Glaucoma is a common and complex neurodegenerative disease characterized by progressive loss of retinal ganglion cells(RGCs)and axons.Currently,there is no effective method to address the cause of RGCs degeneration.Ho...Glaucoma is a common and complex neurodegenerative disease characterized by progressive loss of retinal ganglion cells(RGCs)and axons.Currently,there is no effective method to address the cause of RGCs degeneration.However,studies on neuroprotective strategies for optic neuropathy have increased in recent years.Cell replacement and neuroprotection are major strategies for treating glaucoma and optic neuropathy.Regenerative medicine research into the repair of optic nerve damage using stem cells has Received considerable attention.Stem cells possess the potential for multidirectional differentiation abilities and are capable of producing RGCfriendly microenvironments through paracrine effects.This article reviews a thorough researches of recent advances and approaches in stem cell repair of optic nerve injury,raising the controversies and unresolved issues surrounding the future of stem cells.展开更多
Hepatosteatosis is characterized by abnormal accumulation of triglycerides(TG),leading to prolonged and chronic inflammatory infiltration.To date,there is still a lack of effective and economical therapies for hepatos...Hepatosteatosis is characterized by abnormal accumulation of triglycerides(TG),leading to prolonged and chronic inflammatory infiltration.To date,there is still a lack of effective and economical therapies for hepatosteatosis.Oridonin(ORI)is a major bioactive component extracted from the traditional Chinese medicinal herb Rabdosia rubescens.In this paper,we showed that ORI exerted significant protective effects against hepatic steatosis,inflammation and fibrosis,which was dependent on LXRa signaling.It is reported that LXRa regulated lipid homeostasis between triglyceride(TG)and phosphatidylethanolamine(PE)by promoting ATGL and EPT1 expression.Therefore,we implemented the lipidomic strategy and luciferase reporter assay to verify that ORI contributed to the homeostasis of lipids via the regulation of the ATGL gene associated with TG hydrolysis and the EPT1 gene related to PE synthesis in a LXRadependent manner,and the results showed the TG reduction and PE elevation.In detail,hepatic TG overload and lipotoxicity were reversed after ORI treatment by modulating the ATGL and EPT1 genes,respectively.Taken together,the data provide mechanistic insights to explain the bioactivity of ORI in attenuating TG accumulation and cytotoxicity and introduce exciting opportunities for developing novel natural activators of the LXRa-ATGL/EPT1 axis for pharmacologically treating hepatosteatosis and metabolic disorders.展开更多
Mengniu and Yili have virtually monopolized the traditional Chinese dairy market,while new media marketing and digital strategies have opened up substantial business opportunities for emerging brands.Leveraging a diff...Mengniu and Yili have virtually monopolized the traditional Chinese dairy market,while new media marketing and digital strategies have opened up substantial business opportunities for emerging brands.Leveraging a differentiation strategy,the Adopt A Cow brand has successfully carved out its niche in the market,serving as an exemplary example.However,AY Field,as a self-owned brand by a supplier,faces the challenge of low product awareness among end consumers.This paper primarily concentrates on brand planning for the AY Field milk brand,with a focus on positioning the product for mid-range consumers,including students and office workers.The strategy involves the development of a new logo and packaging design,the selection of sports stars as brand ambassadors,and the implementation of innovative online sales promotions to bolster brand awareness and competitiveness.Research indicates that incorporating raw milk traceability and digital technology to establish a product brand with transparent ranches can significantly enhance AY Field’s competitive edge,facilitating the execution of a differentiated marketing strategy.展开更多
For a considerable duration,the traditional dairy product market in China has been dominated by a dual oligopoly,primarily led by Mengniu and Yili.Regional brands such as Guangming,Junlebao,and Sanyuan have engaged in...For a considerable duration,the traditional dairy product market in China has been dominated by a dual oligopoly,primarily led by Mengniu and Yili.Regional brands such as Guangming,Junlebao,and Sanyuan have engaged in staggered competition,contributing to a pattern of feudal separatism among local brands.AY Group,positioned as a significant independent player in the China dairy industry,has strategically extended its reach downstream in the supply chain,establishing the consumer brand AY Field.Despite possessing a robust advantage in self-owned ranches and delivering high-quality products,AY Field grapples with challenges related to unclear market positioning and low brand awareness among final consumers.This study employs a SWOT analysis to delve into identifying a market positioning strategy that best suits the AY Field brand.The research reveals that the current dynamics of competition in the dairy industry market are predominantly concentrated in the high-end and low-end segments,leaving a noticeable gap in the middle market.Leveraging the natural,high-quality,and competitively priced attributes of AY Field milk,the recommended market position involves supplying ambient liquid milk that aligns with the consumption habits of young individuals and office workers.This strategic positioning aims to offer high-quality products at moderate prices,addressing the specific needs of the identified consumer demographic.展开更多
In the context of the internationalization of higher education,many non-English speaking countries,from Europe to Asia,are promoting English as a medium of instruction(EMI).The EMI in South Korea started earlier and d...In the context of the internationalization of higher education,many non-English speaking countries,from Europe to Asia,are promoting English as a medium of instruction(EMI).The EMI in South Korea started earlier and developed rapidly under the promotion.From the initial“Study Abroad in Korea Plan”to the World Class University(WCU)and Brain Korea 21st century(BK21)PLUS programs,with the support and guidance of the government,South Korea’s higher education has made significant progress,with the global top 100 universities in QS increasing from 1 to 6 in South Korea.展开更多
The teaching abilities of bilingual teachers have emerged as one of the major bottlenecks hindering the further development of Chinese-foreign cooperative education projects.Implementing the JiTT(Just-in-Time Teaching...The teaching abilities of bilingual teachers have emerged as one of the major bottlenecks hindering the further development of Chinese-foreign cooperative education projects.Implementing the JiTT(Just-in-Time Teaching)model in bilingual courses of Chinese-foreign cooperative education can effectively integrate information technology with traditional classroom teaching.This integration enhances teaching quality and effectiveness,encourages university instructors to improve their diverse and collective capabilities,promotes digital development,and contributes to the enhancement of students’learning abilities and overall improvement.展开更多
We report the femtosecond time-resolved studies of room temperature exciton recombination and ultrafast stimulated emission dynamics in ZnO microcrystallite thin films.A free exciton photoluminescence lifetime of a fe...We report the femtosecond time-resolved studies of room temperature exciton recombination and ultrafast stimulated emission dynamics in ZnO microcrystallite thin films.A free exciton photoluminescence lifetime of a few tens of picoseconds and a decay time of a few picoseconds for the stimulated emission were observed.The relatively slow rise time(3ps)for the P band as the result of exciton-exciton scattering compared with the 0.8ps rise time for the N band attributed to electron-hole plasma recombination clearly distinguished the two stimulated emission processes.展开更多
A better understanding of previous accidents is an effective way to reduce the occurrence of similar accidents in the future. In this paper, a complex network approach is adopted to construct a directed weighted hazar...A better understanding of previous accidents is an effective way to reduce the occurrence of similar accidents in the future. In this paper, a complex network approach is adopted to construct a directed weighted hazard network(DWHN) to analyze topological features and evolution of accidents in the subway construction. The nodes are hazards and accidents, the edges are multiple relationships of these nodes and the weight of edges are occurrence times of repetitive relationships. The results indicate that the DWHN possesses the property of small-world with small average path length and large clustering coefficient, indicating that hazards have better connectivity and will spread widely and quickly in the network. Moreover,the DWHN has the property of scale-free network for the cumulative degree distribution follows a power-law distribution.It makes DWHN more vulnerable to target attacks. Controlling key nodes with higher degree, strength and betweenness centrality will destroy the connectivity of DWHN and mitigate the spreading of accidents in the network. This study is helpful for discovering inner relationships and evolutionary features of hazards and accidents in the subway construction.展开更多
基金Supported by Science&Technology Department of Sichuan Province(No.2021YFS0214).
文摘Glaucoma is a common and complex neurodegenerative disease characterized by progressive loss of retinal ganglion cells(RGCs)and axons.Currently,there is no effective method to address the cause of RGCs degeneration.However,studies on neuroprotective strategies for optic neuropathy have increased in recent years.Cell replacement and neuroprotection are major strategies for treating glaucoma and optic neuropathy.Regenerative medicine research into the repair of optic nerve damage using stem cells has Received considerable attention.Stem cells possess the potential for multidirectional differentiation abilities and are capable of producing RGCfriendly microenvironments through paracrine effects.This article reviews a thorough researches of recent advances and approaches in stem cell repair of optic nerve injury,raising the controversies and unresolved issues surrounding the future of stem cells.
基金supported by the National Natural Science Foundation of China(Grant No.:81973388)Marine Economy Development Project of Guangdong Province(Project No.:GDNRC[2021]52)the Key Research and Development Program of Guangdong Province(Program No.:2020B1111030005).
文摘Hepatosteatosis is characterized by abnormal accumulation of triglycerides(TG),leading to prolonged and chronic inflammatory infiltration.To date,there is still a lack of effective and economical therapies for hepatosteatosis.Oridonin(ORI)is a major bioactive component extracted from the traditional Chinese medicinal herb Rabdosia rubescens.In this paper,we showed that ORI exerted significant protective effects against hepatic steatosis,inflammation and fibrosis,which was dependent on LXRa signaling.It is reported that LXRa regulated lipid homeostasis between triglyceride(TG)and phosphatidylethanolamine(PE)by promoting ATGL and EPT1 expression.Therefore,we implemented the lipidomic strategy and luciferase reporter assay to verify that ORI contributed to the homeostasis of lipids via the regulation of the ATGL gene associated with TG hydrolysis and the EPT1 gene related to PE synthesis in a LXRadependent manner,and the results showed the TG reduction and PE elevation.In detail,hepatic TG overload and lipotoxicity were reversed after ORI treatment by modulating the ATGL and EPT1 genes,respectively.Taken together,the data provide mechanistic insights to explain the bioactivity of ORI in attenuating TG accumulation and cytotoxicity and introduce exciting opportunities for developing novel natural activators of the LXRa-ATGL/EPT1 axis for pharmacologically treating hepatosteatosis and metabolic disorders.
基金The 2023 Provincial College Student Innovation and Entrepreneurship Training Program Project“Direct Supply of Raw Milk Traceability Industry Chain-A Milk System Platform for School Enterprise Interconnection”(Project number:S202310424306)。
文摘Mengniu and Yili have virtually monopolized the traditional Chinese dairy market,while new media marketing and digital strategies have opened up substantial business opportunities for emerging brands.Leveraging a differentiation strategy,the Adopt A Cow brand has successfully carved out its niche in the market,serving as an exemplary example.However,AY Field,as a self-owned brand by a supplier,faces the challenge of low product awareness among end consumers.This paper primarily concentrates on brand planning for the AY Field milk brand,with a focus on positioning the product for mid-range consumers,including students and office workers.The strategy involves the development of a new logo and packaging design,the selection of sports stars as brand ambassadors,and the implementation of innovative online sales promotions to bolster brand awareness and competitiveness.Research indicates that incorporating raw milk traceability and digital technology to establish a product brand with transparent ranches can significantly enhance AY Field’s competitive edge,facilitating the execution of a differentiated marketing strategy.
基金The 2023 Provincial College Student Innovation and Entrepreneurship Training Program Project“Direct Supply of Raw Milk Traceability Industry Chain-A Milk System Platform for School Enterprise Interconnection”(Project number:S202310424306)。
文摘For a considerable duration,the traditional dairy product market in China has been dominated by a dual oligopoly,primarily led by Mengniu and Yili.Regional brands such as Guangming,Junlebao,and Sanyuan have engaged in staggered competition,contributing to a pattern of feudal separatism among local brands.AY Group,positioned as a significant independent player in the China dairy industry,has strategically extended its reach downstream in the supply chain,establishing the consumer brand AY Field.Despite possessing a robust advantage in self-owned ranches and delivering high-quality products,AY Field grapples with challenges related to unclear market positioning and low brand awareness among final consumers.This study employs a SWOT analysis to delve into identifying a market positioning strategy that best suits the AY Field brand.The research reveals that the current dynamics of competition in the dairy industry market are predominantly concentrated in the high-end and low-end segments,leaving a noticeable gap in the middle market.Leveraging the natural,high-quality,and competitively priced attributes of AY Field milk,the recommended market position involves supplying ambient liquid milk that aligns with the consumption habits of young individuals and office workers.This strategic positioning aims to offer high-quality products at moderate prices,addressing the specific needs of the identified consumer demographic.
基金Shandong University of Science and Technology Education and Teaching Reform Research and Practice Project“Research on Mixed Mode of Online Course+English Medium Instruction”(JNJG202101)。
文摘In the context of the internationalization of higher education,many non-English speaking countries,from Europe to Asia,are promoting English as a medium of instruction(EMI).The EMI in South Korea started earlier and developed rapidly under the promotion.From the initial“Study Abroad in Korea Plan”to the World Class University(WCU)and Brain Korea 21st century(BK21)PLUS programs,with the support and guidance of the government,South Korea’s higher education has made significant progress,with the global top 100 universities in QS increasing from 1 to 6 in South Korea.
基金This study was supported by Shandong University of Science and Technology Education and Teaching Reform Research and Practice Project“Research on the Blended Teaching Model of Online Courses&All-English Teaching”(JNJG202101).
文摘The teaching abilities of bilingual teachers have emerged as one of the major bottlenecks hindering the further development of Chinese-foreign cooperative education projects.Implementing the JiTT(Just-in-Time Teaching)model in bilingual courses of Chinese-foreign cooperative education can effectively integrate information technology with traditional classroom teaching.This integration enhances teaching quality and effectiveness,encourages university instructors to improve their diverse and collective capabilities,promotes digital development,and contributes to the enhancement of students’learning abilities and overall improvement.
基金Supported by the National Natural Science Foundation of China under Grant No.69608002the Excellent Young Teacher's Foundation of the Minis try of Education.
文摘We report the femtosecond time-resolved studies of room temperature exciton recombination and ultrafast stimulated emission dynamics in ZnO microcrystallite thin films.A free exciton photoluminescence lifetime of a few tens of picoseconds and a decay time of a few picoseconds for the stimulated emission were observed.The relatively slow rise time(3ps)for the P band as the result of exciton-exciton scattering compared with the 0.8ps rise time for the N band attributed to electron-hole plasma recombination clearly distinguished the two stimulated emission processes.
基金supported by the Co-Funding of National Natural Science Foundation of China and Shenhua Group Corporation Ltd(Grant No.U1261212)the Program of Major Achievements Transformation and Industrialization of Beijing Education Commission,China(Grant No.ZDZH20141141301)
文摘A better understanding of previous accidents is an effective way to reduce the occurrence of similar accidents in the future. In this paper, a complex network approach is adopted to construct a directed weighted hazard network(DWHN) to analyze topological features and evolution of accidents in the subway construction. The nodes are hazards and accidents, the edges are multiple relationships of these nodes and the weight of edges are occurrence times of repetitive relationships. The results indicate that the DWHN possesses the property of small-world with small average path length and large clustering coefficient, indicating that hazards have better connectivity and will spread widely and quickly in the network. Moreover,the DWHN has the property of scale-free network for the cumulative degree distribution follows a power-law distribution.It makes DWHN more vulnerable to target attacks. Controlling key nodes with higher degree, strength and betweenness centrality will destroy the connectivity of DWHN and mitigate the spreading of accidents in the network. This study is helpful for discovering inner relationships and evolutionary features of hazards and accidents in the subway construction.
