Objective To explore the role of serum fibrotic indices including hyaluronic acid （HA）, procollagen type Ⅲ NH2-terminal peptide （PCIIIP）, and laminin （LN） in assessing the severity of myocardial fibrosis in chr...Objective To explore the role of serum fibrotic indices including hyaluronic acid （HA）, procollagen type Ⅲ NH2-terminal peptide （PCIIIP）, and laminin （LN） in assessing the severity of myocardial fibrosis in chronic congestive heart failure （CHF）. Methods Serum levels of HA, PCIIIP, and LN in 39 patients with CHF E [14 with New York Heart Association （NYHA） functional class II, 21 with class Ⅲ, 4 with class Ⅳ] and in 46 patients with NYHA functional class I were assessed by radioimmunoassay. Results The serum concentrations of HA, PCMP, and LN were 359.75 ± 84.59 μg/L, 77.88 ± 24. 67 μg/L, 86. 73 ± 23.90 μg/L in CHF group, and 211.60 ±54. 80 μg/L, 64.82 ±23.99 μg/L, 82. 26 ±23.98 μg/L in NYHA functional class Ⅰ group, respectively. The HA level was significantly higher in CHF patients as compared with NYHA functional class Ⅰ group （ P 〈 0.05 ）. However, no difference was found in the levels of PCIIIP and LN between CHF group and NYHA functional class Ⅰ group. The serum HA concentration was negatively correlated with left ventricular ejection fraction （ r = - 0.71, P 〈 0.05 ）. Conclusion Serum HA level may act as an indicator for myocardial fibrosis.展开更多
Additively manufactured Ti-6Al-4V(TC4)parts have been successfully employed as artificial implants in dental and orthopedic surgery due to their excellent mechanical properties.However,the suboptimal corrosion resista...Additively manufactured Ti-6Al-4V(TC4)parts have been successfully employed as artificial implants in dental and orthopedic surgery due to their excellent mechanical properties.However,the suboptimal corrosion resistance limits their applications.The surface characterization and corrosion behavior of micro-arc oxidation(MAO)treated TC4 alloy prepared by selective electron beam melting(SEBM)and selective laser melting(SLM)technologies were compared.The corrosion resistance mechanism of SLM-MAO and SEBM-MAO was clarified through the analysis of the microstructure evolution,surface morphology,and electrochemical experiments.The results show that the anatase-type TiO_(2) is partially transformed into the slankite phase after MAO treatment.The surface roughness of SEBM sample was reduced by MAO coating,while the surface roughness of SLM sample increased after MAO,which is related to the difference between the microstructure of the deposited samples caused by different additive manufacturing technologies.When MAO time was 15 min,SLM-MAO and SEBM-MAO coating displayed the best and the worst corrosion resistance,respectively.展开更多
Ferroelectricity and metallicity are usually believed not to coexist because conducting electrons would screen out static internal electric fields.In 1965,Anderson and Blount proposed the concept of"ferroelectric...Ferroelectricity and metallicity are usually believed not to coexist because conducting electrons would screen out static internal electric fields.In 1965,Anderson and Blount proposed the concept of"ferroelectric metal",however,it is only until recently that very rare ferroelectric metals were reported.Here,by combining high-throughput ab initio calculations and data-driven machine learning method with new electronic orbital based descriptors,we systematically investigated a large family(2964)of two-dimensional(2D)bimetal phosphates,and discovered 60 stable ferroelectrics with out-of-plane polarization,including 16 ferroelectric metals and 44 ferroelectric semiconductors that contain seven multiferroics.The ferroelectricity origins from spontaneous symmetry breaking induced by the opposite displacements of bimetal atoms,and the full-d-orbital coinage metal elements cause larger displacements and polarization than other elements.For 2D ferroelectric metals,the odd electrons per unit cell without spin polarization may lead to a half-filled energy band around Fermi level and is responsible for the metallicity.It is revealed that the conducting electrons mainly move on a single-side surface of the 2D layer,while both the ionic and electric contributions to polarization come from the other side and are vertical to the above layer,thereby causing the coexistence of metallicity and ferroelectricity.Van der Waals heterostructures based on ferroelectric metals may enable the change of Schottky barrier height or the Schottky-Ohmic contact type and induce a dramatic change of their vertical transport properties.Our work greatly expands the family of 2D ferroelectric metals and will spur further exploration of 2D ferroelectric metals.展开更多
Two-dimensional(2D)ferromagnetic and ferroelectric materials attract unprecedented attention due to the spontaneous-symmetry-breaking induced novel properties and multifarious potential applications.Here we systematic...Two-dimensional(2D)ferromagnetic and ferroelectric materials attract unprecedented attention due to the spontaneous-symmetry-breaking induced novel properties and multifarious potential applications.Here we systematically investigate a large family(148)of 2D MGeX3(M=metal elements,X=O/S/Se/Te)by means of the high-throughput first-principles calculations,and focus on their possible ferroic properties including ferromagnetism,ferroelectricity,and ferroelasticity.We discover eight stable 2D ferromagnets including five semiconductors and three half-metals,212D antiferromagnets,and 11 stable 2D ferroelectric semiconductors including two multiferroic materials.Particularly,MnGeSe3 and MnGeTe3 are predicted to be room-temperature 2D ferromagnetic half metals with Tc of 490 and 308 K,respectively.It is probably for the first time that ferroelectricity is uncovered in 2D MGeX3 family,which derives from the spontaneous symmetry breaking induced by unexpected displacements of Ge-Ge atomic pairs,and we also reveal that the electric polarizations are in proportion to the ratio of electronegativity of X and M atoms,and IVB group metal elements are highly favored for 2D ferroelectricity.Magnetic tunnel junction and water-splitting photocatalyst based on 2D ferroic MGeX3 are proposed as examples of wide potential applications.The atlas of ferroicity in 2D MGeX3 materials will spur great interest in experimental studies and would lead to diverse applications.展开更多
K-ion batteries(KIBs)hold great promise for large-scale energy storage.However,the absence of suitable cathode materials limits their practical application.Meanwhile,rationally designing advanced cathode materials for...K-ion batteries(KIBs)hold great promise for large-scale energy storage.However,the absence of suitable cathode materials limits their practical application.Meanwhile,rationally designing advanced cathode materials for KIBs remains an open question.In this work,based on density functional theory calculations,we find that the bond stability of Fe–O is higher than that of Co–O in layered transitional metal(TM)oxides.Additionally,the K-ion migration in the Fe-based layered TM oxide has a significantly lower activation energy barrier than that in the Co-based one.Based on this theoretical prediction,we successfully synthesized a low-cost K_(0.45)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)cathode,which shows excellent structural stability and superior K-storage properties,including durable cycle life and high-rate capability.Moreover,the designed K_(0.45)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)cathode possesses a great full-cell performance with a discharge capacity of~75 mA h g^(-1) and capacity retention of~80%after 100 cycles.The results show that Fe has better structural stability and K-ion diffusion than high-cost Co in layered oxide cathodes,and this finding provides new insights into the design of low-cost and high-performance KIB layered cathodes.This work highlights the feasibility of a theory-guided experiment in screening promising battery materials.展开更多
文摘Objective To explore the role of serum fibrotic indices including hyaluronic acid （HA）, procollagen type Ⅲ NH2-terminal peptide （PCIIIP）, and laminin （LN） in assessing the severity of myocardial fibrosis in chronic congestive heart failure （CHF）. Methods Serum levels of HA, PCIIIP, and LN in 39 patients with CHF E [14 with New York Heart Association （NYHA） functional class II, 21 with class Ⅲ, 4 with class Ⅳ] and in 46 patients with NYHA functional class I were assessed by radioimmunoassay. Results The serum concentrations of HA, PCMP, and LN were 359.75 ± 84.59 μg/L, 77.88 ± 24. 67 μg/L, 86. 73 ± 23.90 μg/L in CHF group, and 211.60 ±54. 80 μg/L, 64.82 ±23.99 μg/L, 82. 26 ±23.98 μg/L in NYHA functional class Ⅰ group, respectively. The HA level was significantly higher in CHF patients as compared with NYHA functional class Ⅰ group （ P 〈 0.05 ）. However, no difference was found in the levels of PCIIIP and LN between CHF group and NYHA functional class Ⅰ group. The serum HA concentration was negatively correlated with left ventricular ejection fraction （ r = - 0.71, P 〈 0.05 ）. Conclusion Serum HA level may act as an indicator for myocardial fibrosis.
基金funded by the National Natural Science Foundation of China (Nos.51671152 and 51874225)the Industrialization Project of Shaanxi Education Department (18JCO19)+1 种基金the Key Research and Development Program of Shaanxi Province (2020ZDLGY13-10)the Science and Technology Plan Project of Xi'an (2020KJRC0048).
文摘Additively manufactured Ti-6Al-4V(TC4)parts have been successfully employed as artificial implants in dental and orthopedic surgery due to their excellent mechanical properties.However,the suboptimal corrosion resistance limits their applications.The surface characterization and corrosion behavior of micro-arc oxidation(MAO)treated TC4 alloy prepared by selective electron beam melting(SEBM)and selective laser melting(SLM)technologies were compared.The corrosion resistance mechanism of SLM-MAO and SEBM-MAO was clarified through the analysis of the microstructure evolution,surface morphology,and electrochemical experiments.The results show that the anatase-type TiO_(2) is partially transformed into the slankite phase after MAO treatment.The surface roughness of SEBM sample was reduced by MAO coating,while the surface roughness of SLM sample increased after MAO,which is related to the difference between the microstructure of the deposited samples caused by different additive manufacturing technologies.When MAO time was 15 min,SLM-MAO and SEBM-MAO coating displayed the best and the worst corrosion resistance,respectively.
基金the National Key R&D Program of China(2018YFA0305800)the Strategic Priority Research Program of Chinese Academy of Sciences(XDB28000000)+2 种基金the National Natural Science Foundation of China(11834014)Beijing Municipal Science and Technology Commission(Z191100007219013)University of Chinese Academy of Sciences。
文摘Ferroelectricity and metallicity are usually believed not to coexist because conducting electrons would screen out static internal electric fields.In 1965,Anderson and Blount proposed the concept of"ferroelectric metal",however,it is only until recently that very rare ferroelectric metals were reported.Here,by combining high-throughput ab initio calculations and data-driven machine learning method with new electronic orbital based descriptors,we systematically investigated a large family(2964)of two-dimensional(2D)bimetal phosphates,and discovered 60 stable ferroelectrics with out-of-plane polarization,including 16 ferroelectric metals and 44 ferroelectric semiconductors that contain seven multiferroics.The ferroelectricity origins from spontaneous symmetry breaking induced by the opposite displacements of bimetal atoms,and the full-d-orbital coinage metal elements cause larger displacements and polarization than other elements.For 2D ferroelectric metals,the odd electrons per unit cell without spin polarization may lead to a half-filled energy band around Fermi level and is responsible for the metallicity.It is revealed that the conducting electrons mainly move on a single-side surface of the 2D layer,while both the ionic and electric contributions to polarization come from the other side and are vertical to the above layer,thereby causing the coexistence of metallicity and ferroelectricity.Van der Waals heterostructures based on ferroelectric metals may enable the change of Schottky barrier height or the Schottky-Ohmic contact type and induce a dramatic change of their vertical transport properties.Our work greatly expands the family of 2D ferroelectric metals and will spur further exploration of 2D ferroelectric metals.
基金This work is supported in part by the National Key R&D Program of China(No.2018YFA0305800)the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB28000000)+2 种基金the National Natural Science Foundation of China(No.11834014)the Beijing Municipal Science and Technology Commission(No.Z118100004218001)the fundamental research funds for the central universities,and University of Chinese Academy of Sciences.
文摘Two-dimensional(2D)ferromagnetic and ferroelectric materials attract unprecedented attention due to the spontaneous-symmetry-breaking induced novel properties and multifarious potential applications.Here we systematically investigate a large family(148)of 2D MGeX3(M=metal elements,X=O/S/Se/Te)by means of the high-throughput first-principles calculations,and focus on their possible ferroic properties including ferromagnetism,ferroelectricity,and ferroelasticity.We discover eight stable 2D ferromagnets including five semiconductors and three half-metals,212D antiferromagnets,and 11 stable 2D ferroelectric semiconductors including two multiferroic materials.Particularly,MnGeSe3 and MnGeTe3 are predicted to be room-temperature 2D ferromagnetic half metals with Tc of 490 and 308 K,respectively.It is probably for the first time that ferroelectricity is uncovered in 2D MGeX3 family,which derives from the spontaneous symmetry breaking induced by unexpected displacements of Ge-Ge atomic pairs,and we also reveal that the electric polarizations are in proportion to the ratio of electronegativity of X and M atoms,and IVB group metal elements are highly favored for 2D ferroelectricity.Magnetic tunnel junction and water-splitting photocatalyst based on 2D ferroic MGeX3 are proposed as examples of wide potential applications.The atlas of ferroicity in 2D MGeX3 materials will spur great interest in experimental studies and would lead to diverse applications.
基金supported by the Fundamental Research Funds for the Central Universities and the Scientific Instrument Developing Project of the Chinese Academy of Sciences(ZDKYYQ20170001)。
文摘K-ion batteries(KIBs)hold great promise for large-scale energy storage.However,the absence of suitable cathode materials limits their practical application.Meanwhile,rationally designing advanced cathode materials for KIBs remains an open question.In this work,based on density functional theory calculations,we find that the bond stability of Fe–O is higher than that of Co–O in layered transitional metal(TM)oxides.Additionally,the K-ion migration in the Fe-based layered TM oxide has a significantly lower activation energy barrier than that in the Co-based one.Based on this theoretical prediction,we successfully synthesized a low-cost K_(0.45)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)cathode,which shows excellent structural stability and superior K-storage properties,including durable cycle life and high-rate capability.Moreover,the designed K_(0.45)Ni_(0.1)Fe_(0.1)Mn_(0.8)O_(2)cathode possesses a great full-cell performance with a discharge capacity of~75 mA h g^(-1) and capacity retention of~80%after 100 cycles.The results show that Fe has better structural stability and K-ion diffusion than high-cost Co in layered oxide cathodes,and this finding provides new insights into the design of low-cost and high-performance KIB layered cathodes.This work highlights the feasibility of a theory-guided experiment in screening promising battery materials.
