Treadmill exercise and mesenchymal stem cell transplantation are both practical and effective methods for the treatment of cerebral ischemia.However,whether there is a synergistic effect between the two remains unclea...Treadmill exercise and mesenchymal stem cell transplantation are both practical and effective methods for the treatment of cerebral ischemia.However,whether there is a synergistic effect between the two remains unclear.In this study,we established rat models of ischemia/reperfusion injury by occlusion of the middle cerebral artery for 2 hours and reperfusion for 24 hours.Rat models were perfused with bone marrow mesenchymal stem cell-derived exosomes(MSC-exos)via the tail vein and underwent 14 successive days of treadmill exercise.Neurological assessment,histopathology,and immunohistochemistry results revealed decreased neuronal apoptosis and cerebral infarct volume,evident synaptic formation and axonal regeneration,and remarkably recovered neurological function in rats subjected to treadmill exercise and MSC-exos treatment.These effects were superior to those in rats subjected to treadmill exercise or MSC-exos treatment alone.Mechanistically,further investigation revealed that the activation of JNK1/c-Jun signaling pathways regulated neuronal apoptosis and synaptic-axonal remodeling.These findings suggest that treadmill exercise may exhibit a synergistic effect with MSC-exos treatment,which may be related to activation of the JNK1/c-Jun signaling pathway.This study provides novel theoretical evidence for the clinical application of treadmill exercise combined with MSC-exos treatment for ischemic cerebrovascular disease.展开更多
The error correction performance of Belief Propagation(BP)decoding for polar codes is satisfactory compared with the Successive Cancellation(SC)decoding.Nevertheless,it has to complete a fixed number of iterations,whi...The error correction performance of Belief Propagation(BP)decoding for polar codes is satisfactory compared with the Successive Cancellation(SC)decoding.Nevertheless,it has to complete a fixed number of iterations,which results in high computational complexity.This necessitates an intelligent identification of successful BP decoding for early termination of the decoding process to avoid unnecessary iterations and minimize the computational complexity of BP decoding.This paper proposes a hybrid technique that combines the“paritycheck”with the“G-matrix”to reduce the computational complexity of BP decoder for polar codes.The proposed hybrid technique takes advantage of the parity-check to intelligently identify the valid codeword at an early stage and terminate the BP decoding process,which minimizes the overhead of the G-matrix and reduces the computational complexity of BP decoding.We explore a detailed mechanism incorporating the parity bits as outer code and prove that the proposed hybrid technique minimizes the computational complexity while preserving the BP error correction performance.Moreover,mathematical formulation for the proposed hybrid technique that minimizes the computation cost of the G-matrix is elaborated.The performance of the proposed hybrid technique is validated by comparing it with the state-of-the-art early stopping criteria for BP decoding.Simulation results show that the proposed hybrid technique reduces the iterations by about 90%of BP decoding in a high Signal-to-Noise Ratio(SNR)(i.e.,3.5~4 dB),and approaches the error correction performance of G-matrix and conventional BP decoder for polar codes.展开更多
By employing a combined approach of density-functional theory(DFT) and dynamical mean-field theory(DMFT) calculations, we examine the structural, electronic, and magnetic characteristics of two distinct strontium ruth...By employing a combined approach of density-functional theory(DFT) and dynamical mean-field theory(DMFT) calculations, we examine the structural, electronic, and magnetic characteristics of two distinct strontium ruthenates: Sr2RuO4,an unconventional superconductor, and the correlated metal SrRuO3, both at 50% Fe-doping level. In both Sr2Fe0.5Ru0.5O4and SrFe0.5Ru0.5O3, the original ruthenium(Ru) and the dopant iron(Fe) atoms adopt 3-dimensional and 2-dimensional G-type structures, respectively. The hybridization between Fe-3d and Ru-4d is comparatively weaker than in other double perovskite systems. The interplay between strong correlations and reduced itinerancy results in significant spin splitting at Fe and Ru sites. Consequently, a charge transfer process, along with the super-exchange effect, leads to antiferromagnetically coupled Fe3+and Ru5+ions and establishes a semiconducting ferrimagnetic order. Subsequent DMFT calculations demonstrate the persistence of the ferrimagnetic order even at room temperature(300 K). These findings align with prior reports on Sr Fe0.5Ru0.5O3, thus reinforcing the notion that 3d–4d transition metal oxides hold considerable promise as candidates for high-performance spintronic devices, such as spin-valve sensors and spintronic giant magnetoresistance devices.展开更多
Objective:To study the application effect of short video combined with BOPPPS teaching mode in clinical anesthesia practice.Method:48 students assigned to clinical anesthesia in digestive endoscopy of Shanxi Bethune H...Objective:To study the application effect of short video combined with BOPPPS teaching mode in clinical anesthesia practice.Method:48 students assigned to clinical anesthesia in digestive endoscopy of Shanxi Bethune Hospital from July 1,2022 to April 1,2023 were selected as research objects.They were randomly divided into the control group(PowerPoint presentation teaching group)and the observation group(short video combined with BOPPPS teaching group),with 24 students in each group.After the internship,the students’theoretical and technical scores were tested,the effects of the two teaching modes were compared,and the students’satisfaction was investigated.Results:The test scores of students in the observation group were significantly better than those in the control group(P<0.05).The short video combined with BOPPPS teaching mode can significantly improve students’learning interest,operation skills,and memory(P<0.05).The students’satisfaction in the observation group was higher than that in the control group(P<0.05).Conclusion:In clinical practice,the application of short video combined with BOPPPS teaching mode has achieved great effect,which is worth further promotion and research.展开更多
Optical Coherence Tomography (OCT) technique is a nondestructive optical detection technology based on low-coherence interferometer and it has become an attractive cultural heritage research method. A 1310 nm source s...Optical Coherence Tomography (OCT) technique is a nondestructive optical detection technology based on low-coherence interferometer and it has become an attractive cultural heritage research method. A 1310 nm source spectral-domain optical coherence tomography (SD-OCT) system based on optical fiber Michelson interferometer and optical spectrum analyzer is proposed and demonstrated for Chinese cultural heritage research. The cross-section OCT images of Chinese pigment samples and jadeite samples can provide a lot of valuable microstructure information for the Chinese cultural heritage research and identification works.展开更多
Background: To study the influence of blood lipid levels on hemorrhagic transformation(HT) and prognosis after acute cerebral infarction(ACI).Methods: Patients with ACI within 72 h of symptoms onset between January 1 ...Background: To study the influence of blood lipid levels on hemorrhagic transformation(HT) and prognosis after acute cerebral infarction(ACI).Methods: Patients with ACI within 72 h of symptoms onset between January 1 st, 2015, and December 31 st, 2016, were retrospectively analyzed. Patients were divided into group A(without HT) and group B(HT). The outcomes were assessed after 3 months of disease onset using the modified Rankin Scale(m RS). An m RS score of 0–2 points indicated excellent prognosis, and an m RS score of 3–6 points indicated poor prognosis.Results: A total of 732 patients conformed to the inclusion criteria, including 628 in group A and 104 in group B. The incidence of HT was 14.2%, and the median onset time was 2 d(interquartile range, 1–7 d). The percentages of patients with large infarct size and cortex involvement in group B were 80.8% and 79.8%, respectively, which were both significantly higher than those in group A(28.7 and 33.4%, respectively). The incidence rate of atrial fibrillation(AF) in group B was significantly higher than that in group A(39.4% vs. 13.9%, P<0.001). The adjusted multivariate analysis results showed that large infarct size, cortex involvement and AF were independent risk factors of HT, while total cholesterol(TC) was a protective factor of HT(OR=0.359, 95% CI 0.136–0.944, P=0.038). With every 1 mmol/L reduction in normal TC levels, the risk of HT increased by 64.1%. The mortality and morbidity at 3 months in group B(21.2% and 76.7%, respectively) were both significantly higher than those in group A(8.0% and 42.8%, respectively). The adjusted multivariate analysis results showed that large infarct size(OR=12.178, 95% CI 5.390–27.516, P<0.001) was an independent risk factor of long-term unfavorable outcomes, whereas low-density lipoprotein cholesterol(LDL-C) was a protective factor(OR=0.538, 95% CI 0.300–0.964, P=0.037). With every 1 mmol/L reduction in normal LDL-C levels, the risk of an unfavorable outcome increased by 46.2%. Major therapies, including intravenous recombinant human tissue plasminogen activator(r TPA), intensive lipid-lowering statins and anti-platelets, were not significantly related to either HT or long-term, post-ACI poor prognosis.Conclusions: For patients with large infarct sizes, especially those with cortex involvement, AF, or lower levels of TC, the risk of HT might increase after ACI. The risk of a long-term unfavorable outcome in these patients might increase with a reduction in LDL-C.展开更多
Research on two-dimensional(2D) materials has been explosively increasing in last seventeen years in varying subjects including condensed matter physics, electronic engineering, materials science, and chemistry since ...Research on two-dimensional(2D) materials has been explosively increasing in last seventeen years in varying subjects including condensed matter physics, electronic engineering, materials science, and chemistry since the mechanical exfoliation of graphene in 2004. Starting from graphene, 2D materials now have become a big family with numerous members and diverse categories. The unique structural features and physicochemical properties of 2D materials make them one class of the most appealing candidates for a wide range of potential applications. In particular, we have seen some major breakthroughs made in the field of 2D materials in last five years not only in developing novel synthetic methods and exploring new structures/properties but also in identifying innovative applications and pushing forward commercialisation. In this review, we provide a critical summary on the recent progress made in the field of 2D materials with a particular focus on last five years. After a brief backgroundintroduction, we first discuss the major synthetic methods for 2D materials, including the mechanical exfoliation, liquid exfoliation, vapor phase deposition, and wet-chemical synthesis as well as phase engineering of 2D materials belonging to the field of phase engineering of nanomaterials(PEN). We then introduce the superconducting/optical/magnetic properties and chirality of 2D materials along with newly emerging magic angle 2D superlattices. Following that, the promising applications of 2D materials in electronics, optoelectronics, catalysis, energy storage, solar cells, biomedicine, sensors, environments, etc. are described sequentially. Thereafter, we present the theoretic calculations and simulations of 2D materials. Finally, after concluding the current progress, we provide some personal discussions on the existing challenges and future outlooks in this rapidly developing field.展开更多
Evidence suggests that interleukin-10(IL-10) deficiency exacerbates inflammation and worsens the outcome of brain ischemia. In view of the critical role of the single nucleotide polymorphic sites-1082(A/G) and-819(C/T...Evidence suggests that interleukin-10(IL-10) deficiency exacerbates inflammation and worsens the outcome of brain ischemia. In view of the critical role of the single nucleotide polymorphic sites-1082(A/G) and-819(C/T) in the promoter region of the IL-10 gene, we hypothesized that they are associated with cerebral infarction morbidity in the Chinese Han population. We genotyped these allelic gene polymorphisms by amplification refractory mutation system-polymerase chain reaction methods in 181 patients with cerebral infarction(cerebral infarction group) and 115 healthy subjects(control group). We identified significant differences in genotype distribution and allele frequency of the IL-10-1082 A/G allele between cerebral infarction and control groups(χ2 = 6.643, P = 0.010). The IL-10-1082 A allele frequency was significantly higher in the cerebral infarction group(92.3%) than in the control group(86.1%)(P = 0.015). Moreover, cerebral infarction risk of the AA genotype was 2-fold higher than with the AG genotype(OR = 2.031, 95%CI: 1.134–3.637). In addition, AA genotype together with hypertension was the independent risk factor of cerebral infarction(OR = 2.073, 95%CI: 1.278–3.364). No statistical difference in genotype distribution or allele frequency of IL-10-819 C/T was found between cerebral infarction and control groups(P > 0.05). These findings suggest that the IL-10-1082 A/G gene polymorphism is involved in cerebral infarction, and increased A allele frequency is closely associated with occurrence of cerebral infarction.展开更多
In this paper,we investigate the coverage optimization for LTE networks considering the network load. The network coverage is defined as the number of served users of evolved Node B(eNB)which is determined by e NBs...In this paper,we investigate the coverage optimization for LTE networks considering the network load. The network coverage is defined as the number of served users of evolved Node B(eNB)which is determined by e NBs' antenna tilt angles(ATA). The coverage is optimized by optimizing the number of served users based on the Modified Particle Swarm Optimization(MPSO)algorithm. Simulation results show that both the number of served users by each e NB and the system throughput are significantly increased. As well,the average load and the bandwidth efficiency of the network are improved.展开更多
BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a life-threatening hyperinflammatory syndrome caused by many genetic defects.STAT1 is a DNAbinding factor that regulates gene transcription.HLH caused by STAT1 gain...BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a life-threatening hyperinflammatory syndrome caused by many genetic defects.STAT1 is a DNAbinding factor that regulates gene transcription.HLH caused by STAT1 gain-offunction(GOF)mutations has rarely been reported and its clinical manifestations and mechanisms are not clearly defined.CASE SUMMARY A 2-year-old boy presented to our hospital with recurrent fever for>20 d.The patient had a personal history of persistent oral candidiasis and inoculation site infection during the past 2 years.Hepatosplenomegaly was noted.Complete blood cell count showed severe anemia,thrombocytopenia and neutropenia.Other laboratory tests showed liver dysfunction,hypertriglyceridemia and decreased fibrinogen.Hemophagocytosis was found in the bone marrow.Chest computed tomography showed a cavitary lesion.Tests for fungal infection were positive.Serum T helper(Th)1/Th2 cytokine determination demonstrated moderately elevated levels of interleukin(IL)-6 and IL-10 with normal interferon(IFN)-γconcentration.Mycobacterium bovis was identified in bronchoalveolar lavage fluid by polymerase chain reaction.Genetic testing identified a heterozygous mutation of c.1154C>T causing a T385M amino acid substitution in STAT1.Despite antibacterial and antifungal therapy,the febrile disease was not controlled.The signs of HLH were relieved after HLH-94 protocol administration,except fever.Fever was not resolved until he received anti-tuberculosis therapy.Hematopoietic stem cell transplantation was refused and the patient died six months later due to severe pneumonia.CONCLUSION Patients with STAT1 GOF mutation have broad clinical manifestations and may develop HLH.This form of HLH presents with normal IFN-γlevel without cytokine storm.展开更多
3D printing is a promising technology used in the fabrication of complex oral dosage delivery pharmaceuticals.This study first reports an innovative color jet 3D printing(CJ-3DP)technology to produce colorful cartoon ...3D printing is a promising technology used in the fabrication of complex oral dosage delivery pharmaceuticals.This study first reports an innovative color jet 3D printing(CJ-3DP)technology to produce colorful cartoon levetiracetam pediatric preparations with high accuracy and reproducibility.For this study,the ideal printing ink consisted of 40%(v/v)isopropanol aqueous solution containing 0.05%(w/w)polyvinylpyrrolidone and 4%(w/w)glycerin,which was satisfied with scale-up of the production.The external and internal spatial structures of the tablets were designed to control the appearance and release,and cartoon tablets with admirable appearances and immediate release characteristics were printed.The dosage model showed a good linear relationship between the model volume and the tablet strength(r>0.999),which proved the potential of personalized administration.The surface roughness indicated that the appearance of the CJ-3DP tablets was significantly better than the first listed 3D printed drug(Spritam R).Moreover,the scanning electron microscopy and porosity results further showed that the tablets have a structure of loose interior and tight exterior,which could ensure good mechanical properties and rapid dispersion characteristics simultaneously.In conclusion,the innovative CJ-3DP technology can be used to fabricate personalized pediatric preparations for improved compliance.Due to the stable formulation and fabrication process,this technology has the potential in scale-up production.展开更多
To investigate the deposition distribution of snow particles in the bogie surfaces of a high-speed train,a snow particle deposition model,based on the critical capture velocity and the critical shear velocity,was elab...To investigate the deposition distribution of snow particles in the bogie surfaces of a high-speed train,a snow particle deposition model,based on the critical capture velocity and the critical shear velocity,was elaborated.Simulations based on the unsteady Reynolds-Averaged Navier-Stokes(RANS)approach coupled with Discrete Phase Model(DPM)were used to analyze the motion of snow particles.The results show that the cross beam of the bogie frame,the anti-snake damper,the intermediate brake clamps in the rear wheels,the traction rod and the anti-rolling torsion bar are prone to accumulate snow.The accumulation mass relating to the vertical surface in the rear region,horizontal surface in the front region and the corner area of the bogie is high.The average snow accumulation mass for each component ordered from high to low is as follow:traction rod,frame,bolster,brake clamp 2,anti-rolling torsion bar,brake clamp 1,transverse damper,axle box 2,axle box 1,air spring,anti-snake damper,tread cleaning device.The snow accumulation mass on the front components of the bogie is more significant than that relating to the rear components.Particularly,the average snow accumulation mass of rear brake clamp 2 and axle box 2 is about twice as high as that of the front brake clamp 1 and axle box 1.展开更多
Topological insulators (TIs) host robust edge or surface states protected by time-reversal symmetry (TRS), which makes them prime candidates for applications in spintronic devices. A promising avenue of research for t...Topological insulators (TIs) host robust edge or surface states protected by time-reversal symmetry (TRS), which makes them prime candidates for applications in spintronic devices. A promising avenue of research for the development of functional TI devices has involved doping of three-dimensional (3D) TI thin film and bulk materials with magnetic elements. This approach aims to break the TRS and open a surface band gap near the Dirac point. Utilizing this gapped surface state allows for a wide range of novel physical effects to be observed, paving a way for applications in spintronics and quantum computation. This review focuses on the research of 3D TIs doped with manganese (Mn). We summarize major progress in the study of Mn doped chalcogenide TIs, including Bi2Se3, Bi2Te3, and Bi2(Te,Se)3. The transport properties, in particular the anomalous Hall effect, of the Mn-doped Bi2Se3 are discussed in detail. Finally, we conclude with future prospects and challenges in further studies of Mn doped TIs.展开更多
Stochastic geometry is widely employed to model cellular network. But in most existing works, base stations(BSs) are modelled following a homogeneous Poisson point process(PPP) for one-tier network, or several indepen...Stochastic geometry is widely employed to model cellular network. But in most existing works, base stations(BSs) are modelled following a homogeneous Poisson point process(PPP) for one-tier network, or several independent homogeneous PPP for multi-tier network, which ignore the dependence among BSs. In this paper, a three-tier UDN(Ultra dense network) with Macrocell BSs(MBS) for basic coverage, Picocell BSs(PBSs) deployed outside the coverage area of MBSs for compensating coverage holes, and Femtocell BSs(FBSs) surrounding MBSs for capacity improvement modelled by point process with inter-tier dependence is proposed. The tier association probability, the coverage probability and area spectrum efficiency(ASE) are derived. Simulation results validate our derivation, and results show that the proposed network model has 25%-45% performance gain in ASE.展开更多
SINR distribution and rate overage distribution are crucial for optimization of deployment of Ultra-dense Het Nets.Most existing literatures assume that BSs have full queues and full-buffer traffic.In fact,due to ultr...SINR distribution and rate overage distribution are crucial for optimization of deployment of Ultra-dense Het Nets.Most existing literatures assume that BSs have full queues and full-buffer traffic.In fact,due to ultra-dense deployment of small cells,traffic in small cell varies dramatically in time and space domains.Hence,it is more practical to investigate scenario with burst traffic.In this paper,we consider a two-tier non-uniform ultra-dense Het Net with burst traffic,where macro BSs are located according to Poisson Point Process(PPP),and pico BSs are located according to Poisson Hole Process(PHP).The closed-form expressions of SINR distribution and rate distribution are derived,and then validated through simulation.Our study shows that different from the result of full buffer case,the SINR distribution and rate distribution of users depend on the average transmission probabilities of BSs in burst traffic case.展开更多
OBJECTIVE To evaluate the predictive value of humanepidermal growth factor receptor-2 (HER-2) and P53 in taxane-based and anthracycline-based neoadjuvant chemotherapy (NAC)in breast cancer.METHODSSixty-two patients wi...OBJECTIVE To evaluate the predictive value of humanepidermal growth factor receptor-2 (HER-2) and P53 in taxane-based and anthracycline-based neoadjuvant chemotherapy (NAC)in breast cancer.METHODSSixty-two patients with breast cancer wereincluded in this study.Twenty-two patients were treated withtaxane-based (taxane group) and 40 with anthracycline-based(anthracycline group).ER,PR,c-erbB2 and P53 were detected byimmunohistochemistry staining before NAC,and FluorescenceIn Situ Hybridization(FISH) was used to detect the HER-2 geneamplification for the cases with the expression of c-erbB2 proteinas (++) or (+++).The efficacy of the regimens was evaluated afterNAC.RESULTS In the anthracycline group,objective response (OR)was observed in 30 out of 40 patients (75%),whereas no response(NR) was observed in 10 patients (25%).In the taxane group,ORwas observed in 15 patients out of 22 patients (68.2%),whereasNR was observed in 7 patients (31.8%).HER-2-negative status wascorrelated with a high OR in both taxane-based and anthracycline-based NAC (P = 0.023 and P = 0.029),whereas P53-negative statuswas correlated with high OR rate in anthracycline-based NAC (P= 0.041).The significant difference of the CR rates was observedbetween the patients took<4 cycles and>4 cycles NAC (4.65% vs.21.05%,P<0.05).CONCLUSION The patients with HER-2 gene non-amplicationmay be sensitive to both taxane-based and anthracycline-basedchemotherapy;the patients without P53 overexpression maysuitable to select anthracycline-based chemotherapy;and properincreased NAC cycles may increase CR rates.展开更多
The tumor suppressor p53 plays a key role in protecting genetic integrity. Its dynamics have important physiological significance, which may be related to the cell fate. Previous experiments have shown that the wild-t...The tumor suppressor p53 plays a key role in protecting genetic integrity. Its dynamics have important physiological significance, which may be related to the cell fate. Previous experiments have shown that the wild-type p53-induced phosphatase 1(Wip1) protein could maintain p53 oscillation. Therefore, we add Wip1 to remodel the p53 network. Firstly,we use the binomial τ-leap algorithm to prove our model stable under internal noise. Then, we make a series of bifurcation diagrams, that is, p53 levels as a function of p53 degradation rate at different Wip1 generation rates. The results illustrate that Wip1 is essential for p53 oscillation. Finally, a two-dimensional bifurcation diagram is made and the stability of some p53 dynamics under external noise is analyzed by potential landscape. Our results may have some implications for artificially interfering with p53 dynamics to achieve tumor suppression.展开更多
The posterior rootlets in L6 and S1 spinal cord of adult male Sprague-Dawley rats underwent electrostimulation. The bladder pressure, urethral perfusion pressure and intracavernous pressure were recorded. When some po...The posterior rootlets in L6 and S1 spinal cord of adult male Sprague-Dawley rats underwent electrostimulation. The bladder pressure, urethral perfusion pressure and intracavernous pressure were recorded. When some posterior rootlets of L6 and S1 were electrostimulated, the intracavernous pressure peaked rapidly, but the bladder pressure and the urethral perfusion pressure curve did not show great change. When other rootlets were stimulated, the bladder pressure changed greatly, but the urethral perfusion pressure and the intracavernous pressure did not show great change. When different rootlets were stimulated, the urethral perfusion pressure changed maximally, but there were no great changes in bladder pressure or intracavernous pressure. Furthermore, stimulation of some rootlets produced simultaneous changes in two or three different pressure measures mentioned above. The results demonstrate that regulation by L6 and S1 posterior rootlets of the rat bladder detrusor, external urethral sphincter and penis cavernous body are significantly distinct. Different rootlets can be distinguished by electrostimulation.展开更多
基金supported by the National Natural Science Foundation of China,No.81772452(to NL)the Fujian Province Joint Funds for the Innovation of Science and Technology,No.2020Y9065(to NL)+1 种基金Fujian Province Special Foundation for Natural Science Innovation Project,No.2016B014(to NL)the Natural Science Foundation of Fujian Province,No.2019J01160(to XHJ).
文摘Treadmill exercise and mesenchymal stem cell transplantation are both practical and effective methods for the treatment of cerebral ischemia.However,whether there is a synergistic effect between the two remains unclear.In this study,we established rat models of ischemia/reperfusion injury by occlusion of the middle cerebral artery for 2 hours and reperfusion for 24 hours.Rat models were perfused with bone marrow mesenchymal stem cell-derived exosomes(MSC-exos)via the tail vein and underwent 14 successive days of treadmill exercise.Neurological assessment,histopathology,and immunohistochemistry results revealed decreased neuronal apoptosis and cerebral infarct volume,evident synaptic formation and axonal regeneration,and remarkably recovered neurological function in rats subjected to treadmill exercise and MSC-exos treatment.These effects were superior to those in rats subjected to treadmill exercise or MSC-exos treatment alone.Mechanistically,further investigation revealed that the activation of JNK1/c-Jun signaling pathways regulated neuronal apoptosis and synaptic-axonal remodeling.These findings suggest that treadmill exercise may exhibit a synergistic effect with MSC-exos treatment,which may be related to activation of the JNK1/c-Jun signaling pathway.This study provides novel theoretical evidence for the clinical application of treadmill exercise combined with MSC-exos treatment for ischemic cerebrovascular disease.
基金This work is partially supported by the National Key Research and Development Project under Grant 2018YFB1802402.
文摘The error correction performance of Belief Propagation(BP)decoding for polar codes is satisfactory compared with the Successive Cancellation(SC)decoding.Nevertheless,it has to complete a fixed number of iterations,which results in high computational complexity.This necessitates an intelligent identification of successful BP decoding for early termination of the decoding process to avoid unnecessary iterations and minimize the computational complexity of BP decoding.This paper proposes a hybrid technique that combines the“paritycheck”with the“G-matrix”to reduce the computational complexity of BP decoder for polar codes.The proposed hybrid technique takes advantage of the parity-check to intelligently identify the valid codeword at an early stage and terminate the BP decoding process,which minimizes the overhead of the G-matrix and reduces the computational complexity of BP decoding.We explore a detailed mechanism incorporating the parity bits as outer code and prove that the proposed hybrid technique minimizes the computational complexity while preserving the BP error correction performance.Moreover,mathematical formulation for the proposed hybrid technique that minimizes the computation cost of the G-matrix is elaborated.The performance of the proposed hybrid technique is validated by comparing it with the state-of-the-art early stopping criteria for BP decoding.Simulation results show that the proposed hybrid technique reduces the iterations by about 90%of BP decoding in a high Signal-to-Noise Ratio(SNR)(i.e.,3.5~4 dB),and approaches the error correction performance of G-matrix and conventional BP decoder for polar codes.
基金Project supported by the starting funds from Northwest University。
文摘By employing a combined approach of density-functional theory(DFT) and dynamical mean-field theory(DMFT) calculations, we examine the structural, electronic, and magnetic characteristics of two distinct strontium ruthenates: Sr2RuO4,an unconventional superconductor, and the correlated metal SrRuO3, both at 50% Fe-doping level. In both Sr2Fe0.5Ru0.5O4and SrFe0.5Ru0.5O3, the original ruthenium(Ru) and the dopant iron(Fe) atoms adopt 3-dimensional and 2-dimensional G-type structures, respectively. The hybridization between Fe-3d and Ru-4d is comparatively weaker than in other double perovskite systems. The interplay between strong correlations and reduced itinerancy results in significant spin splitting at Fe and Ru sites. Consequently, a charge transfer process, along with the super-exchange effect, leads to antiferromagnetically coupled Fe3+and Ru5+ions and establishes a semiconducting ferrimagnetic order. Subsequent DMFT calculations demonstrate the persistence of the ferrimagnetic order even at room temperature(300 K). These findings align with prior reports on Sr Fe0.5Ru0.5O3, thus reinforcing the notion that 3d–4d transition metal oxides hold considerable promise as candidates for high-performance spintronic devices, such as spin-valve sensors and spintronic giant magnetoresistance devices.
基金Shanxi Bethune Hospital Teaching Reform Project(2022JX06)Shanxi Provincial College Teaching Reform and Innovation Project(J20230467)。
文摘Objective:To study the application effect of short video combined with BOPPPS teaching mode in clinical anesthesia practice.Method:48 students assigned to clinical anesthesia in digestive endoscopy of Shanxi Bethune Hospital from July 1,2022 to April 1,2023 were selected as research objects.They were randomly divided into the control group(PowerPoint presentation teaching group)and the observation group(short video combined with BOPPPS teaching group),with 24 students in each group.After the internship,the students’theoretical and technical scores were tested,the effects of the two teaching modes were compared,and the students’satisfaction was investigated.Results:The test scores of students in the observation group were significantly better than those in the control group(P<0.05).The short video combined with BOPPPS teaching mode can significantly improve students’learning interest,operation skills,and memory(P<0.05).The students’satisfaction in the observation group was higher than that in the control group(P<0.05).Conclusion:In clinical practice,the application of short video combined with BOPPPS teaching mode has achieved great effect,which is worth further promotion and research.
文摘Optical Coherence Tomography (OCT) technique is a nondestructive optical detection technology based on low-coherence interferometer and it has become an attractive cultural heritage research method. A 1310 nm source spectral-domain optical coherence tomography (SD-OCT) system based on optical fiber Michelson interferometer and optical spectrum analyzer is proposed and demonstrated for Chinese cultural heritage research. The cross-section OCT images of Chinese pigment samples and jadeite samples can provide a lot of valuable microstructure information for the Chinese cultural heritage research and identification works.
文摘Background: To study the influence of blood lipid levels on hemorrhagic transformation(HT) and prognosis after acute cerebral infarction(ACI).Methods: Patients with ACI within 72 h of symptoms onset between January 1 st, 2015, and December 31 st, 2016, were retrospectively analyzed. Patients were divided into group A(without HT) and group B(HT). The outcomes were assessed after 3 months of disease onset using the modified Rankin Scale(m RS). An m RS score of 0–2 points indicated excellent prognosis, and an m RS score of 3–6 points indicated poor prognosis.Results: A total of 732 patients conformed to the inclusion criteria, including 628 in group A and 104 in group B. The incidence of HT was 14.2%, and the median onset time was 2 d(interquartile range, 1–7 d). The percentages of patients with large infarct size and cortex involvement in group B were 80.8% and 79.8%, respectively, which were both significantly higher than those in group A(28.7 and 33.4%, respectively). The incidence rate of atrial fibrillation(AF) in group B was significantly higher than that in group A(39.4% vs. 13.9%, P<0.001). The adjusted multivariate analysis results showed that large infarct size, cortex involvement and AF were independent risk factors of HT, while total cholesterol(TC) was a protective factor of HT(OR=0.359, 95% CI 0.136–0.944, P=0.038). With every 1 mmol/L reduction in normal TC levels, the risk of HT increased by 64.1%. The mortality and morbidity at 3 months in group B(21.2% and 76.7%, respectively) were both significantly higher than those in group A(8.0% and 42.8%, respectively). The adjusted multivariate analysis results showed that large infarct size(OR=12.178, 95% CI 5.390–27.516, P<0.001) was an independent risk factor of long-term unfavorable outcomes, whereas low-density lipoprotein cholesterol(LDL-C) was a protective factor(OR=0.538, 95% CI 0.300–0.964, P=0.037). With every 1 mmol/L reduction in normal LDL-C levels, the risk of an unfavorable outcome increased by 46.2%. Major therapies, including intravenous recombinant human tissue plasminogen activator(r TPA), intensive lipid-lowering statins and anti-platelets, were not significantly related to either HT or long-term, post-ACI poor prognosis.Conclusions: For patients with large infarct sizes, especially those with cortex involvement, AF, or lower levels of TC, the risk of HT might increase after ACI. The risk of a long-term unfavorable outcome in these patients might increase with a reduction in LDL-C.
文摘Research on two-dimensional(2D) materials has been explosively increasing in last seventeen years in varying subjects including condensed matter physics, electronic engineering, materials science, and chemistry since the mechanical exfoliation of graphene in 2004. Starting from graphene, 2D materials now have become a big family with numerous members and diverse categories. The unique structural features and physicochemical properties of 2D materials make them one class of the most appealing candidates for a wide range of potential applications. In particular, we have seen some major breakthroughs made in the field of 2D materials in last five years not only in developing novel synthetic methods and exploring new structures/properties but also in identifying innovative applications and pushing forward commercialisation. In this review, we provide a critical summary on the recent progress made in the field of 2D materials with a particular focus on last five years. After a brief backgroundintroduction, we first discuss the major synthetic methods for 2D materials, including the mechanical exfoliation, liquid exfoliation, vapor phase deposition, and wet-chemical synthesis as well as phase engineering of 2D materials belonging to the field of phase engineering of nanomaterials(PEN). We then introduce the superconducting/optical/magnetic properties and chirality of 2D materials along with newly emerging magic angle 2D superlattices. Following that, the promising applications of 2D materials in electronics, optoelectronics, catalysis, energy storage, solar cells, biomedicine, sensors, environments, etc. are described sequentially. Thereafter, we present the theoretic calculations and simulations of 2D materials. Finally, after concluding the current progress, we provide some personal discussions on the existing challenges and future outlooks in this rapidly developing field.
基金supported by the National Natural Science Foundation of ChinaNo.81171867+1 种基金a grant from the Key Research Program of Fujian Department of Science and Technology of ChinaNo.2011Y0027
文摘Evidence suggests that interleukin-10(IL-10) deficiency exacerbates inflammation and worsens the outcome of brain ischemia. In view of the critical role of the single nucleotide polymorphic sites-1082(A/G) and-819(C/T) in the promoter region of the IL-10 gene, we hypothesized that they are associated with cerebral infarction morbidity in the Chinese Han population. We genotyped these allelic gene polymorphisms by amplification refractory mutation system-polymerase chain reaction methods in 181 patients with cerebral infarction(cerebral infarction group) and 115 healthy subjects(control group). We identified significant differences in genotype distribution and allele frequency of the IL-10-1082 A/G allele between cerebral infarction and control groups(χ2 = 6.643, P = 0.010). The IL-10-1082 A allele frequency was significantly higher in the cerebral infarction group(92.3%) than in the control group(86.1%)(P = 0.015). Moreover, cerebral infarction risk of the AA genotype was 2-fold higher than with the AG genotype(OR = 2.031, 95%CI: 1.134–3.637). In addition, AA genotype together with hypertension was the independent risk factor of cerebral infarction(OR = 2.073, 95%CI: 1.278–3.364). No statistical difference in genotype distribution or allele frequency of IL-10-819 C/T was found between cerebral infarction and control groups(P > 0.05). These findings suggest that the IL-10-1082 A/G gene polymorphism is involved in cerebral infarction, and increased A allele frequency is closely associated with occurrence of cerebral infarction.
基金supported by National 863 Program(2014AA01A702)National Major Project(2013ZX03001032-004)+1 种基金National Natural Science Foundation(61221002 and 61201170)the Fundamental Research Funds for the Central Universities(CXLX13 093)
文摘In this paper,we investigate the coverage optimization for LTE networks considering the network load. The network coverage is defined as the number of served users of evolved Node B(eNB)which is determined by e NBs' antenna tilt angles(ATA). The coverage is optimized by optimizing the number of served users based on the Modified Particle Swarm Optimization(MPSO)algorithm. Simulation results show that both the number of served users by each e NB and the system throughput are significantly increased. As well,the average load and the bandwidth efficiency of the network are improved.
文摘BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a life-threatening hyperinflammatory syndrome caused by many genetic defects.STAT1 is a DNAbinding factor that regulates gene transcription.HLH caused by STAT1 gain-offunction(GOF)mutations has rarely been reported and its clinical manifestations and mechanisms are not clearly defined.CASE SUMMARY A 2-year-old boy presented to our hospital with recurrent fever for>20 d.The patient had a personal history of persistent oral candidiasis and inoculation site infection during the past 2 years.Hepatosplenomegaly was noted.Complete blood cell count showed severe anemia,thrombocytopenia and neutropenia.Other laboratory tests showed liver dysfunction,hypertriglyceridemia and decreased fibrinogen.Hemophagocytosis was found in the bone marrow.Chest computed tomography showed a cavitary lesion.Tests for fungal infection were positive.Serum T helper(Th)1/Th2 cytokine determination demonstrated moderately elevated levels of interleukin(IL)-6 and IL-10 with normal interferon(IFN)-γconcentration.Mycobacterium bovis was identified in bronchoalveolar lavage fluid by polymerase chain reaction.Genetic testing identified a heterozygous mutation of c.1154C>T causing a T385M amino acid substitution in STAT1.Despite antibacterial and antifungal therapy,the febrile disease was not controlled.The signs of HLH were relieved after HLH-94 protocol administration,except fever.Fever was not resolved until he received anti-tuberculosis therapy.Hematopoietic stem cell transplantation was refused and the patient died six months later due to severe pneumonia.CONCLUSION Patients with STAT1 GOF mutation have broad clinical manifestations and may develop HLH.This form of HLH presents with normal IFN-γlevel without cytokine storm.
基金This work was supported by the National Natural Science Foundation of China(No.82073793)the National Major Science and Technology Projects of China(No.2018ZX09721003-007/No.2018ZX09J18107).
文摘3D printing is a promising technology used in the fabrication of complex oral dosage delivery pharmaceuticals.This study first reports an innovative color jet 3D printing(CJ-3DP)technology to produce colorful cartoon levetiracetam pediatric preparations with high accuracy and reproducibility.For this study,the ideal printing ink consisted of 40%(v/v)isopropanol aqueous solution containing 0.05%(w/w)polyvinylpyrrolidone and 4%(w/w)glycerin,which was satisfied with scale-up of the production.The external and internal spatial structures of the tablets were designed to control the appearance and release,and cartoon tablets with admirable appearances and immediate release characteristics were printed.The dosage model showed a good linear relationship between the model volume and the tablet strength(r>0.999),which proved the potential of personalized administration.The surface roughness indicated that the appearance of the CJ-3DP tablets was significantly better than the first listed 3D printed drug(Spritam R).Moreover,the scanning electron microscopy and porosity results further showed that the tablets have a structure of loose interior and tight exterior,which could ensure good mechanical properties and rapid dispersion characteristics simultaneously.In conclusion,the innovative CJ-3DP technology can be used to fabricate personalized pediatric preparations for improved compliance.Due to the stable formulation and fabrication process,this technology has the potential in scale-up production.
基金supported by the National Key Research and Development Program of China[Grant No.2016YFB1200402].
文摘To investigate the deposition distribution of snow particles in the bogie surfaces of a high-speed train,a snow particle deposition model,based on the critical capture velocity and the critical shear velocity,was elaborated.Simulations based on the unsteady Reynolds-Averaged Navier-Stokes(RANS)approach coupled with Discrete Phase Model(DPM)were used to analyze the motion of snow particles.The results show that the cross beam of the bogie frame,the anti-snake damper,the intermediate brake clamps in the rear wheels,the traction rod and the anti-rolling torsion bar are prone to accumulate snow.The accumulation mass relating to the vertical surface in the rear region,horizontal surface in the front region and the corner area of the bogie is high.The average snow accumulation mass for each component ordered from high to low is as follow:traction rod,frame,bolster,brake clamp 2,anti-rolling torsion bar,brake clamp 1,transverse damper,axle box 2,axle box 1,air spring,anti-snake damper,tread cleaning device.The snow accumulation mass on the front components of the bogie is more significant than that relating to the rear components.Particularly,the average snow accumulation mass of rear brake clamp 2 and axle box 2 is about twice as high as that of the front brake clamp 1 and axle box 1.
基金supported by the National Key Research and Development Program (Project No. 2016YFA0300600)the National Science, Foundation of China (Projects No. 11604374 and No. 61425015)+1 种基金the National Basic Research Program of China (Project No. 2015CB921102)the Strategic Priority Research Program of Chinese Academy of Sciences (Project No. XDB28000000)
文摘Topological insulators (TIs) host robust edge or surface states protected by time-reversal symmetry (TRS), which makes them prime candidates for applications in spintronic devices. A promising avenue of research for the development of functional TI devices has involved doping of three-dimensional (3D) TI thin film and bulk materials with magnetic elements. This approach aims to break the TRS and open a surface band gap near the Dirac point. Utilizing this gapped surface state allows for a wide range of novel physical effects to be observed, paving a way for applications in spintronics and quantum computation. This review focuses on the research of 3D TIs doped with manganese (Mn). We summarize major progress in the study of Mn doped chalcogenide TIs, including Bi2Se3, Bi2Te3, and Bi2(Te,Se)3. The transport properties, in particular the anomalous Hall effect, of the Mn-doped Bi2Se3 are discussed in detail. Finally, we conclude with future prospects and challenges in further studies of Mn doped TIs.
基金partially supported by National 863 Program (2014AA01A702)national major project (2016ZX03001011-005)national natural science foundation project (61521061)
文摘Stochastic geometry is widely employed to model cellular network. But in most existing works, base stations(BSs) are modelled following a homogeneous Poisson point process(PPP) for one-tier network, or several independent homogeneous PPP for multi-tier network, which ignore the dependence among BSs. In this paper, a three-tier UDN(Ultra dense network) with Macrocell BSs(MBS) for basic coverage, Picocell BSs(PBSs) deployed outside the coverage area of MBSs for compensating coverage holes, and Femtocell BSs(FBSs) surrounding MBSs for capacity improvement modelled by point process with inter-tier dependence is proposed. The tier association probability, the coverage probability and area spectrum efficiency(ASE) are derived. Simulation results validate our derivation, and results show that the proposed network model has 25%-45% performance gain in ASE.
基金partially supported by National 863 Program(2014AA01A702)National Basic Research Program of China(973 Program 2012CB316004)National Natural Science Foundation(61271205,61221002 and 61201170)
文摘SINR distribution and rate overage distribution are crucial for optimization of deployment of Ultra-dense Het Nets.Most existing literatures assume that BSs have full queues and full-buffer traffic.In fact,due to ultra-dense deployment of small cells,traffic in small cell varies dramatically in time and space domains.Hence,it is more practical to investigate scenario with burst traffic.In this paper,we consider a two-tier non-uniform ultra-dense Het Net with burst traffic,where macro BSs are located according to Poisson Point Process(PPP),and pico BSs are located according to Poisson Hole Process(PHP).The closed-form expressions of SINR distribution and rate distribution are derived,and then validated through simulation.Our study shows that different from the result of full buffer case,the SINR distribution and rate distribution of users depend on the average transmission probabilities of BSs in burst traffic case.
基金This work was supported by a grant from the Ministry of Public Health Scientific Research Foundation of China(No.WKJ2007-3-001)
文摘OBJECTIVE To evaluate the predictive value of humanepidermal growth factor receptor-2 (HER-2) and P53 in taxane-based and anthracycline-based neoadjuvant chemotherapy (NAC)in breast cancer.METHODSSixty-two patients with breast cancer wereincluded in this study.Twenty-two patients were treated withtaxane-based (taxane group) and 40 with anthracycline-based(anthracycline group).ER,PR,c-erbB2 and P53 were detected byimmunohistochemistry staining before NAC,and FluorescenceIn Situ Hybridization(FISH) was used to detect the HER-2 geneamplification for the cases with the expression of c-erbB2 proteinas (++) or (+++).The efficacy of the regimens was evaluated afterNAC.RESULTS In the anthracycline group,objective response (OR)was observed in 30 out of 40 patients (75%),whereas no response(NR) was observed in 10 patients (25%).In the taxane group,ORwas observed in 15 patients out of 22 patients (68.2%),whereasNR was observed in 7 patients (31.8%).HER-2-negative status wascorrelated with a high OR in both taxane-based and anthracycline-based NAC (P = 0.023 and P = 0.029),whereas P53-negative statuswas correlated with high OR rate in anthracycline-based NAC (P= 0.041).The significant difference of the CR rates was observedbetween the patients took<4 cycles and>4 cycles NAC (4.65% vs.21.05%,P<0.05).CONCLUSION The patients with HER-2 gene non-amplicationmay be sensitive to both taxane-based and anthracycline-basedchemotherapy;the patients without P53 overexpression maysuitable to select anthracycline-based chemotherapy;and properincreased NAC cycles may increase CR rates.
基金National Natural Science Foundation of China(Grant No.11762011).
文摘The tumor suppressor p53 plays a key role in protecting genetic integrity. Its dynamics have important physiological significance, which may be related to the cell fate. Previous experiments have shown that the wild-type p53-induced phosphatase 1(Wip1) protein could maintain p53 oscillation. Therefore, we add Wip1 to remodel the p53 network. Firstly,we use the binomial τ-leap algorithm to prove our model stable under internal noise. Then, we make a series of bifurcation diagrams, that is, p53 levels as a function of p53 degradation rate at different Wip1 generation rates. The results illustrate that Wip1 is essential for p53 oscillation. Finally, a two-dimensional bifurcation diagram is made and the stability of some p53 dynamics under external noise is analyzed by potential landscape. Our results may have some implications for artificially interfering with p53 dynamics to achieve tumor suppression.
基金funded by the National Natural Science Foundation of China,No.30672096
文摘The posterior rootlets in L6 and S1 spinal cord of adult male Sprague-Dawley rats underwent electrostimulation. The bladder pressure, urethral perfusion pressure and intracavernous pressure were recorded. When some posterior rootlets of L6 and S1 were electrostimulated, the intracavernous pressure peaked rapidly, but the bladder pressure and the urethral perfusion pressure curve did not show great change. When other rootlets were stimulated, the bladder pressure changed greatly, but the urethral perfusion pressure and the intracavernous pressure did not show great change. When different rootlets were stimulated, the urethral perfusion pressure changed maximally, but there were no great changes in bladder pressure or intracavernous pressure. Furthermore, stimulation of some rootlets produced simultaneous changes in two or three different pressure measures mentioned above. The results demonstrate that regulation by L6 and S1 posterior rootlets of the rat bladder detrusor, external urethral sphincter and penis cavernous body are significantly distinct. Different rootlets can be distinguished by electrostimulation.
