Addressing the issue of the healthy and coordinated development of the population and economic factors in rural areas will not only help consolidate and expand the achievements of poverty alleviation,but will also lay...Addressing the issue of the healthy and coordinated development of the population and economic factors in rural areas will not only help consolidate and expand the achievements of poverty alleviation,but will also lay a foundation for comprehensive rural revitalization.In this paper,the spatial coupling relationship between the population and economic factors in rural areas in the QinlingDaba Mountains,China,is explored to provide a reference for rural revitalization and regional sustainable development in poverty areas.Sixty-eight county units in rural areas in the Qinling-Daba Mountains,as well as the population and economic factors in rural areas,are used to study the spatial coupling relationship between population and economy,as well as the driving mechanism,in rural areas in the Qinling-Daba Mountains from 2010 to 2020.The results show that a population contraction phenomenon occurred in the rural areas in the Qinling-Daba Mountains,and the spatial agglomeration trends of the population and economic factors were consistent.The agglomeration was mainly located in the suburban areas of the municipal area,and the agglomeration degree was significantly higher in these areas than in other areas.In terms of the spatial distribution,the economic development level of the rural areas in the northeastern part of the Qinling-Daba Mountains was generally higher than that in the central and western parts,and the unbalanced trends of the population and economic spatial differentiation in the eastern and western regions were significant.The spatial coupling relationship between the population and economy changed from coordinated development to economic advancement.This was mainly due to the mutual restriction and joint actions of the industrial structure,capital situation,natural environment,policies,and institutional regulations,among which the industrial structure and capital status had significant effects.展开更多
目的探讨持续高血压状态自发性高血压大鼠(spontaneously hypertensive rats,SHR)血清代谢物改变及可能相关的机制。方法随机各取6只雄性SHR和魏-凯二氏大鼠(Wistar-Kyoto rats,WKY)大鼠分别设为模型和对照组,标准饲养120 d,每周使用BP2...目的探讨持续高血压状态自发性高血压大鼠(spontaneously hypertensive rats,SHR)血清代谢物改变及可能相关的机制。方法随机各取6只雄性SHR和魏-凯二氏大鼠(Wistar-Kyoto rats,WKY)大鼠分别设为模型和对照组,标准饲养120 d,每周使用BP2000检测收缩压(systolic blood pressure,SBP)。取材后对其心肌组织行HE和Masson染色;采用超高效液相色谱质谱联用(ultra-high performance liquid mass spectrometry and tandem mass spectrometry,UPLC-MS)法检测血清差异性代谢物,并进一步对其进行GO与KEGG富集分析。结果模型组SBP呈逐步升高,约于20周龄达高峰后又趋于稳定,且在各时间点均明显高于对照组(P<0.001);伊红-苏木素(hematoxylin-eosin,HE)染色心肌组织排列紊乱,血管壁增厚,管腔缩小,肌间和管腔周围均出现均质粉染物质;Masson染色心肌组织可见大量胶原纤维沉积。血清代谢模式和个体差异代谢物两组间呈现明显分离趋势,共鉴定出44个潜在标志性代谢物,主要涉及神经活性受体配体相互作用、5-羟色胺(5-hydroxytryptamine,5-HT)突触传导通路、花生四烯酸(arachidonic acid,AA)代谢等代谢途径。结论持续高血压状态SHR存在明显的心肌和血管周围纤维化,其代谢模式明显偏离正常大鼠,血清标志性差异代谢物主要与调节交感神经活性与血管舒缩及抑炎有关。展开更多
基金Under the auspices of National Natural Science Foundation of China(No.42071220,42371223)China Postdoctoral Science Foundation(No.2021M701053)Postgraduate Cultivating Innovation and Quality Improvement Action Plan of Henan University(No.SYLYC2022017)。
文摘Addressing the issue of the healthy and coordinated development of the population and economic factors in rural areas will not only help consolidate and expand the achievements of poverty alleviation,but will also lay a foundation for comprehensive rural revitalization.In this paper,the spatial coupling relationship between the population and economic factors in rural areas in the QinlingDaba Mountains,China,is explored to provide a reference for rural revitalization and regional sustainable development in poverty areas.Sixty-eight county units in rural areas in the Qinling-Daba Mountains,as well as the population and economic factors in rural areas,are used to study the spatial coupling relationship between population and economy,as well as the driving mechanism,in rural areas in the Qinling-Daba Mountains from 2010 to 2020.The results show that a population contraction phenomenon occurred in the rural areas in the Qinling-Daba Mountains,and the spatial agglomeration trends of the population and economic factors were consistent.The agglomeration was mainly located in the suburban areas of the municipal area,and the agglomeration degree was significantly higher in these areas than in other areas.In terms of the spatial distribution,the economic development level of the rural areas in the northeastern part of the Qinling-Daba Mountains was generally higher than that in the central and western parts,and the unbalanced trends of the population and economic spatial differentiation in the eastern and western regions were significant.The spatial coupling relationship between the population and economy changed from coordinated development to economic advancement.This was mainly due to the mutual restriction and joint actions of the industrial structure,capital situation,natural environment,policies,and institutional regulations,among which the industrial structure and capital status had significant effects.
文摘目的探讨持续高血压状态自发性高血压大鼠(spontaneously hypertensive rats,SHR)血清代谢物改变及可能相关的机制。方法随机各取6只雄性SHR和魏-凯二氏大鼠(Wistar-Kyoto rats,WKY)大鼠分别设为模型和对照组,标准饲养120 d,每周使用BP2000检测收缩压(systolic blood pressure,SBP)。取材后对其心肌组织行HE和Masson染色;采用超高效液相色谱质谱联用(ultra-high performance liquid mass spectrometry and tandem mass spectrometry,UPLC-MS)法检测血清差异性代谢物,并进一步对其进行GO与KEGG富集分析。结果模型组SBP呈逐步升高,约于20周龄达高峰后又趋于稳定,且在各时间点均明显高于对照组(P<0.001);伊红-苏木素(hematoxylin-eosin,HE)染色心肌组织排列紊乱,血管壁增厚,管腔缩小,肌间和管腔周围均出现均质粉染物质;Masson染色心肌组织可见大量胶原纤维沉积。血清代谢模式和个体差异代谢物两组间呈现明显分离趋势,共鉴定出44个潜在标志性代谢物,主要涉及神经活性受体配体相互作用、5-羟色胺(5-hydroxytryptamine,5-HT)突触传导通路、花生四烯酸(arachidonic acid,AA)代谢等代谢途径。结论持续高血压状态SHR存在明显的心肌和血管周围纤维化,其代谢模式明显偏离正常大鼠,血清标志性差异代谢物主要与调节交感神经活性与血管舒缩及抑炎有关。
