Objective: To observe the clinical effect of 20% deproteinized calfblood extract eye gel on the treatment of mechanical injury to corneal epithelium. Methods: 120 cases of patients with corneal epithelial defect cause...Objective: To observe the clinical effect of 20% deproteinized calfblood extract eye gel on the treatment of mechanical injury to corneal epithelium. Methods: 120 cases of patients with corneal epithelial defect caused by mechanical injury were selected and randomly divided into observation group (60 eyes, deproteinized calfblood extract eye gel in use) and control group (0.3% ofloxacin eye drops in use). Both two groups of patients were given eye gel or eye drops 4 times per day. Moreover, the two groups of eye symptoms and corneal epithelial healing were observed on the 3rd day and the 7th day after drug usage respectively. Results: The effective rates of 20% deproteinized calfblood extract eye gel on the treatment of mechanical corneal epithelial defect on the 3rd day and the 7th day were 78.33% and 93.33% respectively. Meanwhile, the effective rates of 0.3% ofloxacin eye drops were 55.00% and 71.67%. The difference in the comparison of the effective rate between two groups was of statistical significance (p < .05). Conclusions: 20% deproteinized calfblood extract eye gel can significantly promote the healing of corneal epithelium in a short time, and it is worthy to be widely applied clinically.展开更多
Objective: To study the expression of matrix metalloproteinases-2, 9 (MMP-2, MMP-9) of healthy implant and peri-implant sulcular fluid (PISF) by enzyme-linked immunosorbent assay (ELISA) method, and evaluate the level...Objective: To study the expression of matrix metalloproteinases-2, 9 (MMP-2, MMP-9) of healthy implant and peri-implant sulcular fluid (PISF) by enzyme-linked immunosorbent assay (ELISA) method, and evaluate the level of MMP-2 and MMP-9 in sulcular fluid as an objective indicator of tissue inflammation around implants. Methods: A total of 40 implants were selected from 30 patients who were treated with dental implants and were divided into two groups: the inflammatory group and the healthy control group with 20 pieces respectively. ELISA double antibody sandwich method was used to detect the levels of MMP-2 and MMP-9 in PISF. Results: The MMP-2 and MMP-9 expressions were significantly different between the healthy implant group and the peri-implant group (p < .05). The concentration of MMP-2, MMP-9, and the amount of sulcular fluid in the inflammatory implant group were positively correlated with the clinical parameters (probing depth [PD], modified sulcus bleeding index [mSBI]). Conclusions: Under physiological conditions, the levels of MMP-2 and MMP-9 were low. When the periodontal tissue was stimulated by inflammation, the expression levels of MMP-2 and MMP-9 were increased, which could reflect the severity of inflammation. The increase levels of MMP-2 and MMP-9 in PISF could better reflect the health status of peri-implant tissues, which could be used as an objective indicator to assist in the diagnosis of peri-implant inflammation.展开更多
文摘Objective: To observe the clinical effect of 20% deproteinized calfblood extract eye gel on the treatment of mechanical injury to corneal epithelium. Methods: 120 cases of patients with corneal epithelial defect caused by mechanical injury were selected and randomly divided into observation group (60 eyes, deproteinized calfblood extract eye gel in use) and control group (0.3% ofloxacin eye drops in use). Both two groups of patients were given eye gel or eye drops 4 times per day. Moreover, the two groups of eye symptoms and corneal epithelial healing were observed on the 3rd day and the 7th day after drug usage respectively. Results: The effective rates of 20% deproteinized calfblood extract eye gel on the treatment of mechanical corneal epithelial defect on the 3rd day and the 7th day were 78.33% and 93.33% respectively. Meanwhile, the effective rates of 0.3% ofloxacin eye drops were 55.00% and 71.67%. The difference in the comparison of the effective rate between two groups was of statistical significance (p < .05). Conclusions: 20% deproteinized calfblood extract eye gel can significantly promote the healing of corneal epithelium in a short time, and it is worthy to be widely applied clinically.
文摘Objective: To study the expression of matrix metalloproteinases-2, 9 (MMP-2, MMP-9) of healthy implant and peri-implant sulcular fluid (PISF) by enzyme-linked immunosorbent assay (ELISA) method, and evaluate the level of MMP-2 and MMP-9 in sulcular fluid as an objective indicator of tissue inflammation around implants. Methods: A total of 40 implants were selected from 30 patients who were treated with dental implants and were divided into two groups: the inflammatory group and the healthy control group with 20 pieces respectively. ELISA double antibody sandwich method was used to detect the levels of MMP-2 and MMP-9 in PISF. Results: The MMP-2 and MMP-9 expressions were significantly different between the healthy implant group and the peri-implant group (p < .05). The concentration of MMP-2, MMP-9, and the amount of sulcular fluid in the inflammatory implant group were positively correlated with the clinical parameters (probing depth [PD], modified sulcus bleeding index [mSBI]). Conclusions: Under physiological conditions, the levels of MMP-2 and MMP-9 were low. When the periodontal tissue was stimulated by inflammation, the expression levels of MMP-2 and MMP-9 were increased, which could reflect the severity of inflammation. The increase levels of MMP-2 and MMP-9 in PISF could better reflect the health status of peri-implant tissues, which could be used as an objective indicator to assist in the diagnosis of peri-implant inflammation.
