Mental disorders seriously affect people’s health and social stability.This Mendelian randomization(MR)study was designed to investigate the causal relationship between circulating vitamin C(VC)or 25-hydroxyvitamin D...Mental disorders seriously affect people’s health and social stability.This Mendelian randomization(MR)study was designed to investigate the causal relationship between circulating vitamin C(VC)or 25-hydroxyvitamin D(25(OH)D)levels and mental disorders.The data used for the MR analysis were derived from the summary genome-wide association studies(GWAS)database for VC and 25(OH)D and from the Finn Gen consortium for fourteen mental disorders.Based on the inverse variance weighted(IVW)method,we found a potential causal association between circulating VC and anxiety disorders(IVW:OR=1.139,95%CI:1.023-1.269,P=0.018).However,no causal association was found between VC or 25(OH)D and other mental disorders(P>0.05).In the reverse MR analysis,individuals with Alzheimer’s disease was causally associated with higher concentrations of circulating VC(P=0.012),while individuals with anxiety disorders had a negative association between the concentrations of 25(OH)D(P=0.012).However,the current evidence does not support a causal relationship between VC or 25(OH)D and other mental disorders.In addition,there was no causal association between circulating VC and 25(OH)D(P>0.05).Future studies are needed to confirm these findings and to elucidate the mechanisms of potential causality.展开更多
Abstract Chinese air pollution has increased in this century along with the rapid socioeconomic development and resulting anthropogenic emissions. While recent emission control measures have shown encouraging re sults...Abstract Chinese air pollution has increased in this century along with the rapid socioeconomic development and resulting anthropogenic emissions. While recent emission control measures have shown encouraging re sults and have reduced the levels of sulfur dioxide and primary aerosols, the concentrations of other air pollutants continue to grow, particularly secondary pollutants in cluding ozone and secondary aerosols. Meanwhile, a va riety of intentional and unintentional socioeconomic events have temporarily changed the pace, and even the signs, of growth of air pollution. These events include the short-term emission restrictions imposed during the Sino-African Summit, the Beijing Olympics and Para lympics, the Shanghai World Exposition （Shanghai Expo）, the Guangzhou Asian Olympics, and the Shenzhen Uni versiade, as well as the unintentional emission reductions associated with the recent economic recession and the annual Chinese New Year. This paper presents a brief overview of trends and temporary perturbations of Chi nese air pollution since 2000, summarizing studies on anthropogenic emission inventories, atmospheric meas urements, and inverse modeling. It concludes with rec ommendations for future research.展开更多
A robust TV logo detection method based on the modified single shot multibox detector (SSD) is presented. Unlike most other existing methods which can only detect the TV logo from video frames, the proposed method can...A robust TV logo detection method based on the modified single shot multibox detector (SSD) is presented. Unlike most other existing methods which can only detect the TV logo from video frames, the proposed method can also detect the TV logo from photo pictures taken by smartphones or other smart terminals. Firstly, using a simple and effective way of collecting and labelling TV logo, a large-scale TV logo dataset used to train the detection model is built. Then, parameters and loss function of SSD are modified to make it more suitable for the task of TV logo detection. Moreover, a soft-NMS algorithm is introduced to remove the redundant overlapping boxes and obtain the final output box. And also an approach for hard example mining is designed to improve the detection accuracy. Finally, extensive comparison experiments are carried out which take into consideration different image resolutions, logo positions and environmental factors existing in real-world applications. Experimental results demonstrate that the proposed method achieve superior performances in robustness compared to other state-of-the-art methods.展开更多
基金funded by the Nactional Natural Science Foundation of China(81872618)。
文摘Mental disorders seriously affect people’s health and social stability.This Mendelian randomization(MR)study was designed to investigate the causal relationship between circulating vitamin C(VC)or 25-hydroxyvitamin D(25(OH)D)levels and mental disorders.The data used for the MR analysis were derived from the summary genome-wide association studies(GWAS)database for VC and 25(OH)D and from the Finn Gen consortium for fourteen mental disorders.Based on the inverse variance weighted(IVW)method,we found a potential causal association between circulating VC and anxiety disorders(IVW:OR=1.139,95%CI:1.023-1.269,P=0.018).However,no causal association was found between VC or 25(OH)D and other mental disorders(P>0.05).In the reverse MR analysis,individuals with Alzheimer’s disease was causally associated with higher concentrations of circulating VC(P=0.012),while individuals with anxiety disorders had a negative association between the concentrations of 25(OH)D(P=0.012).However,the current evidence does not support a causal relationship between VC or 25(OH)D and other mental disorders.In addition,there was no causal association between circulating VC and 25(OH)D(P>0.05).Future studies are needed to confirm these findings and to elucidate the mechanisms of potential causality.
基金supported by the National Natural Science Foundation of China (Grant Nos. 41005078 and 41175127)
文摘Abstract Chinese air pollution has increased in this century along with the rapid socioeconomic development and resulting anthropogenic emissions. While recent emission control measures have shown encouraging re sults and have reduced the levels of sulfur dioxide and primary aerosols, the concentrations of other air pollutants continue to grow, particularly secondary pollutants in cluding ozone and secondary aerosols. Meanwhile, a va riety of intentional and unintentional socioeconomic events have temporarily changed the pace, and even the signs, of growth of air pollution. These events include the short-term emission restrictions imposed during the Sino-African Summit, the Beijing Olympics and Para lympics, the Shanghai World Exposition （Shanghai Expo）, the Guangzhou Asian Olympics, and the Shenzhen Uni versiade, as well as the unintentional emission reductions associated with the recent economic recession and the annual Chinese New Year. This paper presents a brief overview of trends and temporary perturbations of Chi nese air pollution since 2000, summarizing studies on anthropogenic emission inventories, atmospheric meas urements, and inverse modeling. It concludes with rec ommendations for future research.
基金Supported by the National Natural Science Foundationof China(No.61702466)“Double Tops” Discipline Construction Project
文摘A robust TV logo detection method based on the modified single shot multibox detector (SSD) is presented. Unlike most other existing methods which can only detect the TV logo from video frames, the proposed method can also detect the TV logo from photo pictures taken by smartphones or other smart terminals. Firstly, using a simple and effective way of collecting and labelling TV logo, a large-scale TV logo dataset used to train the detection model is built. Then, parameters and loss function of SSD are modified to make it more suitable for the task of TV logo detection. Moreover, a soft-NMS algorithm is introduced to remove the redundant overlapping boxes and obtain the final output box. And also an approach for hard example mining is designed to improve the detection accuracy. Finally, extensive comparison experiments are carried out which take into consideration different image resolutions, logo positions and environmental factors existing in real-world applications. Experimental results demonstrate that the proposed method achieve superior performances in robustness compared to other state-of-the-art methods.
