A new staggered isolated system developed from the mid-story isolated system is the new staggered story isolated system. There are not many studies on this structure currently. In this study, an 18-story new staggered...A new staggered isolated system developed from the mid-story isolated system is the new staggered story isolated system. There are not many studies on this structure currently. In this study, an 18-story new staggered story isolated system model is established using SAP2000. The dynamic nonlinear dynamic alternate method is used to analyze the structure against progressive collapse. Results show that the structure has good resistance to progressive collapse, and there is no progressive collapse under each working condition. The progressive collapse does not occur for the case of removing only one vertical structural member of the new staggered of isolated system. The side column has big influence on this isolated structures’ progressive collapse;the removal of vertical structural member of the isolation layer has less impact on the structure than the removal of the bottom vertical structural member. After the removing of the member, the internal force of the structure will be redistributed, and the axial force of the adjacent columns will change obviously, showing a trend of “near large and far small”.展开更多
[Objectives]miRNAs play an important role in the proliferation and differentiation of different myoblasts.This study was conducted to elucidate the complex genetic mechanisms that affect the meat production performanc...[Objectives]miRNAs play an important role in the proliferation and differentiation of different myoblasts.This study was conducted to elucidate the complex genetic mechanisms that affect the meat production performance of Sichuan white rabbits and reveal the regulatory role of miRNAs in their muscle growth and meat quality formation.[Methods]Three constructed skeletal muscle libraries of Sichuan white rabbits aged six months were sequenced by the solexa technology to identify known miRNAs,predict new miRNAs and construct an expression profile of muscle miRNAs.[Results]A total of 511 known miRNAs and 42 miRNAs were detected in 34089472 pure sequences,and the proportion of miRNAs with a length of 22 nt was the highest.The number of known miRNA sequences accounted for 71.38%of pure sequences,which was much higher than the proportion of other types of RNAs.The proportion of sequences from exons was 0.38%,indicating a low degree of mRNA degradation in the samples.Base U had the highest proportion at the first position,and the bases with the highest proportions at positions 8 and 10 were U and A,respectively.Muscle-specific miRNAs(miR-1,miR-133,and miR-206)ranked in the top 10 in terms of expression level.The number and expression levels of new miRNAs were lower than those of known miRNAs.The length distribution,base bias at different positions and expression profile characteristics of miRNAs might be related to the biological function of miRNAs in regulating muscle proliferation and differentiation and the action mechanisms with target genes.[Conclusions]The identification and expression of miRNAs in muscle tissues of Sichuan white rabbits will help to understand the complex molecular mechanisms of meat production performance and provide a theoretical basis for the functional research of miRNAs in meat rabbits.展开更多
The biosorption potential of dried activated sludge as a biosorbent for zinc(Ⅱ) removal from aqueous solution was investigated.The effects of initial pH,contact time,initial zinc ion concentration,and adsorbent dosag...The biosorption potential of dried activated sludge as a biosorbent for zinc(Ⅱ) removal from aqueous solution was investigated.The effects of initial pH,contact time,initial zinc ion concentration,and adsorbent dosage on the biosorption processes were determined,and the equilibrium data were modeled by the Langmuir and Freundlich isotherms.The Langmuir isotherm model (R 2=0.999) was proved to fit the equilibrium data much better than the Freundlich isotherm model (R 2=0.918).The monolayer adsorption capacity of dried activated sludge for zinc(Ⅱ) was found to be 17.86 mg/g at pH of 5 and 25°C.The kinetic data were tested using pseudo firstand second-order models.The results suggested that the pseudo second-order model (R 2 > 0.999) was better for the description of the adsorption behavior of zinc(Ⅱ) onto the dried activated sludge.Fourier transform infrared spectral analysis showed that the dominant mechanism of zinc(Ⅱ) biosorption onto the dried activated sludge was the binding between amide groups and zinc ions.展开更多
Traditional watermark embedding schemes inevitably modify the data in a host audio signal and lead to the degradation of the host signal.In this paper,a novel audio zero-watermarking algorithm based on discrete wavele...Traditional watermark embedding schemes inevitably modify the data in a host audio signal and lead to the degradation of the host signal.In this paper,a novel audio zero-watermarking algorithm based on discrete wavelet transform(DWT),discrete cosine transform(DCT),and singular value decomposition(SVD) is presented.The watermark is registered by performing SVD on the coefficients generated through DWT and DCT to avoid data modification and host signal degradation.Simulation results show that the proposed zero-watermarking algorithm is strongly robust to common signal processing methods such as requantization,MP3 compression,resampling,addition of white Gaussian noise,and low-pass filtering.展开更多
AIM:To investigate immunosuppressive agents used to treat inflammatory bowel disease(IBD)in East China. METHODS:A retrospective review was conducted, involving 227 patients with IBD admitted to Sir Run Run Shaw Hospit...AIM:To investigate immunosuppressive agents used to treat inflammatory bowel disease(IBD)in East China. METHODS:A retrospective review was conducted, involving 227 patients with IBD admitted to Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University from June 2000 to December 2007.Data regarding demographic,clinical characteristics and immunosuppressants usage were analyzed. RESULTS:A total of 227 eligible patients were evaluated in this study,including 104 patients with Crohn’s disease and 123 with ulcerative colitis.Among the patients,61 had indications for immunosuppressive agents use.However,only 21 (34.4%)received immunosuppressive agents.Among the 21 patients,6(37.5%)received a subtherapeutic dose of azathioprine with no attempt to increase the dosage.Of the 20 patients that received immunosuppressive agent treatment longer than 6 mo,15 patients went into remission,four patients were not affected and one relapsed.Among these 20 patients,four patients suffered from myelotoxicity and one suffered from hepatotoxicity.CONCLUSION:Immunosuppressive agents are used less frequently to treat IBD patients from East China compared with Western countries.Monitoring immunosuppressive agent use is recommended to optimize dispensation of drugs for IBD in China.展开更多
Essential characteristics for watermark registration and detection without data modification can be used in anaudio zero-watermarking scheme.In this paper,a novel audio zero-watermarking scheme based on discrete wavel...Essential characteristics for watermark registration and detection without data modification can be used in anaudio zero-watermarking scheme.In this paper,a novel audio zero-watermarking scheme based on discrete wavelet transform(DWT) and discrete cosine transform(DCT) is presented.Thewatermark is registered by comparing the mean absolute values of the adjacent frame coefficients after DWT and DCT.Simulation results show that the proposed scheme is stronglyrobusttocommon attacks such as AWGN,downsampling,low-pass filtering,requantization,and MP3 compression.A performance analysis of the proposed scheme shows that all bit error rates after attacks are zero.展开更多
In recent years,with the continuous advancement of the intelligent process of the Internet of Vehicles(IoV),the problem of privacy leakage in IoV has become increasingly prominent.The research on the privacy protectio...In recent years,with the continuous advancement of the intelligent process of the Internet of Vehicles(IoV),the problem of privacy leakage in IoV has become increasingly prominent.The research on the privacy protection of the IoV has become the focus of the society.This paper analyzes the advantages and disadvantages of the existing location privacy protection system structure and algorithms,proposes a privacy protection system structure based on untrusted data collection server,and designs a vehicle location acquisition algorithm based on a local differential privacy and game model.The algorithm first meshes the road network space.Then,the dynamic game model is introduced into the game user location privacy protection model and the attacker location semantic inference model,thereby minimizing the possibility of exposing the regional semantic privacy of the k-location set while maximizing the availability of the service.On this basis,a statistical method is designed,which satisfies the local differential privacy of k-location sets and obtains unbiased estimation of traffic density in different regions.Finally,this paper verifies the algorithm based on the data set of mobile vehicles in Shanghai.The experimental results show that the algorithm can guarantee the user’s location privacy and location semantic privacy while satisfying the service quality requirements,and provide better privacy protection and service for the users of the IoV.展开更多
Blockchain is a technology that uses community validation to synchronize the content of ledgers replicated by multiple users.Although Blockchain derives its origins from technologies introduced decades ago,recently it...Blockchain is a technology that uses community validation to synchronize the content of ledgers replicated by multiple users.Although Blockchain derives its origins from technologies introduced decades ago,recently it has received an astonishing amount of attention in both academic and industry due to its charac-teristics of decentralization,point-to-point transmission,transparency,traceability,non-tampering,and data security.Both researchers and practitioners have recognized that Blockchain can be used to solve complex technical or socio-economic problems.展开更多
Blockchain is a technology that uses community validation to keep synchronized the content of ledgers replicated across multiple users,which is the underlying technology of digital currency like bitcoin.The anonymity ...Blockchain is a technology that uses community validation to keep synchronized the content of ledgers replicated across multiple users,which is the underlying technology of digital currency like bitcoin.The anonymity of blockchain has caused widespread concern.In this paper,we put forward AABN,an Anonymity Assessment model based on Bayesian Network.Firstly,we investigate and analyze the anonymity assessment techniques,and focus on typical anonymity assessment schemes.Then the related concepts involved in the assessment model are introduced and the model construction process is described in detail.Finally,the anonymity in the MIX anonymous network is quantitatively evaluated using the methods of accurate reasoning and approximate reasoning respectively,and the anonymity assessment experiments under different output strategies of the MIX anonymous network are analyzed.展开更多
文摘A new staggered isolated system developed from the mid-story isolated system is the new staggered story isolated system. There are not many studies on this structure currently. In this study, an 18-story new staggered story isolated system model is established using SAP2000. The dynamic nonlinear dynamic alternate method is used to analyze the structure against progressive collapse. Results show that the structure has good resistance to progressive collapse, and there is no progressive collapse under each working condition. The progressive collapse does not occur for the case of removing only one vertical structural member of the new staggered of isolated system. The side column has big influence on this isolated structures’ progressive collapse;the removal of vertical structural member of the isolation layer has less impact on the structure than the removal of the bottom vertical structural member. After the removing of the member, the internal force of the structure will be redistributed, and the axial force of the adjacent columns will change obviously, showing a trend of “near large and far small”.
基金Supported by Science and Technology Achievement Transformation Project of Scientific Research Institutions(2021JDZH0019)National Modern Agricultural Industry Technology System of the Ministry of Agriculture(CARS-43-D-1)+4 种基金Sichuan Provincial Breeding Research(2021YFYZ0033)Special Fund for Basic Scientific Research Business of Sichuan Animal Science Academy(SASA202105SASA202305)Natural Science Foundation of Sichuan Province(2023NSFSC0171)Basic Research for Application of Sichuan Provincial Science and Technology Planning Project(2021YJ0267)。
文摘[Objectives]miRNAs play an important role in the proliferation and differentiation of different myoblasts.This study was conducted to elucidate the complex genetic mechanisms that affect the meat production performance of Sichuan white rabbits and reveal the regulatory role of miRNAs in their muscle growth and meat quality formation.[Methods]Three constructed skeletal muscle libraries of Sichuan white rabbits aged six months were sequenced by the solexa technology to identify known miRNAs,predict new miRNAs and construct an expression profile of muscle miRNAs.[Results]A total of 511 known miRNAs and 42 miRNAs were detected in 34089472 pure sequences,and the proportion of miRNAs with a length of 22 nt was the highest.The number of known miRNA sequences accounted for 71.38%of pure sequences,which was much higher than the proportion of other types of RNAs.The proportion of sequences from exons was 0.38%,indicating a low degree of mRNA degradation in the samples.Base U had the highest proportion at the first position,and the bases with the highest proportions at positions 8 and 10 were U and A,respectively.Muscle-specific miRNAs(miR-1,miR-133,and miR-206)ranked in the top 10 in terms of expression level.The number and expression levels of new miRNAs were lower than those of known miRNAs.The length distribution,base bias at different positions and expression profile characteristics of miRNAs might be related to the biological function of miRNAs in regulating muscle proliferation and differentiation and the action mechanisms with target genes.[Conclusions]The identification and expression of miRNAs in muscle tissues of Sichuan white rabbits will help to understand the complex molecular mechanisms of meat production performance and provide a theoretical basis for the functional research of miRNAs in meat rabbits.
基金supported by the National Natural Science Foundation of China (No. 50778066)the National Science and Technology Support Program of China(No. 2006BAJ04A13)+1 种基金the Program for New Century Excellent Talents in University from the Ministry of Education of China (No. NCET-08-0181)the China Postdoctoral Science Foundation (No. 200801338)
文摘The biosorption potential of dried activated sludge as a biosorbent for zinc(Ⅱ) removal from aqueous solution was investigated.The effects of initial pH,contact time,initial zinc ion concentration,and adsorbent dosage on the biosorption processes were determined,and the equilibrium data were modeled by the Langmuir and Freundlich isotherms.The Langmuir isotherm model (R 2=0.999) was proved to fit the equilibrium data much better than the Freundlich isotherm model (R 2=0.918).The monolayer adsorption capacity of dried activated sludge for zinc(Ⅱ) was found to be 17.86 mg/g at pH of 5 and 25°C.The kinetic data were tested using pseudo firstand second-order models.The results suggested that the pseudo second-order model (R 2 > 0.999) was better for the description of the adsorption behavior of zinc(Ⅱ) onto the dried activated sludge.Fourier transform infrared spectral analysis showed that the dominant mechanism of zinc(Ⅱ) biosorption onto the dried activated sludge was the binding between amide groups and zinc ions.
基金supported by the Open Foundation of Jiangsu Engineering Center of Network Monitoring(Nanjing University of Information Science&Technology)(Grant No.KJR1509)the PAPD fundthe CICAEET fund
文摘Traditional watermark embedding schemes inevitably modify the data in a host audio signal and lead to the degradation of the host signal.In this paper,a novel audio zero-watermarking algorithm based on discrete wavelet transform(DWT),discrete cosine transform(DCT),and singular value decomposition(SVD) is presented.The watermark is registered by performing SVD on the coefficients generated through DWT and DCT to avoid data modification and host signal degradation.Simulation results show that the proposed zero-watermarking algorithm is strongly robust to common signal processing methods such as requantization,MP3 compression,resampling,addition of white Gaussian noise,and low-pass filtering.
基金Supported by Zhejiang Province Natural Science Foundationof China,R2080029 Caoqian Research Group
文摘AIM:To investigate immunosuppressive agents used to treat inflammatory bowel disease(IBD)in East China. METHODS:A retrospective review was conducted, involving 227 patients with IBD admitted to Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University from June 2000 to December 2007.Data regarding demographic,clinical characteristics and immunosuppressants usage were analyzed. RESULTS:A total of 227 eligible patients were evaluated in this study,including 104 patients with Crohn’s disease and 123 with ulcerative colitis.Among the patients,61 had indications for immunosuppressive agents use.However,only 21 (34.4%)received immunosuppressive agents.Among the 21 patients,6(37.5%)received a subtherapeutic dose of azathioprine with no attempt to increase the dosage.Of the 20 patients that received immunosuppressive agent treatment longer than 6 mo,15 patients went into remission,four patients were not affected and one relapsed.Among these 20 patients,four patients suffered from myelotoxicity and one suffered from hepatotoxicity.CONCLUSION:Immunosuppressive agents are used less frequently to treat IBD patients from East China compared with Western countries.Monitoring immunosuppressive agent use is recommended to optimize dispensation of drugs for IBD in China.
基金supported by the Open Foundation of Jiangsu Engineering Center of Network Monitoring(Nanjing University of Information Science&Technology)(Grant No.KJR1509)the PAPD fundthe CICAEET fund
文摘Essential characteristics for watermark registration and detection without data modification can be used in anaudio zero-watermarking scheme.In this paper,a novel audio zero-watermarking scheme based on discrete wavelet transform(DWT) and discrete cosine transform(DCT) is presented.Thewatermark is registered by comparing the mean absolute values of the adjacent frame coefficients after DWT and DCT.Simulation results show that the proposed scheme is stronglyrobusttocommon attacks such as AWGN,downsampling,low-pass filtering,requantization,and MP3 compression.A performance analysis of the proposed scheme shows that all bit error rates after attacks are zero.
基金This work is supported by Major Scientific and Technological Special Project of Guizhou Province(20183001)Research on the education mode for complicate skill students in new media with cross specialty integration(22150117092)+2 种基金Open Foundation of Guizhou Provincial Key Laboratory of Public Big Data(2018BDKFJJ014)Open Foundation of Guizhou Provincial Key Laboratory of Public Big Data(2018BDKFJJ019)Open Foundation of Guizhou Provincial Key Laboratory of Public Big Data(2018BDKFJJ022).
文摘In recent years,with the continuous advancement of the intelligent process of the Internet of Vehicles(IoV),the problem of privacy leakage in IoV has become increasingly prominent.The research on the privacy protection of the IoV has become the focus of the society.This paper analyzes the advantages and disadvantages of the existing location privacy protection system structure and algorithms,proposes a privacy protection system structure based on untrusted data collection server,and designs a vehicle location acquisition algorithm based on a local differential privacy and game model.The algorithm first meshes the road network space.Then,the dynamic game model is introduced into the game user location privacy protection model and the attacker location semantic inference model,thereby minimizing the possibility of exposing the regional semantic privacy of the k-location set while maximizing the availability of the service.On this basis,a statistical method is designed,which satisfies the local differential privacy of k-location sets and obtains unbiased estimation of traffic density in different regions.Finally,this paper verifies the algorithm based on the data set of mobile vehicles in Shanghai.The experimental results show that the algorithm can guarantee the user’s location privacy and location semantic privacy while satisfying the service quality requirements,and provide better privacy protection and service for the users of the IoV.
文摘Blockchain is a technology that uses community validation to synchronize the content of ledgers replicated by multiple users.Although Blockchain derives its origins from technologies introduced decades ago,recently it has received an astonishing amount of attention in both academic and industry due to its charac-teristics of decentralization,point-to-point transmission,transparency,traceability,non-tampering,and data security.Both researchers and practitioners have recognized that Blockchain can be used to solve complex technical or socio-economic problems.
基金supported by the following grants:the National Natural Science Foundation of China under Grant No.61170273the China Scholarship Council under Grant No.[2013]3050+1 种基金CCF-Tencent Open Fund WeBank Special Fuding(CCF-WebankRAGR20180104)the Beijing Natural Science Foundation(4194086)
文摘Blockchain is a technology that uses community validation to keep synchronized the content of ledgers replicated across multiple users,which is the underlying technology of digital currency like bitcoin.The anonymity of blockchain has caused widespread concern.In this paper,we put forward AABN,an Anonymity Assessment model based on Bayesian Network.Firstly,we investigate and analyze the anonymity assessment techniques,and focus on typical anonymity assessment schemes.Then the related concepts involved in the assessment model are introduced and the model construction process is described in detail.Finally,the anonymity in the MIX anonymous network is quantitatively evaluated using the methods of accurate reasoning and approximate reasoning respectively,and the anonymity assessment experiments under different output strategies of the MIX anonymous network are analyzed.
