BACKGROUND There is currently a shortage of accurate,efficient,and precise predictive instruments for rectal neuroendocrine neoplasms(NENs).AIM To develop a predictive model for individuals with rectal NENs(R-NENs)usi...BACKGROUND There is currently a shortage of accurate,efficient,and precise predictive instruments for rectal neuroendocrine neoplasms(NENs).AIM To develop a predictive model for individuals with rectal NENs(R-NENs)using data from a large cohort.METHODS Data from patients with primary R-NENs were retrospectively collected from 17 large-scale referral medical centers in China.Random forest and Cox proportional hazard models were used to identify the risk factors for overall survival and progression-free survival,and two nomograms were constructed.RESULTS A total of 1408 patients with R-NENs were included.Tumor grade,T stage,tumor size,age,and a prognostic nutritional index were important risk factors for prognosis.The GATIS score was calculated based on these five indicators.For overall survival prediction,the respective C-indexes in the training set were 0.915(95%confidence interval:0.866-0.964)for overall survival prediction and 0.908(95%confidence interval:0.872-0.944)for progression-free survival prediction.According to decision curve analysis,net benefit of the GATIS score was higher than that of a single factor.The time-dependent area under the receiver operating characteristic curve showed that the predictive power of the GATIS score was higher than that of the TNM stage and pathological grade at all time periods.CONCLUSION The GATIS score had a good predictive effect on the prognosis of patients with R-NENs,with efficacy superior to that of the World Health Organization grade and TNM stage.展开更多
The rodent running-wheel recording apparatus is a reliable approach for studying cir-cadian rhythm.This study demonstrated how to construct a simple and intelligent running-wheel recording system.The running wheel was...The rodent running-wheel recording apparatus is a reliable approach for studying cir-cadian rhythm.This study demonstrated how to construct a simple and intelligent running-wheel recording system.The running wheel was attached to the cage's base,whereas the Hall sensor was attached to the cage's cover.Then,the RJ25 adaptor relayed the running signal to the main control board.Finally,the main control board was connected to the USB port of the computer with the USB connection.Data were collected using the online-accessible,self-created software Magturning.Through Magturning,generated data were saved and exported in real time.Afterward,the device was validated by collecting data on the locomotor activities of mice under dif-ferent light conditions.In conclusion,this new device can record circadian activity of rodents.Our device is appropriate for interdisciplinary investigations related to biological clock research.展开更多
In recent years,propelled by the rapid iterative advancements in digital imaging technology and the semiconductor industry,encompassing microelectronic design,manufacturing,packaging,and testing,time-of-flight(ToF)-ba...In recent years,propelled by the rapid iterative advancements in digital imaging technology and the semiconductor industry,encompassing microelectronic design,manufacturing,packaging,and testing,time-of-flight(ToF)-based imaging systems for acquiring depth information have garnered considerable attention from both academia and industry.This technology has emerged as a focal point of research within the realm of 3D imaging.Owing to its relatively straightforward principles and exceptional performance,ToF technology finds extensive applications across various domains including human−computer interaction,autonomous driving,industrial inspection,medical and healthcare,augmented reality,smart homes,and 3D reconstruction,among others.Notably,the increasing maturity of ToF-based LiDAR systems is evident in current developments.This paper comprehensively reviews the fundamental principles of ToF technology and LiDAR systems,alongside recent research advancements.It elucidates the innovative aspects and technical challenges encountered in both transmitter(TX)and receiver(RX),providing detailed discussions on corresponding solutions.Furthermore,the paper explores prospective avenues for future research,offering valuable insights for subsequent investigations.展开更多
In order to realize the in-situ evaluation of reinforced concrete bridges subjected to fatigue for a long time or after earthquake, an evaluation method for cumulative damage of concrete structures based on unloading ...In order to realize the in-situ evaluation of reinforced concrete bridges subjected to fatigue for a long time or after earthquake, an evaluation method for cumulative damage of concrete structures based on unloading elastic modulus was proposed. First, according to the concrete stress-strain curve and the statistical relationship between residual strain and cumulative strain, the calculation method of static equivalent strain and residual strain concrete based on unloading elastic modulus and the method for estimating the strength of concrete after damage were proposed. The detailed steps of field test and analysis and the practical damage indicators of residual strain were given. Then, the evaluation method of existing stress and strain of Reinforced Concrete Bridge under dead load and the concept of “equivalent dead load bending moment” were put forward. On this basis, the paper analyzed the root cause of the decrease of bearing capacity of Reinforced Concrete Bridge after fatigue damage, and pointed out that the equivalent strain or residual strain of reinforced concrete increases under the fatigue effect, which led to the decreasing of actual live moment and deformation performance while the ultimate load-carrying capacity remained constant or very little decrease. The evaluation method of structure residual capacity was given, and through comparative analysis of eight T reinforced concrete beams that had been in service for 35 years with the static failure tests, the effectiveness of the method was verified.展开更多
AIM： To study the effect of discoidin I-like domaincontaining protein 3（EDIL3） depletion on the proliferation and epithelial-mesenchymal transition（EMT） in human lens epithelial cells（LECs）. METHODS： RNA inter...AIM： To study the effect of discoidin I-like domaincontaining protein 3（EDIL3） depletion on the proliferation and epithelial-mesenchymal transition（EMT） in human lens epithelial cells（LECs）. METHODS： RNA interference was used to inhibit the expression of EDIL3 in human LECs in vitro. The morphology of cells was observed using an inverted microscope. Cell proliferation was assessed using Ed U kit. Cell migration was investigated using Transwell chamber and EMT of LECs was assessed using confocal microscope and Western blotting. The transforming growth factor β（TGFβ） pathway was investigated using Western blotting. RESULTS： The data showed that silencing EDIL3 expression changed LECs morphology and suppressed LECs proliferation（P〈0.05） and migration（P〈0.01）. Furthermore, the result of Western blotting showed that EDIL3 depletion reduced the expression of α-smooth muscle actin（α-SMA）（P〈0.001） and vimentin（P〈0.01）, while increased the expression of E-cadherin（P〈0.001）. EDIL3 depletion could suppress the phosphorylation of Smad2（P〈0.01） and Smad3（P〈0.01） and the activation of exracellular signal regulated kinase（ERK）（P〈0.05）. CONCLUSION： The findings indicate that EDIL3 might participate in the proliferation and EMT in LECs via TGFβ pathway and may be a potential therapeutic target for the treatment of posterior capsule opacification.展开更多
AIM:To investigate the effects of emergent preopera-tive self-expandable metallic stent (SEMS) vs emer-gent surgery for acute left-sided malignant colonic obstruction. METHODS:Two investigators independently searched ...AIM:To investigate the effects of emergent preopera-tive self-expandable metallic stent (SEMS) vs emer-gent surgery for acute left-sided malignant colonic obstruction. METHODS:Two investigators independently searched the MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials, as well as references of included studies to identify randomized controlled trials (RCTs) that compared two or more surgical approaches for acute colonic obstruction. Summary risk ratios (RR) and 95% CI for colonic stenting and emergent surgery were calculated. RESULTS:Eight studies met the selection criteria, involving 444 patients, of whom 219 underwent SEMS and 225 underwent emergent surgery. Seven studies reported difference of the one-stage stoma rates between the two groups (RR, 0.60; 95% CI:0.48-0.76; P < 0.0001). Only three RCTs described the follow-up stoma rates, which showed no significant difference between the two groups (RR, 0.80; 95% CI:0.59-1.08; P = 0.14). Difference was not significant in the mortality between the two groups (RR, 0.91; 95% CI:0.50-1.66; P = 0.77), but there was significant difference (RR, 0.57; 95% CI:0.44-0.74; P < 0.0001) in the overall morbidity. There were no significant differences between the two groups in the anastomotic leak rate (RR, 0.60; 95% CI: 0.28-1.28; P = 0.19), occurrence of abscesses, including peristomal abscess, intraperitoneal abscess and parietal abscess (RR, 0.83; 95% CI:0.36-1.95; P = 0.68), and other abdominal complications (RR: 0.67; 95% CI: 0.40-1.12; P = 0.13). CONCLUSION:SEMS is not obviously more advantageous than emergent surgery for patients with acute left-sided malignant colonic obstruction.展开更多
It is important for modern hospital management to strengthen medical humanistic care and build a harmonious doctor-patient relationship.Innovative applications of the big data resources of patient experience in modern...It is important for modern hospital management to strengthen medical humanistic care and build a harmonious doctor-patient relationship.Innovative applications of the big data resources of patient experience in modern hospital management facilitate hospital management to realize real-time supervision,dynamic management and s&entitle decision-making based on patients experiences.It is helping the transformation of hospital management from an administrator^perspective to a patients perspective,and from experience-driven to data-driven.The technological innovations in hospital management based on patient experience data can assist the optimization and continuous improvement of healthcare quality,therefore help to increase patient satisfaction to the medical services.展开更多
The phenotypes of protein and amino acid contents were measured in an F9 recombinant inbred line population derived from a cross between Zhenshan 97B and Delong 208. A total of 48 and 64 QTLs were identified in 2004 a...The phenotypes of protein and amino acid contents were measured in an F9 recombinant inbred line population derived from a cross between Zhenshan 97B and Delong 208. A total of 48 and 64 QTLs were identified in 2004 and 2005, respectively. The contribution of each QTL to the phenotypic variation ranged from 4.0% to 43.7%. Most QTLs co-localized, forming 29 QTL clusters on the chromosomes with three major ones detected in both years, which were mapped on chromosomes 1, 7 and 9, respectively. The two QTL clusters for amino acid content, qAa1 and qAa7, influenced almost all the traits with the allele from Zhenshan 97B, and the third QTL cluster for amino acid content, qAa9, increased the lysine content with the allele from Delong 208. A wide coincidence was found between the QTL detected under this study and the loci involved in amino acid metabolism pathways in nitrogen assimilation and transport, or protein biosynthesis. The results would facilitate the identification of candidate genes and could be used in marker-assisted selection for the favorable allele in rice quality improvement.展开更多
The complexity of oral ulcerations poses considerable diagnostic and therapeutic challenges to oral specialists.The expert consensus was conducted to summarize the diagnostic work-up for difficult and complicated oral...The complexity of oral ulcerations poses considerable diagnostic and therapeutic challenges to oral specialists.The expert consensus was conducted to summarize the diagnostic work-up for difficult and complicated oral ulcers,based on factors such as detailed clinical medical history inquiry,histopathological examination,and ulceration-related systemic diseases screening.Not only it can provide a standardized procedure of oral ulceration,but also it can improve the diagnostic efficiency,in order to avoid misdiagnosis and missed diagnosis.展开更多
OBJECTIVE To investigate the effect of quercetin on primary cultured newborn rat cortex neuron cell which is estrogen depletion,and discuss the possible mechanism,to provide new ideas and strategies for developing a d...OBJECTIVE To investigate the effect of quercetin on primary cultured newborn rat cortex neuron cell which is estrogen depletion,and discuss the possible mechanism,to provide new ideas and strategies for developing a drug of neurodegenerative disease.METHODS Rat cortex neurons were isolated from one day old Sprague Dawley rats and treated with estrogen,quercetin and estrogen receptor antagonists(ICI182,780).Cell viability was determined by MTT assay,neurite outgrowth was measured by fluorescent microsope and estrogen receptors were determine by Western blot.RESULTS Quercetin functions like estrogen to increase cortex neuronal cell viability,the Que(50,100μmol·L^(-1))group compared with the control group could significantly improve the activity of the cortical neurons(P<0.05).It can also increase neurite out growth,the Que(50,100μmol·L^(-1))group significantly promoted the formation of synapse,most of the neurons were full,and the synapses of neurons became thick,growth,and connect to a dense neural network.And in the Western blot experiments,Que(50,100μmol·L^(-1))group could obviously increase the expression of estrogen receptor alpha protein,in addition,the neural protective effect of quercetin can be inhibited by ICI182,780.CONCLUSION Quercetin like estrogen can protected cortex neuronal and the effect of quercetin on cortex neuronal cells was mediated by estrogen receptor alpha.展开更多
Traditional seawater desalination requires high amounts of energy, with correspondingly high costs and limited benefits, hindering wider applications of the process. To further improve the comprehensive economic benef...Traditional seawater desalination requires high amounts of energy, with correspondingly high costs and limited benefits, hindering wider applications of the process. To further improve the comprehensive economic benefits of seawater desalination, the desalination load can be combined with renewable energy sources such as solar energy, wind energy, and ocean energy or with the power grid to ensure its effective regulation. Utilizing energy internet(EI) technology, energy balance demand of the regional power grid, and coordinated control between coastal multi-source multi-load and regional distribution network with desalination load is reviewed herein. Several key technologies, including coordinated control of coastal multi-source multi-load system with seawater desalination load, flexible interaction between seawater desalination and regional distribution network, and combined control of coastal multi-source multi-load storage system with seawater desalination load, are discussed in detail. Adoption of the flexible interaction between seawater desalination and regional distribution networks is beneficial for solving water resource problems, improving the ability to dissipate distributed renewable energy, balancing and increasing grid loads, improving the safety and economy of coastal power grids, and achieving coordinated and comprehensive application of power grids, renewable energy sources, and coastal loads.展开更多
The intestinal mucosa is a highly compartmentalized structure that forms a directbarrier between the host intestine and the environment, and its dysfunction couldresult in a serious disease. As T cells, which are impo...The intestinal mucosa is a highly compartmentalized structure that forms a directbarrier between the host intestine and the environment, and its dysfunction couldresult in a serious disease. As T cells, which are important components of themucosal immune system, interact with gut microbiota and maintain intestinalhomeostasis, they may be involved in the process of intestinal barrier dysfunction.P2X7 receptor (P2X7R), a member of the P2X receptors family, mediates the effectsof extracellular adenosine triphosphate and is expressed by most innate or adaptiveimmune cells, including T cells. Current evidence has demonstrated thatP2X7R is involved in inflammation and mediates the survival and differentiationof T lymphocytes, indicating its potential role in the regulation of T cell function.In this review, we summarize the available research about the regulatory role andmechanism of P2X7R on the intestinal mucosa-derived T cells in the setting ofintestinal barrier dysfunction.展开更多
This article investigates channel allocation for cognitive networks, which is difficult to obtain the optimal allocation distribution. We first study interferences between nodes in cognitive networks and establish the...This article investigates channel allocation for cognitive networks, which is difficult to obtain the optimal allocation distribution. We first study interferences between nodes in cognitive networks and establish the channel allocation model with interference constraints. Then we focus on the use of evolutionary algorithms to solve the optimal allocation distribution. We further consider that the search time can be reduced by means of parallel computing, and then a parallel algorithm based APO is proposed. In contrast with the existing algorithms, we decompose the allocation vector into a number of sub-vectors and search for optimal allocation distribution of sub-vector in parallel. In order to speed up converged rate and improve converged value, some typical operations of evolutionary algorithms are modified by two novel operators. Finally, simulation results show that the proposed algorithm drastically outperform other optimal solutions in term of the network utilization.展开更多
仔猪健康是养猪生产效益的重要保证。哺乳仔猪在断奶时面临着环境和营养物质来源改变的双重压力,表现出以生长率和营养物质吸收率降低、肠道功能紊乱及敏感性增加、腹泻和高死亡率为主要特征的断奶应激综合征(Aumaitre和Corring,1978)...仔猪健康是养猪生产效益的重要保证。哺乳仔猪在断奶时面临着环境和营养物质来源改变的双重压力,表现出以生长率和营养物质吸收率降低、肠道功能紊乱及敏感性增加、腹泻和高死亡率为主要特征的断奶应激综合征(Aumaitre和Corring,1978)。由断奶应激导致的仔猪胃肠道功能失调往往给养猪业带来巨大的经济损失(Lallès et al.,2007)。随着我国农业农村部第194号公告的出台,饲料药物添加剂抗生素类已于2020年7月1日正式退出我国畜牧业的历史舞台。展开更多
Metal-air batteries(MABs)have attracted considerable attention as a novel energy technology that can alleviate the severe energy crisis and environmental pollution.Two primary processes,including oxygen reduction reac...Metal-air batteries(MABs)have attracted considerable attention as a novel energy technology that can alleviate the severe energy crisis and environmental pollution.Two primary processes,including oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)occur on the air cathode and dominate the battery performance during battery charging and discharging.Recently,metal-organic frameworks(MOFs)and covalent-organic frameworks(COFs)emerge as promising cathode catalysts due to their structure and composition superiority.The unique characteristics of MOFs and COFs contribute to improved performance.This review mainly summarizes the recent applications of MOFs and COFs in a series of MABs,mainly including lithium-and zinc-air batteries.Additionally,some critical issues are emphasized regarding MOFs and COFs used in other MABs limited progress,their fabrication and alternatives to potential problems.展开更多
基金Supported by National Natural Science Foundation of China,No.82072736 and No.81874184the Key Project of Hubei Health Commission,No.WJ2019Q030.
文摘BACKGROUND There is currently a shortage of accurate,efficient,and precise predictive instruments for rectal neuroendocrine neoplasms(NENs).AIM To develop a predictive model for individuals with rectal NENs(R-NENs)using data from a large cohort.METHODS Data from patients with primary R-NENs were retrospectively collected from 17 large-scale referral medical centers in China.Random forest and Cox proportional hazard models were used to identify the risk factors for overall survival and progression-free survival,and two nomograms were constructed.RESULTS A total of 1408 patients with R-NENs were included.Tumor grade,T stage,tumor size,age,and a prognostic nutritional index were important risk factors for prognosis.The GATIS score was calculated based on these five indicators.For overall survival prediction,the respective C-indexes in the training set were 0.915(95%confidence interval:0.866-0.964)for overall survival prediction and 0.908(95%confidence interval:0.872-0.944)for progression-free survival prediction.According to decision curve analysis,net benefit of the GATIS score was higher than that of a single factor.The time-dependent area under the receiver operating characteristic curve showed that the predictive power of the GATIS score was higher than that of the TNM stage and pathological grade at all time periods.CONCLUSION The GATIS score had a good predictive effect on the prognosis of patients with R-NENs,with efficacy superior to that of the World Health Organization grade and TNM stage.
基金Startup Fund for scientific research,Fujian Medical University,Grant/Award Number:2020QH1039Joint Funds for the Innovation of Science and Technology,Fujian Province,Grant/Award Number:2020Y9114 and 2020Y9119。
文摘The rodent running-wheel recording apparatus is a reliable approach for studying cir-cadian rhythm.This study demonstrated how to construct a simple and intelligent running-wheel recording system.The running wheel was attached to the cage's base,whereas the Hall sensor was attached to the cage's cover.Then,the RJ25 adaptor relayed the running signal to the main control board.Finally,the main control board was connected to the USB port of the computer with the USB connection.Data were collected using the online-accessible,self-created software Magturning.Through Magturning,generated data were saved and exported in real time.Afterward,the device was validated by collecting data on the locomotor activities of mice under dif-ferent light conditions.In conclusion,this new device can record circadian activity of rodents.Our device is appropriate for interdisciplinary investigations related to biological clock research.
文摘In recent years,propelled by the rapid iterative advancements in digital imaging technology and the semiconductor industry,encompassing microelectronic design,manufacturing,packaging,and testing,time-of-flight(ToF)-based imaging systems for acquiring depth information have garnered considerable attention from both academia and industry.This technology has emerged as a focal point of research within the realm of 3D imaging.Owing to its relatively straightforward principles and exceptional performance,ToF technology finds extensive applications across various domains including human−computer interaction,autonomous driving,industrial inspection,medical and healthcare,augmented reality,smart homes,and 3D reconstruction,among others.Notably,the increasing maturity of ToF-based LiDAR systems is evident in current developments.This paper comprehensively reviews the fundamental principles of ToF technology and LiDAR systems,alongside recent research advancements.It elucidates the innovative aspects and technical challenges encountered in both transmitter(TX)and receiver(RX),providing detailed discussions on corresponding solutions.Furthermore,the paper explores prospective avenues for future research,offering valuable insights for subsequent investigations.
文摘In order to realize the in-situ evaluation of reinforced concrete bridges subjected to fatigue for a long time or after earthquake, an evaluation method for cumulative damage of concrete structures based on unloading elastic modulus was proposed. First, according to the concrete stress-strain curve and the statistical relationship between residual strain and cumulative strain, the calculation method of static equivalent strain and residual strain concrete based on unloading elastic modulus and the method for estimating the strength of concrete after damage were proposed. The detailed steps of field test and analysis and the practical damage indicators of residual strain were given. Then, the evaluation method of existing stress and strain of Reinforced Concrete Bridge under dead load and the concept of “equivalent dead load bending moment” were put forward. On this basis, the paper analyzed the root cause of the decrease of bearing capacity of Reinforced Concrete Bridge after fatigue damage, and pointed out that the equivalent strain or residual strain of reinforced concrete increases under the fatigue effect, which led to the decreasing of actual live moment and deformation performance while the ultimate load-carrying capacity remained constant or very little decrease. The evaluation method of structure residual capacity was given, and through comparative analysis of eight T reinforced concrete beams that had been in service for 35 years with the static failure tests, the effectiveness of the method was verified.
基金Supported by the National Natural Science Foundation of China (No.81700839)Military logistics scientific research project (No.BWS12J030)+2 种基金Natural Science Foundation of Shanghai (No.15ZR1413200)Research Foundation for Youth of Second Military Medical University (No.2016QN13)Research Foundation for Youth of Changhai Hospital (No.CH201712)
文摘AIM： To study the effect of discoidin I-like domaincontaining protein 3（EDIL3） depletion on the proliferation and epithelial-mesenchymal transition（EMT） in human lens epithelial cells（LECs）. METHODS： RNA interference was used to inhibit the expression of EDIL3 in human LECs in vitro. The morphology of cells was observed using an inverted microscope. Cell proliferation was assessed using Ed U kit. Cell migration was investigated using Transwell chamber and EMT of LECs was assessed using confocal microscope and Western blotting. The transforming growth factor β（TGFβ） pathway was investigated using Western blotting. RESULTS： The data showed that silencing EDIL3 expression changed LECs morphology and suppressed LECs proliferation（P〈0.05） and migration（P〈0.01）. Furthermore, the result of Western blotting showed that EDIL3 depletion reduced the expression of α-smooth muscle actin（α-SMA）（P〈0.001） and vimentin（P〈0.01）, while increased the expression of E-cadherin（P〈0.001）. EDIL3 depletion could suppress the phosphorylation of Smad2（P〈0.01） and Smad3（P〈0.01） and the activation of exracellular signal regulated kinase（ERK）（P〈0.05）. CONCLUSION： The findings indicate that EDIL3 might participate in the proliferation and EMT in LECs via TGFβ pathway and may be a potential therapeutic target for the treatment of posterior capsule opacification.
文摘AIM:To investigate the effects of emergent preopera-tive self-expandable metallic stent (SEMS) vs emer-gent surgery for acute left-sided malignant colonic obstruction. METHODS:Two investigators independently searched the MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials, as well as references of included studies to identify randomized controlled trials (RCTs) that compared two or more surgical approaches for acute colonic obstruction. Summary risk ratios (RR) and 95% CI for colonic stenting and emergent surgery were calculated. RESULTS:Eight studies met the selection criteria, involving 444 patients, of whom 219 underwent SEMS and 225 underwent emergent surgery. Seven studies reported difference of the one-stage stoma rates between the two groups (RR, 0.60; 95% CI:0.48-0.76; P < 0.0001). Only three RCTs described the follow-up stoma rates, which showed no significant difference between the two groups (RR, 0.80; 95% CI:0.59-1.08; P = 0.14). Difference was not significant in the mortality between the two groups (RR, 0.91; 95% CI:0.50-1.66; P = 0.77), but there was significant difference (RR, 0.57; 95% CI:0.44-0.74; P < 0.0001) in the overall morbidity. There were no significant differences between the two groups in the anastomotic leak rate (RR, 0.60; 95% CI: 0.28-1.28; P = 0.19), occurrence of abscesses, including peristomal abscess, intraperitoneal abscess and parietal abscess (RR, 0.83; 95% CI:0.36-1.95; P = 0.68), and other abdominal complications (RR: 0.67; 95% CI: 0.40-1.12; P = 0.13). CONCLUSION:SEMS is not obviously more advantageous than emergent surgery for patients with acute left-sided malignant colonic obstruction.
文摘It is important for modern hospital management to strengthen medical humanistic care and build a harmonious doctor-patient relationship.Innovative applications of the big data resources of patient experience in modern hospital management facilitate hospital management to realize real-time supervision,dynamic management and s&entitle decision-making based on patients experiences.It is helping the transformation of hospital management from an administrator^perspective to a patients perspective,and from experience-driven to data-driven.The technological innovations in hospital management based on patient experience data can assist the optimization and continuous improvement of healthcare quality,therefore help to increase patient satisfaction to the medical services.
基金supported by grants from the National Program on the Development of Basic Research (Grant No. 2011CB100200)the National Program of High Technology Development (Grant No. 2010AA101801)+1 种基金the National Program of Plant Transgenic Breeding (Grant No. 2008ZX08009-003)the National Natural Science Foundation of China (Grant No. 30671114)
文摘The phenotypes of protein and amino acid contents were measured in an F9 recombinant inbred line population derived from a cross between Zhenshan 97B and Delong 208. A total of 48 and 64 QTLs were identified in 2004 and 2005, respectively. The contribution of each QTL to the phenotypic variation ranged from 4.0% to 43.7%. Most QTLs co-localized, forming 29 QTL clusters on the chromosomes with three major ones detected in both years, which were mapped on chromosomes 1, 7 and 9, respectively. The two QTL clusters for amino acid content, qAa1 and qAa7, influenced almost all the traits with the allele from Zhenshan 97B, and the third QTL cluster for amino acid content, qAa9, increased the lysine content with the allele from Delong 208. A wide coincidence was found between the QTL detected under this study and the loci involved in amino acid metabolism pathways in nitrogen assimilation and transport, or protein biosynthesis. The results would facilitate the identification of candidate genes and could be used in marker-assisted selection for the favorable allele in rice quality improvement.
基金supported by grants from the National Natural Science Foundations of China(No.U19A2005,81771081,81870775)CAMS Innovation Fund for Medical Sciences(CIFMS)(2019-12M-5-004,2020-I2M-C&T-A-023)。
文摘The complexity of oral ulcerations poses considerable diagnostic and therapeutic challenges to oral specialists.The expert consensus was conducted to summarize the diagnostic work-up for difficult and complicated oral ulcers,based on factors such as detailed clinical medical history inquiry,histopathological examination,and ulceration-related systemic diseases screening.Not only it can provide a standardized procedure of oral ulceration,but also it can improve the diagnostic efficiency,in order to avoid misdiagnosis and missed diagnosis.
基金supported by Science and Technology Research Project of Hebei Higher School,Hebei Education Department(ZD2015131)Natural Science Foundation of Hebei Province(H2012405016)
文摘OBJECTIVE To investigate the effect of quercetin on primary cultured newborn rat cortex neuron cell which is estrogen depletion,and discuss the possible mechanism,to provide new ideas and strategies for developing a drug of neurodegenerative disease.METHODS Rat cortex neurons were isolated from one day old Sprague Dawley rats and treated with estrogen,quercetin and estrogen receptor antagonists(ICI182,780).Cell viability was determined by MTT assay,neurite outgrowth was measured by fluorescent microsope and estrogen receptors were determine by Western blot.RESULTS Quercetin functions like estrogen to increase cortex neuronal cell viability,the Que(50,100μmol·L^(-1))group compared with the control group could significantly improve the activity of the cortical neurons(P<0.05).It can also increase neurite out growth,the Que(50,100μmol·L^(-1))group significantly promoted the formation of synapse,most of the neurons were full,and the synapses of neurons became thick,growth,and connect to a dense neural network.And in the Western blot experiments,Que(50,100μmol·L^(-1))group could obviously increase the expression of estrogen receptor alpha protein,in addition,the neural protective effect of quercetin can be inhibited by ICI182,780.CONCLUSION Quercetin like estrogen can protected cortex neuronal and the effect of quercetin on cortex neuronal cells was mediated by estrogen receptor alpha.
基金supported by the State Grid Science and Technology Project, “Study on Multi-source and Multiload Coordination and Optimization Technology Considering Desalination of Sea Water” (No. SGTJDK00DWJS1800011)
文摘Traditional seawater desalination requires high amounts of energy, with correspondingly high costs and limited benefits, hindering wider applications of the process. To further improve the comprehensive economic benefits of seawater desalination, the desalination load can be combined with renewable energy sources such as solar energy, wind energy, and ocean energy or with the power grid to ensure its effective regulation. Utilizing energy internet(EI) technology, energy balance demand of the regional power grid, and coordinated control between coastal multi-source multi-load and regional distribution network with desalination load is reviewed herein. Several key technologies, including coordinated control of coastal multi-source multi-load system with seawater desalination load, flexible interaction between seawater desalination and regional distribution network, and combined control of coastal multi-source multi-load storage system with seawater desalination load, are discussed in detail. Adoption of the flexible interaction between seawater desalination and regional distribution networks is beneficial for solving water resource problems, improving the ability to dissipate distributed renewable energy, balancing and increasing grid loads, improving the safety and economy of coastal power grids, and achieving coordinated and comprehensive application of power grids, renewable energy sources, and coastal loads.
基金Supported by The National Natural Science Foundation of China,No. 81801943Shanghai Pujiang Program,No. 21PJD009The Research Grant for Public Health Key Discipline of Shanghai Municipality,China,No. GWV-10.1-XK26
文摘The intestinal mucosa is a highly compartmentalized structure that forms a directbarrier between the host intestine and the environment, and its dysfunction couldresult in a serious disease. As T cells, which are important components of themucosal immune system, interact with gut microbiota and maintain intestinalhomeostasis, they may be involved in the process of intestinal barrier dysfunction.P2X7 receptor (P2X7R), a member of the P2X receptors family, mediates the effectsof extracellular adenosine triphosphate and is expressed by most innate or adaptiveimmune cells, including T cells. Current evidence has demonstrated thatP2X7R is involved in inflammation and mediates the survival and differentiationof T lymphocytes, indicating its potential role in the regulation of T cell function.In this review, we summarize the available research about the regulatory role andmechanism of P2X7R on the intestinal mucosa-derived T cells in the setting ofintestinal barrier dysfunction.
基金supported in part by the National Natural Science Foundation under Grant No.61072069National Science and Technology Major Project of the Ministry of Science and Technology of China under Grant No.2012ZX03003012
文摘This article investigates channel allocation for cognitive networks, which is difficult to obtain the optimal allocation distribution. We first study interferences between nodes in cognitive networks and establish the channel allocation model with interference constraints. Then we focus on the use of evolutionary algorithms to solve the optimal allocation distribution. We further consider that the search time can be reduced by means of parallel computing, and then a parallel algorithm based APO is proposed. In contrast with the existing algorithms, we decompose the allocation vector into a number of sub-vectors and search for optimal allocation distribution of sub-vector in parallel. In order to speed up converged rate and improve converged value, some typical operations of evolutionary algorithms are modified by two novel operators. Finally, simulation results show that the proposed algorithm drastically outperform other optimal solutions in term of the network utilization.
文摘仔猪健康是养猪生产效益的重要保证。哺乳仔猪在断奶时面临着环境和营养物质来源改变的双重压力,表现出以生长率和营养物质吸收率降低、肠道功能紊乱及敏感性增加、腹泻和高死亡率为主要特征的断奶应激综合征(Aumaitre和Corring,1978)。由断奶应激导致的仔猪胃肠道功能失调往往给养猪业带来巨大的经济损失(Lallès et al.,2007)。随着我国农业农村部第194号公告的出台,饲料药物添加剂抗生素类已于2020年7月1日正式退出我国畜牧业的历史舞台。
基金supported by the National Natural Science Foundation of China(22035003 and 21905142)the Programme of Introducing Talents of Discipline to Universities(No.B18030)+2 种基金the Natural Science Fund of Tianjin(nos.19JCZDJC37200 and19JCQNJC02600)the Youth Scientific and Technical Plan Project of Gansu Province(20JR10RA198)the China Postdoctoral Science Foundation(2019M651008)。
文摘Metal-air batteries(MABs)have attracted considerable attention as a novel energy technology that can alleviate the severe energy crisis and environmental pollution.Two primary processes,including oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)occur on the air cathode and dominate the battery performance during battery charging and discharging.Recently,metal-organic frameworks(MOFs)and covalent-organic frameworks(COFs)emerge as promising cathode catalysts due to their structure and composition superiority.The unique characteristics of MOFs and COFs contribute to improved performance.This review mainly summarizes the recent applications of MOFs and COFs in a series of MABs,mainly including lithium-and zinc-air batteries.Additionally,some critical issues are emphasized regarding MOFs and COFs used in other MABs limited progress,their fabrication and alternatives to potential problems.
