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C-reactive Protein-717A〉 G and-286C 〉T〉A Gene Polymorphism and Ischemic Stroke 被引量:2
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作者 Yan Liu pei-liang geng +6 位作者 Fu-Qin Yan Tong Chen Wei Wang Xu-Dong Tang Jing-Chen Zheng Wei-Ping Wu Zhen-Fu Wang 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第12期1666-1670,共5页
Background:Inflammation plays a pivotal role in the formation and progression of ischemic stroke.Recently,more and more epidemiological studies have focused on the association between C-reactive protein (CRP)-717A ... Background:Inflammation plays a pivotal role in the formation and progression of ischemic stroke.Recently,more and more epidemiological studies have focused on the association between C-reactive protein (CRP)-717A 〉 G and-286C 〉 T 〉 A genetic polymorphisms and ischemic stroke.However,the findings of these researches are not conclusive.Methods:We performed a meta-analysis to determine whether these two polymorphisms are associated with the risk of ischemic stroke.Eligible studies were identified from the database of PubMed,Medline,Embase,Web of Science,CNKI,Weipu,and Wanfang.We calculated odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association.Results:Four articles were included in our study,including 1926 cases and 2678 controls for-717A 〉 G polymorphism,652 cases and 1103 controls for-286C 〉 T 〉 A polymorphism.The results of meta-analysis showed that single nucleotide polymorphism (SNP)-717A 〉 G was not significantly associated with the risk of ischemic stroke (GG vs.AA,OR =1.12,95% CI =0.83-1.50,P =0.207;GG + GA vs.AA,OR =1.04,95% CI =0.93-1.17,P =0.533;GG vs.GA + AA,OR =1.10,95% CI =0.82-1.47,P =0.220).Meta-analysis of SNP-286C 〉 T 〉 A also demonstrated no statistical evidence of a significant association with the risk of ischemic stroke (AA vs.CC,OR =0.86,95% CI =0.59-1.25,P =0.348;AA vs.CC,OR =0.92,95% CI =0.80-1.06,P =0.609;AA vs.CC,OR =0.89,95% CI =0.62-1.30,P =0.374).Conclusions:This meta-analysis demonstrated little evidence to support a role of CRP gene-717A 〉 G,-286C 〉 T 〉 A polymorphisms in ischemic stroke predisposition.However,to draw comprehensive and more reliable conclusions,further larger studies are needed to validate the association between CRP gene polymorphisms and ischemic stroke in various ethnic groups. 展开更多
关键词 C-reactive Protein POLYMORPHISM Ischemic Stroke META-ANALYSIS
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