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Restoring Efficacy to Cotrimoxazole, against Resistant <i>Salmonella pullorum, </i>with <i>Medicinal Synthetic Aluminum-Magnesium Silicate <sup>&reg;</sup></i>[MSAMS: Al<sub>4</sub>(SiO<sub>4</sub>)<sub>3</sub>+ 3Mg<sub>2</sub>SiO<sub>4</sub>→ 2Al<sub>2</sub>Mg<sub>3</sub>(SiO<sub>4</sub>)<sub>3</sub>] 被引量:1
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作者 Maduike Chiehiura Onwubiko Ezeibe Aniefiok Emerson Udom +1 位作者 obiageri favour onyeachonam Ijeoma Joy Ogbonna 《Health》 2019年第9期1162-1168,共7页
To restore efficacy (≥95% infection-reduction) to drugs against resistant infections (now, posing a bigger medical challenge, globally, than even HIV/AIDS), Cotrimoxazole was formulated with a synthetic Aluminum-magn... To restore efficacy (≥95% infection-reduction) to drugs against resistant infections (now, posing a bigger medical challenge, globally, than even HIV/AIDS), Cotrimoxazole was formulated with a synthetic Aluminum-magnesium silicate (Medicinal mineral which molecules are made of Nanoparticles, that is already in use as pharmaceutical-stabilizing agent) and used with antioxidants to treat Cotrimoxazole-resistant Salmonella pulorum infected chicks. Chick-groups A, B and C were fed antioxidants-fortified feed while groups D, E, F, G and H were not. The treatment-groups and their Cotrimoxazole doses/formulations were: A and D (100%/MSAMS-Cotrimoxazole);B and E (75%/MSAMS-Cotrimoxazole);C and F (50%/MSAMS-Cotrimoxazole) and G (100%/Cotrimoxazole). Infection-reductions (96.23% and 94.98%) of the groups of 75%/MSAMS-Cotrimoxazole/antioxidants and 75%/MSAMS-Cotrimoxazole were significantly (P ≤ 0.05) better than 76.99% (100%/Cotrimoxazole);10.04% (50%/MSAMS-Cotrimoxazole/antioxidants);1.60% (50%/MSAMS-Cotrimoxazole);&minus;212.60% (100%/MSAMS-Cotrimoxazole/antioxidants) and &minus;230.96% (100%/MSAMS-Cotrimoxazole). 展开更多
关键词 Cure for RESISTANT Infections Salmonellosis MSAMS
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