Objective: To evaluate the treatment outcome of iron isomaltoside compared with an oral iron supplement in the management of iron deficiency anemia (IDA). Methods: The study included patients with IDA who visited the ...Objective: To evaluate the treatment outcome of iron isomaltoside compared with an oral iron supplement in the management of iron deficiency anemia (IDA). Methods: The study included patients with IDA who visited the Outpatient Clinic of the Department of Hematology, the Affiliated Hospital of Qingdao University from October 2021 to August 2022 and met the inclusion and exclusion criteria. According to the actual application of iron supplementation, the patients were divided into two groups: iron isomaltoside treatment group and oral iron treatment group. Baseline measurements were collected before the start of treatment, and measurements were collected subsequently at intervals of 1 week, 1 month, and 3 months. The hematological parameters analyzed included Hemoglobin (Hb), Mean corpuscular hemoglobin (MCH), Mean Hemoglobin content (MCH), Mean corpuscular Hemoglobin concentration (MCHC), and Platelet (Plt). Safety data and adverse event profiles were recorded. Results: Intra-group comparisons: After 1 month of treatment, the Hb significantly improved (P 0.05). Inter-group comparisons: The biochemical parameters were significantly improved (P 0.05) in the iron isomaltoside group compared with those in the oral iron group after 1 month of iron supplementation in patients with mild and moderate anemia. Adverse reactions were tolerable for the patients in both iron isomaltoside group and oral iron group. Only 1 patient in iron isomaltoside group developed anaphylactic shock during medication and recovered after aggressive rescue. Conclusions: Iron isomaltoside which increases Hb more rapidly compared with the oral iron supplementation has few adverse reactions and good acceptance.展开更多
The polar magnetic fields of the Sun play an important role in governing solar activity and powering fast solar wind.However,because our view of the Sun is limited in the ecliptic plane,the polar regions remain largel...The polar magnetic fields of the Sun play an important role in governing solar activity and powering fast solar wind.However,because our view of the Sun is limited in the ecliptic plane,the polar regions remain largely uncharted.Using the high spatial resolution and polarimetric precision vector magnetograms observed by Hinode from 2012 to 2021,we investigate the long-term variation of the magnetic fields in polar caps at different latitudes.The Hinode magnetic measurements show that the polarity reversal processes in the north and south polar caps are non-simultaneous.The variation of the averaged radial magnetic flux density reveals that,in each polar cap,the polarity reversal is completed successively from the 70°latitude to the pole,reflecting a poleward magnetic flux migration therein.These results clarify the polar magnetic polarity reversal process at different latitudes.展开更多
文摘Objective: To evaluate the treatment outcome of iron isomaltoside compared with an oral iron supplement in the management of iron deficiency anemia (IDA). Methods: The study included patients with IDA who visited the Outpatient Clinic of the Department of Hematology, the Affiliated Hospital of Qingdao University from October 2021 to August 2022 and met the inclusion and exclusion criteria. According to the actual application of iron supplementation, the patients were divided into two groups: iron isomaltoside treatment group and oral iron treatment group. Baseline measurements were collected before the start of treatment, and measurements were collected subsequently at intervals of 1 week, 1 month, and 3 months. The hematological parameters analyzed included Hemoglobin (Hb), Mean corpuscular hemoglobin (MCH), Mean Hemoglobin content (MCH), Mean corpuscular Hemoglobin concentration (MCHC), and Platelet (Plt). Safety data and adverse event profiles were recorded. Results: Intra-group comparisons: After 1 month of treatment, the Hb significantly improved (P 0.05). Inter-group comparisons: The biochemical parameters were significantly improved (P 0.05) in the iron isomaltoside group compared with those in the oral iron group after 1 month of iron supplementation in patients with mild and moderate anemia. Adverse reactions were tolerable for the patients in both iron isomaltoside group and oral iron group. Only 1 patient in iron isomaltoside group developed anaphylactic shock during medication and recovered after aggressive rescue. Conclusions: Iron isomaltoside which increases Hb more rapidly compared with the oral iron supplementation has few adverse reactions and good acceptance.
基金supported by the National Key R&D Programs of China(2019YFA0405000,2022YFF0503800,2022YFF0503000)the Strategic Priority Research Programs of the Chinese Academy of Sciences(XDB0560000,XDB41000000)+1 种基金the National Natural Science Foundations of China(NSFC,Grant Nos.12173005,12273060,12350004,12273061,12222306,and 12073001)the Youth Innovation Promotion Association CAS,and Yunnan Academician Workstation of Wang Jingxiu(No.202005AF150025)。
文摘The polar magnetic fields of the Sun play an important role in governing solar activity and powering fast solar wind.However,because our view of the Sun is limited in the ecliptic plane,the polar regions remain largely uncharted.Using the high spatial resolution and polarimetric precision vector magnetograms observed by Hinode from 2012 to 2021,we investigate the long-term variation of the magnetic fields in polar caps at different latitudes.The Hinode magnetic measurements show that the polarity reversal processes in the north and south polar caps are non-simultaneous.The variation of the averaged radial magnetic flux density reveals that,in each polar cap,the polarity reversal is completed successively from the 70°latitude to the pole,reflecting a poleward magnetic flux migration therein.These results clarify the polar magnetic polarity reversal process at different latitudes.
