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Distribution pattern of Caragana species under the influence of climate gradient in the Inner Mongolia region, China 被引量:7
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作者 liNa XIE ChengCang MA +2 位作者 HongYu GUO qingfang li YuBao GAO 《Journal of Arid Land》 SCIE CSCD 2014年第3期311-323,共13页
There is a strong climate gradient in the Inner Mongolia region, China, with solar radiation and air temperature increasing but precipitation decreasing gradually from the northeast to the southwest. Sixteen Cara- gan... There is a strong climate gradient in the Inner Mongolia region, China, with solar radiation and air temperature increasing but precipitation decreasing gradually from the northeast to the southwest. Sixteen Cara- gana species exist in the Inner Mongolia region. These Caragana species exhibit a distribution pattern across moisture zones and form a geographical replacement series. In order to examine the mechanisms responsible for Caragana species distribution pattern, we selected 12 Caragana species that exhibit a distinct distribution pattern across multiple moisture zones in the Inner Mongolia region, and determined the relationships between the leaf ecological and physiological traits of these Caragana species and the aridity index and solar radiation. Along with the climatic drought gradient and the solar radiation intensification from the northeast to the southwest, leaf eco- logical characteristics of Caragana species changed drastically, i.e. the leaf shape gradually turned from flat into tegular or tubbish; the leaf hair became denser, longer and lighter in color; the leaf area, leaf biomass and specific leaf area (SLA) decreased significantly; the leaf thickness and the ratio of leaf thickness to leaf area increased sig- nificantly; and the leaf chlorophyll content decreased significantly. As the climatic drought stress increased, osmotic potentials of the main osmotic adjustment substances and the cytoplasmic ion concentration of Caragana species increased significantly. Meanwhile, the total and free water contents and water potential of leaves decreased sig- nificantly; the ratio of bound to free water increased significantly; the stomatal conductance and transpiration rate reduced significantly; and the water use efficiency (WUE) increased significantly. In addition, with the intensification of climatic drought stress, peroxidase (POD) and superoxide dismutase (SOD) activities in leaves increased significantly. As a result, the malondialdehyde (MDA) content increased while the oxygen free radical content decreased. Our results showed that most of the leaf ecological and physiological traits of the 12 Caragana species varied in accordance with the climatic drought gradient in the Inner Mongolia region, which reflected the adaptation of the Caragana species to the local climate conditions. With relatively more active metabolism and faster growth, the Caragana species in the northeast had strong competitive abilities; on the other hand, with stronger resistance to climatic drought stress, the Caragana species in the southwest could survive in harsh environments. Based on our results, we con- cluded that both the environmental gradients and the adaptive responses of Caragana species to their environments played important roles in the formation of the Caragana species distribution pattern across the Inner Mongolia region. 展开更多
关键词 ADAPTATION climatic gradient morphological trait osmotic potential water state water metabolism antioxidative enzyme
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Colony-stimulating factor-1 receptor inhibition combined with paclitaxel exerts effective antitumor effects in the treatment of ovarian cancer 被引量:1
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作者 Meijia Yu Yiming Wu +7 位作者 qingfang li Weiqi Hong Yang Yang Xiaoyi Hu Yanfei Yang Tianqi Lu Xia Zhao Xiawei Wei 《Genes & Diseases》 SCIE CSCD 2024年第3期400-416,共17页
Ovarian cancer is the tumor with the highest mortality among gynecological malig-nancies.Studies have confirmed that paclitaxel chemoresistance is associated with increased infiltration of tumor-associated macrophages... Ovarian cancer is the tumor with the highest mortality among gynecological malig-nancies.Studies have confirmed that paclitaxel chemoresistance is associated with increased infiltration of tumor-associated macrophages(TAMs)in the microenvironment.Colony-stimu-lating factor 1(CSF-1)receptor(CSF-1R)plays a key role in regulating the number and differ-entiation of macrophages in certain solid tumors.There are few reports on the effects of targeted inhibition of CSF-1R in combination with chemotherapy on ovarian cancer and the tu-mor microenvironment.Here,we explored the antitumor efficacy and possible mechanisms of the CSF-1R inhibitor pexidartinib(PLX3397)when combined with the first-line chemothera-peutic agent paclitaxel in the treatment of ovarian cancer.We found that CSF-1R is highly ex-pressed in ovarian cancer cells and correlates with poor prognosis.Treatment by PLX3397 in combination with paclitaxel significantly inhibited the growth of ovarian cancer both in vitro and in vivo.Blockade of CSF-1R altered the macrophage phenotype and reprogrammed the immunosuppressive cell population in the tumor microenvironment. 展开更多
关键词 CSF-1R OVARIANCANCER PACLITAXEL PLX3397 Targeted therapy Tumor-associated macrophages
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Recognition and chirality sensing of guanosine-containing nucleotides by an achiral tetraphenylethene-based octacationic cage in water
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作者 Honghong Duan Ting Yang +3 位作者 qingfang li Fan Cao Pingxia Wang liping Cao 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第1期267-270,共4页
The development of molecular probes or systems with the ability of multiple orthogonal responses is an effective approach to precisely detect biomolecules with similar chemical structures.Herein,we report the synthesi... The development of molecular probes or systems with the ability of multiple orthogonal responses is an effective approach to precisely detect biomolecules with similar chemical structures.Herein,we report the synthesis of a water-soluble TPE-based octacationic cage(1)with the compressed TPE-containing bilayer,which endows it with good fluorescence properties and potential conformation chirality.As a result,1 exhibits molecular recognition for anionic nucleotides within its two“claw”-like cavities to form 1:2 host-guest complexes in water,companying with selective turn-off fluorescence and turn-on CD responses to G/GTP over other nucleotides. 展开更多
关键词 Host-guest recognition Chirality sensing Tetraphenylethene Achiral cage Nucleotide
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Targeted therapy for head and neck cancer:signaling pathways and clinical studies 被引量:3
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作者 qingfang li Yan Tie +2 位作者 Aqu Alu Xuelei Ma Huashan Shi 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2023年第2期530-557,共28页
Head and neck cancer(HNC)is malignant,genetically complex and difficult to treat and is the sixth most frequent cancer,with tobacco,alcohol and human papillomavirus being major risk factors.Based on epigenetic data,HN... Head and neck cancer(HNC)is malignant,genetically complex and difficult to treat and is the sixth most frequent cancer,with tobacco,alcohol and human papillomavirus being major risk factors.Based on epigenetic data,HNC is remarkably heterogeneous,and treatment remains challenging.There is a lack of significant improvement in survival and quality of life in patients with HNC.Over half of HNC patients experience locoregional recurrence or distal metastasis despite the current multiple traditional therapeutic strategies and immunotherapy.In addition,resistance to chemotherapy,radiotherapy and some targeted therapies is common.Therefore,it is urgent to explore more effective and tolerable targeted therapies to improve the clinical outcomes of HNC patients.Recent targeted therapy studies have focused on identifying promising biomarkers and developing more effective targeted therapies.A well understanding of the pathogenesis of HNC contributes to learning more about its inner association,which provides novel insight into the development of small molecule inhibitors.In this review,we summarized the vital signaling pathways and discussed the current potential therapeutic targets against critical molecules in HNC,as well as presenting preclinical animal models and ongoing or completed clinical studies about targeted therapy,which may contribute to a more favorable prognosis of HNC.Targeted therapy in combination with other therapies and its limitations were also discussed. 展开更多
关键词 CLINICAL summarized ALCOHOL
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Stabilization and Multiple-Responsive Recognition of Natural Base Pairs in Water by a Cationic Cage 被引量:3
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作者 lin Cheng Ping Tian +2 位作者 qingfang li Anyang li liping Cao 《CCS Chemistry》 CAS 2022年第9期2914-2920,共7页
The hydrogen-bonded(H-bonded)base pairs,double H-bonded A•T and triple H-bonded G•C in DNA,are important units for storing,encoding,and expressing genetic information.Owing to the interference from water,however,the f... The hydrogen-bonded(H-bonded)base pairs,double H-bonded A•T and triple H-bonded G•C in DNA,are important units for storing,encoding,and expressing genetic information.Owing to the interference from water,however,the formation of H-bonded base pairs from short deoxynucleotide fragments such as mono-or di-deoxynucleotide are not easily achieved in aqueous solutions. 展开更多
关键词 host–guest chemistry chiral recognition adaptive chirality tetraphenylethene-based cationic cage base pair
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肌醇应用于多囊卵巢综合征不孕患者的相关研究进展 被引量:7
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作者 李庆芳 朱依敏 《中华生殖与避孕杂志》 CSCD 北大核心 2021年第12期1143-1148,共6页
多囊卵巢综合征(polycystic ovary syndrome,PCOS)是一种多因素导致的内分泌及代谢疾病,常伴有胰岛素抵抗、月经周期紊乱和生育障碍等症状,占无排卵性不孕症的75%。目前多项临床研究证实,肌醇可以改善PCOS患者内分泌及代谢情况,改善高... 多囊卵巢综合征(polycystic ovary syndrome,PCOS)是一种多因素导致的内分泌及代谢疾病,常伴有胰岛素抵抗、月经周期紊乱和生育障碍等症状,占无排卵性不孕症的75%。目前多项临床研究证实,肌醇可以改善PCOS患者内分泌及代谢情况,改善高雄激素血症、氧化应激异常及妊娠结局,且以肌肉肌醇∶D-手性肌醇为40∶1的比例治疗效果最佳。另外,以肌醇为基础的联合用药对PCOS患者也有一定的治疗效果,如二甲双胍、枸橼酸氯米芬及口服避孕药等与肌醇的联合用药。此外,针对PCOS患者肌醇耐受的问题,也有研究进行了探索,本文就此展开综述。 展开更多
关键词 多囊卵巢综合征 不孕症 肌醇 联合用药 妊娠结局
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Aggregation-induced emission and self-assembly of functional tetraphenylethene-based tetracationic dicyclophanes for selective detection of ATP in water 被引量:1
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作者 Chunyan Qin Yawen li +2 位作者 qingfang li Chaochao Yan liping Cao 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第11期3531-3534,共4页
Functional dicyclophanes with various substituents(e.g.,NO_(2),Br,OCH_(3)and OH)were synthesized via one-pot S_(N)2 reaction.Dicyclophanes can form nanospheres via the head-to-tail self-assembly between the cavities a... Functional dicyclophanes with various substituents(e.g.,NO_(2),Br,OCH_(3)and OH)were synthesized via one-pot S_(N)2 reaction.Dicyclophanes can form nanospheres via the head-to-tail self-assembly between the cavities and the TPE units to exhibit aggregation-induced emission(AIE)in aqueous solution.These AIE-active nanospheres with cationic feature exhibited selective recognition with fluorescence response for anionic ATP via electrostatic interactions and hydrophobic effects in water. 展开更多
关键词 Aggregation-induced emission Dicyclophanes Tetraphenylethene Adenosine derivatives FLUORESCENCE
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Successive construction of cucurbit[8]uril-based covalent organic frameworks from a supramolecular organic framework through photochemical reactions in water
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作者 Yawen li Chaochao Yan +1 位作者 qingfang li liping Cao 《Science China Chemistry》 SCIE EI CSCD 2022年第7期1279-1285,共7页
Functional framework materials have been developed for many applications including adsorption, asymmetric catalysis, sensing,drug delivery, optical device, and so on. Here, we report the successive construction of two... Functional framework materials have been developed for many applications including adsorption, asymmetric catalysis, sensing,drug delivery, optical device, and so on. Here, we report the successive construction of two cucurbit[8]uril-based covalent organic frameworks(COFs) including tetraphenylethene-based COF(COF-1) and phenanthrene-based COF(COF-2) from a two-dimensional(2D) periodic cucurbit[8]uril-based supramolecular organic framework(SOF-1) as the prearranged structure via the intermolecular photocycloaddition of the coumarin units and the intramolecular photocyclization of the tetraphenylethene(TPE) units under ultraviolet(UV) irradiation(365 nm) in water. In this case, oxygen(O_(2)) plays an important role in the photocyclization of the TPE units into the phenanthrene units in the transform process from SOF-1 or COF-1 to COF-2. As the TPE units further form phenanthrenes after UV-irradiation, COF-2 exhibits aggregation-caused quenching effect and weak green emission, while COF-1 displays a strong yellow emission due to the aggregation-induced emission. Besides, the adaptive chirality of cationic COF-1 as a biomolecular sensor can be efficiently induced by chiral anionic biomolecules including adenosine-5′-triphosphate(ATP) and adenosine-5′-diphosphate(ADP) to exhibit sensitive negative circular dichroism responses in water. This supramolecular approach to construct COF from SOF via photochemical reactions may open a new opportunity for the construction and application of the water-soluble COFs with well structural controllability, unique photophysical properties,and favorable biocompatibility. 展开更多
关键词 covalent organic framework supramolecular organic framework CUCURBIT[8]URIL photochemical reaction adaptive chirality
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