Streptomyces agglomeratus 5-1-8 with strong anti methicillin-resistant Staphylococcus aureus(MRSA)ability,isolated from the frozen soil of Tibet in China,has a strong ability to kill the multi-drugs-resistant MRSA.To ...Streptomyces agglomeratus 5-1-8 with strong anti methicillin-resistant Staphylococcus aureus(MRSA)ability,isolated from the frozen soil of Tibet in China,has a strong ability to kill the multi-drugs-resistant MRSA.To identify the second-ary metabolism ability of this strain,we describe here the phenotypic characteristics of this strain,along with its high-quality draft genome sequence,its annotation,and analysis.The 7.1M draft genome encodes 6,284 putative open reading frames(ORFs),of which 4,416 ORFs were assigned with clusters of orthologous genes(COG)categories.Also,65 t RNA genes and 24 r RNA operons were identified.The genome contains 12 gene clusters involved in antibiotics production and 1 gene cluster involved in anticancer-compounds production;4 gene clusters belong to polyketides and nonribosomal peptides,1gene cluster belong to the butyrolactone,4 gene clusters belong to the bacteriocin or lantipeptide,and 3 gene clusters belong to the others.This genome-sequence data will facilitate efforts to probe the potential of new antibiotics to kill multidrugs-resistant MRSA.展开更多
基金supported by the National Natural Science Foundation of China (Grant No. 31400437)the international cooperation program of Gansu (1504WKCA097)+1 种基金the application transformationfoundation of CAS (HHS-CGZH-16-02)UK BBSRC China Partnering Grant (BB/J020419/1)
文摘Streptomyces agglomeratus 5-1-8 with strong anti methicillin-resistant Staphylococcus aureus(MRSA)ability,isolated from the frozen soil of Tibet in China,has a strong ability to kill the multi-drugs-resistant MRSA.To identify the second-ary metabolism ability of this strain,we describe here the phenotypic characteristics of this strain,along with its high-quality draft genome sequence,its annotation,and analysis.The 7.1M draft genome encodes 6,284 putative open reading frames(ORFs),of which 4,416 ORFs were assigned with clusters of orthologous genes(COG)categories.Also,65 t RNA genes and 24 r RNA operons were identified.The genome contains 12 gene clusters involved in antibiotics production and 1 gene cluster involved in anticancer-compounds production;4 gene clusters belong to polyketides and nonribosomal peptides,1gene cluster belong to the butyrolactone,4 gene clusters belong to the bacteriocin or lantipeptide,and 3 gene clusters belong to the others.This genome-sequence data will facilitate efforts to probe the potential of new antibiotics to kill multidrugs-resistant MRSA.
