Neutrophils that are mostly related to our body immunity and inflammatory responses are now considered to be an important player in contrast to tumor progression.Along with many controversies,there is much clear evide...Neutrophils that are mostly related to our body immunity and inflammatory responses are now considered to be an important player in contrast to tumor progression.Along with many controversies,there is much clear evidence that shows neutrophils promote the metastasis process via different modes of actions in a different time frame concerning the advancement of cancer.Not only impacting cell proliferation but also they are found to be helping tumor cells in many events like angiogenesis,immune escape,invasion,and finally it leads to cancer metastasis.Tumor microenvironment,key players of cancer growth and progression are also affected by mostly neutrophils and it’s secretory.Tumor associated neutrophils,having certainly different characteristics and expressions,are found high in number around the tumor site and often in pre-metastatic niches.Increased number of premature neutrophils and more neutrophil-extracellular-traps formation is associated with a high degree of metastasis in cancer is observed.As neutrophils has potential role in cancer,more research are warranted in this field to fully understood the overall role of this immune cells and it will helps to open a new way to target neutrophils in therapeutic implications for better cancer treatment.Here we gather currents profile of neutrophils and its role in cancer metastasis and discuss therapeutics strategy.展开更多
文摘Neutrophils that are mostly related to our body immunity and inflammatory responses are now considered to be an important player in contrast to tumor progression.Along with many controversies,there is much clear evidence that shows neutrophils promote the metastasis process via different modes of actions in a different time frame concerning the advancement of cancer.Not only impacting cell proliferation but also they are found to be helping tumor cells in many events like angiogenesis,immune escape,invasion,and finally it leads to cancer metastasis.Tumor microenvironment,key players of cancer growth and progression are also affected by mostly neutrophils and it’s secretory.Tumor associated neutrophils,having certainly different characteristics and expressions,are found high in number around the tumor site and often in pre-metastatic niches.Increased number of premature neutrophils and more neutrophil-extracellular-traps formation is associated with a high degree of metastasis in cancer is observed.As neutrophils has potential role in cancer,more research are warranted in this field to fully understood the overall role of this immune cells and it will helps to open a new way to target neutrophils in therapeutic implications for better cancer treatment.Here we gather currents profile of neutrophils and its role in cancer metastasis and discuss therapeutics strategy.
