus gasseri HMV18 is one of...Human normal flora is a source of probiotics.The safety characteristics of a specific isolate determine its application in foods or drugs.The food-borne-pathogen antagonist strain Lactobacillus gasseri HMV18 is one of the isolates from normal human flora.In this work,we assessed the in vitro pH tolerance,bile tolerance,biogenic amine production,mucin utilization,and safety of in vivo administration to mice to evaluate general health,organ-body weight index,organ histopathological change,whether L.gasseri HMV18 can colonize in the gut or modulate the gut microbiota after oral administration.The results suggest that L.gasseri HMV18 can tolerate pH 3 for 2 h,3%bile for 3 h,biogenic amine negative,mucin usage negative,does not encode verified toxins,and cause no visible change in mice's organs.L.gasseri HMV18 might not colonize in mice's gut,but can significantly affect the structure of gut microbiota.A bibliographical survey suggested that there were as few as 8 opportunistic infection cases from 1984 to 2022 and that the possibility for L.gasseri to cause infection is relatively low.Therefore,this work provides a basis for the foods or drugs application of L.gasseri HMV18 and gives a map of experiments for the safety assessment of probiotics.展开更多
Objective:To study the therapeutic efficacy of patients with ulcerative colitis receiving Bifidobacterium quadruple viable tablets.Methods:49 cases were selected from ulcerative colitis patients who attended the clini...Objective:To study the therapeutic efficacy of patients with ulcerative colitis receiving Bifidobacterium quadruple viable tablets.Methods:49 cases were selected from ulcerative colitis patients who attended the clinic from February 2021 to November 2022,and were randomly grouped into group A for addition of Bifidobacterium quadruple viable tablets treatment,and group B for conventional medication.The efficacy,inflammatory factors,nutritional indexes,and adverse reactions were compared between the groups.Results:The efficacy of UC patients in group A was higher than that in group B(P<0.05);the inflammatory factors in group A were lower than that in group B(P<0.05);nutritional indicators in group A were higher than that in group B(P<0.05);and the adverse reactions of medication in UC patients in group A were lower than that in group B(P<0.05).Conclusion:The treatment of UC patients with the addition of Bifidobacterium quadruple viable tablets can improve the nutritional status of the organism,inhibit the progression of inflammation,and is safe and efficient in treating ulcerative colitis.展开更多
In order to overcome some defects of the traditional immune algorithm, the immune algorithm was improved for solving a path optimization problem in deep immune learning of a gene network. Firstly, the diversity of the...In order to overcome some defects of the traditional immune algorithm, the immune algorithm was improved for solving a path optimization problem in deep immune learning of a gene network. Firstly, the diversity of the solution population was enhanced in the evolution process by improving the memory cell processing method. Moreover, effective gene information was dynamically extracted from the genes of the excellent antibodies to make good vaccines in the process of immune evolution. Worse antibodies were optimized by vaccinating these antibodies, and the convergence of the immune algorithm to the optimal solution was improved. Finally, the feasibility of the improved immune algorithm was verified in the experimental simulation for solving the classic NP problem in deep immune learning of the gene network.展开更多
While lithium-sulfur(Li-S)battery has attracted remarkable attention owing to the high theoretical capacity,its practical application is still hindered by the shuttle and sluggish conversion kinetics of intermediate l...While lithium-sulfur(Li-S)battery has attracted remarkable attention owing to the high theoretical capacity,its practical application is still hindered by the shuttle and sluggish conversion kinetics of intermediate lithium polysulfides(Li PSs).Defect engineering,which can regulate the electronic structure and in turn influence the surface adsorption and catalytic capability,has been regarded as a feasible strategy to deal with the above challenges.However,few studies on nitrogen vacancies and their mechanisms are reported.Herein,cobalt nitride with nitrogen vacancies grown on multi-walled carbon nanotube(CNTCo N-VN)is designed and applied as the separator modification material to investigate the enhancing mechanism of nitrogen vacancies on Li-S batteries.The experimental evidence and theoretical calculation indicate that the introduction of nitrogen vacancies into cobalt nitride can enhance the chemical affinity to Li PSs and effectively hamper the shuttle effect.Meanwhile the reduced band gap of the d-band center of Co and p-band center of N for CNT-Co N-VNand the promoted diffusion of Li^(+) can expedite the solid-liquid and liquid-liquid conversions of sulfur species.Due to these superiorities,the cell with CNT-Co NVNmodified separator delivers a favorable initial capacity of 901 m Ah g^(-1)and a capacity of 660 m Ah g^(-1)can be achieved after 250 cycles at 2 C.This work explores the application of metal nitride with nitrogen vacancies and sheds light on the development of functional separators for high-efficient Li-S batteries.展开更多
Saposhnikovia divaricata(SD)has high medicinal and edible value,but relatively little research has been done on its qual-ity markers(Q-markers).To further clarify the Q-markers of SD with their corresponding pharmacod...Saposhnikovia divaricata(SD)has high medicinal and edible value,but relatively little research has been done on its qual-ity markers(Q-markers).To further clarify the Q-markers of SD with their corresponding pharmacodynamic targets.In this experiment,14 batches of SD were identified and screened for Q-marker candidate components using a combination of HPLC fingerprint with similarity analysis,principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis.Then,network pharmacology was used to predict Q-markers and core targets.The results showed that 5-O-methylvisammioside,cimifugin,and prim-O-glucosylcimifugin could be used as Q-markers of SD;while,MAPK1,MAPK3,PIK3CA,JUN,and MAPK8 were the core targets of SD for drug efficacy.To further evaluate the bind-ing efficiency of Q-markers,molecular docking of the main active ingredients of SD to the core targets was performed.The results showed that the compounds bind well to their targets,and binding energies were all less than-5 kcal/mol.The Q-markers obtained from the screening were closely related to the core target genes,which could achieve therapeutic effects by modulating the relevant signaling pathways.This study offers a reference for the establishment of a set of quality control evaluation system for SD potential Q-markers prediction analysis,and lays the foundation for elucidating the mechanism of actionunderlying itspharmacodynamic substance.展开更多
To investigate the relationship between the alkenone unsaturation index(U^(K′)_(37)) and sea surface temperature(SST) in coastal and continental shelf waters, 58 surface sediment samples were collected from the South...To investigate the relationship between the alkenone unsaturation index(U^(K′)_(37)) and sea surface temperature(SST) in coastal and continental shelf waters, 58 surface sediment samples were collected from the South China Sea(SCS), Taiwan Strait,and East China Sea(ECS). We combined the new results with the previously published 71 data points from the SCS, the shallow water areas of the Yellow Sea(YS) and northern ECS, to form a dataset with sample sites spanning across 6°N and 37°N(including annual SST calibration between 14.3℃ and 28.6℃). With this dataset, we examined the U^(K′)_(37)-SST relationship based on 129 samples from the Western North Pacific(WNP) margin as well as using 85 samples from specific WNP shallow water.The U^(K′)_(37)index from the low-mid latitudinal WNP margin demonstrated a good correlation with the surface annual mean SST(0–50 m water depth;R^(2)=0.89). The slope of linear regression(U^(K′)_(37)-SST) based on the coastal-continental shelf samples with water depth less than 200 m is similar to that of the published global open ocean regression equation. These results confirm that U^(K′)_(37)can be used as a shallow sea water SST proxy in mid-low latitudes of the WNP marginal seas. In addition, our reintegrated U^(K′)_(37)-SST results based on 172 global shallow water samples are similar(similar slopes and intercepts) to the shallow ocean results in the WNP marginal seas. However, the similarity of the regression formula to the open ocean does not imply that the formula is applicable. For example, of the 85 data in the shallow waters from the marginal sea in this study, the majority of data points lie above the regression line, showing positive residuals for U^(K′)_(37). This regression bias appears to be caused by specific marine environments, such as warm ocean currents and/or high nutrient conditions that result in positive U^(K′)_(37)residuals. Taken together,considering the specific temperature and environmental factors in the shallow waters of the low-mid-latitude WNP margin, we propose a nonlinear U^(K′)_(37)-SST regression formula: U^(K′)_(37)=-1.2488+0.1740×SST-0.0035×(SST)2, R2=0.93, N=85, specifically for the environments with SST below 24℃.展开更多
Basal-like breast cancer with a luminal progenitor gene expression profile is an aggressive subtype of breast cancer with a poorer prognosis compared with other subtypes.However,genes that specifically promote basal-l...Basal-like breast cancer with a luminal progenitor gene expression profile is an aggressive subtype of breast cancer with a poorer prognosis compared with other subtypes.However,genes that specifically promote basal-like breast cancer development remain largely unknown.Here,we report that a novel gene C1orf106 plays an important role in maintaining the feature of basal-like/luminal progenitors.C1orf106 is frequently amplified and overexpressed in basal-like breast cancer and is associated with a poor outcome in patients.In human TCGA database,C1orf106 expression was correlated with upregulation of ELF5 and downregulation of GATA3,two transcription factors that regulate mammary gland stem cell fate.Enhanced expression of C1orf106 promotes tumor progression and expression of basal-like/luminal progenitor marker ELF5;depletion of C1orf106 suppresses tumorigenesis and expression of basal-like/luminal progenitor marker GATA3.These findings suggest that C1orf106 maintains the basal-like/luminal progenitor character through balancing the expression of ELF5 and GATA3.Taken together,we demonstrated that C1orf106 is an important regulator for basal-like/luminal progenitors and targeting C1orf106 is of therapeutic value for breast cancer.展开更多
Pillararenes are a new type of supramolecular hosts,and they have been widely applied in drug delivery,catalysis,separation process,and sensors.However,they have rarely been used to produce hydrogen.Here,we report tha...Pillararenes are a new type of supramolecular hosts,and they have been widely applied in drug delivery,catalysis,separation process,and sensors.However,they have rarely been used to produce hydrogen.Here,we report that pillararenes were used as functional molecules to explore photocatalysts and efficiently promoted hydrogen production from water.The most common and easily synthesized pdimethoxy pillar[5]arene(PI-OMe) was employed to form an organic-inorganic hybrid material with titanium dioxide(TiO_(2)),denoted as PI-OMe-TiO_(2).using a convenient sol-gel method.When the material was loaded with Pt nanoparticles,the resulting Pt/PI-OMe-TiO_(2)had a good activity and stability in catalyzing water splitting to produce hydrogen under visible light.The optimized catalyst Pt/PI-OMe-TiO_(2)(5.2 wt%)had a photocatalytic hydrogen production rate of 1736 μmol g^(-1)h^(-1) under visible light(λ> 420 nm)irradiation.The catalyst with a Pt loading of 0.5 wt% and a PI-OMe content of 5.2 wt% also showed good long-term durability after 10 cycles of 50 h testing.The total amount of hydrogen produced was65.01 mmol/g,and the corresponding turnover number(TON) value was 2084.Our findings suggest that pillararene derivatives are promising functional molecules to make efficient and stable hybrid photocatalysts with TiO_(2)and open a new door to hydrogen production using visible light.展开更多
Operating efficiency of universities is widely concerned by the education community.As a non-parametric method for efficiently handling multiple inputs and outputs,data envelopment analysis(DEA)is often used for measu...Operating efficiency of universities is widely concerned by the education community.As a non-parametric method for efficiently handling multiple inputs and outputs,data envelopment analysis(DEA)is often used for measuring the operating efficiency.However,shared input resources are often ignored in the existing DEA studies.In order to remedy the shortcoming with a focus on teaching and research processes of universities,this paper adopts an extended two-stage network DEA approach to measure the operating efficiency of 52 universities in China using a data set in 2014.The main findings show that:(1)Among the operating efficiency of 52 universities,about one third and two thirds of universities are efficient and inefficient,respectively.It may reflect some problems such as inefficient use of resources or unsatisfactory outcomes for these inefficient universities.By giving first priority to universities’teaching or research process,we provide alternative ways for teaching-oriented or research-oriented universities to benchmark and improve their performance.(2)For the heterogeneity efficiency analysis of different universities,the operating efficiency of“non-985”universities are significantly higher than that of“985”universities,while there is only a small difference on the operating efficiency between comprehensive universities and science&engineering universities.Although the efficiency of the central and western universities is slightly better than that of the eastern universities in terms of the average efficiency,there is no significant efficiency difference among the eastern,central,and western regions statistically.Hence,to improve the operating efficiency of Chinese universities,the Chinese government should improve the financial allocation mechanism and introduce successful budget performance management.For the Chinese universities,they should formulate teaching and scientific research plans according to their own research needs and development goals.展开更多
Detection of circulating tumor cells(CTCs)plays an important role in early diagnosis of cancer and personalized therapy.However,isolated CTCs,especially those captured by positive sorting methods,are difficult to cult...Detection of circulating tumor cells(CTCs)plays an important role in early diagnosis of cancer and personalized therapy.However,isolated CTCs,especially those captured by positive sorting methods,are difficult to culture in subsequent assays because the cells have to be labeled or attached to a substrate for separation.In this study,a negative sorting method has been developed for isolation of CTCs through a microfluidic platform integrated with streptavidin-functionalized electro-spun polylactic-co-glycolic acid nanofibers.Through the specific biotin-streptavidin interaction,the device is able to sort out biotinylated anti-CD45 antibody-labeled white blood cells(WBCs)and enrich A549 human cancer cells from the blood or CTCs from patient suffering non-small cell lung cancer.We demonstrate that the WBC capture efficiency is as high as 97.0%,and the recovery rate of cancer cells reaches up to 97.5%.CTCs are enumerated from blood samples of patients suf-fering lung carcinoma.The number of CTCs increased with the progression of NCCN TNM stages and showed statistically significant difference between stage I and later stages.These results suggest that the integrated negative sorting device is promising to be used for diagnosis of cancer.展开更多
In order to optimize the out-of-plane compression performance of the wood structure,wood-based 2-D lattice structures were designed and manufactured with oriented strand board as the panel and birch round stick as the...In order to optimize the out-of-plane compression performance of the wood structure,wood-based 2-D lattice structures were designed and manufactured with oriented strand board as the panel and birch round stick as the core by using a simple insert-glue method.In this experiment,the different thicknesses of the upper and lower panels,the different shavings arrangement directions of the upper and lower panels and the different configurations of the specimens were used to analyze the compression performance of the specimens under multivariable conditions.Through the combination of experimental test and theoretical analysis,we analyzed and compared different failure types of the structure and multiple compression parameters.The results showed that the shavings arrangement direction of the panel has a more important influence on the whole specimen than the thickness of the panel,especially the transverse shavings of the panel can withstand greater shear stress than the longitudinal shavings for a specimen.展开更多
基金financially supported by postdoctoral funding of Hebei Medical UniversityHebei Province Postdoctoral Research Project Funding(B2022003035)+5 种基金Natural Science Foundation of Hebei Province(H2020206579)CAMS Innovation Found for Medical Sciences(2019-I2M-5-055)2023 Scientific Research Projects of Colleges and Universities in Hebei Province(QN2023131)S&T Program of Hebei(18277743D)Undergraduate Innovation Experiment Project from Hebei Medical University(USIP2019008)Spring rain project of Hebei Medical University(CYCZ201906)。
文摘Human normal flora is a source of probiotics.The safety characteristics of a specific isolate determine its application in foods or drugs.The food-borne-pathogen antagonist strain Lactobacillus gasseri HMV18 is one of the isolates from normal human flora.In this work,we assessed the in vitro pH tolerance,bile tolerance,biogenic amine production,mucin utilization,and safety of in vivo administration to mice to evaluate general health,organ-body weight index,organ histopathological change,whether L.gasseri HMV18 can colonize in the gut or modulate the gut microbiota after oral administration.The results suggest that L.gasseri HMV18 can tolerate pH 3 for 2 h,3%bile for 3 h,biogenic amine negative,mucin usage negative,does not encode verified toxins,and cause no visible change in mice's organs.L.gasseri HMV18 might not colonize in mice's gut,but can significantly affect the structure of gut microbiota.A bibliographical survey suggested that there were as few as 8 opportunistic infection cases from 1984 to 2022 and that the possibility for L.gasseri to cause infection is relatively low.Therefore,this work provides a basis for the foods or drugs application of L.gasseri HMV18 and gives a map of experiments for the safety assessment of probiotics.
文摘Objective:To study the therapeutic efficacy of patients with ulcerative colitis receiving Bifidobacterium quadruple viable tablets.Methods:49 cases were selected from ulcerative colitis patients who attended the clinic from February 2021 to November 2022,and were randomly grouped into group A for addition of Bifidobacterium quadruple viable tablets treatment,and group B for conventional medication.The efficacy,inflammatory factors,nutritional indexes,and adverse reactions were compared between the groups.Results:The efficacy of UC patients in group A was higher than that in group B(P<0.05);the inflammatory factors in group A were lower than that in group B(P<0.05);nutritional indicators in group A were higher than that in group B(P<0.05);and the adverse reactions of medication in UC patients in group A were lower than that in group B(P<0.05).Conclusion:The treatment of UC patients with the addition of Bifidobacterium quadruple viable tablets can improve the nutritional status of the organism,inhibit the progression of inflammation,and is safe and efficient in treating ulcerative colitis.
文摘In order to overcome some defects of the traditional immune algorithm, the immune algorithm was improved for solving a path optimization problem in deep immune learning of a gene network. Firstly, the diversity of the solution population was enhanced in the evolution process by improving the memory cell processing method. Moreover, effective gene information was dynamically extracted from the genes of the excellent antibodies to make good vaccines in the process of immune evolution. Worse antibodies were optimized by vaccinating these antibodies, and the convergence of the immune algorithm to the optimal solution was improved. Finally, the feasibility of the improved immune algorithm was verified in the experimental simulation for solving the classic NP problem in deep immune learning of the gene network.
基金supported by the Beijing Institute of Technology Research Fund Program for Young Scholars and the Analysis&Testing Center(Beijing Institute of Technology)the National Natural Science Foundation of China(22179007)。
文摘While lithium-sulfur(Li-S)battery has attracted remarkable attention owing to the high theoretical capacity,its practical application is still hindered by the shuttle and sluggish conversion kinetics of intermediate lithium polysulfides(Li PSs).Defect engineering,which can regulate the electronic structure and in turn influence the surface adsorption and catalytic capability,has been regarded as a feasible strategy to deal with the above challenges.However,few studies on nitrogen vacancies and their mechanisms are reported.Herein,cobalt nitride with nitrogen vacancies grown on multi-walled carbon nanotube(CNTCo N-VN)is designed and applied as the separator modification material to investigate the enhancing mechanism of nitrogen vacancies on Li-S batteries.The experimental evidence and theoretical calculation indicate that the introduction of nitrogen vacancies into cobalt nitride can enhance the chemical affinity to Li PSs and effectively hamper the shuttle effect.Meanwhile the reduced band gap of the d-band center of Co and p-band center of N for CNT-Co N-VNand the promoted diffusion of Li^(+) can expedite the solid-liquid and liquid-liquid conversions of sulfur species.Due to these superiorities,the cell with CNT-Co NVNmodified separator delivers a favorable initial capacity of 901 m Ah g^(-1)and a capacity of 660 m Ah g^(-1)can be achieved after 250 cycles at 2 C.This work explores the application of metal nitride with nitrogen vacancies and sheds light on the development of functional separators for high-efficient Li-S batteries.
基金funded by Fundamental Research Funds for the Central Universities(2572022DJ01)Natural Science Foundation of Heilongjiang Province(LH2022B004)+1 种基金111 Project(B20088)Heilongjiang Touyan Innovation Team Program(Tree Genetics and Breeding Innovation Team).
文摘Saposhnikovia divaricata(SD)has high medicinal and edible value,but relatively little research has been done on its qual-ity markers(Q-markers).To further clarify the Q-markers of SD with their corresponding pharmacodynamic targets.In this experiment,14 batches of SD were identified and screened for Q-marker candidate components using a combination of HPLC fingerprint with similarity analysis,principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis.Then,network pharmacology was used to predict Q-markers and core targets.The results showed that 5-O-methylvisammioside,cimifugin,and prim-O-glucosylcimifugin could be used as Q-markers of SD;while,MAPK1,MAPK3,PIK3CA,JUN,and MAPK8 were the core targets of SD for drug efficacy.To further evaluate the bind-ing efficiency of Q-markers,molecular docking of the main active ingredients of SD to the core targets was performed.The results showed that the compounds bind well to their targets,and binding energies were all less than-5 kcal/mol.The Q-markers obtained from the screening were closely related to the core target genes,which could achieve therapeutic effects by modulating the relevant signaling pathways.This study offers a reference for the establishment of a set of quality control evaluation system for SD potential Q-markers prediction analysis,and lays the foundation for elucidating the mechanism of actionunderlying itspharmacodynamic substance.
基金supported by the Guangzhou Science and Technology Plan Project(Grant No.202102080366)the Guangdong Academy of Sciences(Grant No.2016GDASRC-0209)+1 种基金the Research Grant Council of Hong Kong(Grant No.HKU17311816)the National Natural Science Foundation of China(Grant Nos.42106062,41706039&41606070)。
文摘To investigate the relationship between the alkenone unsaturation index(U^(K′)_(37)) and sea surface temperature(SST) in coastal and continental shelf waters, 58 surface sediment samples were collected from the South China Sea(SCS), Taiwan Strait,and East China Sea(ECS). We combined the new results with the previously published 71 data points from the SCS, the shallow water areas of the Yellow Sea(YS) and northern ECS, to form a dataset with sample sites spanning across 6°N and 37°N(including annual SST calibration between 14.3℃ and 28.6℃). With this dataset, we examined the U^(K′)_(37)-SST relationship based on 129 samples from the Western North Pacific(WNP) margin as well as using 85 samples from specific WNP shallow water.The U^(K′)_(37)index from the low-mid latitudinal WNP margin demonstrated a good correlation with the surface annual mean SST(0–50 m water depth;R^(2)=0.89). The slope of linear regression(U^(K′)_(37)-SST) based on the coastal-continental shelf samples with water depth less than 200 m is similar to that of the published global open ocean regression equation. These results confirm that U^(K′)_(37)can be used as a shallow sea water SST proxy in mid-low latitudes of the WNP marginal seas. In addition, our reintegrated U^(K′)_(37)-SST results based on 172 global shallow water samples are similar(similar slopes and intercepts) to the shallow ocean results in the WNP marginal seas. However, the similarity of the regression formula to the open ocean does not imply that the formula is applicable. For example, of the 85 data in the shallow waters from the marginal sea in this study, the majority of data points lie above the regression line, showing positive residuals for U^(K′)_(37). This regression bias appears to be caused by specific marine environments, such as warm ocean currents and/or high nutrient conditions that result in positive U^(K′)_(37)residuals. Taken together,considering the specific temperature and environmental factors in the shallow waters of the low-mid-latitude WNP margin, we propose a nonlinear U^(K′)_(37)-SST regression formula: U^(K′)_(37)=-1.2488+0.1740×SST-0.0035×(SST)2, R2=0.93, N=85, specifically for the environments with SST below 24℃.
基金supported by the Ministry of Science and Technology of China (2016YFC1302103 and 2015CB553906)the National Natural Science Foundation of China (81230051, 81472734,31170711, 81321003, and 30830048)+3 种基金the Beijing Natural Science Foundation (7120002)the 111 Project of the Ministry of Education, Peking University (BMU2018JC004, BMU20120314, and BMU20130364)a Leading Academic Discipline Project of Beijing Education Bureau to H.Za grant from the National Natural Science Foundation of China (81773199) to J.Z
文摘Basal-like breast cancer with a luminal progenitor gene expression profile is an aggressive subtype of breast cancer with a poorer prognosis compared with other subtypes.However,genes that specifically promote basal-like breast cancer development remain largely unknown.Here,we report that a novel gene C1orf106 plays an important role in maintaining the feature of basal-like/luminal progenitors.C1orf106 is frequently amplified and overexpressed in basal-like breast cancer and is associated with a poor outcome in patients.In human TCGA database,C1orf106 expression was correlated with upregulation of ELF5 and downregulation of GATA3,two transcription factors that regulate mammary gland stem cell fate.Enhanced expression of C1orf106 promotes tumor progression and expression of basal-like/luminal progenitor marker ELF5;depletion of C1orf106 suppresses tumorigenesis and expression of basal-like/luminal progenitor marker GATA3.These findings suggest that C1orf106 maintains the basal-like/luminal progenitor character through balancing the expression of ELF5 and GATA3.Taken together,we demonstrated that C1orf106 is an important regulator for basal-like/luminal progenitors and targeting C1orf106 is of therapeutic value for breast cancer.
基金financial support from the Natural Science Foundation of Hainan Province,China (No. 219QN151)the National Natural Science Foundation of China (No. 21801052)+1 种基金the Hainan University Start-up fund (No. KYQD(ZR)1852)the construction program of research platform in Hainan University (No.ZY2019HN09)。
文摘Pillararenes are a new type of supramolecular hosts,and they have been widely applied in drug delivery,catalysis,separation process,and sensors.However,they have rarely been used to produce hydrogen.Here,we report that pillararenes were used as functional molecules to explore photocatalysts and efficiently promoted hydrogen production from water.The most common and easily synthesized pdimethoxy pillar[5]arene(PI-OMe) was employed to form an organic-inorganic hybrid material with titanium dioxide(TiO_(2)),denoted as PI-OMe-TiO_(2).using a convenient sol-gel method.When the material was loaded with Pt nanoparticles,the resulting Pt/PI-OMe-TiO_(2)had a good activity and stability in catalyzing water splitting to produce hydrogen under visible light.The optimized catalyst Pt/PI-OMe-TiO_(2)(5.2 wt%)had a photocatalytic hydrogen production rate of 1736 μmol g^(-1)h^(-1) under visible light(λ> 420 nm)irradiation.The catalyst with a Pt loading of 0.5 wt% and a PI-OMe content of 5.2 wt% also showed good long-term durability after 10 cycles of 50 h testing.The total amount of hydrogen produced was65.01 mmol/g,and the corresponding turnover number(TON) value was 2084.Our findings suggest that pillararene derivatives are promising functional molecules to make efficient and stable hybrid photocatalysts with TiO_(2)and open a new door to hydrogen production using visible light.
基金This research was supported by National Natural Science Foundation of China under Grants(Nos.71601064,72071067,71801067,71871081)the Major Project of the National Social Science Foundation of China(No.18ZDA064).
文摘Operating efficiency of universities is widely concerned by the education community.As a non-parametric method for efficiently handling multiple inputs and outputs,data envelopment analysis(DEA)is often used for measuring the operating efficiency.However,shared input resources are often ignored in the existing DEA studies.In order to remedy the shortcoming with a focus on teaching and research processes of universities,this paper adopts an extended two-stage network DEA approach to measure the operating efficiency of 52 universities in China using a data set in 2014.The main findings show that:(1)Among the operating efficiency of 52 universities,about one third and two thirds of universities are efficient and inefficient,respectively.It may reflect some problems such as inefficient use of resources or unsatisfactory outcomes for these inefficient universities.By giving first priority to universities’teaching or research process,we provide alternative ways for teaching-oriented or research-oriented universities to benchmark and improve their performance.(2)For the heterogeneity efficiency analysis of different universities,the operating efficiency of“non-985”universities are significantly higher than that of“985”universities,while there is only a small difference on the operating efficiency between comprehensive universities and science&engineering universities.Although the efficiency of the central and western universities is slightly better than that of the eastern universities in terms of the average efficiency,there is no significant efficiency difference among the eastern,central,and western regions statistically.Hence,to improve the operating efficiency of Chinese universities,the Chinese government should improve the financial allocation mechanism and introduce successful budget performance management.For the Chinese universities,they should formulate teaching and scientific research plans according to their own research needs and development goals.
基金the National Natural Science Foundation of China(21405012 and 81761148028)the Science and Technology Commission of Shanghai Municipality(19XD1400100 and 20DZ2254900)the Shanghai Education Commission through the Shanghai Leading Talents Program,and the 111 Project(BP0719035).
文摘Detection of circulating tumor cells(CTCs)plays an important role in early diagnosis of cancer and personalized therapy.However,isolated CTCs,especially those captured by positive sorting methods,are difficult to culture in subsequent assays because the cells have to be labeled or attached to a substrate for separation.In this study,a negative sorting method has been developed for isolation of CTCs through a microfluidic platform integrated with streptavidin-functionalized electro-spun polylactic-co-glycolic acid nanofibers.Through the specific biotin-streptavidin interaction,the device is able to sort out biotinylated anti-CD45 antibody-labeled white blood cells(WBCs)and enrich A549 human cancer cells from the blood or CTCs from patient suffering non-small cell lung cancer.We demonstrate that the WBC capture efficiency is as high as 97.0%,and the recovery rate of cancer cells reaches up to 97.5%.CTCs are enumerated from blood samples of patients suf-fering lung carcinoma.The number of CTCs increased with the progression of NCCN TNM stages and showed statistically significant difference between stage I and later stages.These results suggest that the integrated negative sorting device is promising to be used for diagnosis of cancer.
基金Supports of National Natural Science Foundation of China(No.31470581)Fundamental Research Funds for the Central Universities(No.2572016EBJ1)Northeast Forestry University College-level Innovative Training Program Project Funding(No.CL201802)are gratefully acknowledged.
文摘In order to optimize the out-of-plane compression performance of the wood structure,wood-based 2-D lattice structures were designed and manufactured with oriented strand board as the panel and birch round stick as the core by using a simple insert-glue method.In this experiment,the different thicknesses of the upper and lower panels,the different shavings arrangement directions of the upper and lower panels and the different configurations of the specimens were used to analyze the compression performance of the specimens under multivariable conditions.Through the combination of experimental test and theoretical analysis,we analyzed and compared different failure types of the structure and multiple compression parameters.The results showed that the shavings arrangement direction of the panel has a more important influence on the whole specimen than the thickness of the panel,especially the transverse shavings of the panel can withstand greater shear stress than the longitudinal shavings for a specimen.
