Ischemic stroke occurs when blood supply to the brain is interrupted. This can cause irreversible injury to the cen- tral nervous system （CNS） tissue. Each year in the United States almost 800,000 people experience ...Ischemic stroke occurs when blood supply to the brain is interrupted. This can cause irreversible injury to the cen- tral nervous system （CNS） tissue. Each year in the United States almost 800,000 people experience a new or recur- rent stroke. 15% of stroke patients die shortly after insult and only 10% recover completely, leaving the majority of surviving stroke patients with disabilities. Tissue-type plasminogen activator （tPA） is the only available therapy for stroke but its clinical use is limited because of associ- ated danger of intracranial hemorrhage. Therefore, there is an emergent need for stroke therapeutics that are safe and effective when administered at a later time point after insult.展开更多
Mitochondrial translocator protein（TSPO）has been a somewhat mysterious player in searching for its true biological functions.TSPO is involved in mitochondrial cholesterol transport and steroids biosynthesis and pred...Mitochondrial translocator protein（TSPO）has been a somewhat mysterious player in searching for its true biological functions.TSPO is involved in mitochondrial cholesterol transport and steroids biosynthesis and predominantly expressed in steroid-synthesizing tissues including the central nervous system（CNS）.However,展开更多
基金supported by grants from the National Institutes of Health[R01NS061983,R01ES015988]Shriners Hospitals for Children to W.D
文摘Ischemic stroke occurs when blood supply to the brain is interrupted. This can cause irreversible injury to the cen- tral nervous system （CNS） tissue. Each year in the United States almost 800,000 people experience a new or recur- rent stroke. 15% of stroke patients die shortly after insult and only 10% recover completely, leaving the majority of surviving stroke patients with disabilities. Tissue-type plasminogen activator （tPA） is the only available therapy for stroke but its clinical use is limited because of associ- ated danger of intracranial hemorrhage. Therefore, there is an emergent need for stroke therapeutics that are safe and effective when administered at a later time point after insult.
基金part supported by grants from the National Institutes of Health[R01NS061983,R01ES015988 and R01HD087566)]Shriners Hospitals for Children to WD
文摘Mitochondrial translocator protein（TSPO）has been a somewhat mysterious player in searching for its true biological functions.TSPO is involved in mitochondrial cholesterol transport and steroids biosynthesis and predominantly expressed in steroid-synthesizing tissues including the central nervous system（CNS）.However,
