<b>Background:</b> Approximately 11% of cancer cases are diagnosed in people of childbearing age. Borderline ovarian tumors (BOTs) make up 10%-15% of all ovarian epithelial malignancies. More than one-thir...<b>Background:</b> Approximately 11% of cancer cases are diagnosed in people of childbearing age. Borderline ovarian tumors (BOTs) make up 10%-15% of all ovarian epithelial malignancies. More than one-third of all BOTs occur in women under 4<span style="letter-spacing:-0.1pt;">0 years of age. Maintaining the fertility of cured patients is the common goal of both oncologists and reproductologists. <b>Aim:</b> Giving young women diagnosed with a prognostically worse type of BOT and after bilateral adnexectomy the possibility to have their genetically own children by the method of <i>ex vivo</i> oocyte collection. <b>Case Presentation:</b> A 34-year-old nulligravid woman with BOT underwent right laparoscopic salpingo-oophorectom</span>y. Histologically, a serious borderline tumor with a micropapillary pattern and a tumor locus on the ovarian surface were found. Due to histopathology, the onc<span style="letter-spacing:0.2pt;">ologist recommended re-staging surgery: laparotomy, left salpingo-</span>oophorectomy, omentectomy and hysterectomy. The patient refused a hysterectomy as she was planning to get pregnant with her partner. To maintain her fertility, controlled hormonal hyperstimulation and <i>ex vivo</i> aspiration of follicles from the ovary after salpingo-oophorectomy was performed. <i>Ex vivo</i> follicle expiration yielded 10 oocytes. 9 mature oocytes were fertilized by ICSI. The 6 embryos of the highest quality were individually frozen by vitrification. Cryoembryotransfer will be scheduled with the consent of the oncologist. <b>Conclusion:</b> This method is suitable for young women with BOT after bilateral salpingo-oophorectomy in whom <i>ex vivo</i> oocyte collection prevents possible leakage of tumor cells into the abdominal cavity, unlike during the conventional <i>in vivo</i> collection prior to surgery.</span><span lang="EN-US"><o:p></o:p></span> </p>展开更多
文摘<b>Background:</b> Approximately 11% of cancer cases are diagnosed in people of childbearing age. Borderline ovarian tumors (BOTs) make up 10%-15% of all ovarian epithelial malignancies. More than one-third of all BOTs occur in women under 4<span style="letter-spacing:-0.1pt;">0 years of age. Maintaining the fertility of cured patients is the common goal of both oncologists and reproductologists. <b>Aim:</b> Giving young women diagnosed with a prognostically worse type of BOT and after bilateral adnexectomy the possibility to have their genetically own children by the method of <i>ex vivo</i> oocyte collection. <b>Case Presentation:</b> A 34-year-old nulligravid woman with BOT underwent right laparoscopic salpingo-oophorectom</span>y. Histologically, a serious borderline tumor with a micropapillary pattern and a tumor locus on the ovarian surface were found. Due to histopathology, the onc<span style="letter-spacing:0.2pt;">ologist recommended re-staging surgery: laparotomy, left salpingo-</span>oophorectomy, omentectomy and hysterectomy. The patient refused a hysterectomy as she was planning to get pregnant with her partner. To maintain her fertility, controlled hormonal hyperstimulation and <i>ex vivo</i> aspiration of follicles from the ovary after salpingo-oophorectomy was performed. <i>Ex vivo</i> follicle expiration yielded 10 oocytes. 9 mature oocytes were fertilized by ICSI. The 6 embryos of the highest quality were individually frozen by vitrification. Cryoembryotransfer will be scheduled with the consent of the oncologist. <b>Conclusion:</b> This method is suitable for young women with BOT after bilateral salpingo-oophorectomy in whom <i>ex vivo</i> oocyte collection prevents possible leakage of tumor cells into the abdominal cavity, unlike during the conventional <i>in vivo</i> collection prior to surgery.</span><span lang="EN-US"><o:p></o:p></span> </p>
