BACKGROUND It is possible that this condition will lead to urosepsis and progressive deterioration of renal function in the absence of surgical intervention.Several recent clinical studies have shown that multi-tract ...BACKGROUND It is possible that this condition will lead to urosepsis and progressive deterioration of renal function in the absence of surgical intervention.Several recent clinical studies have shown that multi-tract percutaneous nephrolithotomy(MPCNL)has a similar stone free rate(SFR)as standard percutaneous nephrolithotomy(S-PCNL).As a result,M-PCNL was also recommended as a treatment option for staghorn calculi.AIM To examine the perioperative and long-term results of ultrasonography-guided single-and M-PCNL.METHODS This was a retrospective cohort study.Between March 2021 and January 2022,the urology department of our hospital selected patients for the treatment of staghorn calculi using percutaneous nephrolithotomy.The primary outcomes were com plication rate and SFR,and the characteristics of patients,operative parameters,laboratory measurements were also collected.RESULTS In total,345 patients were enrolled in the study(186 in the S-PCNL group and 159 in the M-PCNL group).The SFR in the M-PCNL group was significantly higher than that in the S-PCNL group(P=0.033).Moreover,the incidence rates of hydrothorax(P=0.03)and postoperative infection(P=0.012)were higher in the M-PCNL group than in the S-PCNL group.Logistic regression analysis demonstrated that post-operative white blood cell count(OR=2.57,95%CI:1.90-3.47,P<0.001)and stone size(OR=1.59,95%CI:1.27-2.00,P<0.001)were associated with a higher overall complication rate in the S-PCNL group.Body mass index(OR=1.22,95%CI:1.06-1.40,P=0.004)and stone size(OR=1.70,95%CI:1.35-2.15,P<0.001)were associated with increased overall complications in the M-PCNL group.CONCLUSION Multiple access tracts can facilitate higher SFR while slightly increasing the incidence of acceptable complications.展开更多
The discrete ordinates(S N)method requires numerous angular unknowns to achieve the desired accu-racy for shielding calculations involving strong anisotropy.Our objective is to develop an angular adaptive algorithm in...The discrete ordinates(S N)method requires numerous angular unknowns to achieve the desired accu-racy for shielding calculations involving strong anisotropy.Our objective is to develop an angular adaptive algorithm in the S N method to automatically optimize the angular distribution and minimize angular discretization errors with lower expenses.The proposed method enables linear dis-continuous finite element quadrature sets over an icosahe-dron to vary their quadrature orders in a one-twentieth sphere so that fine resolutions can be applied to the angular domains that are important.An error estimation that operates in conjunction with the spherical harmonics method is developed to determine the locations where more refinement is required.The adaptive quadrature sets are applied to three duct problems,including the Kobayashi benchmarks and the IRI-TUB research reactor,which emphasize the ability of this method to resolve neutron streaming through ducts with voids.The results indicate that the performance of the adaptive method is more effi-cient than that of uniform quadrature sets for duct transport problems.Our adaptive method offers an appropriate placement of angular unknowns to accurately integrate angular fluxes while reducing the computational costs in terms of unknowns and run times.展开更多
AIM： To investigate the prognostic significance of phosphatase regenerating liver 3 （PRL-3） protein expression in gastric cancer.METHODS： PRL-3 expression in paraffin-embedded tumor specimens from 293 patients wit...AIM： To investigate the prognostic significance of phosphatase regenerating liver 3 （PRL-3） protein expression in gastric cancer.METHODS： PRL-3 expression in paraffin-embedded tumor specimens from 293 patients with gastric cancer was studied retrospectively by immunohistochemistry. Nonoclonal antibody specifically against PRL-3, 3B6, was obtained with hybridoma technique.RESULTS： Positive PRL-3 expression was detected in 43.3% （227 of 293） of gastric cancer cases. High expression of PRL-3 was positively correlated with tumor size, depth of invasion, vascular/lymphatic invasion, lymph node metastasis, high TNM stage and tumor recurrence. Patients with positive PRL-3 expression had a significantly lower 5-year survival rate than those with negative expression （28.3% vs 52.9%, P 〈 0.0001）. Patients who received curative surgery, and with positive PRL-3 expression had a significant shorter overall survival and disease-free disadvantage over patients with negative expression （hazard ratio of 16.7 and 16.6, respectively; P 〈 0.0001 for both）. Multivariate analysis revealed that PRL-3 expression was an independent prognostic indicator for overall and disease-free survival of gastric cancer patients, particularly for survival in TNM stage Ⅲ patients. CONCLUSION： PRL-3 expression is a new independent prognostic indicator to predict the potential of recurrence and survival in patients with gastric cancer at the time of tumor resection,展开更多
There is urgent need for medical journals to optimize their publishing processes and strategies to satisfy the huge need for medical scientists to publish their articles,and then obtain better prestige and impact in s...There is urgent need for medical journals to optimize their publishing processes and strategies to satisfy the huge need for medical scientists to publish their articles,and then obtain better prestige and impact in scientific and research commtmity.These strategies include optimizing the process of peer-review,utilizing open-access publishing models actively,finding ways of saving costs and getting revenue,smartly dealing with research fraud or misconduct,maintaining sound relationship with pharmaceutical companies,and managing to provide relevant and useful information for clinical practitioners and researchers.Scientists,publishers,societies and organizations need to work together to publish internationally renowned medical journals.展开更多
The 8th National Gastric Cancer Academic Conference, organized by Gastric Cancer Association of Chinese Anti- cancer Association and co-hosted by Beijing Cancer Hospital, Chinese Journal of Cancer Research （CJCR）, T...The 8th National Gastric Cancer Academic Conference, organized by Gastric Cancer Association of Chinese Anti- cancer Association and co-hosted by Beijing Cancer Hospital, Chinese Journal of Cancer Research （CJCR）, Translational Gastrointestinal Cancer （TGC）, Chinese Journal of Gastrointestinal Surgery, and Chinese Journal of Practical Surgery, was held at Beijing International Convention Center from June 15 to 16, 2013. Prof. Dr. Jiafu Ji, MD, FACS, the president of Gastric Cancer Committee, Chinese Anti-Cancer Association （CACA） and Editor-in-Chief of TGC, was the chairman of the conference （Figure 1）. Prof. Dr. Yan Sun, MD, academician of Chinese Academy of Engineering （CAE）, was the honorary chairman of the展开更多
文摘BACKGROUND It is possible that this condition will lead to urosepsis and progressive deterioration of renal function in the absence of surgical intervention.Several recent clinical studies have shown that multi-tract percutaneous nephrolithotomy(MPCNL)has a similar stone free rate(SFR)as standard percutaneous nephrolithotomy(S-PCNL).As a result,M-PCNL was also recommended as a treatment option for staghorn calculi.AIM To examine the perioperative and long-term results of ultrasonography-guided single-and M-PCNL.METHODS This was a retrospective cohort study.Between March 2021 and January 2022,the urology department of our hospital selected patients for the treatment of staghorn calculi using percutaneous nephrolithotomy.The primary outcomes were com plication rate and SFR,and the characteristics of patients,operative parameters,laboratory measurements were also collected.RESULTS In total,345 patients were enrolled in the study(186 in the S-PCNL group and 159 in the M-PCNL group).The SFR in the M-PCNL group was significantly higher than that in the S-PCNL group(P=0.033).Moreover,the incidence rates of hydrothorax(P=0.03)and postoperative infection(P=0.012)were higher in the M-PCNL group than in the S-PCNL group.Logistic regression analysis demonstrated that post-operative white blood cell count(OR=2.57,95%CI:1.90-3.47,P<0.001)and stone size(OR=1.59,95%CI:1.27-2.00,P<0.001)were associated with a higher overall complication rate in the S-PCNL group.Body mass index(OR=1.22,95%CI:1.06-1.40,P=0.004)and stone size(OR=1.70,95%CI:1.35-2.15,P<0.001)were associated with increased overall complications in the M-PCNL group.CONCLUSION Multiple access tracts can facilitate higher SFR while slightly increasing the incidence of acceptable complications.
基金supported by the National Natural Science Foundation of China(No.11975097)the Fundamental Research Funds for the Central Universities(No.2019MS038).
文摘The discrete ordinates(S N)method requires numerous angular unknowns to achieve the desired accu-racy for shielding calculations involving strong anisotropy.Our objective is to develop an angular adaptive algorithm in the S N method to automatically optimize the angular distribution and minimize angular discretization errors with lower expenses.The proposed method enables linear dis-continuous finite element quadrature sets over an icosahe-dron to vary their quadrature orders in a one-twentieth sphere so that fine resolutions can be applied to the angular domains that are important.An error estimation that operates in conjunction with the spherical harmonics method is developed to determine the locations where more refinement is required.The adaptive quadrature sets are applied to three duct problems,including the Kobayashi benchmarks and the IRI-TUB research reactor,which emphasize the ability of this method to resolve neutron streaming through ducts with voids.The results indicate that the performance of the adaptive method is more effi-cient than that of uniform quadrature sets for duct transport problems.Our adaptive method offers an appropriate placement of angular unknowns to accurately integrate angular fluxes while reducing the computational costs in terms of unknowns and run times.
基金Supported by Grant for Key Technology Research and Development Program 2002BA711A06National Basic Research Priorities Program 973 Project 1998051203the Ministry of Science and Technology of China,and grant H020920030390,from the Beijing Science and Technology Commission
文摘AIM： To investigate the prognostic significance of phosphatase regenerating liver 3 （PRL-3） protein expression in gastric cancer.METHODS： PRL-3 expression in paraffin-embedded tumor specimens from 293 patients with gastric cancer was studied retrospectively by immunohistochemistry. Nonoclonal antibody specifically against PRL-3, 3B6, was obtained with hybridoma technique.RESULTS： Positive PRL-3 expression was detected in 43.3% （227 of 293） of gastric cancer cases. High expression of PRL-3 was positively correlated with tumor size, depth of invasion, vascular/lymphatic invasion, lymph node metastasis, high TNM stage and tumor recurrence. Patients with positive PRL-3 expression had a significantly lower 5-year survival rate than those with negative expression （28.3% vs 52.9%, P 〈 0.0001）. Patients who received curative surgery, and with positive PRL-3 expression had a significant shorter overall survival and disease-free disadvantage over patients with negative expression （hazard ratio of 16.7 and 16.6, respectively; P 〈 0.0001 for both）. Multivariate analysis revealed that PRL-3 expression was an independent prognostic indicator for overall and disease-free survival of gastric cancer patients, particularly for survival in TNM stage Ⅲ patients. CONCLUSION： PRL-3 expression is a new independent prognostic indicator to predict the potential of recurrence and survival in patients with gastric cancer at the time of tumor resection,
文摘There is urgent need for medical journals to optimize their publishing processes and strategies to satisfy the huge need for medical scientists to publish their articles,and then obtain better prestige and impact in scientific and research commtmity.These strategies include optimizing the process of peer-review,utilizing open-access publishing models actively,finding ways of saving costs and getting revenue,smartly dealing with research fraud or misconduct,maintaining sound relationship with pharmaceutical companies,and managing to provide relevant and useful information for clinical practitioners and researchers.Scientists,publishers,societies and organizations need to work together to publish internationally renowned medical journals.
文摘The 8th National Gastric Cancer Academic Conference, organized by Gastric Cancer Association of Chinese Anti- cancer Association and co-hosted by Beijing Cancer Hospital, Chinese Journal of Cancer Research （CJCR）, Translational Gastrointestinal Cancer （TGC）, Chinese Journal of Gastrointestinal Surgery, and Chinese Journal of Practical Surgery, was held at Beijing International Convention Center from June 15 to 16, 2013. Prof. Dr. Jiafu Ji, MD, FACS, the president of Gastric Cancer Committee, Chinese Anti-Cancer Association （CACA） and Editor-in-Chief of TGC, was the chairman of the conference （Figure 1）. Prof. Dr. Yan Sun, MD, academician of Chinese Academy of Engineering （CAE）, was the honorary chairman of the
