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纵隔肿物活检小标本的获取与病理报告指南 被引量:1
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作者 付浩 中国胸腺瘤协作组全体成员 +7 位作者 Alberto Marchevsky Alex Marx Philipp Strobel Saul Suster Federico Venuta mirella marino Samuel Yousem Maureen Zakowski 《中国肺癌杂志》 CAS 北大核心 2014年第2期104-109,共6页
目前,胸腺恶性肿瘤治疗方案大多是根据术后病理确定,然而,多数临床治疗决策需要在术前通过活检小标本的病理报告来制定。所以,术前活检小标本的正确获取和病理解读对治疗决策的制定显得非常重要[1]。这些标本包括细针活检标本,带... 目前,胸腺恶性肿瘤治疗方案大多是根据术后病理确定,然而,多数临床治疗决策需要在术前通过活检小标本的病理报告来制定。所以,术前活检小标本的正确获取和病理解读对治疗决策的制定显得非常重要[1]。这些标本包括细针活检标本,带芯穿刺活检标本和手术切取活检标本[2-7]。由于胸腺肿瘤的病理诊断对组织的获取方法和获取量都有较高的要求,加之对病理的描述也没有统一的标准,使得小标本在诊断胸腺瘤方面存在诸多问题。为此,ITMIG在病理科医生和外科医生回顾相关文献和提出初步建议的基础上,经集体讨论制定了活检规范操作流程,提出了对纵隔肿物小活检标本处理和病理报告的建议。旨在为术前患者的治疗提供一个统一和具有循证医学证据的方法;同时,将有利于全球数据之间的比较和开展合作研究,充分利用医疗资源。 展开更多
关键词 肿物活检 术后病理 纵隔肿物 小标本 报告指南 肿瘤治疗方案 活检标本 循证医学证据
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Hepatitis C and double-hit B cell lymphoma successfully treated by antiviral therapy 被引量:2
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作者 Giovanni Galati Lorenzo Rampa +5 位作者 Umberto Vespasiani-Gentilucci mirella marino Francesco Pisani Carlo Cota Alessandro Guidi Antonio Picardi 《World Journal of Hepatology》 CAS 2016年第29期1244-1250,共7页
B cells lymphoma is one of the most challenging extrahepatic manifestations of hepatitis C virus(HCV). Recently, a new kind of B-cell lymphoma, named doublehit B(DHL), was characterized with an aggressive clinical cou... B cells lymphoma is one of the most challenging extrahepatic manifestations of hepatitis C virus(HCV). Recently, a new kind of B-cell lymphoma, named doublehit B(DHL), was characterized with an aggressive clinical course whereas a potential association with HCV was not investigated. The new antiviral direct agents(DAAs) against HCV are effective and curative in the majority of HCV infections. We report the first case, to our knowledge, of DHL and HCV-infection successfully treated by new DAAs. According to our experience, a DHL must be suspected in case of HCV-related lymphoma, and an early diagnosis could direct towards a different hematological management because a worse prognosis might be expected. A possible effect of DAAs on DHL regression should be investigated, but eradicating HCV would avoid life-threatening reactivation of viral hepatitis during pharmacological immunosuppression in oncohaematological diseases. 展开更多
关键词 Hepatitis C LYMPHOMA Direct antiviral agents Double hit lymphoma Chronic hepatitis C
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Everolimus plus long-acting somatostatin analogs in thymic epithelial malignancies 被引量:1
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作者 Giovannella Palmieri Carlo Buonerba +5 位作者 Piera Federico Luigi Formisano Lucia Nappi Giuseppe Di Lorenzo mirella marino Vincenzo Damiano 《World Journal of Clinical Oncology》 CAS 2012年第7期111-115,共5页
Although thymic epithelial tumors(TETs) are rare in the general population, they represent the most frequently diagnosed primary malignant tumor of the anterior mediastinum. Unlike localized disease, metastatic diseas... Although thymic epithelial tumors(TETs) are rare in the general population, they represent the most frequently diagnosed primary malignant tumor of the anterior mediastinum. Unlike localized disease, metastatic disease is invariably fatal. While several chemotherapy agents have proven to be effective in TETs, somatostatin analogs are the only targeted agents with an established role in this disease. Everolimus is an m TOR inhibitor with multiple application in oncology. In this report, we show for the first time that everolimus was effective in two heavily pretreated patients with advanced TETs, with a progression-free survival longer than 1 year and minimal toxicity. 展开更多
关键词 THYMOMA EVEROLIMUS mTOR MEDIASTINUM Target
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