The cancer cell metastasis is a major death reason for patients with non-small cell lung cancer(NSCLC).Although researchers have disclosed that interleukin 17(IL-17)can increase matrix metalloproteinases(MMPs)inductio...The cancer cell metastasis is a major death reason for patients with non-small cell lung cancer(NSCLC).Although researchers have disclosed that interleukin 17(IL-17)can increase matrix metalloproteinases(MMPs)induction causing NSCLC cell metastasis,the underlying mechanism remains unclear.In the study,we found that IL-17 receptor A(IL-17RA),p300,p-STAT3,Ack-STAT3,and MMP19 were up-regulated both in NSCLC tissues and NSCLC cells stimulated with IL-17.p300,STAT3 and MMP19 overexpression or knockdown could raise or reduce IL-17-induced p-STAT3,Ack-STAT3 and MMP19 level as well as the cell migration and invasion.Mechanism investigation revealed that STAT3 and p300 bound to the same region(−544 to−389 nt)of MMP19 promoter,and p300 could acetylate STAT3-K631 elevating STAT3 transcriptional activity,p-STAT3 or MMP19 expression and the cell mobility exposed to IL-17.Meanwhile,p300-mediated STAT3-K631 acetylation and its Y705-phosphorylation could interact,synergistically facilitating MMP19 gene transcription and enhancing cell migration and invasion.Besides,the animal experiments exhibited that the nude mice inoculated with NSCLC cells by silencing p300,STAT3 or MMP19 gene plus IL-17 treatment,the nodule number,and MMP19,Ack-STAT3,or p-STAT3 production in the lung metastatic nodules were all alleviated.Collectively,these outcomes uncover that IL-17-triggered NSCLC metastasis involves up-regulating MMP19 expression via the interaction of STAT3-K631 acetylation by p300 and its Y705-phosphorylation,which provides a new mechanistic insight and potential strategy for NSCLC metastasis and therapy.展开更多
The effects of buried oxide(BOX)layer on the capacitance of SiGe heterojunction photo-transistor(HPT),including the collector-substrate capacitance,the base-collector capacitance,and the base-emitter capacitance,are s...The effects of buried oxide(BOX)layer on the capacitance of SiGe heterojunction photo-transistor(HPT),including the collector-substrate capacitance,the base-collector capacitance,and the base-emitter capacitance,are studied by using a silicon-on-insulator(SOI)substrate as compared with the devices on native Si substrates.By introducing the BOX layer into Si-based SiGe HPT,the maximum photo-characteristic frequency ft,opt of SOI-based SiGe HPT reaches up to 24.51 GHz,which is 1.5 times higher than the value obtained from Si-based SiGe HPT.In addition,the maximum optical cut-off frequency fβ,opt,namely its 3-dB bandwidth,reaches up to 1.13 GHz,improved by 1.18 times.However,with the increase of optical power or collector current,this improvement on the frequency characteristic from BOX layer becomes less dominant as confirmed by reducing the 3-dB bandwidth of SOI-based SiGe HPT which approaches to the 3-dB bandwidth of Si-based SiGe HPT at higher injection conditions.展开更多
INTRODUCTION Japan’s first successful lunar landing mission,Smart Lander for Investigating Moon(SLIM),was landed on the Moon on January 19th,2024.SLIM made a precise landing within 100 m of the targeted landing zone(...INTRODUCTION Japan’s first successful lunar landing mission,Smart Lander for Investigating Moon(SLIM),was landed on the Moon on January 19th,2024.SLIM made a precise landing within 100 m of the targeted landing zone(central coordinates 13.316°S,25.251°E),which is located around the Shioli crater(D=270 m,central coordinates as 13.33°S,25.23°E)in the southwestern ejecta of the Theophilus crater(D=98.6 km,central coordinates as 11.45°S,26.28°E).展开更多
In this paper, we study the Pohozaev identity associated with a Henon-Lane-Emden system involving the fractional Laplacian:■in a star-shaped and bounded domain Ω for s ∈(0,1). As an application of our identity, we ...In this paper, we study the Pohozaev identity associated with a Henon-Lane-Emden system involving the fractional Laplacian:■in a star-shaped and bounded domain Ω for s ∈(0,1). As an application of our identity, we deduce the nonexistence of positive solutions in the critical and supercritical cases.展开更多
基金National Natural Science Foundation of China(Grants Numbers 81902878 and 81971468).
文摘The cancer cell metastasis is a major death reason for patients with non-small cell lung cancer(NSCLC).Although researchers have disclosed that interleukin 17(IL-17)can increase matrix metalloproteinases(MMPs)induction causing NSCLC cell metastasis,the underlying mechanism remains unclear.In the study,we found that IL-17 receptor A(IL-17RA),p300,p-STAT3,Ack-STAT3,and MMP19 were up-regulated both in NSCLC tissues and NSCLC cells stimulated with IL-17.p300,STAT3 and MMP19 overexpression or knockdown could raise or reduce IL-17-induced p-STAT3,Ack-STAT3 and MMP19 level as well as the cell migration and invasion.Mechanism investigation revealed that STAT3 and p300 bound to the same region(−544 to−389 nt)of MMP19 promoter,and p300 could acetylate STAT3-K631 elevating STAT3 transcriptional activity,p-STAT3 or MMP19 expression and the cell mobility exposed to IL-17.Meanwhile,p300-mediated STAT3-K631 acetylation and its Y705-phosphorylation could interact,synergistically facilitating MMP19 gene transcription and enhancing cell migration and invasion.Besides,the animal experiments exhibited that the nude mice inoculated with NSCLC cells by silencing p300,STAT3 or MMP19 gene plus IL-17 treatment,the nodule number,and MMP19,Ack-STAT3,or p-STAT3 production in the lung metastatic nodules were all alleviated.Collectively,these outcomes uncover that IL-17-triggered NSCLC metastasis involves up-regulating MMP19 expression via the interaction of STAT3-K631 acetylation by p300 and its Y705-phosphorylation,which provides a new mechanistic insight and potential strategy for NSCLC metastasis and therapy.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61604106,61774012,and 61901010)the Beijing Future Chip Technology High Precision Innovation Center Research Fund,China(Grant No.KYJJ2016008)+1 种基金the Beijing Municipal Natural Science Foundation,China(Grant No.4192014)the Municipal Natural Science Foundation of Shangdong Province,China(Grant No.ZR2014FL025).
文摘The effects of buried oxide(BOX)layer on the capacitance of SiGe heterojunction photo-transistor(HPT),including the collector-substrate capacitance,the base-collector capacitance,and the base-emitter capacitance,are studied by using a silicon-on-insulator(SOI)substrate as compared with the devices on native Si substrates.By introducing the BOX layer into Si-based SiGe HPT,the maximum photo-characteristic frequency ft,opt of SOI-based SiGe HPT reaches up to 24.51 GHz,which is 1.5 times higher than the value obtained from Si-based SiGe HPT.In addition,the maximum optical cut-off frequency fβ,opt,namely its 3-dB bandwidth,reaches up to 1.13 GHz,improved by 1.18 times.However,with the increase of optical power or collector current,this improvement on the frequency characteristic from BOX layer becomes less dominant as confirmed by reducing the 3-dB bandwidth of SOI-based SiGe HPT which approaches to the 3-dB bandwidth of Si-based SiGe HPT at higher injection conditions.
基金supported by the National Natural Science Foundation of China(Nos.42241108,42302263,62227901)the Strategic Priority Research Program of Chinese Academy of Science(No.XDB41000000).
文摘INTRODUCTION Japan’s first successful lunar landing mission,Smart Lander for Investigating Moon(SLIM),was landed on the Moon on January 19th,2024.SLIM made a precise landing within 100 m of the targeted landing zone(central coordinates 13.316°S,25.251°E),which is located around the Shioli crater(D=270 m,central coordinates as 13.33°S,25.23°E)in the southwestern ejecta of the Theophilus crater(D=98.6 km,central coordinates as 11.45°S,26.28°E).
基金This work was supported by the National Natural Science Foundation of China （Grant No. 40871111） and the Scientific and Technological Innovation Application of immobilized edible fungus residue in electroplating wastewater treatment： a case study in Beijing City Chinese Academy of Sciences.
基金supported by NSFC(Grant No.11571176)the second author is supported by NSFC(Grant No.11571057)
文摘In this paper, we study the Pohozaev identity associated with a Henon-Lane-Emden system involving the fractional Laplacian:■in a star-shaped and bounded domain Ω for s ∈(0,1). As an application of our identity, we deduce the nonexistence of positive solutions in the critical and supercritical cases.
