A new 1,4-amidocyanation of 1,3-enynes with N-amidopyridin-1-ium salts and TMSCN using a copper and photoredox synergetic catalysis for producingα-amido allenyl nitriles is developed.Employing N-amidopyridin-1-ium sa...A new 1,4-amidocyanation of 1,3-enynes with N-amidopyridin-1-ium salts and TMSCN using a copper and photoredox synergetic catalysis for producingα-amido allenyl nitriles is developed.Employing N-amidopyridin-1-ium salts as the amidyl radical precursors,the reaction enables the formation of two new bonds,one C(sp^(3))-N bond and one C(sp^(2))-C(sp)bond,in a single reaction step.This reaction represents a mild,general route to the construction of theα-amido allenyl nitrile architectures,which characterizes a broad scope,a good functional group compatibility and an excellent selectivity.展开更多
基金the National Natural Science Foundation of China(No.22271245)for the financial supportthe Yantai“Double Hundred Plan”the Talent Induction Program for Youth Innovation Teams in Colleges and Universities of Shan-dong Province。
文摘A new 1,4-amidocyanation of 1,3-enynes with N-amidopyridin-1-ium salts and TMSCN using a copper and photoredox synergetic catalysis for producingα-amido allenyl nitriles is developed.Employing N-amidopyridin-1-ium salts as the amidyl radical precursors,the reaction enables the formation of two new bonds,one C(sp^(3))-N bond and one C(sp^(2))-C(sp)bond,in a single reaction step.This reaction represents a mild,general route to the construction of theα-amido allenyl nitrile architectures,which characterizes a broad scope,a good functional group compatibility and an excellent selectivity.
