AIM: To compare the qualitative and quantitative features among untreated polypoidal choroidal vasculopathy(PCV), neovascular age-related macular degeneration(nv-AMD) and central serous chorioretinopathy(CSC) using op...AIM: To compare the qualitative and quantitative features among untreated polypoidal choroidal vasculopathy(PCV), neovascular age-related macular degeneration(nv-AMD) and central serous chorioretinopathy(CSC) using optical coherence tomography(OCT) and OCT angiography(OCTA).METHODS: This retrospective study included 16 eyes with thin-choroid PCV, 18 eyes with thick-choroid PCV, 16 eyes with nv-AMD and 17 eyes with CSC, respectively. The indicators were obtained by OCT and OCTA.RESULTS: Sub-foveal choroidal thickness(SFCT) in CSC was thicker compared to other groups(all P<0.05). SFCT in nv-AMD was thicker compared to thin-choroid PCV, but thinner compared with thick-choroid PCV(both P<0.05). As the ratio of thickness of Haller's layer to thickness of SFCT, which of thin-choroid PCV was significantly higher than CSC(P<0.001). Likewise, thick-choroid PCV had significantly higher ratio than nv-AMD(P=0.016) or CSC(P<0.001). There were differences among them in pigment epithelium detachment(PED). The whole-superficial retinal vessel density(RVD), deep RVD and choroidal capillary vessel density(CCVD) in CSC were significantly higher compared to other three groups, respectively(all P<0.05). The whole CCVD in nv-AMD was higher compared to thick-choroid PCV(P=0.032). Cross-sectional local angiographic form was 87.50%, 83.33%, 0 and 35.29% in thin-choroid PCV, thickchoroid PCV, nv-AMD and CSC, respectively. Cross-sectional diffuse angiographic form was 12.50%, 16.67%, 100% and 5.88% in thin-choroid PCV, thick-choroid PCV, nv-AMD and CSC, respectively.CONCLUSION: Combination of OCT and OCTA can effectively observe the significant alterations existed in PCV, CSC and nv-AMD, and there are distinctive differences among them. The pathogenesis is not exactly the same between PCV and nv-AMD, or PCV and CSC.展开更多
AIM: To compare the ocular fundus features of highly myopic eyes with and without macular Bruch’s membrane(BM) defects and investigate the associations between macular BM defects and other myopic lesions.METHODS: Thi...AIM: To compare the ocular fundus features of highly myopic eyes with and without macular Bruch’s membrane(BM) defects and investigate the associations between macular BM defects and other myopic lesions.METHODS: This retrospective, observational case series included 262 eyes(139 patients) with high myopia(HM) refractive error ≥-6.0 diopters(D) or axial length ≥26.5 mm from March 2019 to December 2019.The patients underwent a comprehensive ophthalmic examination, including sweptsource optical coherence tomography(SS-OCT).The features of macular BM defects and other ocular fundus lesions were examined in OCT images.RESULTS: Totally 51 eyes(19.5%) were detected with macular BM defects, which were characterized by a lack of BM, retinal pigment epithelium(RPE), and an almost complete loss of photoreceptors or choriocapillaris.Eyes with macular BM defects had worse best-corrected visual acuity(BCVA) than those without(P<0.001).Dome-shaped macula(DSM, P=0.042), retinal cysts(P=0.006), choroidal neovascularization(CNV, P<0.001), choroidal defects and abnormality(P=0.003), scleral defects(P=0.015), scleral deformation(P=0.005), posterior staphyloma(P=0.011), and perforating vessels(P<0.001) occurred more frequently in eyes with macular BM defects.In multivariate analysis, the presence of macular BM defects remained the significant association with presence of DSM(P=0.013), scleral defects(P=0.015), posterior staphyloma(P=0.001), perforating vessels(P<0.001) and CNV(P=0.004).CONCLUSION: Macular BM defects has a prevalence of approximately 20% in HM and it has tight association with other myopic fundus lesions.BM might be crucial in the pathogenesis of myopic fundus lesions due to its biomechanical function.A comprehensive understanding of BM’s role is useful for further researches about myopic lesions.展开更多
Dear Editor,We present the first patient with Peters’ anomaly-related glaucoma undergoing CO_(2) laser-assisted sclerectomy surgery(CLASS) and trabeculectomy combination therapy.Peters’ anomaly is a complex congenit...Dear Editor,We present the first patient with Peters’ anomaly-related glaucoma undergoing CO_(2) laser-assisted sclerectomy surgery(CLASS) and trabeculectomy combination therapy.Peters’ anomaly is a complex congenital eye disease, which is categorized as dysplasia of anterior segment.展开更多
The major vascular complications associated with diabetes make the management of diabetic mellitus erectile dysfunction(DMED)a challenging endeavor.Notable factors contributing to DMED include oxidative stress,nitric ...The major vascular complications associated with diabetes make the management of diabetic mellitus erectile dysfunction(DMED)a challenging endeavor.Notable factors contributing to DMED include oxidative stress,nitric oxide(NO)/cyclic guanosine monophosphate(cGMP)pathway activation,and apoptosis,while nitro-oleic acid(NO,-OA)has been shown to be beneficial in treating these aspects of this condition.We,herein,investigated the effects and possible mechanisms of NO,-OA on erectile function as assessed in a streptozotocin-induced rat model of diabetes.Our results revealed that the erectile function of DMED rats was significantly impaired compared with that of the control group.However,in response to 4 weeks of NO,-OA treatment,there was an improvement in erectile function.The expression of oxidative stress-related indicators was significantly increased and the NO/cGMP pathway was impaired in the DMED group.The expression of proapoptotic factors was increased,while that of antiapoptotic factors was decreased in the DMED group.Moreover,the cell morphology in the cavernous tissue of the DMED group also changed adversely.NO,-OA treatment significantly reversed all these changes observed in the DMED group.In conclusion,NO,-OA treatment partially improved erectile function in DMED rats through mechanisms that included inhibition of oxidative stress,activation of the NO/cGMP pathway,and a reduction in apoptosis.展开更多
At the end of 2022,the adjustment of the coronavirus disease 2019(COVID-19)pandemic control policy in China resulted in alarge-scale increase in public infection.To compare the fertility parameters of male patients be...At the end of 2022,the adjustment of the coronavirus disease 2019(COVID-19)pandemic control policy in China resulted in alarge-scale increase in public infection.To compare the fertility parameters of male patients before and after the adjustments ofthe COVID-19 pandemic control policy in China,we collected data on patients’medical histories and laboratory examinations ontheir first visits between June 2022 and March 2023 in five different hospitals.Data were divided into five groups according tothe timeline of the policy adjustment.The data we collected from male patients included semen quality and serum reproductivehormone levels,and intergroup comparisons were made using the Mann–Whitney U and Chi-square tests.In total,16784 casesunderwent regular semen analysis,11180 had sperm morphology assessments,and 7200 had reproductive hormone analyses.Thedata showed declining trends in semen volume,sperm motility,and the progressive sperm motility rate after the policy adjustment.Subgroup comparison revealed an initial decrease and gradual recovery in progressive motility rate.Sperm morphology analysisshowed increased neck and tail abnormalities after the policy adjustment.No significant change in hormone levels was observed.Following the adjustment of the COVID-19 prevention policy in China,a decline in sperm motility and morphology was observed.This trend may gradually recover over 2 months.After the policy adjustment,reproductive hormone levels were relatively stablethroughout,except for an increase in luteinizing hormone(LH).These changes in semen parameters suggest that the policyadjustment had a short-to medium-term impact on male reproductive function.展开更多
This study aimed to describe endoscopic anatomy of the seminal tract and summarize our experience of transutricular seminal vesiculoscopy(TSV)guided by rea卜time transrectal ultrasonography(TRUS)in managing persistent...This study aimed to describe endoscopic anatomy of the seminal tract and summarize our experience of transutricular seminal vesiculoscopy(TSV)guided by rea卜time transrectal ultrasonography(TRUS)in managing persistent hematospermia.A total of 281 consecutive patients with persistent hematospermia who underwent TSV with or without real-time TRUS were enrolled in this single-center,prospective,observational study.The median follow-up period was 36.5(range:8.0-97.5)months.TSV was successfully performed in 272(96.8%)patients.The approach of a 4.5/6 F rigid vesiculoscope entering the seminal tract was categorized into four types on the basis of endoscopic presentation of the ejaculatory duct orifice and verumontanum.Seven(2.6%),74(27.2%),64(23.5%),and 127(46.7%)patients had Types I(through the ejaculatory duct in the urethra),II(through the ejaculatory duct in the prostatic utricle),III(transutricular fenestration through a thin membrane),and IV(real-time transrectal ultrasound-guided transutricular fenestration)approach,respectively.In patients who successfully underwent surgery,bleeding occurred in the seminal vesicle in 249(91.5%)patients.Seminal vesiculitis,calculus in the prostatic utricle,calculus in the ejaculatory duct,calculus in the seminal vesicle,prostatic utricle cysts,and seminal vesicle cysts were observed in 213(78.3%),96(35.3%),22(8.1%),81(29.8%),25(9.2%),and 11(4.0%)patients,respectively.Hematospermia was alleviated or disappeared in 244(89.7%)patients 12 months after surgery.Fifteen patients had recurrent hematospermia,and the median time to recurrence was 7.5(range:2.0-18.5)months.TSV guided by TRUS may contribute to successful postoperative outcomes in managing persistent hematospermia.展开更多
The aim of this study is to evaluate the benefits of laparoscopic Doppler ultrasound （LDU） application during laparoscopic varicocelectomy （LV）, and to compare the surgical outcomes and complications between LDU-a...The aim of this study is to evaluate the benefits of laparoscopic Doppler ultrasound （LDU） application during laparoscopic varicocelectomy （LV）, and to compare the surgical outcomes and complications between LDU-assisted LV （LDU-LV） and conventional LV for infertile patients with varicoceles; 147 infertile patients were randomly divided into two groups. Operative and postoperative parameters, semen parameters, and the pregnancy rate were compared. There were no differences in baseline demographics. The operative time was significantly longer in LDU-LV group than LV group. The incidence of postoperative hydrocele was 1.4% （1/72） in LDU-LV group versus 10.7% （8/75） in LV group, which showed a significant difference （P〈 0.05）. However, other surgical outcomes, such as postoperative hospital stay, postoperative recurrence, and testicular atrophy, were similar between the two groups. Sperm concentration and sperm motility were significantly increased in both groups at 3, 6, and 12 months after surgery （P 〈 0.01）, and they were higher in LDU-LV than LV group in 12 months after surgery （34.21 ± 6.36 vs 29.99 ± 6.04 for concentration, P〈 0.05; 40.72±8.12 vs 37.31 ± 6.12 for motility, P〈 0.05）. Sperm morphology was comparable between the two groups. The pregnancy rate showed no significant difference （44.4% of the LDU-LV vs 37.3% of the LV, P〉 0.05）. In conclusion, compared with LV, LDU-LV could safely and effectively ligate all spermatic veins and preserve spermatic arteries without leading to high varicocele recurrence and postoperative hydrocele. Given the benefits that sperm counts as well as sperm motility favoring LDU-LV, we recommend that LDU should be routinely used as an effective tool to improve outcomes and safety of laparoscopic varicocelectomy.展开更多
Although elevated prolactin levels have been shown to inhibit penile erection,the relationship between prolactin and erection of the penile tip or base has not been extensively researched.We therefore investigated the...Although elevated prolactin levels have been shown to inhibit penile erection,the relationship between prolactin and erection of the penile tip or base has not been extensively researched.We therefore investigated the prolactin's effects on erecti on of the penile tip and base,with a cross-secti onal study of 135 patie nts with erectile dysfuncti on,based on scores of M21 on the In ternational Index of Erectile Function-5.All patients were tested for nocturnal penile tumescenee,blood pressure,serum glucose,total cholesterol,triglyceride,high-density lipoprotein,low-density lipoprotein,luteinizing hormone,follicle-stimulating hormone,prolactin,estradiol,testosterone,and progesterone.Univariate and multivariate analyses were used to assess the associations between prolactin levels and erection at the penile tip and base.We found no obvious relati on ship between erection time at penile tip and prolactin levels,but observed a negative correlation between base erection time and prolactin level(hazard ratio:-2.68;95%confidence interval[Cl]:-5.13-0.22).With increasing prolactin concentration,multivariate analysis showed obvious reduction in base erection time among patients with normal Rigiscan results(hazard ratio:-3.10;95%Cl:-7.96-1.77;P<0.05).Our data indicate that prolactin inhibits penile erection,particularly at the penile base.In addition,when the effective erection time of the penile base lasts longer than 10 min,prolactin has a more obvious inhibitory effect on penile base erection.展开更多
The aim of our study was to investigate the role of platelet parameters including mean platelet volume (MPV)and platelet count (PC) in the pathogenesis of penile arteriogenic erectile dysfunction (ED)and to evaluate t...The aim of our study was to investigate the role of platelet parameters including mean platelet volume (MPV)and platelet count (PC) in the pathogenesis of penile arteriogenic erectile dysfunction (ED)and to evaluate the association between the platelet parameters and arteriogenic ED.There were 244 patients with ED (based on the International Index of Erectile Function [IIEF]-5≤21)and 60 healthy controls (IIEF-5 >21)enrolled.All participants were asked to undergo a laboratory examination,and penile vascular function was evaluated using penile color Doppler ultrasonography (pDUS).Among these ED patients,24 patients with no abnormality on nocturnal penile tumescence (NPT)and 84 with normal vasculature or mixed vascular abnormalities were excluded.The other patients were classified into three groups as follows:control (n =60),arteriogenic ED (n =99),and venous leakage (n =37) groups.MPV and PC were significantly higher in the arteriogenic ED group compared with the venous and control groups (P<0.05). Receiver operating characteristic curve analysis revealed that the area under the curve for MPV to predict arteriogenic ED was 0.707. MPV≥9.65 fl was recognized as a cut-off value for potential arteriogenic ED (sensitivity:47.5%;specificity:91.7%).A significant inverse correlation was detected between MPV and lO-min peak systolic velocity (PSV)(r =-0.34;P <0.001)in the arteriogenic ED group.These findings suggest that the MPV might be a powerful indicator to predict and diagnose arteriogenic ED,and MPV may be a marker for ED when using pDUS.展开更多
基金Supported by National Natural Science Foundation of China(No.81670879)
文摘AIM: To compare the qualitative and quantitative features among untreated polypoidal choroidal vasculopathy(PCV), neovascular age-related macular degeneration(nv-AMD) and central serous chorioretinopathy(CSC) using optical coherence tomography(OCT) and OCT angiography(OCTA).METHODS: This retrospective study included 16 eyes with thin-choroid PCV, 18 eyes with thick-choroid PCV, 16 eyes with nv-AMD and 17 eyes with CSC, respectively. The indicators were obtained by OCT and OCTA.RESULTS: Sub-foveal choroidal thickness(SFCT) in CSC was thicker compared to other groups(all P<0.05). SFCT in nv-AMD was thicker compared to thin-choroid PCV, but thinner compared with thick-choroid PCV(both P<0.05). As the ratio of thickness of Haller's layer to thickness of SFCT, which of thin-choroid PCV was significantly higher than CSC(P<0.001). Likewise, thick-choroid PCV had significantly higher ratio than nv-AMD(P=0.016) or CSC(P<0.001). There were differences among them in pigment epithelium detachment(PED). The whole-superficial retinal vessel density(RVD), deep RVD and choroidal capillary vessel density(CCVD) in CSC were significantly higher compared to other three groups, respectively(all P<0.05). The whole CCVD in nv-AMD was higher compared to thick-choroid PCV(P=0.032). Cross-sectional local angiographic form was 87.50%, 83.33%, 0 and 35.29% in thin-choroid PCV, thickchoroid PCV, nv-AMD and CSC, respectively. Cross-sectional diffuse angiographic form was 12.50%, 16.67%, 100% and 5.88% in thin-choroid PCV, thick-choroid PCV, nv-AMD and CSC, respectively.CONCLUSION: Combination of OCT and OCTA can effectively observe the significant alterations existed in PCV, CSC and nv-AMD, and there are distinctive differences among them. The pathogenesis is not exactly the same between PCV and nv-AMD, or PCV and CSC.
文摘AIM: To compare the ocular fundus features of highly myopic eyes with and without macular Bruch’s membrane(BM) defects and investigate the associations between macular BM defects and other myopic lesions.METHODS: This retrospective, observational case series included 262 eyes(139 patients) with high myopia(HM) refractive error ≥-6.0 diopters(D) or axial length ≥26.5 mm from March 2019 to December 2019.The patients underwent a comprehensive ophthalmic examination, including sweptsource optical coherence tomography(SS-OCT).The features of macular BM defects and other ocular fundus lesions were examined in OCT images.RESULTS: Totally 51 eyes(19.5%) were detected with macular BM defects, which were characterized by a lack of BM, retinal pigment epithelium(RPE), and an almost complete loss of photoreceptors or choriocapillaris.Eyes with macular BM defects had worse best-corrected visual acuity(BCVA) than those without(P<0.001).Dome-shaped macula(DSM, P=0.042), retinal cysts(P=0.006), choroidal neovascularization(CNV, P<0.001), choroidal defects and abnormality(P=0.003), scleral defects(P=0.015), scleral deformation(P=0.005), posterior staphyloma(P=0.011), and perforating vessels(P<0.001) occurred more frequently in eyes with macular BM defects.In multivariate analysis, the presence of macular BM defects remained the significant association with presence of DSM(P=0.013), scleral defects(P=0.015), posterior staphyloma(P=0.001), perforating vessels(P<0.001) and CNV(P=0.004).CONCLUSION: Macular BM defects has a prevalence of approximately 20% in HM and it has tight association with other myopic fundus lesions.BM might be crucial in the pathogenesis of myopic fundus lesions due to its biomechanical function.A comprehensive understanding of BM’s role is useful for further researches about myopic lesions.
基金Supported by Beijing Tongren Hospital(No.2020-YJJ-ZZL-017)。
文摘Dear Editor,We present the first patient with Peters’ anomaly-related glaucoma undergoing CO_(2) laser-assisted sclerectomy surgery(CLASS) and trabeculectomy combination therapy.Peters’ anomaly is a complex congenital eye disease, which is categorized as dysplasia of anterior segment.
基金The Rongxiang Regenerative Medicine Foundation of Shandong University(No.2019SDRX-xx)supported this study.
文摘The major vascular complications associated with diabetes make the management of diabetic mellitus erectile dysfunction(DMED)a challenging endeavor.Notable factors contributing to DMED include oxidative stress,nitric oxide(NO)/cyclic guanosine monophosphate(cGMP)pathway activation,and apoptosis,while nitro-oleic acid(NO,-OA)has been shown to be beneficial in treating these aspects of this condition.We,herein,investigated the effects and possible mechanisms of NO,-OA on erectile function as assessed in a streptozotocin-induced rat model of diabetes.Our results revealed that the erectile function of DMED rats was significantly impaired compared with that of the control group.However,in response to 4 weeks of NO,-OA treatment,there was an improvement in erectile function.The expression of oxidative stress-related indicators was significantly increased and the NO/cGMP pathway was impaired in the DMED group.The expression of proapoptotic factors was increased,while that of antiapoptotic factors was decreased in the DMED group.Moreover,the cell morphology in the cavernous tissue of the DMED group also changed adversely.NO,-OA treatment significantly reversed all these changes observed in the DMED group.In conclusion,NO,-OA treatment partially improved erectile function in DMED rats through mechanisms that included inhibition of oxidative stress,activation of the NO/cGMP pathway,and a reduction in apoptosis.
基金supported by a grant from the Beijing Municipal NaturalScience Foundation(No.7194332)the Shandong Province Natural ScienceFoundation(No.ZR2022ZD19).
文摘At the end of 2022,the adjustment of the coronavirus disease 2019(COVID-19)pandemic control policy in China resulted in alarge-scale increase in public infection.To compare the fertility parameters of male patients before and after the adjustments ofthe COVID-19 pandemic control policy in China,we collected data on patients’medical histories and laboratory examinations ontheir first visits between June 2022 and March 2023 in five different hospitals.Data were divided into five groups according tothe timeline of the policy adjustment.The data we collected from male patients included semen quality and serum reproductivehormone levels,and intergroup comparisons were made using the Mann–Whitney U and Chi-square tests.In total,16784 casesunderwent regular semen analysis,11180 had sperm morphology assessments,and 7200 had reproductive hormone analyses.Thedata showed declining trends in semen volume,sperm motility,and the progressive sperm motility rate after the policy adjustment.Subgroup comparison revealed an initial decrease and gradual recovery in progressive motility rate.Sperm morphology analysisshowed increased neck and tail abnormalities after the policy adjustment.No significant change in hormone levels was observed.Following the adjustment of the COVID-19 prevention policy in China,a decline in sperm motility and morphology was observed.This trend may gradually recover over 2 months.After the policy adjustment,reproductive hormone levels were relatively stablethroughout,except for an increase in luteinizing hormone(LH).These changes in semen parameters suggest that the policyadjustment had a short-to medium-term impact on male reproductive function.
基金the National Nature Science Foundation of China(Grant No.81670625)Shandong Province Natural Science Foundation-Doctoral Fund(No.ZR2017BH104)Shandong Province Natural Science Foundation-Surface Project(No.ZR2018MH006).
文摘This study aimed to describe endoscopic anatomy of the seminal tract and summarize our experience of transutricular seminal vesiculoscopy(TSV)guided by rea卜time transrectal ultrasonography(TRUS)in managing persistent hematospermia.A total of 281 consecutive patients with persistent hematospermia who underwent TSV with or without real-time TRUS were enrolled in this single-center,prospective,observational study.The median follow-up period was 36.5(range:8.0-97.5)months.TSV was successfully performed in 272(96.8%)patients.The approach of a 4.5/6 F rigid vesiculoscope entering the seminal tract was categorized into four types on the basis of endoscopic presentation of the ejaculatory duct orifice and verumontanum.Seven(2.6%),74(27.2%),64(23.5%),and 127(46.7%)patients had Types I(through the ejaculatory duct in the urethra),II(through the ejaculatory duct in the prostatic utricle),III(transutricular fenestration through a thin membrane),and IV(real-time transrectal ultrasound-guided transutricular fenestration)approach,respectively.In patients who successfully underwent surgery,bleeding occurred in the seminal vesicle in 249(91.5%)patients.Seminal vesiculitis,calculus in the prostatic utricle,calculus in the ejaculatory duct,calculus in the seminal vesicle,prostatic utricle cysts,and seminal vesicle cysts were observed in 213(78.3%),96(35.3%),22(8.1%),81(29.8%),25(9.2%),and 11(4.0%)patients,respectively.Hematospermia was alleviated or disappeared in 244(89.7%)patients 12 months after surgery.Fifteen patients had recurrent hematospermia,and the median time to recurrence was 7.5(range:2.0-18.5)months.TSV guided by TRUS may contribute to successful postoperative outcomes in managing persistent hematospermia.
文摘The aim of this study is to evaluate the benefits of laparoscopic Doppler ultrasound （LDU） application during laparoscopic varicocelectomy （LV）, and to compare the surgical outcomes and complications between LDU-assisted LV （LDU-LV） and conventional LV for infertile patients with varicoceles; 147 infertile patients were randomly divided into two groups. Operative and postoperative parameters, semen parameters, and the pregnancy rate were compared. There were no differences in baseline demographics. The operative time was significantly longer in LDU-LV group than LV group. The incidence of postoperative hydrocele was 1.4% （1/72） in LDU-LV group versus 10.7% （8/75） in LV group, which showed a significant difference （P〈 0.05）. However, other surgical outcomes, such as postoperative hospital stay, postoperative recurrence, and testicular atrophy, were similar between the two groups. Sperm concentration and sperm motility were significantly increased in both groups at 3, 6, and 12 months after surgery （P 〈 0.01）, and they were higher in LDU-LV than LV group in 12 months after surgery （34.21 ± 6.36 vs 29.99 ± 6.04 for concentration, P〈 0.05; 40.72±8.12 vs 37.31 ± 6.12 for motility, P〈 0.05）. Sperm morphology was comparable between the two groups. The pregnancy rate showed no significant difference （44.4% of the LDU-LV vs 37.3% of the LV, P〉 0.05）. In conclusion, compared with LV, LDU-LV could safely and effectively ligate all spermatic veins and preserve spermatic arteries without leading to high varicocele recurrence and postoperative hydrocele. Given the benefits that sperm counts as well as sperm motility favoring LDU-LV, we recommend that LDU should be routinely used as an effective tool to improve outcomes and safety of laparoscopic varicocelectomy.
基金This work was supported by the National Nature Science Foundation of China(No.81670625 and No.81470969)the Shandong Province Natural Science Foundation(No.ZR2017BH104,No.ZR2018MH006,No.ZR2018BH007 and No.ZR2015PH023)the Youth Foundation and Ybuth Talent Foundation of the Second Hospital of Shandong University(No.2018YT32 and No.Y2015010038).
文摘Although elevated prolactin levels have been shown to inhibit penile erection,the relationship between prolactin and erection of the penile tip or base has not been extensively researched.We therefore investigated the prolactin's effects on erecti on of the penile tip and base,with a cross-secti onal study of 135 patie nts with erectile dysfuncti on,based on scores of M21 on the In ternational Index of Erectile Function-5.All patients were tested for nocturnal penile tumescenee,blood pressure,serum glucose,total cholesterol,triglyceride,high-density lipoprotein,low-density lipoprotein,luteinizing hormone,follicle-stimulating hormone,prolactin,estradiol,testosterone,and progesterone.Univariate and multivariate analyses were used to assess the associations between prolactin levels and erection at the penile tip and base.We found no obvious relati on ship between erection time at penile tip and prolactin levels,but observed a negative correlation between base erection time and prolactin level(hazard ratio:-2.68;95%confidence interval[Cl]:-5.13-0.22).With increasing prolactin concentration,multivariate analysis showed obvious reduction in base erection time among patients with normal Rigiscan results(hazard ratio:-3.10;95%Cl:-7.96-1.77;P<0.05).Our data indicate that prolactin inhibits penile erection,particularly at the penile base.In addition,when the effective erection time of the penile base lasts longer than 10 min,prolactin has a more obvious inhibitory effect on penile base erection.
基金by grants from Shandong Province Natural Science Foundation-Doctoral Fund (ZR2017BH 104, ZR2018MH006and ZR2018BH007).
文摘The aim of our study was to investigate the role of platelet parameters including mean platelet volume (MPV)and platelet count (PC) in the pathogenesis of penile arteriogenic erectile dysfunction (ED)and to evaluate the association between the platelet parameters and arteriogenic ED.There were 244 patients with ED (based on the International Index of Erectile Function [IIEF]-5≤21)and 60 healthy controls (IIEF-5 >21)enrolled.All participants were asked to undergo a laboratory examination,and penile vascular function was evaluated using penile color Doppler ultrasonography (pDUS).Among these ED patients,24 patients with no abnormality on nocturnal penile tumescence (NPT)and 84 with normal vasculature or mixed vascular abnormalities were excluded.The other patients were classified into three groups as follows:control (n =60),arteriogenic ED (n =99),and venous leakage (n =37) groups.MPV and PC were significantly higher in the arteriogenic ED group compared with the venous and control groups (P<0.05). Receiver operating characteristic curve analysis revealed that the area under the curve for MPV to predict arteriogenic ED was 0.707. MPV≥9.65 fl was recognized as a cut-off value for potential arteriogenic ED (sensitivity:47.5%;specificity:91.7%).A significant inverse correlation was detected between MPV and lO-min peak systolic velocity (PSV)(r =-0.34;P <0.001)in the arteriogenic ED group.These findings suggest that the MPV might be a powerful indicator to predict and diagnose arteriogenic ED,and MPV may be a marker for ED when using pDUS.
