期刊文献+
共找到2篇文章
< 1 >
每页显示 20 50 100
人乳寡糖对大鼠结直肠组织放射性肠损伤保护作用研究 被引量:1
1
作者 艾默 杨宏 +1 位作者 曲冬颖 姚爱林 《创伤与急危重病医学》 2022年第4期281-286,共6页
目的 探讨人乳寡糖(HMOs)预处理对大鼠结直肠组织放射性损伤的保护作用。方法 选取30只健康SD大鼠,随机分为空白对照组、放射(IR)组、IR+HMOs组。IR组及IR+HMOs组予10 Gy的60Co γ射线一次性全腹照射,HMOs组照射前3 d口饲HMOs(10 mg/kg... 目的 探讨人乳寡糖(HMOs)预处理对大鼠结直肠组织放射性损伤的保护作用。方法 选取30只健康SD大鼠,随机分为空白对照组、放射(IR)组、IR+HMOs组。IR组及IR+HMOs组予10 Gy的60Co γ射线一次性全腹照射,HMOs组照射前3 d口饲HMOs(10 mg/kg)。大鼠接受辐射后第7日经心脏采血后处死并留取结直肠标本。苏木精伊红染色观察肠绒毛长度及肠隐窝数量并对其进行计数;采用免疫组织化学染色方法检测组织中肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)等炎性因子;采用蛋白免疫印迹法检测肠细胞中细胞紧密连接蛋白Occludin、Claudin-1以及细胞骨架蛋白Zo-1水平;生物化学法检测丙二醛(MDA)、超氧化物歧化酶(SOD)以及还原型谷胱甘肽(GSH)水平。结果 与仅接受放射治疗的大鼠比较,HMOs预防治疗大鼠绒毛长度缩短程度降低,肠隐窝数目损伤较小,差异有统计学意义(P<0.05)。IR+HMOs组大鼠肠组织中TNF-α、IL-6水平明显低于IR组,差异有统计学意义(P<0.05)。IR组大鼠肠上皮细胞中Occludin、 Claudin-1以及Zo-1水平较空白对照组均明显减少(P<0.05),IR+HMOs组Occludin、 Claudin-1以及Zo-1蛋白水平较IR组均有较明显升高(P<0.05)。IR组与空白对照组相比较,MDA水平明显增高(P<0.05),SOD及GSH水平明显下降(P<0.05),IR+HMOs组与IR组相比较,MDA水平明显下降(P<0.05),SOD及GSH明显增高(P<0.05)。结论 HMOs预处理可通过抑制炎症反应及氧化应激反应减轻大鼠放射性结直肠损伤。 展开更多
关键词 放射性肠损伤 人乳寡糖 炎症反应 氧化应激
下载PDF
Surgical high ligation of the ovarian vein and preservation of ovarian function for twisted ovarian tumors 被引量:6
2
作者 LI Ju YU Yue-xin +2 位作者 SUN Chun-yan XUE Dan qu dong-ying 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第20期3744-3746,共3页
Background Appendectomy is the traditional surgica pulmonary embolism, ovarian necrosis, and secondary Methods We performed surgery for adnexal torsion removal of the ovarian tumor. procedure for correcting torsion of... Background Appendectomy is the traditional surgica pulmonary embolism, ovarian necrosis, and secondary Methods We performed surgery for adnexal torsion removal of the ovarian tumor. procedure for correcting torsion of the adnexa. Although it prevents nfection, it can have critical adverse effects on the ovarian function. in 12 patients, using high ligation of the ovarian vein, followed by Results Blood flow in the residual ovary gradually returned to normal within 1-3 months, and a dominant follicle could be seen in the residual ovary within 2-6 months post-surgery in all the 12 cases. Menstruation recovered in these three cases within 2-3 months. Postoperative intrauterine pregnancies occurred in two cases, with a corpus luteum graviditatis in the residual ovary in one case, while the other patient underwent labor after 13 months and a normal ovary on the affected side was seen at cesarean section. Conclusions This new surgical technique involving high ligation of the ovarian vein for adnexal torsion allowed successful preservation of the residual ovary and ovarian blood distribution, and can thus be used for the treatment of primary diseases of the ovary. The surgical procedure is simple, safe, and effective, and warrants extensive application inclinical practice. 展开更多
关键词 adnexal torsion LIGATION ovarian vein new surgical technique
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部