BACKGROUND Cervical dystonia(CD)is a type of muscle tone disorder that usually occurs in the neck muscles.Due to the intermittent or continuous involuntary contraction of the neck muscles,the head and neck are twisted...BACKGROUND Cervical dystonia(CD)is a type of muscle tone disorder that usually occurs in the neck muscles.Due to the intermittent or continuous involuntary contraction of the neck muscles,the head and neck are twisted and skewed and some postural abnormalities occur.Long-term abnormal posture or pain can cause negative emotions in patients,which can affect their quality of life.CASE SUMMARY This case report included a 37-year-old woman who was diagnosed with CD associated with anxiety and depression;the accompanying symptoms were head and neck tilt of approximately 90°to the right and mental abnormality.After two courses of acupuncture treatment,the patient’s head and neck can be maintained in a normal position,and the negative emotions can be relieved.CONCLUSION This case indicates that acupuncture can effectively improve CD and the emotional state and quality of life of patients,making it an effective alternative treatment for the condition.展开更多
BACKGROUND: It is a globally challenging problem to differentially diagnose biliary atresia (BA) from other disease processes causing infantile cholestatic jaundice. The high frequency ultrasonography (HUS) yields muc...BACKGROUND: It is a globally challenging problem to differentially diagnose biliary atresia (BA) from other disease processes causing infantile cholestatic jaundice. The high frequency ultrasonography (HUS) yields much improved spatial resolution and therefore, might show better image in BA diagnostic examination. The present study was to evaluate the HUS on the diagnosis of BA in infants with jaundice. METHODS: Fifty-one infants with neonatal jaundice were scanned with ultrasonography. Images included gallbladder, bile duct, right hepatic artery (RHA), portal vein (PV) and triangular cord (TC) sign, magnetic resonance imaging and additionally laboratory tests and histopathology reports were assessed. RESULTS: Twenty-three BA and 28 non-BA cases were con firmed. The sensitivity, specificity, and accuracy of HUS were 91.3%, 92.9%, and 92.2%, respectively. All of these indices were significantly higher than those of conventional ultrasonography (P<0.01) and MR cholangiopancreatography (P<0.05). The HUS features, included a positive TC sign, an increased RHA diameter and RHA-diameter to portal-vein-diameter ratio (RHA/PV) and abnormal gallbladder, were important in the diagnosis of BA. CONCLUSION: HUS provided better imaging of BA and should be considered as a primary modality in the differential diagnosis of infantile jaundice.展开更多
OBJECTIVE: To assess the value of color Doppler ultrasonography in monitoring normal orthotopic livertransplantation and postoperative complications.METHODS: Forty-one patients after orthotopic liver transplantation w...OBJECTIVE: To assess the value of color Doppler ultrasonography in monitoring normal orthotopic livertransplantation and postoperative complications.METHODS: Forty-one patients after orthotopic liver transplantation were examined by using colorDoppler flow imaging to observe the hepatic blood flow and change of ultrasonography of the hepaticparenchyma and bile duct. The measured indexes included maximum blood flow velocity, time-averageblood flow velocity (TAV), resistance index (RI) and diameter of the bile duct.RESULTS: Among 41 patients, 17 (41.5%) suffered from liver transplant rejection. Of the 17patients, 13 (76.4%) showed decrease of TAV of the portal vein, 15 (88.25%) low-amplitudesingle-phase serrated wave or negative biphasic wave of the hepatic vein, 9 (52.9%) increased hepaticarterial RI, and 5 (29.4%) slightly dilated bile duct. Sonography showed disappearance of the hepaticartery blood flow around the portal vein in 5 (12.2%) of the 41 patients with hepatic artery thrombosisin the postoperative period. Slight dilatation of the intrahepatic bile duct was found in 3 (7.3%) of the41 patients in the early postoperational period and it normalized within 2 weeks. Ultrasonography of20 patients (48.8%) revealed a visible dilatation of the intrahepatic bile duct, which was worseninggradually. The causes of bile duct dilatation included biliary stricture in 2 patients (10%), stone in 15patients (75%) and others in 3 patients (15%).CONCLUSIONS: Color Doppler ultrasonography is valuable for monitoring normal liver transplantationand postoperative complications.展开更多
Objective:To explore the effect differences between moxibustion and donepezil hydrochloride on the attention network function of patients with mild cognitive impairment(MCI).Methods:A total of 64 patients of MCI were ...Objective:To explore the effect differences between moxibustion and donepezil hydrochloride on the attention network function of patients with mild cognitive impairment(MCI).Methods:A total of 64 patients of MCI were randomly divided into the moxibustion group and donepezil hydrochloride group,32 cases in each one.On the basis of conventional treatment,the patients in the moxibustion group were given moxibustion,6 times a week,and the patients in the donepezil hydrochloride group were given donepezil hydrochloride orally,5 mg/day.The course of treatment was 60 days for both of the groups.Cognitive attention network function and activities of daily living(ADL)score were examined before and after treatment.Results:The differences of alerting reaction time(RT),executive control RT,overall mean RT and accuracy of the moxibustion group after treatment were significantly higher than those of the donepezil hydrochloride group[alert:(60.3±3.3)ms vs(48.3±3.7)ms,P<0.05;executive control:(81.2±3.2)ms vs(91.7±4.2)ms,P<0.05;total reaction time:(500.4±17.2)ms vs(536.2±20.1)ms.P<0.05;accuracy:(83.7±4.6)%vs(77.4±4.3)%,P<0.05].After treatment,the ADL scores of the both groups were significantly higher than those before treatment[the moxibustion group:(56.47±4.02)points vs(41.53±4.06)points,P<0.05;the donepezil hydrochloride group:(50.75±4.05)points vs(40.84±3.67)points,P<0.05],and the ADL score of the moxibustion group was significantly higher than that of the donepezil hydrochloride group[(56.47±4.02)points vs(50.75±4.05)points,P<0.05].Conclusion:Compared with donepezil hydrochloride,moxibustion has a better effect on the cognitive function of MCI patients.展开更多
Background:Vessels with different microcirculation patterns are required for glioblastoma(GBM)growth.However,details of the microcirculation patterns in GBM remain unclear.Here,we examined the microcirculation pattern...Background:Vessels with different microcirculation patterns are required for glioblastoma(GBM)growth.However,details of the microcirculation patterns in GBM remain unclear.Here,we examined the microcirculation patterns of GBM and analyzed their roles in patient prognosis together with two well-known GMB prognosis factors(O^(6)-methylguanine DNA methyltransferase[MGMT]promoter methylation status and isocitrate dehydrogenase[IDH]mutations).Methods:Eighty GBM clinical specimens were collected from patients diagnosed between January 2000 and December 2012.The microcirculation patterns,including endothelium-dependent vessels(EDVs),extracellular matrix-dependent vessels(ECMDVs),GBM cell-derived vessels(GDVs),and mosaic vessels(MVs),were evaluated by immunohistochemistry(IHC)and immunofluorescence(IF)staining in both GBM clinical specimens and xenograft tissues.Vascular density assessments and three-dimensional reconstruction were performed.MGMT promoter methylation status was determined by methylation-specific PCR,and IDH1/2 mutations were detected by Sanger sequencing.The relationship between the microcirculation patterns and patient prognosis was analyzed by Kaplan-Meier method.Results:All 4 microcirculation patterns were observed in both GBM clinical specimens and xenograft tissues.EDVs were detected in all tissue samples,while the other three patterns were observed in a small number of tissue samples(ECMDVs in 27.5%,GDVs in 43.8%,and MVs in 52.5%tissue samples).GDV-positive patients had a median survival of 9.56 months versus 13.60 months for GDV-negative patients(P=0.015).In MGMT promoter-methylated cohort,GDV-positive patients had a median survival of 6.76 months versus 14.23 months for GDV-negative patients(P=0.022).Conclusion:GDVs might be a negative predictor for the survival of GBM patients,even in those with MGMT promoter methylation.展开更多
基金Supported by Anhui Provincial Key R&D Program,No.202304295107020102。
文摘BACKGROUND Cervical dystonia(CD)is a type of muscle tone disorder that usually occurs in the neck muscles.Due to the intermittent or continuous involuntary contraction of the neck muscles,the head and neck are twisted and skewed and some postural abnormalities occur.Long-term abnormal posture or pain can cause negative emotions in patients,which can affect their quality of life.CASE SUMMARY This case report included a 37-year-old woman who was diagnosed with CD associated with anxiety and depression;the accompanying symptoms were head and neck tilt of approximately 90°to the right and mental abnormality.After two courses of acupuncture treatment,the patient’s head and neck can be maintained in a normal position,and the negative emotions can be relieved.CONCLUSION This case indicates that acupuncture can effectively improve CD and the emotional state and quality of life of patients,making it an effective alternative treatment for the condition.
基金supported by agrant from the New Technology and Service Project of Tongji Hospital(2008057)
文摘BACKGROUND: It is a globally challenging problem to differentially diagnose biliary atresia (BA) from other disease processes causing infantile cholestatic jaundice. The high frequency ultrasonography (HUS) yields much improved spatial resolution and therefore, might show better image in BA diagnostic examination. The present study was to evaluate the HUS on the diagnosis of BA in infants with jaundice. METHODS: Fifty-one infants with neonatal jaundice were scanned with ultrasonography. Images included gallbladder, bile duct, right hepatic artery (RHA), portal vein (PV) and triangular cord (TC) sign, magnetic resonance imaging and additionally laboratory tests and histopathology reports were assessed. RESULTS: Twenty-three BA and 28 non-BA cases were con firmed. The sensitivity, specificity, and accuracy of HUS were 91.3%, 92.9%, and 92.2%, respectively. All of these indices were significantly higher than those of conventional ultrasonography (P<0.01) and MR cholangiopancreatography (P<0.05). The HUS features, included a positive TC sign, an increased RHA diameter and RHA-diameter to portal-vein-diameter ratio (RHA/PV) and abnormal gallbladder, were important in the diagnosis of BA. CONCLUSION: HUS provided better imaging of BA and should be considered as a primary modality in the differential diagnosis of infantile jaundice.
文摘OBJECTIVE: To assess the value of color Doppler ultrasonography in monitoring normal orthotopic livertransplantation and postoperative complications.METHODS: Forty-one patients after orthotopic liver transplantation were examined by using colorDoppler flow imaging to observe the hepatic blood flow and change of ultrasonography of the hepaticparenchyma and bile duct. The measured indexes included maximum blood flow velocity, time-averageblood flow velocity (TAV), resistance index (RI) and diameter of the bile duct.RESULTS: Among 41 patients, 17 (41.5%) suffered from liver transplant rejection. Of the 17patients, 13 (76.4%) showed decrease of TAV of the portal vein, 15 (88.25%) low-amplitudesingle-phase serrated wave or negative biphasic wave of the hepatic vein, 9 (52.9%) increased hepaticarterial RI, and 5 (29.4%) slightly dilated bile duct. Sonography showed disappearance of the hepaticartery blood flow around the portal vein in 5 (12.2%) of the 41 patients with hepatic artery thrombosisin the postoperative period. Slight dilatation of the intrahepatic bile duct was found in 3 (7.3%) of the41 patients in the early postoperational period and it normalized within 2 weeks. Ultrasonography of20 patients (48.8%) revealed a visible dilatation of the intrahepatic bile duct, which was worseninggradually. The causes of bile duct dilatation included biliary stricture in 2 patients (10%), stone in 15patients (75%) and others in 3 patients (15%).CONCLUSIONS: Color Doppler ultrasonography is valuable for monitoring normal liver transplantationand postoperative complications.
基金Supported by National natural science foundation:81574075Natural Science Foundation of Anhui Province:1608085MH184。
文摘Objective:To explore the effect differences between moxibustion and donepezil hydrochloride on the attention network function of patients with mild cognitive impairment(MCI).Methods:A total of 64 patients of MCI were randomly divided into the moxibustion group and donepezil hydrochloride group,32 cases in each one.On the basis of conventional treatment,the patients in the moxibustion group were given moxibustion,6 times a week,and the patients in the donepezil hydrochloride group were given donepezil hydrochloride orally,5 mg/day.The course of treatment was 60 days for both of the groups.Cognitive attention network function and activities of daily living(ADL)score were examined before and after treatment.Results:The differences of alerting reaction time(RT),executive control RT,overall mean RT and accuracy of the moxibustion group after treatment were significantly higher than those of the donepezil hydrochloride group[alert:(60.3±3.3)ms vs(48.3±3.7)ms,P<0.05;executive control:(81.2±3.2)ms vs(91.7±4.2)ms,P<0.05;total reaction time:(500.4±17.2)ms vs(536.2±20.1)ms.P<0.05;accuracy:(83.7±4.6)%vs(77.4±4.3)%,P<0.05].After treatment,the ADL scores of the both groups were significantly higher than those before treatment[the moxibustion group:(56.47±4.02)points vs(41.53±4.06)points,P<0.05;the donepezil hydrochloride group:(50.75±4.05)points vs(40.84±3.67)points,P<0.05],and the ADL score of the moxibustion group was significantly higher than that of the donepezil hydrochloride group[(56.47±4.02)points vs(50.75±4.05)points,P<0.05].Conclusion:Compared with donepezil hydrochloride,moxibustion has a better effect on the cognitive function of MCI patients.
基金National Basic Research Program of China,Grant/Award Number:2015CB755505National Natural Science Foundation of China,Grant/Award Numbers:30973478,81372685,81572479,81672484+4 种基金Guangzhou Science Technology Project,Grant/Award Numbers:201508020125,201803010056Science and Technology Planning Project of Guangdong Province,Grant/Award Number:2016A020213004Natural Science Foundation of Guangdong Province,Grant/Award Number:S2013040012894Shenzhen Innovation Project of Scientific and Technology,Grant/Award Number:JCYJ20140416094330210We sincerely appreciate the generous help from the core facility in the Department of Experimental Research,Sun Yat-sen University Cancer Center.
文摘Background:Vessels with different microcirculation patterns are required for glioblastoma(GBM)growth.However,details of the microcirculation patterns in GBM remain unclear.Here,we examined the microcirculation patterns of GBM and analyzed their roles in patient prognosis together with two well-known GMB prognosis factors(O^(6)-methylguanine DNA methyltransferase[MGMT]promoter methylation status and isocitrate dehydrogenase[IDH]mutations).Methods:Eighty GBM clinical specimens were collected from patients diagnosed between January 2000 and December 2012.The microcirculation patterns,including endothelium-dependent vessels(EDVs),extracellular matrix-dependent vessels(ECMDVs),GBM cell-derived vessels(GDVs),and mosaic vessels(MVs),were evaluated by immunohistochemistry(IHC)and immunofluorescence(IF)staining in both GBM clinical specimens and xenograft tissues.Vascular density assessments and three-dimensional reconstruction were performed.MGMT promoter methylation status was determined by methylation-specific PCR,and IDH1/2 mutations were detected by Sanger sequencing.The relationship between the microcirculation patterns and patient prognosis was analyzed by Kaplan-Meier method.Results:All 4 microcirculation patterns were observed in both GBM clinical specimens and xenograft tissues.EDVs were detected in all tissue samples,while the other three patterns were observed in a small number of tissue samples(ECMDVs in 27.5%,GDVs in 43.8%,and MVs in 52.5%tissue samples).GDV-positive patients had a median survival of 9.56 months versus 13.60 months for GDV-negative patients(P=0.015).In MGMT promoter-methylated cohort,GDV-positive patients had a median survival of 6.76 months versus 14.23 months for GDV-negative patients(P=0.022).Conclusion:GDVs might be a negative predictor for the survival of GBM patients,even in those with MGMT promoter methylation.
