As promising anode candidates for potassium-ion batteries(PIBs),antimony sulfide(Sb_(2)S_(3))possesses high specific capacity but suffers from massive volume expansion and sluggish kinetics due to the large K^(+)inser...As promising anode candidates for potassium-ion batteries(PIBs),antimony sulfide(Sb_(2)S_(3))possesses high specific capacity but suffers from massive volume expansion and sluggish kinetics due to the large K^(+)insertion,resulting in inferior cycling and rate performance.To address these challenges,a yolk-shell structured Sb_(2)S_(3)confined in N,S co-doped hollow carbon nanorod(YS-Sb_(2)S_(3)@NSC)working as a viable anode for PIBs is proposed.As directly verified by in situ transmission electron microscopy(TEM),the buffer space between the Sb_(2)S_(3)core and thin carbon shell can effectively accommodate the large expansion stress of Sb_(2)S_(3)without cracking the shell and the carbon shell can accelerate electron transport and K^(+)diffusion,which plays a significant role in reinforcing the structural stability and facilitating charge transfer.As a result,the YS-Sb_(2)S_(3)@NSC electrode delivers a high reversible K^(+)storage capacity of 594.58 m A h g^(-1)at 0.1 A g^(-1)and a long cycle life with a slight capacity degradation(0.01%per cycle)for 2000 cycles at 1 A g^(-1)while maintaining outstanding rate capability.Importantly,utilizing in in situ/ex situ microscopic and spectroscopic characterizations,the origins of performance enhancement and K^(+)storage mechanism of Sb_(2)S_(3)were clearly elucidated.This work provides valuable insights into the rational design of high-performance and durable transition metal sulfides-based anodes for PIBs.展开更多
This paper is devoted to the study of a (2 + 1)-dimensional extended Potential Boiti-Leon-Manna-Pempinelli equation. Firstly, By means of the standard Weiss Tabor Carnevale approach and Kruskal’s simplification, we p...This paper is devoted to the study of a (2 + 1)-dimensional extended Potential Boiti-Leon-Manna-Pempinelli equation. Firstly, By means of the standard Weiss Tabor Carnevale approach and Kruskal’s simplification, we prove the painlevé non integrability of the equation. Secondly, A new breather solution and lump type solution are obtained based on the parameter limit method and Hirota’s bilinear method. Besides, some interaction behavior between lump type solution and N-soliton solutions (N is any positive integer) are studied. We construct the existence theorem of the interaction solution and give the process of calculation and proof. We also give a concrete example to illustrate the effectiveness of the theorem, and some spatial structure figures are displayed to reflect the evolutionary behavior of the interaction solutions with the change of soliton number N and time t.展开更多
The comprehensive detection and identification of active ingredients in complex matrices is a crucial challenge.Liquid chromatography coupled with high-resolution mass spectrometry(LC-HRMS)is the most prominent analyt...The comprehensive detection and identification of active ingredients in complex matrices is a crucial challenge.Liquid chromatography coupled with high-resolution mass spectrometry(LC-HRMS)is the most prominent analytical platform for the exploration of novel active compounds from complex matrices.However,the LC-HRMS-based analysis workflow suffers from several bottleneck issues,such as trace content of target compounds,limited acquisition for fragment information,and uncertainty in interpreting relevant MS2 spectra.Lycibarbarspermidines are vital antioxidant active ingredients in Lycii Fructus,while the reported structures are merely focused on dicaffeoylspermidines due to their low content.To comprehensively detect the new structures of lycibarbarspermidine derivatives,a“depict”strategy was developed in this study.First,potential new lycibarbarspermidine derivatives were designed according to the biosynthetic pathway,and a comprehensive database was established,which enlarged the coverage of lycibarbarspermidine derivatives.Second,the polarity-oriented sample preparation of potential new compounds increased the concentration of the target compounds.Third,the construction of the molecular network based on the fragmentation pathway of lycibarbarspermidine derivatives broadened the comprehensiveness of identification.Finally,the weak response signals were captured by data-dependent scanning(DDA)followed by parallel reaction monitoring(PRM),and the efficiency of acquiring MS2 fragment ions of target compounds was significantly improved.Based on the integrated strategy above,210 lycibarbarspermidine derivatives were detected and identified from Lycii Fructus,and in particular,170 potential new compounds were structurally characterized.The integrated strategy improved the sensitivity of detection and the coverage of low-response components,and it is expected to be a promising pipeline for discovering new compounds.展开更多
Accurate and reliable fault detection is essential for the safe operation of electric vehicles.Support vector data description(SVDD)has been widely used in the field of fault detection.However,constructing the hypersp...Accurate and reliable fault detection is essential for the safe operation of electric vehicles.Support vector data description(SVDD)has been widely used in the field of fault detection.However,constructing the hypersphere boundary only describes the distribution of unlabeled samples,while the distribution of faulty samples cannot be effectively described and easilymisses detecting faulty data due to the imbalance of sample distribution.Meanwhile,selecting parameters is critical to the detection performance,and empirical parameterization is generally timeconsuming and laborious and may not result in finding the optimal parameters.Therefore,this paper proposes a semi-supervised data-driven method based on which the SVDD algorithm is improved and achieves excellent fault detection performance.By incorporating faulty samples into the underlying SVDD model,training deals better with the problem of missing detection of faulty samples caused by the imbalance in the distribution of abnormal samples,and the hypersphere boundary ismodified to classify the samplesmore accurately.The Bayesian Optimization NSVDD(BO-NSVDD)model was constructed to quickly and accurately optimize hyperparameter combinations.In the experiments,electric vehicle operation data with four common fault types are used to evaluate the performance with other five models,and the results show that the BO-NSVDD model presents superior detection performance for each type of fault data,especially in the imperceptible early and minor faults,which has seen very obvious advantages.Finally,the strong robustness of the proposed method is verified by adding different intensities of noise in the dataset.展开更多
目的探讨早发型重度子痫前期(early onset severe pre-eclampsia,EOSP)患者血清表面活性蛋白A(surfactant associated protein A,SPA)、表面活性蛋白D(surfactant associated protein D,SPD)及同型半胱氨酸(homocysteine,Hcy)表达及临...目的探讨早发型重度子痫前期(early onset severe pre-eclampsia,EOSP)患者血清表面活性蛋白A(surfactant associated protein A,SPA)、表面活性蛋白D(surfactant associated protein D,SPD)及同型半胱氨酸(homocysteine,Hcy)表达及临床意义。方法选取2020年8月~2021年8月期间邯郸市中心医院诊治的124例EOSP患者为研究对象,以同期60例健康体检孕妇为对照组。酶联免疫吸附实验(ELISA)检测各组血清SPA,SPD及Hcy水平。比较两组一般资料及血清SPA,SPD及Hcy水平的差异。Pearson相关分析血清SPA,SPD及Hcy水平与临床参数的相关性。多因素Logistic回归分析影响EOSP发生的影响因素。受试者工作曲线(ROC)分析血清SPA,SPD及Hcy对EOSP的诊断价值。结果相比于对照组,EOSP组血清SPA(13.27±5.14ng/ml vs 22.14±6.04ng/ml),SPD(8.73±2.38ng/ml vs19.34±3.46ng/ml)水平明显降低,Hcy(15.27±3.13μmol/L vs 8.35±2.32μmol/L)水平明显升高,差异具有统计学意义(t=10.353,24.299,15.214,均P<0.05)。EOSP组患者血清SPA,SPD水平与新生儿出生体质量呈正相关(r=0.515,0.447,均P<0.05),与体质量指数、舒张压、收缩压和24h尿蛋白定量呈负相关(r=-0.604~-0.413,均P<0.05);血清Hcy水平与新生儿出生体质量呈负相关(r=-0.538,P<0.05),与体质量指数、舒张压、收缩压和24h尿蛋白定量呈正相关(r=0.420~0.610,均P<0.05)。24h尿蛋白定量[1.266(1.110~1.444)]、舒张压[1.270(1.071~1.506)]、SPA[0.865(0.778~0.962)],SPD[0.877(0.781~0.985)]及Hcy[1.347(1.084~1.675)]是影响EOSP发生的独立因素。血清SPA,SPD和Hcy联合检测对EOSP诊断的曲线下面积(95%CI)为0.909(0.877~0.945),显著高于SPA,SPD和Hcy各指标单独检测0.780(0.726~0.836),0.758(0.705~0.810),0.740(0.692~0.789),差异具有统计学意义(Z=4.370,5.567,7.702,均P<0.05)。结论子痫前期患者血清SPA和SPD降低,Hcy升高,三者共同参与EOSP疾病发生发展,是影响ES-PE发生的独立危险因素。展开更多
Ni-rich layered oxides are considered promising cathodes for advanced lithium-ion batteries(LIBs)in the future,owing to their high capacity and low cost.However,the issues on structural and interfacial stability of Ni...Ni-rich layered oxides are considered promising cathodes for advanced lithium-ion batteries(LIBs)in the future,owing to their high capacity and low cost.However,the issues on structural and interfacial stability of Ni-rich cathodes still pose substantial obstacles in the practical application of advanced LIBs.Here,we employ a one-step method to synthesize a B-doped and La_(4)NiLiO_(8)-coated LiNi_(0.82)5Co_(0.115)Mn_(0.06)O_(2)(BL-1)cathode with reliable structure and interface,for the first time.The La_(4)NiLiO_(8)coating layer can prevent cathodes from electrolyte assault and facilitate Li+diffusion kinetics.Moreover,B-doping can effectively restrain the pernicious H_(2)-H_(3) phase transition and adjust the orientation of primary particles to a radial alignment,which is obstructive to the arise of microcracks induced by the change of anisotropic volume.Specifically,when tested in pouch cells,the BL-1 cathode exhibits outstanding capacity retention of 93.49%after 500 cycles at 1 C.This dual-modification strategy dramatically enhances the stability of the structure and interface for Ni-rich cathode materials,consequently accelerating the commercialization process of high-energy–density LIBs.展开更多
BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian population.Although nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants signif...BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian population.Although nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants significantly improve the predictive sensitivity of TIL,more than 50%of cases of this toxicity cannot be predicted by this mutation.The potential use of the 6-thioguanine nucleotide(6TGN)level to predict TIL has been explored,but no decisive conclusion has been reached.Can we increase the predictive sensitivity based on 6TGN by subgrouping patients according to their NUDT15 R139C genotypes?AIM To determine the 6TGN cut-off levels after dividing patients into subgroups according to their NUDT15 R139C genotypes.METHODS Patients’clinical and epidemiological characteristics were collected from medical records from July 2014 to February 2017.NUDT15 R139C,thiopurine S methyltransferase,and 6TGN concentrations were measured.RESULTS A total of 411 Crohn’s disease patients were included.TIL was observed in 72 individuals with a median 6TGN level of 323.4 pmol/8×10^8 red blood cells(RBC),which was not different from that of patients without TIL(P=0.071).Then,we compared the 6TGN levels based on NUDT15 R139C.For CC(n=342)and CT(n=65)genotypes,the median 6TGN level in patients with TIL was significantly higher than that in patients without(474.8 vs 306.0 pmol/8×10^8 RBC,P=9.4×10-^5;291.7 vs 217.6 pmol/8×10^8 RBC,P=0.039,respectively).The four TT carriers developed TIL,with a median 6TGN concentration of 135.8 pmol/8×10^8 RBC.The 6TGN cut-off levels were 411.5 and 319.2 pmol/8×108 RBC for the CC and CT groups,respectively.CONCLUSION The predictive sensitivity of TIL based on 6TGN is dramatically increased after subgrouping according to NUDT15 R139C genotypes.Applying 6TGN cut-off levels to adjust thiopurine therapies based on NUDT15 is strongly recommended.展开更多
BACKGROUND Upper urinary tract stones are very common in my country,with an incidence of 1%to 5%in the North and an even higher incidence of 5%to 10%in the south.The incidence rate in the south is higher than that in ...BACKGROUND Upper urinary tract stones are very common in my country,with an incidence of 1%to 5%in the North and an even higher incidence of 5%to 10%in the south.The incidence rate in the south is higher than that in the north,mainly due to the water quality,climate and eating habits of the region.From the perspective of sex,incidence is more likely in males than females.In the high-incidence population,young adults are most prone to stones.Men in the age range of 25 to 40 years are more likely to have stones.AIM To observe the therapeutic effect of minimally invasive percutaneous nephrolithotomy(mPCNL)on upper urinary tract stones and its influence on the renal function of patients.METHODS Patients with upper urinary tract stones who were treated in our hospital from February 2017 to March 2018 were selected as research subjects and were divided into the PCNL group and the mPCNL group according to the random number table method.The general conditions of the two groups of patients were observed during the perioperative period,and the differences in stone clearance,pain,renal function indicators and complication rates were compared between the two groups to determine which were statistically significant(P<0.05).RESULTS The operation time of the mPCNL group was longer than that of the PCNL group(t=-34.392,P<0.001),and the intraoperative blood loss of the mPCNL group was more than that of the PCNL group(t=34.090,P<0.001).There was no difference in renal function indices between the two groups of patients before treatment,and there was no difference in the levels of serum creatinine,β2 microglobulin or retinol binding protein in the mPCNL group after treatment.The visual analog scale score of patients in the mPCNL group was lower than that of the PCNL group(t=12.191,P<0.001),and there was no significant difference in the stone clearance rate between the two groups(χ2 value=1.013,P=0.314).There was no significant difference in the incidence of urine extravasation,dyspnea and peripheral organ damage between the two groups(χ2 value=1.053,P=0.305).At 1 mo after treatment and 3 mo after treatment,the quality of life of the mPCNL group was lower than that of the PCNL group,and the Qmax level of the mPCNL group was higher than that of the PCNL group.CONCLUSION mPCNL has a good therapeutic effect on upper urinary tract stones,with a high stone clearance rate without causing kidney damage or increasing the incidence of complications,and thus has good application value.展开更多
基金supported by the National Natural Science Foundation of China(Grants Nos.52072323 and 52122211)the"Double-First Class"Foundation of Materials and Intelligent Manufacturing Discipline of Xiamen Universitythe State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources(Grant No.LAPS22005)。
文摘As promising anode candidates for potassium-ion batteries(PIBs),antimony sulfide(Sb_(2)S_(3))possesses high specific capacity but suffers from massive volume expansion and sluggish kinetics due to the large K^(+)insertion,resulting in inferior cycling and rate performance.To address these challenges,a yolk-shell structured Sb_(2)S_(3)confined in N,S co-doped hollow carbon nanorod(YS-Sb_(2)S_(3)@NSC)working as a viable anode for PIBs is proposed.As directly verified by in situ transmission electron microscopy(TEM),the buffer space between the Sb_(2)S_(3)core and thin carbon shell can effectively accommodate the large expansion stress of Sb_(2)S_(3)without cracking the shell and the carbon shell can accelerate electron transport and K^(+)diffusion,which plays a significant role in reinforcing the structural stability and facilitating charge transfer.As a result,the YS-Sb_(2)S_(3)@NSC electrode delivers a high reversible K^(+)storage capacity of 594.58 m A h g^(-1)at 0.1 A g^(-1)and a long cycle life with a slight capacity degradation(0.01%per cycle)for 2000 cycles at 1 A g^(-1)while maintaining outstanding rate capability.Importantly,utilizing in in situ/ex situ microscopic and spectroscopic characterizations,the origins of performance enhancement and K^(+)storage mechanism of Sb_(2)S_(3)were clearly elucidated.This work provides valuable insights into the rational design of high-performance and durable transition metal sulfides-based anodes for PIBs.
文摘This paper is devoted to the study of a (2 + 1)-dimensional extended Potential Boiti-Leon-Manna-Pempinelli equation. Firstly, By means of the standard Weiss Tabor Carnevale approach and Kruskal’s simplification, we prove the painlevé non integrability of the equation. Secondly, A new breather solution and lump type solution are obtained based on the parameter limit method and Hirota’s bilinear method. Besides, some interaction behavior between lump type solution and N-soliton solutions (N is any positive integer) are studied. We construct the existence theorem of the interaction solution and give the process of calculation and proof. We also give a concrete example to illustrate the effectiveness of the theorem, and some spatial structure figures are displayed to reflect the evolutionary behavior of the interaction solutions with the change of soliton number N and time t.
基金国际原子能机构全球协调研究项目(Coordinated Research Project,CRP):"Develop Advanced Techniques for Trad Verification and Anomaly Detection Using Data Generated from Radiation Detection System"(J02015)。
基金the Fundamental Research Funds for the Central Universities in China(Grant No.:2020-JYB-ZDGG-033).
文摘The comprehensive detection and identification of active ingredients in complex matrices is a crucial challenge.Liquid chromatography coupled with high-resolution mass spectrometry(LC-HRMS)is the most prominent analytical platform for the exploration of novel active compounds from complex matrices.However,the LC-HRMS-based analysis workflow suffers from several bottleneck issues,such as trace content of target compounds,limited acquisition for fragment information,and uncertainty in interpreting relevant MS2 spectra.Lycibarbarspermidines are vital antioxidant active ingredients in Lycii Fructus,while the reported structures are merely focused on dicaffeoylspermidines due to their low content.To comprehensively detect the new structures of lycibarbarspermidine derivatives,a“depict”strategy was developed in this study.First,potential new lycibarbarspermidine derivatives were designed according to the biosynthetic pathway,and a comprehensive database was established,which enlarged the coverage of lycibarbarspermidine derivatives.Second,the polarity-oriented sample preparation of potential new compounds increased the concentration of the target compounds.Third,the construction of the molecular network based on the fragmentation pathway of lycibarbarspermidine derivatives broadened the comprehensiveness of identification.Finally,the weak response signals were captured by data-dependent scanning(DDA)followed by parallel reaction monitoring(PRM),and the efficiency of acquiring MS2 fragment ions of target compounds was significantly improved.Based on the integrated strategy above,210 lycibarbarspermidine derivatives were detected and identified from Lycii Fructus,and in particular,170 potential new compounds were structurally characterized.The integrated strategy improved the sensitivity of detection and the coverage of low-response components,and it is expected to be a promising pipeline for discovering new compounds.
基金supported partially by NationalNatural Science Foundation of China(NSFC)(No.U21A20146)Collaborative Innovation Project of Anhui Universities(No.GXXT-2020-070)+8 种基金Cooperation Project of Anhui Future Technology Research Institute and Enterprise(No.2023qyhz32)Development of a New Dynamic Life Prediction Technology for Energy Storage Batteries(No.KH10003598)Opening Project of Key Laboratory of Electric Drive and Control of Anhui Province(No.DQKJ202304)Anhui Provincial Department of Education New Era Education Quality Project(No.2023dshwyx019)Special Fund for Collaborative Innovation between Anhui Polytechnic University and Jiujiang District(No.2022cyxtb10)Key Research and Development Program of Wuhu City(No.2022yf42)Open Research Fund of Anhui Key Laboratory of Detection Technology and Energy Saving Devices(No.JCKJ2021B06)Anhui Provincial Graduate Student Innovation and Entrepreneurship Practice Project(No.2022cxcysj123)Key Scientific Research Project for Anhui Universities(No.2022AH050981).
文摘Accurate and reliable fault detection is essential for the safe operation of electric vehicles.Support vector data description(SVDD)has been widely used in the field of fault detection.However,constructing the hypersphere boundary only describes the distribution of unlabeled samples,while the distribution of faulty samples cannot be effectively described and easilymisses detecting faulty data due to the imbalance of sample distribution.Meanwhile,selecting parameters is critical to the detection performance,and empirical parameterization is generally timeconsuming and laborious and may not result in finding the optimal parameters.Therefore,this paper proposes a semi-supervised data-driven method based on which the SVDD algorithm is improved and achieves excellent fault detection performance.By incorporating faulty samples into the underlying SVDD model,training deals better with the problem of missing detection of faulty samples caused by the imbalance in the distribution of abnormal samples,and the hypersphere boundary ismodified to classify the samplesmore accurately.The Bayesian Optimization NSVDD(BO-NSVDD)model was constructed to quickly and accurately optimize hyperparameter combinations.In the experiments,electric vehicle operation data with four common fault types are used to evaluate the performance with other five models,and the results show that the BO-NSVDD model presents superior detection performance for each type of fault data,especially in the imperceptible early and minor faults,which has seen very obvious advantages.Finally,the strong robustness of the proposed method is verified by adding different intensities of noise in the dataset.
文摘目的探讨早发型重度子痫前期(early onset severe pre-eclampsia,EOSP)患者血清表面活性蛋白A(surfactant associated protein A,SPA)、表面活性蛋白D(surfactant associated protein D,SPD)及同型半胱氨酸(homocysteine,Hcy)表达及临床意义。方法选取2020年8月~2021年8月期间邯郸市中心医院诊治的124例EOSP患者为研究对象,以同期60例健康体检孕妇为对照组。酶联免疫吸附实验(ELISA)检测各组血清SPA,SPD及Hcy水平。比较两组一般资料及血清SPA,SPD及Hcy水平的差异。Pearson相关分析血清SPA,SPD及Hcy水平与临床参数的相关性。多因素Logistic回归分析影响EOSP发生的影响因素。受试者工作曲线(ROC)分析血清SPA,SPD及Hcy对EOSP的诊断价值。结果相比于对照组,EOSP组血清SPA(13.27±5.14ng/ml vs 22.14±6.04ng/ml),SPD(8.73±2.38ng/ml vs19.34±3.46ng/ml)水平明显降低,Hcy(15.27±3.13μmol/L vs 8.35±2.32μmol/L)水平明显升高,差异具有统计学意义(t=10.353,24.299,15.214,均P<0.05)。EOSP组患者血清SPA,SPD水平与新生儿出生体质量呈正相关(r=0.515,0.447,均P<0.05),与体质量指数、舒张压、收缩压和24h尿蛋白定量呈负相关(r=-0.604~-0.413,均P<0.05);血清Hcy水平与新生儿出生体质量呈负相关(r=-0.538,P<0.05),与体质量指数、舒张压、收缩压和24h尿蛋白定量呈正相关(r=0.420~0.610,均P<0.05)。24h尿蛋白定量[1.266(1.110~1.444)]、舒张压[1.270(1.071~1.506)]、SPA[0.865(0.778~0.962)],SPD[0.877(0.781~0.985)]及Hcy[1.347(1.084~1.675)]是影响EOSP发生的独立因素。血清SPA,SPD和Hcy联合检测对EOSP诊断的曲线下面积(95%CI)为0.909(0.877~0.945),显著高于SPA,SPD和Hcy各指标单独检测0.780(0.726~0.836),0.758(0.705~0.810),0.740(0.692~0.789),差异具有统计学意义(Z=4.370,5.567,7.702,均P<0.05)。结论子痫前期患者血清SPA和SPD降低,Hcy升高,三者共同参与EOSP疾病发生发展,是影响ES-PE发生的独立危险因素。
基金financially supported by the National Natural Science Foundation of China(51774051,52072323,52122211)the Science and Technology Planning Project of Hunan Province(2019RS2034)+1 种基金the Hunan High-tech Industry Science and Technology Innovation Leading Plan(2020GK2072)the Changsha City Fund for Distinguished and Innovative Young Scholars(KQ1707014)。
文摘Ni-rich layered oxides are considered promising cathodes for advanced lithium-ion batteries(LIBs)in the future,owing to their high capacity and low cost.However,the issues on structural and interfacial stability of Ni-rich cathodes still pose substantial obstacles in the practical application of advanced LIBs.Here,we employ a one-step method to synthesize a B-doped and La_(4)NiLiO_(8)-coated LiNi_(0.82)5Co_(0.115)Mn_(0.06)O_(2)(BL-1)cathode with reliable structure and interface,for the first time.The La_(4)NiLiO_(8)coating layer can prevent cathodes from electrolyte assault and facilitate Li+diffusion kinetics.Moreover,B-doping can effectively restrain the pernicious H_(2)-H_(3) phase transition and adjust the orientation of primary particles to a radial alignment,which is obstructive to the arise of microcracks induced by the change of anisotropic volume.Specifically,when tested in pouch cells,the BL-1 cathode exhibits outstanding capacity retention of 93.49%after 500 cycles at 1 C.This dual-modification strategy dramatically enhances the stability of the structure and interface for Ni-rich cathode materials,consequently accelerating the commercialization process of high-energy–density LIBs.
基金Supported by the National Natural Science Foundation of China,No.81573507,No.81473283,No.81173131,and No.81320108027Guangdong Provincial Key Laboratory Construction Foundation,No.2017B030314030+1 种基金The National Key Research and Development Program,No.2016YFC0905003the 111 Project,No.B16047
文摘BACKGROUND Thiopurine-induced leukopenia(TIL)is a life-threatening toxicity and occurs with a high frequency in the Asian population.Although nucleoside diphosphate-linked moiety X-type motif 15(NUDT15)variants significantly improve the predictive sensitivity of TIL,more than 50%of cases of this toxicity cannot be predicted by this mutation.The potential use of the 6-thioguanine nucleotide(6TGN)level to predict TIL has been explored,but no decisive conclusion has been reached.Can we increase the predictive sensitivity based on 6TGN by subgrouping patients according to their NUDT15 R139C genotypes?AIM To determine the 6TGN cut-off levels after dividing patients into subgroups according to their NUDT15 R139C genotypes.METHODS Patients’clinical and epidemiological characteristics were collected from medical records from July 2014 to February 2017.NUDT15 R139C,thiopurine S methyltransferase,and 6TGN concentrations were measured.RESULTS A total of 411 Crohn’s disease patients were included.TIL was observed in 72 individuals with a median 6TGN level of 323.4 pmol/8×10^8 red blood cells(RBC),which was not different from that of patients without TIL(P=0.071).Then,we compared the 6TGN levels based on NUDT15 R139C.For CC(n=342)and CT(n=65)genotypes,the median 6TGN level in patients with TIL was significantly higher than that in patients without(474.8 vs 306.0 pmol/8×10^8 RBC,P=9.4×10-^5;291.7 vs 217.6 pmol/8×10^8 RBC,P=0.039,respectively).The four TT carriers developed TIL,with a median 6TGN concentration of 135.8 pmol/8×10^8 RBC.The 6TGN cut-off levels were 411.5 and 319.2 pmol/8×108 RBC for the CC and CT groups,respectively.CONCLUSION The predictive sensitivity of TIL based on 6TGN is dramatically increased after subgrouping according to NUDT15 R139C genotypes.Applying 6TGN cut-off levels to adjust thiopurine therapies based on NUDT15 is strongly recommended.
文摘BACKGROUND Upper urinary tract stones are very common in my country,with an incidence of 1%to 5%in the North and an even higher incidence of 5%to 10%in the south.The incidence rate in the south is higher than that in the north,mainly due to the water quality,climate and eating habits of the region.From the perspective of sex,incidence is more likely in males than females.In the high-incidence population,young adults are most prone to stones.Men in the age range of 25 to 40 years are more likely to have stones.AIM To observe the therapeutic effect of minimally invasive percutaneous nephrolithotomy(mPCNL)on upper urinary tract stones and its influence on the renal function of patients.METHODS Patients with upper urinary tract stones who were treated in our hospital from February 2017 to March 2018 were selected as research subjects and were divided into the PCNL group and the mPCNL group according to the random number table method.The general conditions of the two groups of patients were observed during the perioperative period,and the differences in stone clearance,pain,renal function indicators and complication rates were compared between the two groups to determine which were statistically significant(P<0.05).RESULTS The operation time of the mPCNL group was longer than that of the PCNL group(t=-34.392,P<0.001),and the intraoperative blood loss of the mPCNL group was more than that of the PCNL group(t=34.090,P<0.001).There was no difference in renal function indices between the two groups of patients before treatment,and there was no difference in the levels of serum creatinine,β2 microglobulin or retinol binding protein in the mPCNL group after treatment.The visual analog scale score of patients in the mPCNL group was lower than that of the PCNL group(t=12.191,P<0.001),and there was no significant difference in the stone clearance rate between the two groups(χ2 value=1.013,P=0.314).There was no significant difference in the incidence of urine extravasation,dyspnea and peripheral organ damage between the two groups(χ2 value=1.053,P=0.305).At 1 mo after treatment and 3 mo after treatment,the quality of life of the mPCNL group was lower than that of the PCNL group,and the Qmax level of the mPCNL group was higher than that of the PCNL group.CONCLUSION mPCNL has a good therapeutic effect on upper urinary tract stones,with a high stone clearance rate without causing kidney damage or increasing the incidence of complications,and thus has good application value.
