Cold stimulation has been shown to regulate glucose,lipid,and amino acid metabolism,while also increasing heat production and energy expenditure in the body.Disordered energy metabolism is a key factor in the onset an...Cold stimulation has been shown to regulate glucose,lipid,and amino acid metabolism,while also increasing heat production and energy expenditure in the body.Disordered energy metabolism is a key factor in the onset and progression of chronic metabolic conditiones such as diabetes,obesity,and cardiovascular disease.Recent research has unveiled the myriad pathways through which cold stimulation affects human energy metabolism.This article provides an overview of how cold stimulation affects energy metabolism across the three major metabolic pathways.Furthermore,it explores the implications and potential therapeutic applications of cold stimulation in the prevention and treatment of various metabolic diseases.展开更多
Objective:To investigate the optimal management of patients with epidermal growth factor receptor gene(EGFR)mutant locally advanced non-small cell lung cancer(LA-NSCLC).Methods:Patients with unresectable stage III lun...Objective:To investigate the optimal management of patients with epidermal growth factor receptor gene(EGFR)mutant locally advanced non-small cell lung cancer(LA-NSCLC).Methods:Patients with unresectable stage III lung adenocarcinoma(LAC)harboring EGFR mutations from 2012 to 2018 were analyzed retrospectively,and were categorized into three groups according to the primary treat-ment:chemoradiotherpy(CRT)(group 1),combined radiation therapy(RT)and EGFR-tyrosine kinase inhibitors(TKI)with/without chemotherapy(group 2),and EGFR-TKI alone until tumor progression(group 3).Inverse probability of multiple treatment weighting(IPTW)of propensity score was used to compare overall survival(OS)and progression free survival(PFS)between treatments and account for confounding.Results:A total of 104,105,and 231 patients were categorized into groups 1,2,and 3,respectively.After IPTW adjustment,the median PFS for each group was 12.4,26.2,and 16.2 months(log-rank P<0.001),and the median OS was 51.0,67.4 and 49.3 months(log-rank P=0.084),respectively.Compared with those in group 1,patients in group 2 had significantly improved PFS[adjusted hazard ratio HR(aHR),0.40;95% confidence interval(CI):0.29,0.54;P<0.001]and OS(aHR,0.61;95%CI:0.38,0.98;P=0.039).Patients in group 3 had prolonged PFS(aHR,0.66;95%CI:0.50,0.87;P=0.003),but not OS(aHR,0.90;95%CI:0.62,1.32;P=0.595).Doubly robust IPTW analysis and multivariable Cox regression analysis yielded similar findings.Conclusions:EGFR-TKIs after chemoradiation or combined with radiation alone correlated with the longest PFS and OS(versus CRT or TKIs alone)in patients with EGFR-mutant unresectable LA-NSCLC.Well-designed prospec-tive trials were warranted.展开更多
基金The research was supported by the National Natural Science Foundation of China(No.82170262,to Fang S H)Heilongjiang Province Applied Technology Research and Development Plan(GA20C009,to E M Y)The Natural Science Foundation of Heilongjiang Province(TD2020H001,to Yu B).
文摘Cold stimulation has been shown to regulate glucose,lipid,and amino acid metabolism,while also increasing heat production and energy expenditure in the body.Disordered energy metabolism is a key factor in the onset and progression of chronic metabolic conditiones such as diabetes,obesity,and cardiovascular disease.Recent research has unveiled the myriad pathways through which cold stimulation affects human energy metabolism.This article provides an overview of how cold stimulation affects energy metabolism across the three major metabolic pathways.Furthermore,it explores the implications and potential therapeutic applications of cold stimulation in the prevention and treatment of various metabolic diseases.
基金founded by the National Natural Sciences Foundation Key Program(grant number:81572971)CAMS Innovation Fund for Medical Sciences(grant number:2017-I2M-1-005)+2 种基金Sanming Project of Medicine in Shenzhen(grant number:SZSM201612063)National Natural Sciences Foundation Key Program of China(grant number:81572971)National Key R&D Program of China(grant number:2018YFC1312104).
文摘Objective:To investigate the optimal management of patients with epidermal growth factor receptor gene(EGFR)mutant locally advanced non-small cell lung cancer(LA-NSCLC).Methods:Patients with unresectable stage III lung adenocarcinoma(LAC)harboring EGFR mutations from 2012 to 2018 were analyzed retrospectively,and were categorized into three groups according to the primary treat-ment:chemoradiotherpy(CRT)(group 1),combined radiation therapy(RT)and EGFR-tyrosine kinase inhibitors(TKI)with/without chemotherapy(group 2),and EGFR-TKI alone until tumor progression(group 3).Inverse probability of multiple treatment weighting(IPTW)of propensity score was used to compare overall survival(OS)and progression free survival(PFS)between treatments and account for confounding.Results:A total of 104,105,and 231 patients were categorized into groups 1,2,and 3,respectively.After IPTW adjustment,the median PFS for each group was 12.4,26.2,and 16.2 months(log-rank P<0.001),and the median OS was 51.0,67.4 and 49.3 months(log-rank P=0.084),respectively.Compared with those in group 1,patients in group 2 had significantly improved PFS[adjusted hazard ratio HR(aHR),0.40;95% confidence interval(CI):0.29,0.54;P<0.001]and OS(aHR,0.61;95%CI:0.38,0.98;P=0.039).Patients in group 3 had prolonged PFS(aHR,0.66;95%CI:0.50,0.87;P=0.003),but not OS(aHR,0.90;95%CI:0.62,1.32;P=0.595).Doubly robust IPTW analysis and multivariable Cox regression analysis yielded similar findings.Conclusions:EGFR-TKIs after chemoradiation or combined with radiation alone correlated with the longest PFS and OS(versus CRT or TKIs alone)in patients with EGFR-mutant unresectable LA-NSCLC.Well-designed prospec-tive trials were warranted.
