<span style="font-family:Verdana;">A sensitive and eco-friendly method was developed for the spectrophotometric determination of Lisinopril (LSP) in bulk and pharmaceutical formulations by cloud point ...<span style="font-family:Verdana;">A sensitive and eco-friendly method was developed for the spectrophotometric determination of Lisinopril (LSP) in bulk and pharmaceutical formulations by cloud point extraction technique. The method was based on the formation of a blue</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">colored coordination complex between Lisinopril (LSP) and Cobalt Thiocyanate (CTC) at a suitable pH.</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">The Complex in aqueous medium</span><span style="font-family:Verdana;"> was extracted into surfactant layer by cloud point extraction using</span><span style="font-family:Verdana;"> a non-ionic surfactant Triton X-114 and then the surfactant layer was dissolved in a suitable volume of ethanol and the amount of Lisinopril was determined spectrophotometrically at a wavelength of 625</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">nm.</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">The conditions like concentration of the drug, concentration of CTC and of Triton X-114, P</span><sup><span style="font-family:Verdana;">H</span></sup></span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> etc. were optimized by OFAT (One Factor At a Time) method. The linear range of calibration curve was 1</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:Verdana;">6 μg/ml and the linear regression equation with a correlation coefficient of 0.99996 was y = 0.0021</span><span style="font-family:""> </span><span style="font-family:Verdana;">+</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.084x.</span><span style="font-family:""> </span><span style="font-family:Verdana;">Preconcentration and enrichment factors were found to be 100 and 3.12 respectively, achieving the detection limit of 0.0588</span><span style="font-family:""> </span><span style="font-family:Verdana;">μg/ml. The proposed method was successfully applied for the determination of LSP in the drug formulations. The obtained values were in agreement with the values as quoted by the manufacturers.展开更多
In present days many types of materials are used to reduce the environmental pollution in the world which includes nanomaterials. Nanopesticides increase the efficacy, durability and reduction in the amount of active ...In present days many types of materials are used to reduce the environmental pollution in the world which includes nanomaterials. Nanopesticides increase the efficacy, durability and reduction in the amount of active constituent. The potential applications of nanotechnology in pesticides are quick decomposition in soil or plant, targeted delivery, apparent solubility and controlled release. In this communication the author reported a neonicatonoid insecticide called as Nano-acetamiprid and it is widely used to control fungal infections in different crops like cotton, leafy vegetables, citrus fruits, pome etc. The author reported a facile method i.e. a new Nano-acetamiprid for plant disease control and its subsequent characterization of encapsulated complex using polycaprolactone as an encapsulated agent. Nano-acetamiprid encapsulated particles were characterized by dynamic light scattering (DLS), ultraviolet spectroscopy and scanning electron microscopy (SEM). To ascertain the formation and the stability of nanoencapsulated acetamiprid pesticide, the maximum absorption spectra formulated at 421 nm and unformulated pesticide at 520 nm were observed. The size distribution was noted at 40 - 50 nm. The bioactivity study was conducted against various Aspergillus niger. The performance of nano particles was many fold times effective when compared to the original parental particles. The bio-assay of Nano-acetamiprid shows better results when compared to the normal commercial acetamiprid.展开更多
文摘<span style="font-family:Verdana;">A sensitive and eco-friendly method was developed for the spectrophotometric determination of Lisinopril (LSP) in bulk and pharmaceutical formulations by cloud point extraction technique. The method was based on the formation of a blue</span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">colored coordination complex between Lisinopril (LSP) and Cobalt Thiocyanate (CTC) at a suitable pH.</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">The Complex in aqueous medium</span><span style="font-family:Verdana;"> was extracted into surfactant layer by cloud point extraction using</span><span style="font-family:Verdana;"> a non-ionic surfactant Triton X-114 and then the surfactant layer was dissolved in a suitable volume of ethanol and the amount of Lisinopril was determined spectrophotometrically at a wavelength of 625</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">nm.</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">The conditions like concentration of the drug, concentration of CTC and of Triton X-114, P</span><sup><span style="font-family:Verdana;">H</span></sup></span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> etc. were optimized by OFAT (One Factor At a Time) method. The linear range of calibration curve was 1</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:Verdana;">6 μg/ml and the linear regression equation with a correlation coefficient of 0.99996 was y = 0.0021</span><span style="font-family:""> </span><span style="font-family:Verdana;">+</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.084x.</span><span style="font-family:""> </span><span style="font-family:Verdana;">Preconcentration and enrichment factors were found to be 100 and 3.12 respectively, achieving the detection limit of 0.0588</span><span style="font-family:""> </span><span style="font-family:Verdana;">μg/ml. The proposed method was successfully applied for the determination of LSP in the drug formulations. The obtained values were in agreement with the values as quoted by the manufacturers.
文摘In present days many types of materials are used to reduce the environmental pollution in the world which includes nanomaterials. Nanopesticides increase the efficacy, durability and reduction in the amount of active constituent. The potential applications of nanotechnology in pesticides are quick decomposition in soil or plant, targeted delivery, apparent solubility and controlled release. In this communication the author reported a neonicatonoid insecticide called as Nano-acetamiprid and it is widely used to control fungal infections in different crops like cotton, leafy vegetables, citrus fruits, pome etc. The author reported a facile method i.e. a new Nano-acetamiprid for plant disease control and its subsequent characterization of encapsulated complex using polycaprolactone as an encapsulated agent. Nano-acetamiprid encapsulated particles were characterized by dynamic light scattering (DLS), ultraviolet spectroscopy and scanning electron microscopy (SEM). To ascertain the formation and the stability of nanoencapsulated acetamiprid pesticide, the maximum absorption spectra formulated at 421 nm and unformulated pesticide at 520 nm were observed. The size distribution was noted at 40 - 50 nm. The bioactivity study was conducted against various Aspergillus niger. The performance of nano particles was many fold times effective when compared to the original parental particles. The bio-assay of Nano-acetamiprid shows better results when compared to the normal commercial acetamiprid.
