Biodegradable magnesium alloys are promising candidates for temporary fracture fixation devices in orthopedics;nevertheless,its fast degradation rate at the initial stage after implantation remains as one of the main ...Biodegradable magnesium alloys are promising candidates for temporary fracture fixation devices in orthopedics;nevertheless,its fast degradation rate at the initial stage after implantation remains as one of the main challenges to be resolved.ZrO_(2)-based coatings to reduce the degradation rate of the Mg-implants are an attractive solution since they show high biocompatibility and stability.In this work,the degradation,cytotoxicity,and antibacterial performance of ZrO_(2)thin films deposited by magnetron sputtering on a Mg-Zn-Ca alloy was evaluated.Short-term degradation of ZrO_(2)-coated and uncoated samples was assessed considering electrochemical techniques and H_(2)evolution(gas chromatography).Additionally,long term degradation was assessed by mass-loss measurements.The results showed that a 380 nm ZrO_(2)coating reduces the degradation rate and H_(2)evolution of the alloy during the initial 3 days after immersion but allows the degradation of the bare alloy for the long-term.The ZrO_(2)coating does not compromise the biocompatibility of the alloy and permits better cell adhesion and proliferation of mesenchymal stem cells directly on its surface,in comparison to the bare alloy.Finally,the ZrO_(2)coating prevents the adhesion and biofilm formation of S.aureus.展开更多
基金supported by CONACYT-Frontera-1740,CONACy T-CB-288101,CONACy T-299703,and DGAPAPAPIIT-IN101419 projectssupport from the CONACYT Ph.D.-scholarship(CVU 606030)+2 种基金the program Doctorado en Ciencia e Ingeniería de Materials at the Universidad Nacional Autónoma de Méxicothe support from the program Maestría y Doctorado en Ciencias Médicas,Odontológicas y de la Salud at the Universidad Nacional Autónoma de México and the Ph.D.scholarship from CONACy T(CVU 856985)the support from the program Posgrado de Doctorado en Ciencias en Biomedicina y Biotecnología Molecular,Escuela Nacional de Ciencias Biológicas at the Instituto Politécnico Nacional and the Ph.D.scholarship from CONACy T(CVU 739515)
文摘Biodegradable magnesium alloys are promising candidates for temporary fracture fixation devices in orthopedics;nevertheless,its fast degradation rate at the initial stage after implantation remains as one of the main challenges to be resolved.ZrO_(2)-based coatings to reduce the degradation rate of the Mg-implants are an attractive solution since they show high biocompatibility and stability.In this work,the degradation,cytotoxicity,and antibacterial performance of ZrO_(2)thin films deposited by magnetron sputtering on a Mg-Zn-Ca alloy was evaluated.Short-term degradation of ZrO_(2)-coated and uncoated samples was assessed considering electrochemical techniques and H_(2)evolution(gas chromatography).Additionally,long term degradation was assessed by mass-loss measurements.The results showed that a 380 nm ZrO_(2)coating reduces the degradation rate and H_(2)evolution of the alloy during the initial 3 days after immersion but allows the degradation of the bare alloy for the long-term.The ZrO_(2)coating does not compromise the biocompatibility of the alloy and permits better cell adhesion and proliferation of mesenchymal stem cells directly on its surface,in comparison to the bare alloy.Finally,the ZrO_(2)coating prevents the adhesion and biofilm formation of S.aureus.
