Phenyl-C_(61)-butyric acid methyl ester(PCBM) serves as a common electron transport layer(ETL) in inverted p-i-n structure perovskite solar cells(IPSCs),yet energy barriers and insufficient passivation at the PCBM-per...Phenyl-C_(61)-butyric acid methyl ester(PCBM) serves as a common electron transport layer(ETL) in inverted p-i-n structure perovskite solar cells(IPSCs),yet energy barriers and insufficient passivation at the PCBM-perovskite interface hinder device effectiveness and durability.In this study,we present a series of novel Fullerene Phenylacid Ester Derivatives(FPEDs:FPP,FTPP,FDPP) incorporated into PCBM.Our investigations illustrate that FPEDs effectively act to passivate the perovskite surface by forming robust interactions with uncoordinated Pb^(2+) ions via the phosphine oxide groups present in their molecular structures,thereby enhancing the stability of the devices.Moreover,these additives elevate the energy level of the lowest unoccupied molecular orbital(LUMO) of ETL,diminish the electron injection barrier,and enhance the efficiency of interlayer electron transport.Incorporating FPEDs enhances ETL coverage on the perovskite layer,reducing leakage current significantly.Notably,Devices with PCBM/FTPP achieved a peak PCE of 23.62% and showed superior stability,maintaining 96,8% of the initial PCE after 500 h,while control devices retained merely 80.7% over the same period.展开更多
Background Hesperidin is a citrus flavonoid with anti-inflammatory and antioxidant potential. However, its protective effects on bovine mammary epithelial cells(b MECs) exposed to oxidative stress have not been elucid...Background Hesperidin is a citrus flavonoid with anti-inflammatory and antioxidant potential. However, its protective effects on bovine mammary epithelial cells(b MECs) exposed to oxidative stress have not been elucidated.Results In this study, we investigated the effects of hesperidin on H_(2)O_(2)-induced oxidative stress in b MECs and the underlying molecular mechanism. We found that hesperidin attenuated H_(2)O_(2)-induced cell damage by reducing reactive oxygen species(ROS) and malondialdehyde(MDA) levels, increasing catalase(CAT) activity, and improving cell proliferation and mitochondrial membrane potential. Moreover, hesperidin activated the Keap1/Nrf2/ARE signaling pathway by inducing the nuclear translocation of Nrf2 and the expression of its downstream genes NQO1 and HO-1, which are antioxidant enzymes involved in ROS scavenging and cellular redox balance. The protective effects of hesperidin were blocked by the Nrf2 inhibitor ML385, indicating that they were Nrf2 dependent.Conclusions Our results suggest that hesperidin could protect b MECs from oxidative stress injury by activating the Nrf2 signaling pathway, suggesting that hesperidin as a natural antioxidant has positive potential as a feed additive or plant drug to promote the health benefits of bovine mammary.展开更多
The interfacial interaction between HMX molecules and coating materials is the key to the safety performance of explosives and has received extensive attention.However,screening suitable coating agents to enhance the ...The interfacial interaction between HMX molecules and coating materials is the key to the safety performance of explosives and has received extensive attention.However,screening suitable coating agents to enhance the interfacial effect to obtain high-energy and low-sensitivity explosives has long been a major challenge.In this work,HMX-PEI/rGO/g-C_(3)N_(4)(HPrGC)composites were innovatively prepared by a multi-level coating strategy of two-dimensional graphite rGO and g-C_(3)N_(4).The g-C_(3)N_(4) used for desensitization has a richπ-conjugated system and shows outstanding ability in reducing friction sensitivity.The hierarchical structure of HPrGC formed by electrostatic self-assembly andπ-πstacking can effectively dissipate energy accumulation under heat and mechanical stimulation through structural evolution,thus exhibiting a prominent synergistic desensitization effect on HMX.The results show that rGO/gC_(3)N_(4) coating has no effect on the crystal structure and chemical structure of HMX.More importantly,the perfect combination of g-C_(3)N_(4) and rGO endows HPrGC with enhanced thermal stability and ideal mechanical sensitivity(IS:21 J,FS:216 N).Obviously,the new fabrication of HPrGC enriches the variety of desensitizer materials and helps to deepen the understanding of the interaction between explosives and coatings.展开更多
In this study, the mechanisms of the anode phenomena and anode erosion with various contact materials were investigated. Arc parameters were calculated, and the anode temperature was predicted with a transient self-co...In this study, the mechanisms of the anode phenomena and anode erosion with various contact materials were investigated. Arc parameters were calculated, and the anode temperature was predicted with a transient self-consistent model. The simulation results predicted a constricted arc column and obvious anode phenomena in Cu–Cr alloy contacts than in W–Cu alloy contacts.This observation could be the reason for the concentrated anode erosion in Cu–Cr alloys. For the contacts made by pure tungsten(W) and W–Cu alloy, the anode temperature increased rapidly because of the low specific heat of W. However, the maximum energy flux from the arc column to the anode surface was lower than in other cases. The simulation results were compared with experimental results.展开更多
Objective:Our goal was to examine the impact of Zhuangshen Gujing decoction on proteinuria associated with chronic nephritis.Methods:72 patients with chronic nephritis proteinuria were divided randomly into two groups...Objective:Our goal was to examine the impact of Zhuangshen Gujing decoction on proteinuria associated with chronic nephritis.Methods:72 patients with chronic nephritis proteinuria were divided randomly into two groups;one group was treated with Zhuangshen Gujing(n=36;treatment group)and the other group was treated with irbesartan(n=36;control group).After 6 months’treatment,urine protein and renal function were evaluated.Results:Proteinuria resolved completely in four patients in the treatment group;complete disease resolution was observed only among three individuals in the control group.Of the 32 cases remaining in the treatment group,15 had substantial responses to Zhuangshen Gujing decoction,9 had partial responses,and 8 had no response to treatment;the overall the response rate was 73.33%.Among the 33 cases remaining in the control group,12 had a substantial response to irbesartan,5 had a partial response,and 16 had no response to treatment;the overall response rate among the controls was 57.67%(P=0.031).We also observed statistically significant differences with respect to quantitative comparisons of urinary protein at 24 days after a single course of treatment(P=0.001).Conclusion:Zhuangshen Gujing decoction is effective in treating chronic nephritis proteinuria.展开更多
With the rapid development of wind power, wind turbines are accompanied by a large quantity of power electronic converters connected to the grid, causing changes in the characteristics of the power system and leading ...With the rapid development of wind power, wind turbines are accompanied by a large quantity of power electronic converters connected to the grid, causing changes in the characteristics of the power system and leading to increasingly serious sub-synchronous oscillation (SSO) problems, which urgently require the generalized classification and characterization of the emerging oscillation problems. This paper classifies and characterizes the emerging types of SSO caused by grid-connected wind turbines to address these issues. Finally, the impact of the typical system parameters changes on the oscillation pattern is analyzed in depth to provide effective support for the subsequent suppression and prevention of SSO.展开更多
L1 is one of the largest offshore gas fields currently under development.In order to optimize the related design,nodal analysis is applied(including proper consideration of the plant productivity,sensitivity to the tu...L1 is one of the largest offshore gas fields currently under development.In order to optimize the related design,nodal analysis is applied(including proper consideration of the plant productivity,sensitivity to the tubing size,erosion effects,liquid carrying performance,and tubing string).As a result of such approach,it is shown that 13Cr material should be chosen as the appropriate tubing material.Moreover,3-1/2 inches 9.3 lb/ft N80 tubing,4-1/2 inches 12.75 lb/ft N80 tubing,5-1/2 inches 17 lb/ft N80 tubing should be used for a gas production rate under 80×10^(4)m^(3)/d,between 80×10^(4)m^(3)/d and 120×10^(4)m^(3)/d and above 120×10^(4)m^(3)/d,respectively.展开更多
Stomach adenocarcinoma (STAD) is the fifth most prevalent cancer and the third leading cause of cancer-related death in the world and is more common in Asia than in most Western countries. There is an urgent need to i...Stomach adenocarcinoma (STAD) is the fifth most prevalent cancer and the third leading cause of cancer-related death in the world and is more common in Asia than in most Western countries. There is an urgent need to identify potential novel oncogenes and tumor suppressor genes, and biomarkers for STAD. 6652 differentially expressed genes were identified between STAD and normal samples based on the transcriptome data analysis of the TCGA and GEO databases. 13 key modules were identified in STAD by WGCNA analysis. 293 potential STAD associated genes were identified from intersection by Venn Diagram. The 293 intersected genes were enriched in cell cortex and infection by GO and KEGG analysis. 10 hub genes were identified from PPI and Cytoscape analyses of the intersected genes. KLF4/CGN low and SHH/LIF high expression were associated with short overall survival of Asian STAD patients. Bioinformatics analysis revealed potential novel tumor suppressors (KLF4/CGN), oncogenes (SHH/LIF) and biomarkers for diagnosis, therapy and prognosis of STAD, specifically for Asian patients.展开更多
Oncolytic virus (OV) is a kind of virus that can preferentially infect and kill tumor cells. The second oncolytic virus drug was oncolytic herpes simplex virus (oHSV) Talimogene Laherparepvec (T-VEC). HSV-1 infectious...Oncolytic virus (OV) is a kind of virus that can preferentially infect and kill tumor cells. The second oncolytic virus drug was oncolytic herpes simplex virus (oHSV) Talimogene Laherparepvec (T-VEC). HSV-1 infectious cell culture protein 34.5 (ICP34.5) and latency-associated transcript (LAT) genes are closely related to virus selective infection and latent infection. Their engineering is essential for constructing efficient and safe oHSV. We summarized the mechanisms of ICP34.5 and LAT in the course of HSV-1 infection and reviewed the engineered oHSVs. We are aimed to provide an insight in developing oHSV in the future.展开更多
Acupuncture has reportedly improved memory and cognitive impairment in both animal and clinical studies. It may be an effective treatment for Alzheimer's disease (AD). The purpose of this meta-analysis was to revi...Acupuncture has reportedly improved memory and cognitive impairment in both animal and clinical studies. It may be an effective treatment for Alzheimer's disease (AD). The purpose of this meta-analysis was to review the effectiveness of acupuncture for the treatment of AD. Eight databases were searched for articles published up to and including July 2017, and 13 studies fulfilling the inclusion criteria were identified. The main outcomes assessed were clinical efficacy rate, Mini-Mental State Examination score, Ability of Daily Living Scale score, Alzheimer's Disease Assessment Scale-Cognition score, Hasegawa's Dementia Scale (HDS) score, and adverse events. The methodological quality of the articles was assessed using Cochrane's risk of bias. All the studies compared the efficacy of acupuncture with that of medication, and were published in Chinese journals. Meta-analysis revealed that acupuncture yielded positive results as determined via all the indexes scored except the HDS (95% CI -0.26 to 0.90, Z=0.35, P=0.73). Only one of the studies reported adverse events associated with acupuncture and medication. The rate of adverse events in the medication group was 13%. In most of the studies assessed in the current metaanalysis, acupuncture alone was better than conventional western medicines for the treatment of AD.展开更多
One-dimensional blast response of continuous-density graded cellular rods was investigated theoretically and numerically. Analytical model based on the rigid-plastic hardening(R-PH) model was used to predict the blast...One-dimensional blast response of continuous-density graded cellular rods was investigated theoretically and numerically. Analytical model based on the rigid-plastic hardening(R-PH) model was used to predict the blast response of density-graded cellular rods. Finite element(FE) analysis was performed using a new model based on the 3 D Voronoi technique. The FE results have a good agreement with the analytical predictions. The blast response and energy absorption of cellular rods with the same mass but different density distributions were examined under different blast loading. As a blast resistance structure, cellular materials with high energy absorption and low impulse transmit is attractive. However, high energy absorption and low impulse transmit cannot be achieved at the same time by changing the density distribution. The energy absorption capacity increases with the initial blast pressure and characteristic time of the exponentially decaying blast loading. By contract, when the blast loading exceeds the resistance capacity of cellular material, the transmitted stress will be enhanced which is detrimental to the structure being protected.展开更多
Zr was added to Ti−Nb−Fe alloys to develop low elastic modulus and high strengthβ-Ti alloys for biomedical applications.Ingots of Ti−12Nb−2Fe−(2,4,6,8,10)Zr(at.%)were prepared by arc melting and then subjected to hom...Zr was added to Ti−Nb−Fe alloys to develop low elastic modulus and high strengthβ-Ti alloys for biomedical applications.Ingots of Ti−12Nb−2Fe−(2,4,6,8,10)Zr(at.%)were prepared by arc melting and then subjected to homogenization,cold rolling,and solution treatments.The phases and microstructures of the alloys were analyzed by optical microscopy,X-ray diffraction,and transmission electron microscopy.The mechanical properties were measured by tensile tests.The results indicate that Zr and Fe cause a remarkable solid-solution strengthening effect on the alloys;thus,all the alloys show yield and ultimate tensile strengths higher than 510 MPa and 730 MPa,respectively.Zr plays a weak role in the deformation mechanism.Further,twinning occurs in all the deformed alloys and is beneficial to both strength and plasticity.Ti−12Nb−2Fe−(8,10)Zr alloys with metastableβphases show low elastic modulus,high tensile strength,and good plasticity and are suitable candidate materials for biomedical implants.展开更多
A new design route was presented to fabricate cobalt aluminum-layered double hydroxide(CoAl-LDH)thin layers whichgrow on carbon spheres(CSs)through a growth method.The CoAl-LDH thin layers consist of nanoflakes with a...A new design route was presented to fabricate cobalt aluminum-layered double hydroxide(CoAl-LDH)thin layers whichgrow on carbon spheres(CSs)through a growth method.The CoAl-LDH thin layers consist of nanoflakes with a thickness of20nm.The galvanostatic charge-discharge test of the CoAl-LDH/CSs composite shows a great specific capacitance of1198F/g at1A/g(based on the mass of the CoAl-LDH/CSs composite)in6mol/L KOH solution,and the composite displays an impressive specificcapacitance of920F/g even at a high current density of10A/g.Moreover,the composite remains a specific capacitance of928F/gafter1000cycles at2A/g,and the specific capacitance retention is84%,indicating that the composite has high specific capacitance,excellent rate capability and good cycling stability in comparison to pristine CoAl-LDH.展开更多
The increasing threat of explosions on the battle field and the terrorist action requires the development of more effective blast resistance materials and structures.Curved structure can support the external loads eff...The increasing threat of explosions on the battle field and the terrorist action requires the development of more effective blast resistance materials and structures.Curved structure can support the external loads effectively by virtue of their spatial curvature.In review of the excellent energy absorption property of auxetic structure,employing auxetic structure as core material in curved sandwich shows the potential to improve the protection performance.In this study,a novel cylindrical sandwich panel with double arrow auxetic(DAA) core was designed and the numerical model was built by ABAQUS.Due to the complexity of the structure,systematic parameter study and optimal design are conducted.Two cases of optimal design were considered,case1 focuses on reducing the deflection and mass of the structure,while case2 focuses on reducing the deflection and increasing the energy absorption per unit mass.Parameter study and optimal design were conducted based on Latin Hypercube Sampling(LHD)method,artificial neural networks(ANN) metamodel and the nondominated sorting genetic algorithm(NSGA-Ⅱ).The Pareto front was obtained and the cylindrical DAA structure performed much better than its equal solid panel in both blast resistance and energy absorption capacity.Optimization results can be used as a reference for different applications.展开更多
基金funded by Key R&D projects of Chongqing Municipal Bureau of Science and Technology(No.CSTC2021jscxgksb-N0021)2022 Postgraduate intelligent medicine Special research and development plan of Chongqing Medical University(No.YJSZHYX202206).
文摘目的随着老龄化社会进程加速,老年人躯体衰弱和肌少症的患病率逐年上升,并带来诸多不良影响。膳食营养是防治躯体衰弱和肌少症的重要方式,但在社区环境中实施膳食营养干预受到诸多复杂因素影响。本综述旨在对相关研究中的促进和障碍因素进行系统综述,为制订相关健康管理方案提供参考。方法在Pub Med. .Web of Science 、Medline(Ovid). Embase(Ovid)和Cochrane Library 数据库进行检索,发表时间限定为建库至2023年1月。使用主题词和自由词组合完成检索。使用英国牛津大学循证医学中心质性研究质量评价工具(the Critical Appraisal Skills Program Qualiative Sudies Checklist)对 纳入研究进行质量评价。利用社会生态建模框架对提取的信息进行编码和分析。本综述方案已在PROSPERO注册(CRD42022381339)。结果共纳入10项研究。其中,4项研究仅进行营养相关干预,而膳食营养和运动干预相结合的有6项。根据社会生态模型,从个体特征、外部环境和干预措施3个层面对促进和障碍因素进行了总结,包含10个副主题。结论对社区中的躯体衰弱和肌少症老年人实施膳食营养干预措施时,应整合个人内部动机和外部支持,为参与者制订“量身定制”的干预方案,并最大程度地优化可利用的人力和物理资源。
基金Natural Science Foundation of China (51972278)Outstanding Youth Science and Technology Talents Program of Sichuan (19JCQN0085)Open Project of State Key Laboratory of Environment-friendly Energy Materials (Southwest University of Science and Technology, 21fksy19)。
文摘Phenyl-C_(61)-butyric acid methyl ester(PCBM) serves as a common electron transport layer(ETL) in inverted p-i-n structure perovskite solar cells(IPSCs),yet energy barriers and insufficient passivation at the PCBM-perovskite interface hinder device effectiveness and durability.In this study,we present a series of novel Fullerene Phenylacid Ester Derivatives(FPEDs:FPP,FTPP,FDPP) incorporated into PCBM.Our investigations illustrate that FPEDs effectively act to passivate the perovskite surface by forming robust interactions with uncoordinated Pb^(2+) ions via the phosphine oxide groups present in their molecular structures,thereby enhancing the stability of the devices.Moreover,these additives elevate the energy level of the lowest unoccupied molecular orbital(LUMO) of ETL,diminish the electron injection barrier,and enhance the efficiency of interlayer electron transport.Incorporating FPEDs enhances ETL coverage on the perovskite layer,reducing leakage current significantly.Notably,Devices with PCBM/FTPP achieved a peak PCE of 23.62% and showed superior stability,maintaining 96,8% of the initial PCE after 500 h,while control devices retained merely 80.7% over the same period.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDA26040304)。
文摘Background Hesperidin is a citrus flavonoid with anti-inflammatory and antioxidant potential. However, its protective effects on bovine mammary epithelial cells(b MECs) exposed to oxidative stress have not been elucidated.Results In this study, we investigated the effects of hesperidin on H_(2)O_(2)-induced oxidative stress in b MECs and the underlying molecular mechanism. We found that hesperidin attenuated H_(2)O_(2)-induced cell damage by reducing reactive oxygen species(ROS) and malondialdehyde(MDA) levels, increasing catalase(CAT) activity, and improving cell proliferation and mitochondrial membrane potential. Moreover, hesperidin activated the Keap1/Nrf2/ARE signaling pathway by inducing the nuclear translocation of Nrf2 and the expression of its downstream genes NQO1 and HO-1, which are antioxidant enzymes involved in ROS scavenging and cellular redox balance. The protective effects of hesperidin were blocked by the Nrf2 inhibitor ML385, indicating that they were Nrf2 dependent.Conclusions Our results suggest that hesperidin could protect b MECs from oxidative stress injury by activating the Nrf2 signaling pathway, suggesting that hesperidin as a natural antioxidant has positive potential as a feed additive or plant drug to promote the health benefits of bovine mammary.
基金the financial support from the National Natural Science Foundation of China (Grant No.51972278)the Open Project of the State Key Laboratory of Environment-friendly Energy Materials (Southwest University of Science and Technology,Grant No.20fksy16)。
文摘The interfacial interaction between HMX molecules and coating materials is the key to the safety performance of explosives and has received extensive attention.However,screening suitable coating agents to enhance the interfacial effect to obtain high-energy and low-sensitivity explosives has long been a major challenge.In this work,HMX-PEI/rGO/g-C_(3)N_(4)(HPrGC)composites were innovatively prepared by a multi-level coating strategy of two-dimensional graphite rGO and g-C_(3)N_(4).The g-C_(3)N_(4) used for desensitization has a richπ-conjugated system and shows outstanding ability in reducing friction sensitivity.The hierarchical structure of HPrGC formed by electrostatic self-assembly andπ-πstacking can effectively dissipate energy accumulation under heat and mechanical stimulation through structural evolution,thus exhibiting a prominent synergistic desensitization effect on HMX.The results show that rGO/gC_(3)N_(4) coating has no effect on the crystal structure and chemical structure of HMX.More importantly,the perfect combination of g-C_(3)N_(4) and rGO endows HPrGC with enhanced thermal stability and ideal mechanical sensitivity(IS:21 J,FS:216 N).Obviously,the new fabrication of HPrGC enriches the variety of desensitizer materials and helps to deepen the understanding of the interaction between explosives and coatings.
基金supported by the Sichuan Science and Technology Program (No. 2024NSFSC0867)National Natural Science Foundation of China (No. 52377157)。
文摘In this study, the mechanisms of the anode phenomena and anode erosion with various contact materials were investigated. Arc parameters were calculated, and the anode temperature was predicted with a transient self-consistent model. The simulation results predicted a constricted arc column and obvious anode phenomena in Cu–Cr alloy contacts than in W–Cu alloy contacts.This observation could be the reason for the concentrated anode erosion in Cu–Cr alloys. For the contacts made by pure tungsten(W) and W–Cu alloy, the anode temperature increased rapidly because of the low specific heat of W. However, the maximum energy flux from the arc column to the anode surface was lower than in other cases. The simulation results were compared with experimental results.
文摘Objective:Our goal was to examine the impact of Zhuangshen Gujing decoction on proteinuria associated with chronic nephritis.Methods:72 patients with chronic nephritis proteinuria were divided randomly into two groups;one group was treated with Zhuangshen Gujing(n=36;treatment group)and the other group was treated with irbesartan(n=36;control group).After 6 months’treatment,urine protein and renal function were evaluated.Results:Proteinuria resolved completely in four patients in the treatment group;complete disease resolution was observed only among three individuals in the control group.Of the 32 cases remaining in the treatment group,15 had substantial responses to Zhuangshen Gujing decoction,9 had partial responses,and 8 had no response to treatment;the overall the response rate was 73.33%.Among the 33 cases remaining in the control group,12 had a substantial response to irbesartan,5 had a partial response,and 16 had no response to treatment;the overall response rate among the controls was 57.67%(P=0.031).We also observed statistically significant differences with respect to quantitative comparisons of urinary protein at 24 days after a single course of treatment(P=0.001).Conclusion:Zhuangshen Gujing decoction is effective in treating chronic nephritis proteinuria.
基金financially supported by the State Key Laboratory from Structural Chemistry, Chinese Academy of Sciences (20190008)the Basic Science and Technology Research Project of Wenzhou (G20190007, ZG2017027)financial support from BUCT-WZU Joint Fund
基金National Key Research and Development Program of China under Grant No.2017YFB0902002.
文摘With the rapid development of wind power, wind turbines are accompanied by a large quantity of power electronic converters connected to the grid, causing changes in the characteristics of the power system and leading to increasingly serious sub-synchronous oscillation (SSO) problems, which urgently require the generalized classification and characterization of the emerging oscillation problems. This paper classifies and characterizes the emerging types of SSO caused by grid-connected wind turbines to address these issues. Finally, the impact of the typical system parameters changes on the oscillation pattern is analyzed in depth to provide effective support for the subsequent suppression and prevention of SSO.
基金supported by the National Natural Science Foundation of China(Grant No.52174015)the Scientific Research Project of CNOOC(China)Co.,Ltd.“Research on key technologies for drilling and completion of 20 million cubic meters in Western Nanhai Oilfield”(No.CNOOC-KJ135ZDXM38ZJ05ZJ).
文摘L1 is one of the largest offshore gas fields currently under development.In order to optimize the related design,nodal analysis is applied(including proper consideration of the plant productivity,sensitivity to the tubing size,erosion effects,liquid carrying performance,and tubing string).As a result of such approach,it is shown that 13Cr material should be chosen as the appropriate tubing material.Moreover,3-1/2 inches 9.3 lb/ft N80 tubing,4-1/2 inches 12.75 lb/ft N80 tubing,5-1/2 inches 17 lb/ft N80 tubing should be used for a gas production rate under 80×10^(4)m^(3)/d,between 80×10^(4)m^(3)/d and 120×10^(4)m^(3)/d and above 120×10^(4)m^(3)/d,respectively.
文摘Stomach adenocarcinoma (STAD) is the fifth most prevalent cancer and the third leading cause of cancer-related death in the world and is more common in Asia than in most Western countries. There is an urgent need to identify potential novel oncogenes and tumor suppressor genes, and biomarkers for STAD. 6652 differentially expressed genes were identified between STAD and normal samples based on the transcriptome data analysis of the TCGA and GEO databases. 13 key modules were identified in STAD by WGCNA analysis. 293 potential STAD associated genes were identified from intersection by Venn Diagram. The 293 intersected genes were enriched in cell cortex and infection by GO and KEGG analysis. 10 hub genes were identified from PPI and Cytoscape analyses of the intersected genes. KLF4/CGN low and SHH/LIF high expression were associated with short overall survival of Asian STAD patients. Bioinformatics analysis revealed potential novel tumor suppressors (KLF4/CGN), oncogenes (SHH/LIF) and biomarkers for diagnosis, therapy and prognosis of STAD, specifically for Asian patients.
文摘Oncolytic virus (OV) is a kind of virus that can preferentially infect and kill tumor cells. The second oncolytic virus drug was oncolytic herpes simplex virus (oHSV) Talimogene Laherparepvec (T-VEC). HSV-1 infectious cell culture protein 34.5 (ICP34.5) and latency-associated transcript (LAT) genes are closely related to virus selective infection and latent infection. Their engineering is essential for constructing efficient and safe oHSV. We summarized the mechanisms of ICP34.5 and LAT in the course of HSV-1 infection and reviewed the engineered oHSVs. We are aimed to provide an insight in developing oHSV in the future.
基金The study was supported by the National Natural Science Foundation of China (No.81574065).
文摘Acupuncture has reportedly improved memory and cognitive impairment in both animal and clinical studies. It may be an effective treatment for Alzheimer's disease (AD). The purpose of this meta-analysis was to review the effectiveness of acupuncture for the treatment of AD. Eight databases were searched for articles published up to and including July 2017, and 13 studies fulfilling the inclusion criteria were identified. The main outcomes assessed were clinical efficacy rate, Mini-Mental State Examination score, Ability of Daily Living Scale score, Alzheimer's Disease Assessment Scale-Cognition score, Hasegawa's Dementia Scale (HDS) score, and adverse events. The methodological quality of the articles was assessed using Cochrane's risk of bias. All the studies compared the efficacy of acupuncture with that of medication, and were published in Chinese journals. Meta-analysis revealed that acupuncture yielded positive results as determined via all the indexes scored except the HDS (95% CI -0.26 to 0.90, Z=0.35, P=0.73). Only one of the studies reported adverse events associated with acupuncture and medication. The rate of adverse events in the medication group was 13%. In most of the studies assessed in the current metaanalysis, acupuncture alone was better than conventional western medicines for the treatment of AD.
文摘One-dimensional blast response of continuous-density graded cellular rods was investigated theoretically and numerically. Analytical model based on the rigid-plastic hardening(R-PH) model was used to predict the blast response of density-graded cellular rods. Finite element(FE) analysis was performed using a new model based on the 3 D Voronoi technique. The FE results have a good agreement with the analytical predictions. The blast response and energy absorption of cellular rods with the same mass but different density distributions were examined under different blast loading. As a blast resistance structure, cellular materials with high energy absorption and low impulse transmit is attractive. However, high energy absorption and low impulse transmit cannot be achieved at the same time by changing the density distribution. The energy absorption capacity increases with the initial blast pressure and characteristic time of the exponentially decaying blast loading. By contract, when the blast loading exceeds the resistance capacity of cellular material, the transmitted stress will be enhanced which is detrimental to the structure being protected.
基金the Natural Science Foundation of Shanghai,China(No.15ZR1428400)Shanghai Engineering Research Center of High-Performance Medical Device Materials,China(No.20DZ2255500)the Project of Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development,Tohoku University,sponsored by Ministry,Education,Culture,Sports,Science and Technology,Japan,and the Grant-in Aid for Scientific Research(C)(No.20K05139)from JSPS(Japan Society for the Promotion of Science),Tokyo,Japan.
文摘Zr was added to Ti−Nb−Fe alloys to develop low elastic modulus and high strengthβ-Ti alloys for biomedical applications.Ingots of Ti−12Nb−2Fe−(2,4,6,8,10)Zr(at.%)were prepared by arc melting and then subjected to homogenization,cold rolling,and solution treatments.The phases and microstructures of the alloys were analyzed by optical microscopy,X-ray diffraction,and transmission electron microscopy.The mechanical properties were measured by tensile tests.The results indicate that Zr and Fe cause a remarkable solid-solution strengthening effect on the alloys;thus,all the alloys show yield and ultimate tensile strengths higher than 510 MPa and 730 MPa,respectively.Zr plays a weak role in the deformation mechanism.Further,twinning occurs in all the deformed alloys and is beneficial to both strength and plasticity.Ti−12Nb−2Fe−(8,10)Zr alloys with metastableβphases show low elastic modulus,high tensile strength,and good plasticity and are suitable candidate materials for biomedical implants.
基金Project(21471162) supported by the National Natural Science Foundation of ChinaProject(2015H6016) supported by the Science and Technology Project of Fujian Province,China
文摘A new design route was presented to fabricate cobalt aluminum-layered double hydroxide(CoAl-LDH)thin layers whichgrow on carbon spheres(CSs)through a growth method.The CoAl-LDH thin layers consist of nanoflakes with a thickness of20nm.The galvanostatic charge-discharge test of the CoAl-LDH/CSs composite shows a great specific capacitance of1198F/g at1A/g(based on the mass of the CoAl-LDH/CSs composite)in6mol/L KOH solution,and the composite displays an impressive specificcapacitance of920F/g even at a high current density of10A/g.Moreover,the composite remains a specific capacitance of928F/gafter1000cycles at2A/g,and the specific capacitance retention is84%,indicating that the composite has high specific capacitance,excellent rate capability and good cycling stability in comparison to pristine CoAl-LDH.
文摘The increasing threat of explosions on the battle field and the terrorist action requires the development of more effective blast resistance materials and structures.Curved structure can support the external loads effectively by virtue of their spatial curvature.In review of the excellent energy absorption property of auxetic structure,employing auxetic structure as core material in curved sandwich shows the potential to improve the protection performance.In this study,a novel cylindrical sandwich panel with double arrow auxetic(DAA) core was designed and the numerical model was built by ABAQUS.Due to the complexity of the structure,systematic parameter study and optimal design are conducted.Two cases of optimal design were considered,case1 focuses on reducing the deflection and mass of the structure,while case2 focuses on reducing the deflection and increasing the energy absorption per unit mass.Parameter study and optimal design were conducted based on Latin Hypercube Sampling(LHD)method,artificial neural networks(ANN) metamodel and the nondominated sorting genetic algorithm(NSGA-Ⅱ).The Pareto front was obtained and the cylindrical DAA structure performed much better than its equal solid panel in both blast resistance and energy absorption capacity.Optimization results can be used as a reference for different applications.
