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Controlling the lateral and vertical dimensions of Bi2Se3 nanoplates via seeded growth 被引量:1
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作者 Awei Zhuang Yuzhou Zhao +5 位作者 Xianli Liu mingrui xu Youcheng Wang Unyong Jeong Xiaoping Wang Jie Zeng 《Nano Research》 SCIE EI CAS CSCD 2015年第1期246-256,共11页
Modulation of the morphology of nanostructures is often a rewarding but challenging task. We have employed the seeded growth method and induced kinetic control to synthesize Bi2Se3 nanoplates with modifiable morpholog... Modulation of the morphology of nanostructures is often a rewarding but challenging task. We have employed the seeded growth method and induced kinetic control to synthesize Bi2Se3 nanoplates with modifiable morphology. By manipulating the rate at which precursor solutions were injected into seeds solution with syringe pumps, two distinctive growth modes could be realized. With a fast injection, the thickness of Bi2Se3 nanoplates slightly increased from N7.5 nm (seeds) to -9.5 nm while the edge length grew up from ~160 nm (seeds) to N12 ~tm, after 6 successive rounds of seeded growth. With a slow injection, the thickness and edge length increased simultaneously to -35 nm and -6 b^m after 6 rounds of growth, respectively. These two modes could be viewed as a competition between atomic deposition and surface migration. The products showed interesting, thickness-dependent Raman properties. In addition, NIR transparent, highly conductive and flexible Bi2Se3 thin films with different thicknesses were constructed by the assembly of the as-synthesized Bi2Se3 nanoplates. This approach based on seeded growth and kinetic control can significantly promote the development of versatile nanostructures with diverse morphology. 展开更多
关键词 bismuth selenide NANOPLATES seeded growth kinetic control
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Single-cell transcriptomic profiling of the hypothalamic median eminence during aging
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作者 Zhen-Hua Chen Si Li +4 位作者 mingrui xu Candace CLiu Hongying Ye Ben Wang Qing-Feng Wu 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2022年第6期523-536,共14页
Aging is a slow and progressive natural process that compromises the normal functions of cells,tissues,organs,and systems.The aging of the hypothalamic median eminence(ME),a structural gate linking neural and endocrin... Aging is a slow and progressive natural process that compromises the normal functions of cells,tissues,organs,and systems.The aging of the hypothalamic median eminence(ME),a structural gate linking neural and endocrine systems,may impair hormone release,energy homeostasis,and central sensing of circulating molecules,leading to systemic and reproductive aging.However,the molecular and cellular features of ME aging remain largely unknown.Here,we describe the transcriptional landscape of young and middleaged mouse ME at single-cell resolution,revealing the common and cell type-specific transcriptional changes with age.The transcriptional changes in cell-intrinsic programs,cell-cell crosstalk,and cellextrinsic factors highlight five molecular features of ME aging and also implicate several potentially druggable targets at cellular,signaling,and molecular levels.Importantly,our results suggest that vascular and leptomeningeal cells may lead the asynchronized aging process among diverse cell types and drive local inflammation and cellular senescence via a unique secretome.Together,our study uncovers how intrinsic and extrinsic features of each cell type in the hypothalamic ME are changed by the aging process,which will facilitate our understanding of brain aging and provide clues for efficient anti-aging intervention at the middle-aged stage. 展开更多
关键词 Hypothalamic median eminence Single-cell transcriptomic analysis Vascular and leptomeningeal cells AGING
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