The homogeneity-breaking instability of the periodic solutions triggered by Hopf bifurcations of a diffusive Gierer-Meinhart system is studied in this paper.Sufficient conditions on the diffusion coefficients and the ...The homogeneity-breaking instability of the periodic solutions triggered by Hopf bifurcations of a diffusive Gierer-Meinhart system is studied in this paper.Sufficient conditions on the diffusion coefficients and the cross diffusion coefficients were derived to guarantee the occurrence of the aforementioned homogeneity-breaking instability.展开更多
Load forecasting is a crucial aspect of intelligent Virtual Power Plant(VPP)management and ameans of balancing the relationship between distributed power grids and traditional power grids.However,due to the continuous...Load forecasting is a crucial aspect of intelligent Virtual Power Plant(VPP)management and ameans of balancing the relationship between distributed power grids and traditional power grids.However,due to the continuous emergence of power consumption peaks,the power supply quality of the power grid cannot be guaranteed.Therefore,an intelligent calculation method is required to effectively predict the load,enabling better power grid dispatching and ensuring the stable operation of the power grid.This paper proposes a decentralized heterogeneous federated distillation learning algorithm(DHFDL)to promote trusted federated learning(FL)between different federates in the blockchain.The algorithm comprises two stages:common knowledge accumulation and personalized training.In the first stage,each federate on the blockchain is treated as ameta-distribution.After aggregating the knowledge of each federate circularly,the model is uploaded to the blockchain.In the second stage,other federates on the blockchain download the trained model for personalized training,both of which are based on knowledge distillation.Experimental results demonstrate that the DHFDL algorithmproposed in this paper can resist a higher proportion of malicious code compared to FedAvg and a Blockchain-based Federated Learning framework with Committee consensus(BFLC).Additionally,by combining asynchronous consensus with the FL model training process,the DHFDL training time is the shortest,and the training efficiency of decentralized FL is improved.展开更多
Heterogeneous pressure-carrying medium was employed to establish a differentiated pressure field on sheet metal in flexible die forming process in this work,which aimed at matching the non-symmetric shape of target co...Heterogeneous pressure-carrying medium was employed to establish a differentiated pressure field on sheet metal in flexible die forming process in this work,which aimed at matching the non-symmetric shape of target component and improving metal inflow to avoid local tensile instability.Specifically,metal inflow corresponding to the differentiated pressure field was analytically evaluated.Forming of a typical non-symmetric shell component was experimentally and numerically studied based on the proposed method.Compared with forming processes based on the uniform pressure,difference of metal inflow in two sides of the non-symmetric component increased from 2.16 mm to 3.36 mm and metal inflow in critical region increased by 11.9%when differentiated pressure field(taking heterogeneous elastomer#4–3 for example)was employed.The resultant maximum thinning ratio decreased by 4.2% and the uniformity of shell thickness increased by 16.9%.With the decrease of Shore hardness of elastomer in the formed region,stress path in the ready-to-form region transferred towards the bi-axial tension stress state,i.e.,stress ratio(a)increased.And,stress triaxiality(η)in characteristic regions were regulated appropriately,which decreased the risk of tensile instability.It was attributed to the decreased normal pressure and frictional resistance at sheet/elastomer interface in the formed region.展开更多
To address the increasing need for detecting and validating protein biomarkers in clinical specimens,mass spectrometry(MS)-based targeted proteomic techniques,including the selected reaction monitoring(SRM),parallel r...To address the increasing need for detecting and validating protein biomarkers in clinical specimens,mass spectrometry(MS)-based targeted proteomic techniques,including the selected reaction monitoring(SRM),parallel reaction monitoring(PRM),and massively parallel dataindependent acquisition(DIA),have been developed.For optimal performance,they require the fragment ion spectra of targeted peptides as prior knowledge.In this report,we describe a MS pipeline and spectral resource to support targeted proteomics studies for human tissue samples.To build the spectral resource,we integrated common open-source MS computational tools to assemble a freely accessible computational workflow based on Docker.We then applied the workflow to generate DPHL,a comprehensive DIA pan-human library,from 1096 data-dependent acquisition(DDA)MS raw files for 16 types of cancer samples.This extensive spectral resource was then applied to a proteomic study of 17 prostate cancer(PCa)patients.Thereafter,PRM validation was applied to a larger study of 57 PCa patients and the differential expression of three proteins in prostate tumor was validated.As a second application,the DPHL spectral resource was applied to a study consisting of plasma samples from 19 diffuse large B cell lymphoma(DLBCL)patients and 18 healthy control subjects.Differentially expressed proteins between DLBCL patients and healthy control subjects were detected by DIA-MS and confirmed by PRM.These data demonstrate that the DPHL supports DIA and PRM MS pipelines for robust protein biomarker discovery.DPHL is freely accessible at https://www.iprox.org/page/project.html?id=IPX0001400000.展开更多
Flow cytometry has become a powerful cell analysis technique for modern clinical diagnosis and biological research. Even though great success has been achieved using flow cytometry, this technique still suffers from s...Flow cytometry has become a powerful cell analysis technique for modern clinical diagnosis and biological research. Even though great success has been achieved using flow cytometry, this technique still suffers from some limitations, such as the use of specific immune biomarkers and fluorescent dyes. In contrast, the novel deformability cytometry achieves label-free identification of cells according to their different mechanical properties.展开更多
The lacrimal endoscope is applied to the diagnosis and therapy of the disorders of the lacrimal system in combination with laser or micro drills under orthophoria.The changes of mucous membranes,the characteristics of...The lacrimal endoscope is applied to the diagnosis and therapy of the disorders of the lacrimal system in combination with laser or micro drills under orthophoria.The changes of mucous membranes,the characteristics of pathological changes and the predilection sites of lacrimal system diseases were initially approached.One hundred and forty six pairs of eyes of 128 patients with lacrimal system disease were observed by the lacrimal endoscope in the Ophthalmology Department of Tongji Hospital from June 2006 to March 2007.The dynamic changes in mucous membranes,lesion sites,secreted substances and formation of membrane could be observed under orthophoria.Combined with laser or micro drill,the endoscope was applied to the therapy of lacrimal system disorders and the difference before and after the treatment was observed.Results are as follows:(1)The examination and therapy using the lacrimal endoscope were completed under topical anesthesia in 122 patients,and 6 patients of neonatorum dacryocystitis were examined and treated under general anaesthesia.All patients reported painless.(2)Sharp images of the lacrimal system were obtained by the endoscope.Normal lacrimal mucosal membrane was smooth and light pink,expanded and unobstructed during irrigation.In chronic dacryocystitis patients,the inhomo-geneous colour of mucosal membranes was red and white,with different degrees offibrotic membranes at the superior,middle and inferior parts of the nasolacrimal canals and secreted substances at sac could be observed.The lacrimal ducts could not be expanded and obstructed during irrigation.The patients with lacrimal system obstruction had different extents of membrane formation,and stenosis or complete obstruction of the lacrimal duct could be observed,and the corresponding mucosal membrane was not smooth which could not be expanded and obstructed during irrigation.(3)After the treatment by the endoscope combined with laser or micro drill,the major proliferation of the membrane disappeared and the lacrimal duct was unobstructed during irrigation.The cure rate and effective rate were 80.1%and 93.1%,respectively.The lacrimal endoscope is a new method in the diagnosis of lacrimal system diseases.Through a combination with laser or micro drill to carry out the therapy under orthophoria,it will bring a great change to the diagnosis and therapy of lacrimal system diseases.展开更多
Successful global cities present a spectrum of development strategies but share the benefit of the reciprocal dynamics between tailored education systems and matching labour markets.This paper examines burgeoning citi...Successful global cities present a spectrum of development strategies but share the benefit of the reciprocal dynamics between tailored education systems and matching labour markets.This paper examines burgeoning cities in China and investigates the effects of the heterogeneous educational trajectories of young migrant workers in urban China on their labour market performance.Drawing on the National Migrant Dynamics Monitoring Survey,this paper finds striking wage variations among the young migrant population.Migrant workers who attended high schools in current receiving cities earned less than their counterparts who received senior-secondary education elsewhere.Students following the academic track were better off than students following the vocational track.To further explore what has prevented the urban labour market from rewarding migrants who studied in a receiving city,where the education system is expected to better cater to the city’s specific industrial needs,we tested and found evidence of the mediating effects of job industry and occupation.In addition to engaging with empirical debates in the field,this paper develops a theoretical framework to model how the qualitative attributes of an education system affect wage variations among migrant workers.展开更多
基金Sponsored by the National Natural Science Foundation of China(Grant Nos.12061033,2020GG0130,2020MS04007,2020BS11,and NJZZ22286).
文摘The homogeneity-breaking instability of the periodic solutions triggered by Hopf bifurcations of a diffusive Gierer-Meinhart system is studied in this paper.Sufficient conditions on the diffusion coefficients and the cross diffusion coefficients were derived to guarantee the occurrence of the aforementioned homogeneity-breaking instability.
基金supported by the Research and application of Power Business Data Security and Trusted Collaborative Sharing Technology Based on Blockchain and Multi-Party Security Computing(J2022057).
文摘Load forecasting is a crucial aspect of intelligent Virtual Power Plant(VPP)management and ameans of balancing the relationship between distributed power grids and traditional power grids.However,due to the continuous emergence of power consumption peaks,the power supply quality of the power grid cannot be guaranteed.Therefore,an intelligent calculation method is required to effectively predict the load,enabling better power grid dispatching and ensuring the stable operation of the power grid.This paper proposes a decentralized heterogeneous federated distillation learning algorithm(DHFDL)to promote trusted federated learning(FL)between different federates in the blockchain.The algorithm comprises two stages:common knowledge accumulation and personalized training.In the first stage,each federate on the blockchain is treated as ameta-distribution.After aggregating the knowledge of each federate circularly,the model is uploaded to the blockchain.In the second stage,other federates on the blockchain download the trained model for personalized training,both of which are based on knowledge distillation.Experimental results demonstrate that the DHFDL algorithmproposed in this paper can resist a higher proportion of malicious code compared to FedAvg and a Blockchain-based Federated Learning framework with Committee consensus(BFLC).Additionally,by combining asynchronous consensus with the FL model training process,the DHFDL training time is the shortest,and the training efficiency of decentralized FL is improved.
基金supported by the National Natural Science Foundation of China(No.52275329,No.51905156,and No.51805309)Natural Science Foundation of Henan(No.232300421059)the fellowship of China Postdoctoral Science Foundation(No.2020M672221)。
文摘Heterogeneous pressure-carrying medium was employed to establish a differentiated pressure field on sheet metal in flexible die forming process in this work,which aimed at matching the non-symmetric shape of target component and improving metal inflow to avoid local tensile instability.Specifically,metal inflow corresponding to the differentiated pressure field was analytically evaluated.Forming of a typical non-symmetric shell component was experimentally and numerically studied based on the proposed method.Compared with forming processes based on the uniform pressure,difference of metal inflow in two sides of the non-symmetric component increased from 2.16 mm to 3.36 mm and metal inflow in critical region increased by 11.9%when differentiated pressure field(taking heterogeneous elastomer#4–3 for example)was employed.The resultant maximum thinning ratio decreased by 4.2% and the uniformity of shell thickness increased by 16.9%.With the decrease of Shore hardness of elastomer in the formed region,stress path in the ready-to-form region transferred towards the bi-axial tension stress state,i.e.,stress ratio(a)increased.And,stress triaxiality(η)in characteristic regions were regulated appropriately,which decreased the risk of tensile instability.It was attributed to the decreased normal pressure and frictional resistance at sheet/elastomer interface in the formed region.
基金supported by the National Natural Science Foundation of China(Grant No.81972492)National Science Fund for Young Scholars(Grant No.21904107)+7 种基金Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars(Grant No.LR19C050001)Hangzhou Agriculture and Society Advancement Program(Grant No.20190101A04)Westlake Startup Grantresearch funds from the National Cancer Centre Singapore and Singapore General Hospital,Singaporethe National Key R&D Program of China(Grant No.2016YFC0901704)Zhejiang Innovation Discipline Project of Laboratory Animal Genetic Engineering(Grant No.201510)the Netherlands Cancer Society(Grant No.NKI 2014-6651)The Netherlands Organization for Scientific Research(NWO)-Middelgroot(Grant No.91116017)
文摘To address the increasing need for detecting and validating protein biomarkers in clinical specimens,mass spectrometry(MS)-based targeted proteomic techniques,including the selected reaction monitoring(SRM),parallel reaction monitoring(PRM),and massively parallel dataindependent acquisition(DIA),have been developed.For optimal performance,they require the fragment ion spectra of targeted peptides as prior knowledge.In this report,we describe a MS pipeline and spectral resource to support targeted proteomics studies for human tissue samples.To build the spectral resource,we integrated common open-source MS computational tools to assemble a freely accessible computational workflow based on Docker.We then applied the workflow to generate DPHL,a comprehensive DIA pan-human library,from 1096 data-dependent acquisition(DDA)MS raw files for 16 types of cancer samples.This extensive spectral resource was then applied to a proteomic study of 17 prostate cancer(PCa)patients.Thereafter,PRM validation was applied to a larger study of 57 PCa patients and the differential expression of three proteins in prostate tumor was validated.As a second application,the DPHL spectral resource was applied to a study consisting of plasma samples from 19 diffuse large B cell lymphoma(DLBCL)patients and 18 healthy control subjects.Differentially expressed proteins between DLBCL patients and healthy control subjects were detected by DIA-MS and confirmed by PRM.These data demonstrate that the DPHL supports DIA and PRM MS pipelines for robust protein biomarker discovery.DPHL is freely accessible at https://www.iprox.org/page/project.html?id=IPX0001400000.
基金supported by the National Natural Science Foundation of China (51875103, 81727801 and 51775111)the Natural Science Foundation of Jiangsu Province (BK20190064)+1 种基金the Six Talent Peaks Project of Jiangsu Province (SWYY-005)the Zhishan Youth Scholar Program of SEU。
文摘Flow cytometry has become a powerful cell analysis technique for modern clinical diagnosis and biological research. Even though great success has been achieved using flow cytometry, this technique still suffers from some limitations, such as the use of specific immune biomarkers and fluorescent dyes. In contrast, the novel deformability cytometry achieves label-free identification of cells according to their different mechanical properties.
基金supported by the Fund of Tongji Hospital New Technique and Therapy in 2006.
文摘The lacrimal endoscope is applied to the diagnosis and therapy of the disorders of the lacrimal system in combination with laser or micro drills under orthophoria.The changes of mucous membranes,the characteristics of pathological changes and the predilection sites of lacrimal system diseases were initially approached.One hundred and forty six pairs of eyes of 128 patients with lacrimal system disease were observed by the lacrimal endoscope in the Ophthalmology Department of Tongji Hospital from June 2006 to March 2007.The dynamic changes in mucous membranes,lesion sites,secreted substances and formation of membrane could be observed under orthophoria.Combined with laser or micro drill,the endoscope was applied to the therapy of lacrimal system disorders and the difference before and after the treatment was observed.Results are as follows:(1)The examination and therapy using the lacrimal endoscope were completed under topical anesthesia in 122 patients,and 6 patients of neonatorum dacryocystitis were examined and treated under general anaesthesia.All patients reported painless.(2)Sharp images of the lacrimal system were obtained by the endoscope.Normal lacrimal mucosal membrane was smooth and light pink,expanded and unobstructed during irrigation.In chronic dacryocystitis patients,the inhomo-geneous colour of mucosal membranes was red and white,with different degrees offibrotic membranes at the superior,middle and inferior parts of the nasolacrimal canals and secreted substances at sac could be observed.The lacrimal ducts could not be expanded and obstructed during irrigation.The patients with lacrimal system obstruction had different extents of membrane formation,and stenosis or complete obstruction of the lacrimal duct could be observed,and the corresponding mucosal membrane was not smooth which could not be expanded and obstructed during irrigation.(3)After the treatment by the endoscope combined with laser or micro drill,the major proliferation of the membrane disappeared and the lacrimal duct was unobstructed during irrigation.The cure rate and effective rate were 80.1%and 93.1%,respectively.The lacrimal endoscope is a new method in the diagnosis of lacrimal system diseases.Through a combination with laser or micro drill to carry out the therapy under orthophoria,it will bring a great change to the diagnosis and therapy of lacrimal system diseases.
文摘Successful global cities present a spectrum of development strategies but share the benefit of the reciprocal dynamics between tailored education systems and matching labour markets.This paper examines burgeoning cities in China and investigates the effects of the heterogeneous educational trajectories of young migrant workers in urban China on their labour market performance.Drawing on the National Migrant Dynamics Monitoring Survey,this paper finds striking wage variations among the young migrant population.Migrant workers who attended high schools in current receiving cities earned less than their counterparts who received senior-secondary education elsewhere.Students following the academic track were better off than students following the vocational track.To further explore what has prevented the urban labour market from rewarding migrants who studied in a receiving city,where the education system is expected to better cater to the city’s specific industrial needs,we tested and found evidence of the mediating effects of job industry and occupation.In addition to engaging with empirical debates in the field,this paper develops a theoretical framework to model how the qualitative attributes of an education system affect wage variations among migrant workers.
