The design and manufacture of anti-scaling surface is a prospective way to prevent scaling in oil field.In this work,a novel superhydrophobic Cu^(2+)-loaded and DTPMPA-modified anodized copper oxide(S-Cu^(2+)/D-ACO)co...The design and manufacture of anti-scaling surface is a prospective way to prevent scaling in oil field.In this work,a novel superhydrophobic Cu^(2+)-loaded and DTPMPA-modified anodized copper oxide(S-Cu^(2+)/D-ACO)coating was fabricated by modification of 1H,1H,2H,2H-perfluorodecyltriethoxysilane.The valid storing of scale inhibitors at the coating surface and the interfacial release of Cu^(2+)ions contribute to enhancing the anti-scaling of the S-Cu^(2+)/D-ACO coating.The water contact angle of the S-Cu^(2+)/D-ACO coating is 163.03°and exhibits superhydrophobicity,which makes it difficult for CaCO_(3)to deposit at the surface of the coating.DTPMPA will steadily lurk into the inner space,and Cu^(2+)will be loaded at the interface in the form of the DTPMPA:Cu^(2+)chelate.During the deposition of CaCO_(3),the dynamic release of DTPMPA can be realized by transferring DTPMPA:Cu^(2+)to DTPMPA:Ca^(2+).Interestingly,the released Cu^(2+)hinders the active growth of CaCO_(3).After 48 h of scaling,the mass of CaCO_(3)scale at the S-Cu^(2+)/D-ACO coating surface is only 44.1%that of the anodized copper oxide coating.The excellent anti-scaling performance of the S-Cu^(2+)/D-ACO coating is determined by the synergistic effect of the DTPMPA lurking and dynamic release,as well as the Cu^(2+)inhibition at the interface of superhydrophobic coating and against CaCO_(3)deposition.This research provides a new exploration for designing and fabricating anti-scaling superhydrophobic surface for oil field development.展开更多
Objective:The objective is to study the network pharmacology of Qixiong formula(QXF)and explore the mechanism of QXF in the treatment of oligoasthenospermia.Materials and Methods:Using Traditional Chinese Medicine Sys...Objective:The objective is to study the network pharmacology of Qixiong formula(QXF)and explore the mechanism of QXF in the treatment of oligoasthenospermia.Materials and Methods:Using Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),a Bioinformatics Analysis Tool for Molecular mech ANism of Traditional Chinese Medicine(BATMAN-traditional Chinese medicine),and an encyclopaedia of traditional Chinese medicine(ETCM)databases as well as data from relevant studies,the effective components and targets of QXF were obtained.Genes associated with oligospermia were screened using Gene Cards,OMIM,Dis Ge Net,Drug Bank,and GAD databases.The intersection target was obtained by mapping the target to the gene,and the protein interaction network was created using the STRING database to screen the core target of QXF in the treatment of oligospermia.The intersection target was enriched using gene ontology(GO)and the Kyoto Encyclopedia of genes and genomes(KEGG)pathway analysis with the DAVID database.The network of the disease drug target pathway was drawn using Cytoscape software.Results:Overall,536 active components of QXF and 40 core targets for the treatment of oligoasthenozoospermia were obtained.The analysis of GO and KEGG showed that QXF is mainly involved in oxidative stress,cell motility,nutritional response,and other biological processes.Through the regulation of FOXO,p53,PI3 K/Akt,MAPK,mammalian target of rapamycin,Foxo,Wnt,and other signaling pathways,QXF played a role in the treatment of oligoasthenospermia.Conclusion:QXF has multi-component,multi-target,and multi-channel characteristics,providing a new way to study the mechanism of QXF in the treatment of oligoasthenospermia.展开更多
基金financially supported by the National Science Foundation for Distinguished Young Scholars of China(Grant No.51925403)the Major Research Plan of National Natural Science Foundation of China(Grant No.91934302)the National Science Foundation of China(21676052,21606042)
文摘The design and manufacture of anti-scaling surface is a prospective way to prevent scaling in oil field.In this work,a novel superhydrophobic Cu^(2+)-loaded and DTPMPA-modified anodized copper oxide(S-Cu^(2+)/D-ACO)coating was fabricated by modification of 1H,1H,2H,2H-perfluorodecyltriethoxysilane.The valid storing of scale inhibitors at the coating surface and the interfacial release of Cu^(2+)ions contribute to enhancing the anti-scaling of the S-Cu^(2+)/D-ACO coating.The water contact angle of the S-Cu^(2+)/D-ACO coating is 163.03°and exhibits superhydrophobicity,which makes it difficult for CaCO_(3)to deposit at the surface of the coating.DTPMPA will steadily lurk into the inner space,and Cu^(2+)will be loaded at the interface in the form of the DTPMPA:Cu^(2+)chelate.During the deposition of CaCO_(3),the dynamic release of DTPMPA can be realized by transferring DTPMPA:Cu^(2+)to DTPMPA:Ca^(2+).Interestingly,the released Cu^(2+)hinders the active growth of CaCO_(3).After 48 h of scaling,the mass of CaCO_(3)scale at the S-Cu^(2+)/D-ACO coating surface is only 44.1%that of the anodized copper oxide coating.The excellent anti-scaling performance of the S-Cu^(2+)/D-ACO coating is determined by the synergistic effect of the DTPMPA lurking and dynamic release,as well as the Cu^(2+)inhibition at the interface of superhydrophobic coating and against CaCO_(3)deposition.This research provides a new exploration for designing and fabricating anti-scaling superhydrophobic surface for oil field development.
基金supported by the Youth Program of the National Natural Science Foundation of China(81703929)the Fundamental Research Funds for Central Public Welfare research institutes(ZZ070855,ZZ11-062)Beijing Traditional Chinese Medicine Science and Technology Development Fund Project(JJ-2020-76)
文摘Objective:The objective is to study the network pharmacology of Qixiong formula(QXF)and explore the mechanism of QXF in the treatment of oligoasthenospermia.Materials and Methods:Using Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),a Bioinformatics Analysis Tool for Molecular mech ANism of Traditional Chinese Medicine(BATMAN-traditional Chinese medicine),and an encyclopaedia of traditional Chinese medicine(ETCM)databases as well as data from relevant studies,the effective components and targets of QXF were obtained.Genes associated with oligospermia were screened using Gene Cards,OMIM,Dis Ge Net,Drug Bank,and GAD databases.The intersection target was obtained by mapping the target to the gene,and the protein interaction network was created using the STRING database to screen the core target of QXF in the treatment of oligospermia.The intersection target was enriched using gene ontology(GO)and the Kyoto Encyclopedia of genes and genomes(KEGG)pathway analysis with the DAVID database.The network of the disease drug target pathway was drawn using Cytoscape software.Results:Overall,536 active components of QXF and 40 core targets for the treatment of oligoasthenozoospermia were obtained.The analysis of GO and KEGG showed that QXF is mainly involved in oxidative stress,cell motility,nutritional response,and other biological processes.Through the regulation of FOXO,p53,PI3 K/Akt,MAPK,mammalian target of rapamycin,Foxo,Wnt,and other signaling pathways,QXF played a role in the treatment of oligoasthenospermia.Conclusion:QXF has multi-component,multi-target,and multi-channel characteristics,providing a new way to study the mechanism of QXF in the treatment of oligoasthenospermia.
