Tree plantations are an important forest resource that substantively contributes to climate change mitigation and carbon sequestration.As the area and standing volume of tree plantations in China have increased,issues...Tree plantations are an important forest resource that substantively contributes to climate change mitigation and carbon sequestration.As the area and standing volume of tree plantations in China have increased,issues such as unreasonable structure,low productivity,limited ecological functionality and diminishing ecological stability have occurred,which hinder the ability of tree plantations to enhance carbon sequestration.This study outlined the trajectory of carbon sequestration and its associated benefits in tree plantations by examining the current state of tree plantation establishment and growth,elucidated the strategies for advantages of carbon sequestration and climate change mitigation in planted forests,and summarized the existing problems with tree plantations.This paper underscores the pressing need for concerted efforts to boost carbon sequestration within planted forests and proposes management and development strategies for Chinese tree plantations.In the future,it will be necessary to apply scientific theories to practice and develop multi-objective management optimization models for the high-quality development of tree plantations.This will involve establishing a cohesive national carbon trading market,improving the prediction of carbon sequestration,and identifying priority zones for afforestation and reforestation,to better serve China’s national strategy for achieving peak carbon and carbon neutrality.展开更多
Background： The purpose of this study was to analyze the effects of all clinical characteristics on the overall survival time, in order to provide a basis for determining the prognostic factor of patients with pancre...Background： The purpose of this study was to analyze the effects of all clinical characteristics on the overall survival time, in order to provide a basis for determining the prognostic factor of patients with pancreatic cancer. Methods： A total of 103 pancreatic cancer patients were admitted to the Department of Radiotherapy and Chemotherapy of the Ruijin Hospital, Shanghai Jiaotong University School of Medicine, between January 2002 and December 2012. There were 68 men and 35 women; the median age was 62 years. Diagnoses of pancreatic cancer in all patients were confirmed by histopathology, cytology, or clinical diagnosis. The Kaplan-Meier method was performed to calculate the overall survival rate. The log-rank method was used to examine the univariate analysis. The Cox regression model was performed for multivariate analysis. Results： The median survival time was 293 days, the 1-, 2-, and 3-year survival rates were 27.18%, 5.83%, and 1.94%, respectively. Cox regression analysis revealed that age （P=0.015）, Karnofsky performance status （PS） （P=0.002）, surgical types （P〈0.001）, and platelet counts （P〈0.001） were independent prognostic factors affecting the overall survival of patients with pancreatic cancer. Conclusions＂ Pancreatic cancer had a poor prognosis, the general physical condition, age, the availability of radical surgery, and platelet counts were factors influencing the overall survival of patients with pancreatic cancer.展开更多
p53 is mutated in half of cancer cases.However,no p53-targeting drugs have been approved.Here,we reposition decitabine for triple-negative breast cancer(TNBC),a subtype with frequent p53 mutations and extremely poor p...p53 is mutated in half of cancer cases.However,no p53-targeting drugs have been approved.Here,we reposition decitabine for triple-negative breast cancer(TNBC),a subtype with frequent p53 mutations and extremely poor prognosis.In a retrospective study on tissue microarrays with 132 TNBC cases,DNMT1 overexpression was associated with p53 mutations(P=0.037)and poor overall survival(OS)(P=0.010).In a prospective DEciTabinE and Carboplatin in TNBC(DETECT)trial(NCT03295552),decitabine with carboplatin produced an objective response rate(ORR)of 42%in 12 patients with stage IV TNBC.Among the 9 trialed patients with available TP53 sequencing results,the 6 patients with p53 mutations had higher ORR(3/6 vs.0/3)and better OS(16.0 vs.4.0 months)than the patients with wild-type p53.In a mechanistic study,isogenic TNBC cell lines harboring DETECT-derived p53 mutations exhibited higher DNMT1 expression and decitabine sensitivity than the cell line with wild-type p53.In the DETECT trial,decitabine induced strong immune responses featuring the striking upregulation of the innate immune player IRF7 in the p53-mutated TNBC cell line(upregulation by 16-fold)and the most responsive patient with TNBC.Our integrative studies reveal the potential of repurposing decitabine for the treatment of p53-mutated TNBC and suggest IRF7 as a potential biomarker for decitabine-based treatments.展开更多
Secondary succession is the process by which a community develops into a climax community over time.However,knowledge on the mechanisms,relating to soil legacy effects(soil chemistry and enzyme activity)and plant-soil...Secondary succession is the process by which a community develops into a climax community over time.However,knowledge on the mechanisms,relating to soil legacy effects(soil chemistry and enzyme activity)and plant-soil feedback(PSF),driving community succession remains limited.In this work,we examined the PSF associated with three succession stage species through a 2-year greenhouse experiment.Setaria viridis,Stipa bungeana,and Bothriochloa ischemum were selected to represent dominant and representative early-,mid-,and late-successional stage species,respectively,of semiarid grasslands on the Loess Plateau.In response to the different soil origin,the shoot biomass of early-,mid-,and late-species were all higher when grown in their own soil than in other species’soils,which indicated that the PSF of three species were positive.Over two growth periods,the early-species experienced a negative PSF,but the mid-and late-species experienced negative,neutral and positive PSF in the soil of early-,mid-and late-species,respectively.Our study demonstrates that soil legacy effects and PSF have a significant impact on community succession processes.展开更多
Exotic species invasion represent important causes of harming the structure,function,and ecological environment in ecosystems.Yet,knowledge remains limited on the invasibility(invasion advantage of exotic species)and ...Exotic species invasion represent important causes of harming the structure,function,and ecological environment in ecosystems.Yet,knowledge remains limited on the invasibility(invasion advantage of exotic species)and recoverability(recovery ability of native species)of a plant community following invasion depend on its successional stages.We selected three grasses of Setaria viridis,Artemisia gmelinii,and Bothriochloa ischemum representing early(E),middle(M),and late(L)successional species,respectively.Meanwhile,the grasses of Panicum virgatum was selected to represent exotic species(invasion species).Three types of soil were collected to treat the three E,M,and L successional species,and one type of soil was collected to treat the exotic species.We compared the performance of the three native plant species and one exotic species grown in their“own”and“other”soils in a 2-year greenhouse experiment.Our study showed that exotic species performed better in soils of E and M successional species than in the soil of L successional species.After exotic species removed,E and M successional species exhibited poor growth in the soil of exotic species,while that of L successional species performed poor in field exotic species soils,but performed better in soils disturbed by exotic species.Our study demonstrated that the invasibility and recoverability of native plant communities changed with vegetation succession.展开更多
基金supported by the National Natural Science Foundation of China(U2243225)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA23070201)the Fundamental Research Funds for the Central Universities in China(2023HHZX002).
文摘Tree plantations are an important forest resource that substantively contributes to climate change mitigation and carbon sequestration.As the area and standing volume of tree plantations in China have increased,issues such as unreasonable structure,low productivity,limited ecological functionality and diminishing ecological stability have occurred,which hinder the ability of tree plantations to enhance carbon sequestration.This study outlined the trajectory of carbon sequestration and its associated benefits in tree plantations by examining the current state of tree plantation establishment and growth,elucidated the strategies for advantages of carbon sequestration and climate change mitigation in planted forests,and summarized the existing problems with tree plantations.This paper underscores the pressing need for concerted efforts to boost carbon sequestration within planted forests and proposes management and development strategies for Chinese tree plantations.In the future,it will be necessary to apply scientific theories to practice and develop multi-objective management optimization models for the high-quality development of tree plantations.This will involve establishing a cohesive national carbon trading market,improving the prediction of carbon sequestration,and identifying priority zones for afforestation and reforestation,to better serve China’s national strategy for achieving peak carbon and carbon neutrality.
文摘Background： The purpose of this study was to analyze the effects of all clinical characteristics on the overall survival time, in order to provide a basis for determining the prognostic factor of patients with pancreatic cancer. Methods： A total of 103 pancreatic cancer patients were admitted to the Department of Radiotherapy and Chemotherapy of the Ruijin Hospital, Shanghai Jiaotong University School of Medicine, between January 2002 and December 2012. There were 68 men and 35 women; the median age was 62 years. Diagnoses of pancreatic cancer in all patients were confirmed by histopathology, cytology, or clinical diagnosis. The Kaplan-Meier method was performed to calculate the overall survival rate. The log-rank method was used to examine the univariate analysis. The Cox regression model was performed for multivariate analysis. Results： The median survival time was 293 days, the 1-, 2-, and 3-year survival rates were 27.18%, 5.83%, and 1.94%, respectively. Cox regression analysis revealed that age （P=0.015）, Karnofsky performance status （PS） （P=0.002）, surgical types （P〈0.001）, and platelet counts （P〈0.001） were independent prognostic factors affecting the overall survival of patients with pancreatic cancer. Conclusions＂ Pancreatic cancer had a poor prognosis, the general physical condition, age, the availability of radical surgery, and platelet counts were factors influencing the overall survival of patients with pancreatic cancer.
基金supported by the National Natural Science Foundation of China(No.82130075 to Min Lu,No.82073292 to Min Lu,No.81772797 to Xiaosong Chen,No.82072937 to Xiaosong Chen,No.82072897 to Kunwei Shen,No.82002773 to Zheng Wang,No.81900157 to Ying Liang)SJTU Transmed Awards Research(to Min Lu),Shanghai Municipal Education Commission-Gaofeng Clinical Medicine(No.828318 to Min Lu and No.20172007 to Xiaosong Chen)+4 种基金Shanghai Excellent Youth Academic Leader(No.20XD1422700 to Min Lu)Program of Shanghai Science and Technology Committee(No.21S11900100 to Min Lu)Dawn Program of Shanghai Education Commission(No.21SG18 to Min Lu)Samuel Waxman Cancer Research Foundation(to Min Lu)Foundation of National Facility for Translational Medicine(Shanghai)(No.NRCTM(SH)-2021-08).
文摘p53 is mutated in half of cancer cases.However,no p53-targeting drugs have been approved.Here,we reposition decitabine for triple-negative breast cancer(TNBC),a subtype with frequent p53 mutations and extremely poor prognosis.In a retrospective study on tissue microarrays with 132 TNBC cases,DNMT1 overexpression was associated with p53 mutations(P=0.037)and poor overall survival(OS)(P=0.010).In a prospective DEciTabinE and Carboplatin in TNBC(DETECT)trial(NCT03295552),decitabine with carboplatin produced an objective response rate(ORR)of 42%in 12 patients with stage IV TNBC.Among the 9 trialed patients with available TP53 sequencing results,the 6 patients with p53 mutations had higher ORR(3/6 vs.0/3)and better OS(16.0 vs.4.0 months)than the patients with wild-type p53.In a mechanistic study,isogenic TNBC cell lines harboring DETECT-derived p53 mutations exhibited higher DNMT1 expression and decitabine sensitivity than the cell line with wild-type p53.In the DETECT trial,decitabine induced strong immune responses featuring the striking upregulation of the innate immune player IRF7 in the p53-mutated TNBC cell line(upregulation by 16-fold)and the most responsive patient with TNBC.Our integrative studies reveal the potential of repurposing decitabine for the treatment of p53-mutated TNBC and suggest IRF7 as a potential biomarker for decitabine-based treatments.
基金supported by the National Natural Science Foundation of China(U1832202,11888101,11920101005,12141402,and 12274459)the Chinese Academy of Sciences(QYZDB-SSW-SLH043,XDB33020100,and XDB28000000)+4 种基金the Beijing Municipal Science and Technology Commission(Z171100002017018,and Z200005)the National Key R&D Program of China(2018YFE0202600,2022YFA1403100,and 2022YFA1403800)the Fundamental Research Funds for the Central Universities and Research Funds of Renmin University of China(RUC)(18XNLG14,19XNLG13,19XNLG17,and 20XNH062)the Synergic Extreme Condition User Facility,Beijing,ChinaBeijing National Laboratory for Condensed Matter Physics。
基金funded by the National Natural Science Foundation of China(42130717)the Shaanxi Science Fund for Distinguished Young Scholars(2021JC-50)。
文摘Secondary succession is the process by which a community develops into a climax community over time.However,knowledge on the mechanisms,relating to soil legacy effects(soil chemistry and enzyme activity)and plant-soil feedback(PSF),driving community succession remains limited.In this work,we examined the PSF associated with three succession stage species through a 2-year greenhouse experiment.Setaria viridis,Stipa bungeana,and Bothriochloa ischemum were selected to represent dominant and representative early-,mid-,and late-successional stage species,respectively,of semiarid grasslands on the Loess Plateau.In response to the different soil origin,the shoot biomass of early-,mid-,and late-species were all higher when grown in their own soil than in other species’soils,which indicated that the PSF of three species were positive.Over two growth periods,the early-species experienced a negative PSF,but the mid-and late-species experienced negative,neutral and positive PSF in the soil of early-,mid-and late-species,respectively.Our study demonstrates that soil legacy effects and PSF have a significant impact on community succession processes.
基金This research were funded by the National Natural Science Foundation of China(41907409 and 41771557)Special Scientific Research Project of Education Department of Shaanxi Provincial Government(19JK0524).
文摘Exotic species invasion represent important causes of harming the structure,function,and ecological environment in ecosystems.Yet,knowledge remains limited on the invasibility(invasion advantage of exotic species)and recoverability(recovery ability of native species)of a plant community following invasion depend on its successional stages.We selected three grasses of Setaria viridis,Artemisia gmelinii,and Bothriochloa ischemum representing early(E),middle(M),and late(L)successional species,respectively.Meanwhile,the grasses of Panicum virgatum was selected to represent exotic species(invasion species).Three types of soil were collected to treat the three E,M,and L successional species,and one type of soil was collected to treat the exotic species.We compared the performance of the three native plant species and one exotic species grown in their“own”and“other”soils in a 2-year greenhouse experiment.Our study showed that exotic species performed better in soils of E and M successional species than in the soil of L successional species.After exotic species removed,E and M successional species exhibited poor growth in the soil of exotic species,while that of L successional species performed poor in field exotic species soils,but performed better in soils disturbed by exotic species.Our study demonstrated that the invasibility and recoverability of native plant communities changed with vegetation succession.
