Objective:To study organisms in cases of early neonatal sepsis,and sensitivity patterns of these isolates.Methods:All pregnant mothers admitted from Jan 2006-Dec 2006 were registered.Neonates delivered at the hospital...Objective:To study organisms in cases of early neonatal sepsis,and sensitivity patterns of these isolates.Methods:All pregnant mothers admitted from Jan 2006-Dec 2006 were registered.Neonates delivered at the hospital were examined upto 72 hours of birth,with special emphasis on the signs and symptoms of suspected sepsis.Neonates with no maternal or neonatal risk factor were included in the study,blood examination and appropriate cultures were taken.Antibiotics as cephatexime and amikacin were started on empirical bases until final cultures report was received.In cases of negative cultures,antibiotics were stopped.Other wise it continued according to culture and sensitivity for 10 to 14 days.Results:Among these 257 cases,113 neonates full filled our criteria.Staph aureus being the commonest organism in our study(59.29%)followed by Klebsiella pneumoniae(19.47%)and Entrococci(19.47%).These findings are not consistent with other studies in the country.Conclusion:Neonatal sepsis is a major cause of mortality and morbidity.Choice of antibiotic should depend on the local studies from time to time.展开更多
Novel coronavirus,SARS-CoV-2 is responsible for causing a pandemic that has affected individuals worldwide,over 192 million people and about 4.1 million people died so far.The spread is ongoing and the numbers are sti...Novel coronavirus,SARS-CoV-2 is responsible for causing a pandemic that has affected individuals worldwide,over 192 million people and about 4.1 million people died so far.The spread is ongoing and the numbers are still increasing.Numerous therapeutic approaches have been explored and developed during this pandemic.Immunotherapy with virus-specific antibodies in convalescent plasma(CP)has shown potential benefits for various pathogenic diseases.In many instances,it is the only available and safe management option for the COVID-19 patients.Here we describe two confirmed cases of COVID-19 from two different geographical areas that were managed with standard treatment modalities initially.Both of the patients were presented with high-grade fever,dry cough,and sore throat.Lab reports showed increased values of D-dimer,serum ferritin,leukocyte count(LC),Lactate dehydrogenase(LDH),and C-reactive protein(CRP).Chest X-ray showed bilateral infiltration(multifocal and bilateral ground-glass opacities and consolidations with peripheral and basal predominance),consistent with the previous reports on COVID-19 infection.The patients received conservative treatment according to the hospital's protocol.The convalescent plasma(from recovered patients)infusion was the last treatment given to both patients.After the convalescent plasma transfusion,both patients showed a reduction of viral load,an increase of anti-SARS-CoV-2 IgG and IgM antibodies,reduction in lung infiltration,with no adverse events.However,further randomized controlled trials are needed to investigate the full scope of safety and efficacy(both short and long-term)of convalescent plasma therapy for COVID-19 and other related infections.展开更多
文摘Objective:To study organisms in cases of early neonatal sepsis,and sensitivity patterns of these isolates.Methods:All pregnant mothers admitted from Jan 2006-Dec 2006 were registered.Neonates delivered at the hospital were examined upto 72 hours of birth,with special emphasis on the signs and symptoms of suspected sepsis.Neonates with no maternal or neonatal risk factor were included in the study,blood examination and appropriate cultures were taken.Antibiotics as cephatexime and amikacin were started on empirical bases until final cultures report was received.In cases of negative cultures,antibiotics were stopped.Other wise it continued according to culture and sensitivity for 10 to 14 days.Results:Among these 257 cases,113 neonates full filled our criteria.Staph aureus being the commonest organism in our study(59.29%)followed by Klebsiella pneumoniae(19.47%)and Entrococci(19.47%).These findings are not consistent with other studies in the country.Conclusion:Neonatal sepsis is a major cause of mortality and morbidity.Choice of antibiotic should depend on the local studies from time to time.
文摘Novel coronavirus,SARS-CoV-2 is responsible for causing a pandemic that has affected individuals worldwide,over 192 million people and about 4.1 million people died so far.The spread is ongoing and the numbers are still increasing.Numerous therapeutic approaches have been explored and developed during this pandemic.Immunotherapy with virus-specific antibodies in convalescent plasma(CP)has shown potential benefits for various pathogenic diseases.In many instances,it is the only available and safe management option for the COVID-19 patients.Here we describe two confirmed cases of COVID-19 from two different geographical areas that were managed with standard treatment modalities initially.Both of the patients were presented with high-grade fever,dry cough,and sore throat.Lab reports showed increased values of D-dimer,serum ferritin,leukocyte count(LC),Lactate dehydrogenase(LDH),and C-reactive protein(CRP).Chest X-ray showed bilateral infiltration(multifocal and bilateral ground-glass opacities and consolidations with peripheral and basal predominance),consistent with the previous reports on COVID-19 infection.The patients received conservative treatment according to the hospital's protocol.The convalescent plasma(from recovered patients)infusion was the last treatment given to both patients.After the convalescent plasma transfusion,both patients showed a reduction of viral load,an increase of anti-SARS-CoV-2 IgG and IgM antibodies,reduction in lung infiltration,with no adverse events.However,further randomized controlled trials are needed to investigate the full scope of safety and efficacy(both short and long-term)of convalescent plasma therapy for COVID-19 and other related infections.
