As the continuous development of the industrial revolution,nanomaterials with excellent characteristics have been widely applied in various fields,greatly increasing the probability of human exposure to nanomaterials ...As the continuous development of the industrial revolution,nanomaterials with excellent characteristics have been widely applied in various fields,greatly increasing the probability of human exposure to nanomaterials and the concerns about the potential nanotoxicity.Existing studies have shown that the toxicity of nanomaterials may be closely related to oxidative stress,inflammatory response,phagocytosis dysfunction,DNA damage,etc.Based on our focus,nanomaterials may cross the human barrier through various channels and disrupt various cell-cell junctions,while the integrity of cellular barrier is a necessary for the normal physiological function of various organs.However,until now,there is still a lack of systematic discussion in this field.This review illustrates the importance of cell-cell junctions in maintaining various organ functions and highlights the mechanism of various nanomaterials disrupt cell-cell junctions,as well as the possible damage to various organs,such as brain,eye,lung,breast,intestine,placenta,testis,heart,liver,kidney,skin,etc.Awareness of the potential negative effects of nanomaterials will help scientists deeply understand the limitations of nanotechnology,inspiring them to develop safer and more efficient nanomaterials for future personalized nanomedicine.展开更多
Cytoskeleton plays a significant role in the shape change,migration,movement,adhesion,cytokinesis,and phagocytosis of tumor cells.In clinical practice,some anti-cancer drugs achieve cytoskeletal therapeutic effects by...Cytoskeleton plays a significant role in the shape change,migration,movement,adhesion,cytokinesis,and phagocytosis of tumor cells.In clinical practice,some anti-cancer drugs achieve cytoskeletal therapeutic effects by acting on different cytoskeletal protein components.However,in the absence of cell-specific targeting,unnecessary cytoskeletal recombination in organisms would be disastrous,which would also bring about severe side effects during anticancer process.Nanomedicine have been proven to be superior to some small molecule drugs in cancer treatment due to better stability and targeting,and lower side effects.Therefore,this review summarized the recent developments of various nanomaterials disturbing cytoskeleton for enhanced cancer therapeutics,including carbon,noble metals,metal oxides,black phosphorus,calcium,silicon,polymers,peptides,and metal-organic frameworks,etc.A comprehensive analysis of the characteristics of cytoskeleton therapy as well as the future prospects and challenges towards clinical application were also discussed.We aim to drive on this emerging topic through refreshing perspectives based on our own work and what we have also learnt from others.This review will help researchers quickly understand relevant cytoskeletal therapeutic information to further advance the development of cancer nanomedicine.展开更多
基金the National Natural Science Foundation of China(Nos.22104073 and 22004048)the Natural Science Foundation of Shandong Province of China(Nos.ZR2021QB119,2022HWYQ-079,and ZR2020QB171)the Youth Innovation Science and Technology Program of Shandong Provincial Universities(No.2021KJ100).
文摘As the continuous development of the industrial revolution,nanomaterials with excellent characteristics have been widely applied in various fields,greatly increasing the probability of human exposure to nanomaterials and the concerns about the potential nanotoxicity.Existing studies have shown that the toxicity of nanomaterials may be closely related to oxidative stress,inflammatory response,phagocytosis dysfunction,DNA damage,etc.Based on our focus,nanomaterials may cross the human barrier through various channels and disrupt various cell-cell junctions,while the integrity of cellular barrier is a necessary for the normal physiological function of various organs.However,until now,there is still a lack of systematic discussion in this field.This review illustrates the importance of cell-cell junctions in maintaining various organ functions and highlights the mechanism of various nanomaterials disrupt cell-cell junctions,as well as the possible damage to various organs,such as brain,eye,lung,breast,intestine,placenta,testis,heart,liver,kidney,skin,etc.Awareness of the potential negative effects of nanomaterials will help scientists deeply understand the limitations of nanotechnology,inspiring them to develop safer and more efficient nanomaterials for future personalized nanomedicine.
基金the National Natural Science Foundation of China(22104073)the Natural Science Foundation of Shandong(ZR2021QA100,ZR2021QB119,2022HWYQ-079)the Youth Innovation Science and Technology Program of Shandong Provincial Universities(2021KJ100).
文摘Cytoskeleton plays a significant role in the shape change,migration,movement,adhesion,cytokinesis,and phagocytosis of tumor cells.In clinical practice,some anti-cancer drugs achieve cytoskeletal therapeutic effects by acting on different cytoskeletal protein components.However,in the absence of cell-specific targeting,unnecessary cytoskeletal recombination in organisms would be disastrous,which would also bring about severe side effects during anticancer process.Nanomedicine have been proven to be superior to some small molecule drugs in cancer treatment due to better stability and targeting,and lower side effects.Therefore,this review summarized the recent developments of various nanomaterials disturbing cytoskeleton for enhanced cancer therapeutics,including carbon,noble metals,metal oxides,black phosphorus,calcium,silicon,polymers,peptides,and metal-organic frameworks,etc.A comprehensive analysis of the characteristics of cytoskeleton therapy as well as the future prospects and challenges towards clinical application were also discussed.We aim to drive on this emerging topic through refreshing perspectives based on our own work and what we have also learnt from others.This review will help researchers quickly understand relevant cytoskeletal therapeutic information to further advance the development of cancer nanomedicine.
