Objective：To investigate the effect of cardiomyocyte proliferation induced by human hepatocyte growth factor（HGF）in pigs with chronic myocardial infarction（CMI）.Methods：A steerable,deflectable 7F catheter incorp...Objective：To investigate the effect of cardiomyocyte proliferation induced by human hepatocyte growth factor（HGF）in pigs with chronic myocardial infarction（CMI）.Methods：A steerable,deflectable 7F catheter incorporating a 27-guage needle was advanced percutaneously to the left ventricular myocardium of 18 pigs with CMI.Pigs were randomized（1：1：1）to receive adenoviral vector HGF（total dose,1×10^10 genome copies）,which was administered as five injections into the infarcted myocardium（total,1.0 mL）,or saline,or Ad-null（control groups）.Injections were guided by Ensite NavX left ventricular electroanatomical mapping.HGF and cyclin proteins were detected by western blot and immunoprecipitation analysis.Histological and immunohistochemical analysis determined proliferating cardiomyocytes.Myocardial perfusion and cardiac function were estimated by Gated-Single Photon Emission Computed Tomography（G-SPECT）.Results：Western blot analyses showed that HGF were predominantly expressed in the infarct core and border in the myocardium of the infarcted heart.G-SPECT analysis indicated that the HGF group had better cardiac function and myocardial perfusion four weeks after the injection of Ad-HGF than before the injection of Ad-HGF.After treatment there were more proliferating cardiomyocytes in the HGF group compared to either of the control groups.Furthermore,the HGF group myocardial samples expressed higher levels of p-Akt,cyclin A,cyclin E,cyclin D1,cdk2,cdk4 than those in the control groups.Conclusion：The over-expression of HGF activates pro-survival pathways,induces cardiomyocyte proliferation,and improves the perfusion and function of the porcine CMI heart.展开更多
This paper tackles pose tracking and model refinement, one of the fundamental work for 3D photogrammetry. The researches belong to the videometrics, an interdisciplinewhich combines computer vision, digital image proc...This paper tackles pose tracking and model refinement, one of the fundamental work for 3D photogrammetry. The researches belong to the videometrics, an interdisciplinewhich combines computer vision, digital image processing, photogrammetry and optical measurement. Related works are summarized briefly in this paper. This paper studies the problem of pose tracking for target with 3D model. For the target with accurate 3D model, line model based pose tracking methods are proposed for target which is rich in line features. Experimental results indicate that the proposed methods track the target pose accurately. Normal distance iterative reweighted least squares and distance image iterative least squares methods are proposed to process more general targets. This paper adopts bundle adjustment to tackle pose tracking in image sequence for target with inaccurate 3D line model. The proposed method optimizes the model line parameters and the pose parameters simultaneously. The model line orientation, position and mean angle error, mean position error of the pose are 0.3°,3.5 mm and 0.12°,20.1 mm in simulation experiments of satellite pose tracking. Line features are used to track target pose with unknown 3D model through image sequence. The model line parameters and pose parameters are optimized under the framework of SFM. In simulation experiments, the reconstructed line orientation, position error and mean angle error, mean position error of pose are 0.4°,7.5 mm and 0.16°,23.5 mm.展开更多
Multi-modal image matching is crucial in aerospace applications because it can fully exploit the complementary and valuable information contained in the amount and diversity of remote sensing images.However,it remains...Multi-modal image matching is crucial in aerospace applications because it can fully exploit the complementary and valuable information contained in the amount and diversity of remote sensing images.However,it remains a challenging task due to significant non-linear radiometric,geometric differences,and noise across different sensors.To improve the performance of heterologous image matching,this paper proposes a normalized self-similarity region descriptor to extract consistent structural information.We first construct the pointwise self-similarity region descriptor based on the Euclidean distance between adjacent image blocks to reflect the structural properties of multi-modal images.Then,a linear normalization approach is used to form Modality Independent Region Descriptor(MIRD),which can effectively distinguish structural features such as points,lines,corners,and flat between multi-modal images.To further improve the matching accuracy,the included angle cosine similarity metric is adopted to exploit the directional vector information of multi-dimensional feature descriptors.The experimental results show that the proposed MIRD has better matching accuracy and robustness for various multi-modal image matching than the state-of-the-art methods.MIRD can effectively extract consistent geometric structure features and suppress the influence of SAR speckle noise using non-local neighboring image blocks operation,effectively applied to various multi-modal image matching.展开更多
Deep learning significantly improves the accuracy of remote sensing image scene classification,benefiting from the large-scale datasets.However,annotating the remote sensing images is time-consuming and even tough for...Deep learning significantly improves the accuracy of remote sensing image scene classification,benefiting from the large-scale datasets.However,annotating the remote sensing images is time-consuming and even tough for experts.Deep neural networks trained using a few labeled samples usually generalize less to new unseen images.In this paper,we propose a semi-supervised approach for remote sensing image scene classification based on the prototype-based consistency,by exploring massive unlabeled images.To this end,we,first,propose a feature enhancement module to extract discriminative features.This is achieved by focusing the model on the foreground areas.Then,the prototype-based classifier is introduced to the framework,which is used to acquire consistent feature representations.We conduct a series of experiments on NWPU-RESISC45 and Aerial Image Dataset(AID).Our method improves the State-Of-The-Art(SOTA)method on NWPU-RESISC45 from 92.03%to 93.08%and on AID from 94.25%to 95.24%in terms of accuracy.展开更多
Three-dimensional(3D)imaging with structured light is crucial in diverse scenarios,ranging from intelligent manufacturing and medicine to entertainment.However,current structured light methods rely on projector-camera...Three-dimensional(3D)imaging with structured light is crucial in diverse scenarios,ranging from intelligent manufacturing and medicine to entertainment.However,current structured light methods rely on projector-camera synchronization,limiting the use of affordable imaging devices and their consumer applications.In this work,we introduce an asynchronous structured light imaging approach based on generative deep neural networks to relax the synchronization constraint,accomplishing the challenges of fringe pattern aliasing,without relying on any a priori constraint of the projection system.To overcome this need,we propose a generative deep neural network with U-Net-like encoder-decoder architecture to learn the underlying fringe features directly by exploring the intrinsic prior principles in the fringe pattern aliasing.We train within an adversarial learning framework and supervise the network training via a statisticsinformed loss function.We demonstrate that by evaluating the performance on fields of intensity,phase,and 3D reconstruction.It is shown that the trained network can separate aliased fringe patterns for producing comparable results with the synchronous one:the absolute error is no greater than 8μm,and the standard deviation does not exceed 3μm.Evaluation results on multiple objects and pattern types show it could be generalized for any asynchronous structured light scene.展开更多
The measurement of wing dynamic deformation in morphing aircraft is crucial for achieving closed-loop control and evaluating structural safety.For variable-sweep wings with active large deformation,this paper proposes...The measurement of wing dynamic deformation in morphing aircraft is crucial for achieving closed-loop control and evaluating structural safety.For variable-sweep wings with active large deformation,this paper proposes a novel videogrammetric method for full-field dynamic deformation measurement.A stereo matching method based on epipolar geometry constraint and topological constraint is presented to find the corresponding targets between stereo images.In addition,a new method based on affine transformation combined with adjacent closest point matching is developed,aiming to achieve fast and automatic tracking of targets in time-series images with large deformation.A calculation model for dynamic deformation parameters is established to obtain the displacement,sweep variable angle,and span variation.To verify the proposed method,a dynamic deformation measurement experiment is conducted on a variable-sweep wing model.The results indicate that the actual accuracy of the proposed method is approximately 0.02%of the measured area(e.g.,0.32 mm in a 1.6 m scale).During one morphing course,the sweep variable angle,the span variation and the displacement increase gradually,and then decrease.The maximum sweep variable angle is 36.6°,and the span variation is up to 101.13 mm.The overall configuration of the wing surface is effectively reconstructed under different morphing states.展开更多
The dynamic failure behavior of CoCrFeNi High-Entropy Alloy(HEA)under plane biaxial stress was investigated in detail.The dynamic biaxial tensile tests were conducted using an Electromagnetic Biaxial Split Hopkinson T...The dynamic failure behavior of CoCrFeNi High-Entropy Alloy(HEA)under plane biaxial stress was investigated in detail.The dynamic biaxial tensile tests were conducted using an Electromagnetic Biaxial Split Hopkinson Tensile Bar(EBSHTB)system.For comparison,the quasi-static uniaxial and biaxial tensile tests,as well as dynamic uniaxial tensile tests,were per-formed respectively.A cruciform specimen suitable for large plastic deformation was designed and employed in the experiments.The Finite Element Method(FEM)verified that the improved cruciform specimen could satisfy the basic requirements.The feasibility of the proposed specimen was further confirmed through loading tests.Finally,the quasi-static and dynamic yield loci of the HEA in the first quadrant of the principal stress space were plotted.The results indicate that the alloy exhibits obvious strain hardening effect and strain rate strengthening effect,the yield locus and plastic work contours can be accurately described by Hill'48 criterion.展开更多
Inflammation can initiate osteolysis,which is the breakdown of bone by fully developed osteoclasts.The com-pound Oleandrin is recognized for its effects against inflammation and tumors.Our objective was to examine the...Inflammation can initiate osteolysis,which is the breakdown of bone by fully developed osteoclasts.The com-pound Oleandrin is recognized for its effects against inflammation and tumors.Our objective was to examine the effects of Oleandrin on osteoclastogenesis and osteolysis,both in vitro and in vivo.In vitro,the impact of Oleandrin on osteoclastogenesis was assessed using CCK-8 assays,TRAP staining,and bone resorption assays.Ad-ditionally,a mouse model of osteolysis caused by LPS injection into the calvaria was used to conduct an in vivo investigation,examining bone histomorphology,histology,and immunohistochemistry.In vitro,concentrations of 5 nM and 10 nM of Oleandrin were found to be non-cytotoxic based on the results obtained.In vitro,Olean-drin hindered the osteoclastogenesis and bone resorption induced by RANKL.Oleandrin successfully inhibited the phosphorylation of NF-κB p65 and PI3K p85 in osteolytic tissue,thereby suppressing LPS-induced inflammatory osteolysis in mice calvaria during the in vivo study.Furthermore,the Oleandrin-treated group exhibited a note-worthy decrease in the expression level of NFATc1,which is a crucial controller of osteoclastogenesis.To sum up,our discoveries indicate that Oleandrin could hinder osteoclastogenesis and bone resorption,thereby having the ability to suppress inflammation-induced osteolysis.The underlying mechanism involves the NF-κB/PI3K pathway and inhibition of NFATc1 activation.Therefore,the findings suggest that Oleandrin holds potential as a therapeutic remedy for osteolytic ailments.展开更多
Due to the portability and anti-interference ability,vision-based shipborne aircraft automatic landing systems have attracted the attention of researchers.In this paper,a Monocular Camera and Laser Range Finder(MC-LRF...Due to the portability and anti-interference ability,vision-based shipborne aircraft automatic landing systems have attracted the attention of researchers.In this paper,a Monocular Camera and Laser Range Finder(MC-LRF)-based pose measurement system is designed for shipborne aircraft automatic landing.First,the system represents the target ship using a set of sparse landmarks,and a two-stage model is adopted to detect landmarks on the target ship.The rough 6D pose is measured by solving a Perspective-n-Point problem.Then,once the rough pose is measured,a region-based pose refinement is used to continuously track the 6D pose in the subsequent image sequences.To address the low accuracy of monocular pose measurement in the depth direction,the designed system adopts a laser range finder to obtain an accurate range value.The measured rough pose is iteratively optimized using the accurate range measurement.Experimental results on synthetic and real images show that the system achieves robust and precise pose measurement of the target ship during automatic landing.The measurement means error is within 0.4in rotation,and 0.2%in translation,meeting the requirements for automatic fixed-wing aircraft landing.展开更多
Optical dynamic measurements are widely used for non-contact vibration,continuous deformation,or moving objects.Various measurement techniques were developed for different deformation amplitudes.This paper reviews thr...Optical dynamic measurements are widely used for non-contact vibration,continuous deformation,or moving objects.Various measurement techniques were developed for different deformation amplitudes.This paper reviews three types of technique for different measurement ranges:interferometric techniques for deformation or vibration(nanometer to submillimeter amplitude)whose measurement accuracies rely on phase extraction of interferometric signal;imaging based techniques for deformation or vibration(micrometer to centimeter amplitude)with the aid of moire,structured light,and man-made speckles,whose sensitivities is from 1/100 to 1/10 pixel;and videometrics for large deformation or movement detection(greater than centimeter amplitude).Many research groups have improved measurement capabilities for these three techniques to meet particular industrial application requirements.展开更多
To investigate the non-uniform distribution of different gases passing through the parallel cyclones,experiments were conducted on a circulating fluidized bed(CFB)equipped with six asymmetrical cyclones.A multi-tracer...To investigate the non-uniform distribution of different gases passing through the parallel cyclones,experiments were conducted on a circulating fluidized bed(CFB)equipped with six asymmetrical cyclones.A multi-tracer gas method was used,with CO,O_(2),and CO_(2) chosen to represent gases with different properties in the flue gas at the inlets of the cyclones.The uniformity of multi-gas distribution was evaluated by measuring the concentration deviations of each tracer gas passing through individual cyclones.The results indicate that the concentrations of multi-tracer gases are higher in the middle cyclone among the three,which are located on the tracer gas injection side during the test of single-side secondary air(SA)tracing.The maximum concentration deviation of tracer gases is for CO_(2),while the minimum is for CO.At the three cyclone inlets on the opposite side,the tracer gas with higher density exhibits a more uniform distribution,and the gas uniformity decreases as the density decreases.The effects of superficial velocity,SA ratio,bed inventory,and tracer gas injection region on the uniformity of gas distribution were studied.The results show that superficial velocity and SA ratio primarily affect the uniformity of higher density gases,while bed inventory has a greater influence on lower density gases.The gas distributions are most non-uniform,especially for CO_(2),when the tracer gas injection region is near the rear wall closer to the induced draft fan during the test of regional SA tracing.展开更多
Transcatheter aortic valve replacement (TAVR) has the advantages of less trauma and faster postoperative recovery, which has brought the possibility to the elderly patient with valvular heart disease and is gradually ...Transcatheter aortic valve replacement (TAVR) has the advantages of less trauma and faster postoperative recovery, which has brought the possibility to the elderly patient with valvular heart disease and is gradually replacing surgical aortic valve replacement (SAVR). The interventional valve used in TAVR needs to be compressed and transported through the catheter to the lesion site, and can still recover its original shape, structure and performance. This process requires that the material should be flexible, and the rigid mechanical valves in SAVR are not suitable. Recently, decellularized biological valves have been widely used in clinical practice, but their poor durability causes a limitation for long-term implantation. Therefore, the anti-calcification modification of biological valves and the design of new polymeric valves with good biostability have gained considerable attention. This review summarizes the calcification mechanism of biological valves and the research progress in anti-calcification modification strategies. Besides, the development of new polymeric valves is included, with special attention to representative cases, such as polysiloxane, polytetrafluor- ethylene, poly(styrene-block-isobutylene-block-styrene), and polyurethane- based materials. Finally, the challenges and future perspectives of artificial heart valve materials are discussed.展开更多
基金financially supported by a project grant of the key faculty of Medical Renaissance program of Jiangsu Province,National Basic Research Program(973 program,2008CB517303)
文摘Objective：To investigate the effect of cardiomyocyte proliferation induced by human hepatocyte growth factor（HGF）in pigs with chronic myocardial infarction（CMI）.Methods：A steerable,deflectable 7F catheter incorporating a 27-guage needle was advanced percutaneously to the left ventricular myocardium of 18 pigs with CMI.Pigs were randomized（1：1：1）to receive adenoviral vector HGF（total dose,1×10^10 genome copies）,which was administered as five injections into the infarcted myocardium（total,1.0 mL）,or saline,or Ad-null（control groups）.Injections were guided by Ensite NavX left ventricular electroanatomical mapping.HGF and cyclin proteins were detected by western blot and immunoprecipitation analysis.Histological and immunohistochemical analysis determined proliferating cardiomyocytes.Myocardial perfusion and cardiac function were estimated by Gated-Single Photon Emission Computed Tomography（G-SPECT）.Results：Western blot analyses showed that HGF were predominantly expressed in the infarct core and border in the myocardium of the infarcted heart.G-SPECT analysis indicated that the HGF group had better cardiac function and myocardial perfusion four weeks after the injection of Ad-HGF than before the injection of Ad-HGF.After treatment there were more proliferating cardiomyocytes in the HGF group compared to either of the control groups.Furthermore,the HGF group myocardial samples expressed higher levels of p-Akt,cyclin A,cyclin E,cyclin D1,cdk2,cdk4 than those in the control groups.Conclusion：The over-expression of HGF activates pro-survival pathways,induces cardiomyocyte proliferation,and improves the perfusion and function of the porcine CMI heart.
基金The National Natural Science Foundation of China (11472302,11332012).
文摘This paper tackles pose tracking and model refinement, one of the fundamental work for 3D photogrammetry. The researches belong to the videometrics, an interdisciplinewhich combines computer vision, digital image processing, photogrammetry and optical measurement. Related works are summarized briefly in this paper. This paper studies the problem of pose tracking for target with 3D model. For the target with accurate 3D model, line model based pose tracking methods are proposed for target which is rich in line features. Experimental results indicate that the proposed methods track the target pose accurately. Normal distance iterative reweighted least squares and distance image iterative least squares methods are proposed to process more general targets. This paper adopts bundle adjustment to tackle pose tracking in image sequence for target with inaccurate 3D line model. The proposed method optimizes the model line parameters and the pose parameters simultaneously. The model line orientation, position and mean angle error, mean position error of the pose are 0.3°,3.5 mm and 0.12°,20.1 mm in simulation experiments of satellite pose tracking. Line features are used to track target pose with unknown 3D model through image sequence. The model line parameters and pose parameters are optimized under the framework of SFM. In simulation experiments, the reconstructed line orientation, position error and mean angle error, mean position error of pose are 0.4°,7.5 mm and 0.16°,23.5 mm.
基金supported by the National Natural Science Foundation of China,China(No.61801491)。
文摘Multi-modal image matching is crucial in aerospace applications because it can fully exploit the complementary and valuable information contained in the amount and diversity of remote sensing images.However,it remains a challenging task due to significant non-linear radiometric,geometric differences,and noise across different sensors.To improve the performance of heterologous image matching,this paper proposes a normalized self-similarity region descriptor to extract consistent structural information.We first construct the pointwise self-similarity region descriptor based on the Euclidean distance between adjacent image blocks to reflect the structural properties of multi-modal images.Then,a linear normalization approach is used to form Modality Independent Region Descriptor(MIRD),which can effectively distinguish structural features such as points,lines,corners,and flat between multi-modal images.To further improve the matching accuracy,the included angle cosine similarity metric is adopted to exploit the directional vector information of multi-dimensional feature descriptors.The experimental results show that the proposed MIRD has better matching accuracy and robustness for various multi-modal image matching than the state-of-the-art methods.MIRD can effectively extract consistent geometric structure features and suppress the influence of SAR speckle noise using non-local neighboring image blocks operation,effectively applied to various multi-modal image matching.
基金supported in part by the National Natural Science Foundation of China(No.12302252)。
文摘Deep learning significantly improves the accuracy of remote sensing image scene classification,benefiting from the large-scale datasets.However,annotating the remote sensing images is time-consuming and even tough for experts.Deep neural networks trained using a few labeled samples usually generalize less to new unseen images.In this paper,we propose a semi-supervised approach for remote sensing image scene classification based on the prototype-based consistency,by exploring massive unlabeled images.To this end,we,first,propose a feature enhancement module to extract discriminative features.This is achieved by focusing the model on the foreground areas.Then,the prototype-based classifier is introduced to the framework,which is used to acquire consistent feature representations.We conduct a series of experiments on NWPU-RESISC45 and Aerial Image Dataset(AID).Our method improves the State-Of-The-Art(SOTA)method on NWPU-RESISC45 from 92.03%to 93.08%and on AID from 94.25%to 95.24%in terms of accuracy.
基金funding from the National Natural Science Foundation of China(Grant Nos.62375078 and 12002197)the Youth Talent Launching Program of Shanghai University+2 种基金the General Science Foundation of Henan Province(Grant No.222300420427)the Key Research Project Plan for Higher Education Institutions in Henan Province(Grant No.24ZX011)the National Key Laboratory of Ship Structural Safety
文摘Three-dimensional(3D)imaging with structured light is crucial in diverse scenarios,ranging from intelligent manufacturing and medicine to entertainment.However,current structured light methods rely on projector-camera synchronization,limiting the use of affordable imaging devices and their consumer applications.In this work,we introduce an asynchronous structured light imaging approach based on generative deep neural networks to relax the synchronization constraint,accomplishing the challenges of fringe pattern aliasing,without relying on any a priori constraint of the projection system.To overcome this need,we propose a generative deep neural network with U-Net-like encoder-decoder architecture to learn the underlying fringe features directly by exploring the intrinsic prior principles in the fringe pattern aliasing.We train within an adversarial learning framework and supervise the network training via a statisticsinformed loss function.We demonstrate that by evaluating the performance on fields of intensity,phase,and 3D reconstruction.It is shown that the trained network can separate aliased fringe patterns for producing comparable results with the synchronous one:the absolute error is no greater than 8μm,and the standard deviation does not exceed 3μm.Evaluation results on multiple objects and pattern types show it could be generalized for any asynchronous structured light scene.
基金supported by the National Natural Science Foundation of China(Grant No.12202282).
文摘The measurement of wing dynamic deformation in morphing aircraft is crucial for achieving closed-loop control and evaluating structural safety.For variable-sweep wings with active large deformation,this paper proposes a novel videogrammetric method for full-field dynamic deformation measurement.A stereo matching method based on epipolar geometry constraint and topological constraint is presented to find the corresponding targets between stereo images.In addition,a new method based on affine transformation combined with adjacent closest point matching is developed,aiming to achieve fast and automatic tracking of targets in time-series images with large deformation.A calculation model for dynamic deformation parameters is established to obtain the displacement,sweep variable angle,and span variation.To verify the proposed method,a dynamic deformation measurement experiment is conducted on a variable-sweep wing model.The results indicate that the actual accuracy of the proposed method is approximately 0.02%of the measured area(e.g.,0.32 mm in a 1.6 m scale).During one morphing course,the sweep variable angle,the span variation and the displacement increase gradually,and then decrease.The maximum sweep variable angle is 36.6°,and the span variation is up to 101.13 mm.The overall configuration of the wing surface is effectively reconstructed under different morphing states.
基金supported by the National Natural Science Foundation of China (Nos.11922211,11832015,11527803)the 111 Project,China (No.BP0719007)the Science Challenge Project,China (No.TZ2018001).
文摘The dynamic failure behavior of CoCrFeNi High-Entropy Alloy(HEA)under plane biaxial stress was investigated in detail.The dynamic biaxial tensile tests were conducted using an Electromagnetic Biaxial Split Hopkinson Tensile Bar(EBSHTB)system.For comparison,the quasi-static uniaxial and biaxial tensile tests,as well as dynamic uniaxial tensile tests,were per-formed respectively.A cruciform specimen suitable for large plastic deformation was designed and employed in the experiments.The Finite Element Method(FEM)verified that the improved cruciform specimen could satisfy the basic requirements.The feasibility of the proposed specimen was further confirmed through loading tests.Finally,the quasi-static and dynamic yield loci of the HEA in the first quadrant of the principal stress space were plotted.The results indicate that the alloy exhibits obvious strain hardening effect and strain rate strengthening effect,the yield locus and plastic work contours can be accurately described by Hill'48 criterion.
基金National Natural Science Foundation of China(82272165)Shanghai Municipal Commission of Health and Family Planning’s Science and Research Fund(202040141)+2 种基金Shanghai Municipality Science and Technology Commission(20ZR1451800,22ZR1457200)Shanghai Municipal Health Commission(2022YQ006)Shanghai Tongren Hospital(TRKYRC-xx202203).
文摘Inflammation can initiate osteolysis,which is the breakdown of bone by fully developed osteoclasts.The com-pound Oleandrin is recognized for its effects against inflammation and tumors.Our objective was to examine the effects of Oleandrin on osteoclastogenesis and osteolysis,both in vitro and in vivo.In vitro,the impact of Oleandrin on osteoclastogenesis was assessed using CCK-8 assays,TRAP staining,and bone resorption assays.Ad-ditionally,a mouse model of osteolysis caused by LPS injection into the calvaria was used to conduct an in vivo investigation,examining bone histomorphology,histology,and immunohistochemistry.In vitro,concentrations of 5 nM and 10 nM of Oleandrin were found to be non-cytotoxic based on the results obtained.In vitro,Olean-drin hindered the osteoclastogenesis and bone resorption induced by RANKL.Oleandrin successfully inhibited the phosphorylation of NF-κB p65 and PI3K p85 in osteolytic tissue,thereby suppressing LPS-induced inflammatory osteolysis in mice calvaria during the in vivo study.Furthermore,the Oleandrin-treated group exhibited a note-worthy decrease in the expression level of NFATc1,which is a crucial controller of osteoclastogenesis.To sum up,our discoveries indicate that Oleandrin could hinder osteoclastogenesis and bone resorption,thereby having the ability to suppress inflammation-induced osteolysis.The underlying mechanism involves the NF-κB/PI3K pathway and inhibition of NFATc1 activation.Therefore,the findings suggest that Oleandrin holds potential as a therapeutic remedy for osteolytic ailments.
基金co-supported by the National Natural Science Foundation of China,China(No.12272404)the Postgraduate Research Innovation Project of Hunan Province of China,China(No.CX20210016).
文摘Due to the portability and anti-interference ability,vision-based shipborne aircraft automatic landing systems have attracted the attention of researchers.In this paper,a Monocular Camera and Laser Range Finder(MC-LRF)-based pose measurement system is designed for shipborne aircraft automatic landing.First,the system represents the target ship using a set of sparse landmarks,and a two-stage model is adopted to detect landmarks on the target ship.The rough 6D pose is measured by solving a Perspective-n-Point problem.Then,once the rough pose is measured,a region-based pose refinement is used to continuously track the 6D pose in the subsequent image sequences.To address the low accuracy of monocular pose measurement in the depth direction,the designed system adopts a laser range finder to obtain an accurate range value.The measured rough pose is iteratively optimized using the accurate range measurement.Experimental results on synthetic and real images show that the system achieves robust and precise pose measurement of the target ship during automatic landing.The measurement means error is within 0.4in rotation,and 0.2%in translation,meeting the requirements for automatic fixed-wing aircraft landing.
文摘Optical dynamic measurements are widely used for non-contact vibration,continuous deformation,or moving objects.Various measurement techniques were developed for different deformation amplitudes.This paper reviews three types of technique for different measurement ranges:interferometric techniques for deformation or vibration(nanometer to submillimeter amplitude)whose measurement accuracies rely on phase extraction of interferometric signal;imaging based techniques for deformation or vibration(micrometer to centimeter amplitude)with the aid of moire,structured light,and man-made speckles,whose sensitivities is from 1/100 to 1/10 pixel;and videometrics for large deformation or movement detection(greater than centimeter amplitude).Many research groups have improved measurement capabilities for these three techniques to meet particular industrial application requirements.
基金financed by the Key Project of the National Research Program of China(grant No.2020YFB0606201).
文摘To investigate the non-uniform distribution of different gases passing through the parallel cyclones,experiments were conducted on a circulating fluidized bed(CFB)equipped with six asymmetrical cyclones.A multi-tracer gas method was used,with CO,O_(2),and CO_(2) chosen to represent gases with different properties in the flue gas at the inlets of the cyclones.The uniformity of multi-gas distribution was evaluated by measuring the concentration deviations of each tracer gas passing through individual cyclones.The results indicate that the concentrations of multi-tracer gases are higher in the middle cyclone among the three,which are located on the tracer gas injection side during the test of single-side secondary air(SA)tracing.The maximum concentration deviation of tracer gases is for CO_(2),while the minimum is for CO.At the three cyclone inlets on the opposite side,the tracer gas with higher density exhibits a more uniform distribution,and the gas uniformity decreases as the density decreases.The effects of superficial velocity,SA ratio,bed inventory,and tracer gas injection region on the uniformity of gas distribution were studied.The results show that superficial velocity and SA ratio primarily affect the uniformity of higher density gases,while bed inventory has a greater influence on lower density gases.The gas distributions are most non-uniform,especially for CO_(2),when the tracer gas injection region is near the rear wall closer to the induced draft fan during the test of regional SA tracing.
基金the International Collaboration Project between China and Bulgaria from Ministry of Science and Technology,Grant/Award Number:KP-06-China/6-20.11.2020Key research and development program of Zhejiang Province,Grant/Award Number:2022C01106+1 种基金the Natural Science Foundation of China,Grant/Award Number:51873188the ZJU DPSENEWMED Biomedical Polymers and Devices Research&Development Lab。
文摘Transcatheter aortic valve replacement (TAVR) has the advantages of less trauma and faster postoperative recovery, which has brought the possibility to the elderly patient with valvular heart disease and is gradually replacing surgical aortic valve replacement (SAVR). The interventional valve used in TAVR needs to be compressed and transported through the catheter to the lesion site, and can still recover its original shape, structure and performance. This process requires that the material should be flexible, and the rigid mechanical valves in SAVR are not suitable. Recently, decellularized biological valves have been widely used in clinical practice, but their poor durability causes a limitation for long-term implantation. Therefore, the anti-calcification modification of biological valves and the design of new polymeric valves with good biostability have gained considerable attention. This review summarizes the calcification mechanism of biological valves and the research progress in anti-calcification modification strategies. Besides, the development of new polymeric valves is included, with special attention to representative cases, such as polysiloxane, polytetrafluor- ethylene, poly(styrene-block-isobutylene-block-styrene), and polyurethane- based materials. Finally, the challenges and future perspectives of artificial heart valve materials are discussed.
