Dear Editor,Klebsiella pneumoniae(Kp)has become the most important bacterial pathogen causing high mortality rates in clinical patients due to the continuous evolution to several important variants such as carbapenem-...Dear Editor,Klebsiella pneumoniae(Kp)has become the most important bacterial pathogen causing high mortality rates in clinical patients due to the continuous evolution to several important variants such as carbapenem-resistant(CR-Kp),hypervirulent(hvKp)and both CR and hv K.pneumoniae(CR-hvKp).The high mortality caused by clinical hvKp is attributed to the non-response to antibiotic treatment.展开更多
Salmonella Corvallis ST1541 has recently emerged as a globally disseminated pathogenic strain that often causes severe food-borne infections.Unlike most pandemic serotypes of Salmonella,the ST1541 strains harbored Col...Salmonella Corvallis ST1541 has recently emerged as a globally disseminated pathogenic strain that often causes severe food-borne infections.Unlike most pandemic serotypes of Salmonella,the ST1541 strains harbored ColRNA1 plasmids that contain qnr-like determinants known to be responsible for the increasing incidence of ciprofloxacin-resistant food-borne Salmonella infections.In this study,we conducted a genomic analysis of a global collection of 388 S.Corvallis ST1541 strains collected within a twenty-year period.We investigated the genetic characteristics of plasmid-mediated quinolone resistance(PMQR)plasmids harbored by these S.Corvallis strains,established a mini-mum spanning tree(MST)to determine the temporal and spatial distribution of the top 10 MST clusters,inferred a time-phylogenies for the major sub-lineages and traced the routes of international dissemination of this serotype strains.Bayesian algorithm predicted that UK might be the origin of S.Corvallis strains currently prevalent in various countries.This idea is supported by the observation of the emergence of intercontinental-disseminated clonal strains and extensive transmission of the extensive-drug resistance(XDR)-encoding plasmid pSA663.This study there-fore provides valuable insight into the evolution of globally transmitted S.Corvallis strains and suggests a need to strengthen cooperation between different countries to control the dissemination of these drug-resistant bacteria.展开更多
基金funded by the Theme-Based Research Scheme(T11-104/22-R)the Research Impact Fund(R5011-18F)from the Research Grant Council of the Government of China HongKong SAR.
文摘Dear Editor,Klebsiella pneumoniae(Kp)has become the most important bacterial pathogen causing high mortality rates in clinical patients due to the continuous evolution to several important variants such as carbapenem-resistant(CR-Kp),hypervirulent(hvKp)and both CR and hv K.pneumoniae(CR-hvKp).The high mortality caused by clinical hvKp is attributed to the non-response to antibiotic treatment.
基金supported by the Key Research and Development Program of Guangdong Province(Grant number,2022B1111040002)the Collaborative Research Fund from Research Grant Council of the Government of Hong Kong SAR(Grant numbers,C7147-20G,C7003-20G).
文摘Salmonella Corvallis ST1541 has recently emerged as a globally disseminated pathogenic strain that often causes severe food-borne infections.Unlike most pandemic serotypes of Salmonella,the ST1541 strains harbored ColRNA1 plasmids that contain qnr-like determinants known to be responsible for the increasing incidence of ciprofloxacin-resistant food-borne Salmonella infections.In this study,we conducted a genomic analysis of a global collection of 388 S.Corvallis ST1541 strains collected within a twenty-year period.We investigated the genetic characteristics of plasmid-mediated quinolone resistance(PMQR)plasmids harbored by these S.Corvallis strains,established a mini-mum spanning tree(MST)to determine the temporal and spatial distribution of the top 10 MST clusters,inferred a time-phylogenies for the major sub-lineages and traced the routes of international dissemination of this serotype strains.Bayesian algorithm predicted that UK might be the origin of S.Corvallis strains currently prevalent in various countries.This idea is supported by the observation of the emergence of intercontinental-disseminated clonal strains and extensive transmission of the extensive-drug resistance(XDR)-encoding plasmid pSA663.This study there-fore provides valuable insight into the evolution of globally transmitted S.Corvallis strains and suggests a need to strengthen cooperation between different countries to control the dissemination of these drug-resistant bacteria.
