In modern terminology,“organoids”refer to cells that grow in a specific three-dimensional(3D)environment in vitro,sharing similar structures with their source organs or tissues.Observing themorphology or growth char...In modern terminology,“organoids”refer to cells that grow in a specific three-dimensional(3D)environment in vitro,sharing similar structures with their source organs or tissues.Observing themorphology or growth characteristics of organoids through a microscope is a commonly used method of organoid analysis.However,it is difficult,time-consuming,and inaccurate to screen and analyze organoids only manually,a problem which cannot be easily solved with traditional technology.Artificial intelligence(AI)technology has proven to be effective in many biological and medical research fields,especially in the analysis of single-cell or hematoxylin/eosin stained tissue slices.When used to analyze organoids,AI should also provide more efficient,quantitative,accurate,and fast solutions.In this review,we will first briefly outline the application areas of organoids and then discuss the shortcomings of traditional organoid measurement and analysis methods.Secondly,we will summarize the development from machine learning to deep learning and the advantages of the latter,and then describe how to utilize a convolutional neural network to solve the challenges in organoid observation and analysis.Finally,we will discuss the limitations of current AI used in organoid research,as well as opportunities and future research directions.展开更多
Efficient sterilization by a plasma photocatalytic system(PPS)requires strong synergy between plasma and photocatalyst to inactivate microorganisms while suppressing the formation of secondary pollutants.Here,we repor...Efficient sterilization by a plasma photocatalytic system(PPS)requires strong synergy between plasma and photocatalyst to inactivate microorganisms while suppressing the formation of secondary pollutants.Here,we report that a PPS constructed from a needle array corona discharge and Au/TiO2plasmonic nanocatalyst could remarkably improve the sterilization of Escherichia coli(E.coli)and alleviate formation of the discharge pollutant O3.At 6 kV,the combination of corona discharge and Au/TiO2achieves sterilization efficiency of 100%within an exposure time of 5 min.At 5 kV and an exposure time of 8 min,the presence of Au/TiO2improves sterilization efficiency of the corona discharge from 73%to 91%and reduces the O3concentration from 0.38 to 0.04 ppm,whereas the presence of TiO2reduces the sterilization efficiency and O3concentration to 66%and 0.17 ppm,respectively.The Au/TiO2in the PPS enables a uniform corona discharge,enhances the interaction between plasma,E.coli and nanocatalysts,and suppresses the formation of O3.Further,the Au/TiO2can be excited by ultraviolet-visible light emitted from the plasma to generate electron-hole pairs,and thus contributes to the formation of reactive radicals and the oxidative inactivation of E.coli.The PPS constructed from a needle array corona discharge and Au-based plasmonic nanocatalyst provides a promising approach for developing high-efficiency sterilization techniques.展开更多
The weights of ten important traits of sugarcane, including the number of hair groups, plant height, defoliation capability, stalk diameter, ratooning property, stalk number of disease resistance, cane yield, sucrose ...The weights of ten important traits of sugarcane, including the number of hair groups, plant height, defoliation capability, stalk diameter, ratooning property, stalk number of disease resistance, cane yield, sucrose content and sugar yield, were distributed with the Analytic Hierarchy Process （AHP） method. Ten Yuetang series of sugarcane lines were evaluated by Dynamic Technique for Order Preference by Similarity to Ideal Solution （DTOPSIS）. AHP results indicated that the weights of ten traits were 0. 013 4, 0.022 7, O. 030 2, 0.040 8, 0.065 3, 0.088 1, 0.116 2, 0. 160 6, 0.198 4 and 0.264 5, respectively, with random consistency ratio C.R. =0.098 1 〈0.1, suggesting that the distribution of the weights of evaluation indicators was reasonable. Comprehensive evaluation of 10 sugarcane lines by DTOPSLS method combining with the conclusion of AHP showed that the comprehensive performances of Yuetang 03-393 and Yuetang 03-373 were much better than other sugarcane lines, with relative approach degree Ci ranking the first and second, respectively, which was basically consistent with the practical survey, suggesting that Yuetang 03-393 and Yuetang 03-373 were suitable for large-scale popularization. The above results confirmed the feasibility of applying AHP and DTOPSIS in comprehensive evaluation of new crop varieties and provided reference for the breeding of new sugarcane lines.展开更多
The voluminous Choke Shield basalts and flood basalts are distributed in the central Ethiopian Plateau.They are tholeiitic in composition and have OIB-like geochemical features.The ca.23 Ma Choke Shield basalts have S...The voluminous Choke Shield basalts and flood basalts are distributed in the central Ethiopian Plateau.They are tholeiitic in composition and have OIB-like geochemical features.The ca.23 Ma Choke Shield basalts have SiO_(2)(47.1 wt.%-59.6 wt.%),MgO(1.01 wt.%-7.8 wt.%),Na_(2)O+K_(2)O(2.7 wt.%-8.4 wt.%),and display right inclined REE patterns((La/Yb)N=21.4-24.2) with enrichment of Nb,Ta,Zr,Hf and Pb in the primitive mantle-normalized trace element diagrams.They show low initial ^(87)Sr/^(86)Sr ratios(0.703 47-0.703 77) and high ε_(Nd)(t) values(+4.4 to+5.0).In comparison,the 24Ma high-Ti(HT1) flood basalts have SiO_(2)(38.9 wt.%-50.8 wt.%),MgO(3.9 wt.%-11.4 wt.%),Na_(2)O+K_(2)O(1.6 wt.%-5.8 wt.%), and display right inclined REE patterns((La/Yb)N=24-130.3) with enrichment of Nb,Ta,Zr,Hf,and Pb.They also show low initial ^(87)Sr/^(86)Sr ratios(0.703 30-0.704 44) and highε_(Nd)(t) values(+2.2 to+5.3).Both types of basalts were contaminated by minor crustal materials and underwent fractional crystallization of clinopyroxene,plagioclase,olivine,and minor Fe-Ti oxide.The Choke Shield basalts were generated by 1%-5% melting of garnet-spinel to phlogopite-bearing spinel lherzolite in a shallow zone of the mantle plume,while the flood basalts were formed by <20% melting of amphibole-bearing garnet to garnet-spinel lherzolite in a deeper zone of the same mantle plume.The mantle source beneath the central Ethiopian Plateau was significantly heterogeneous during the Tertiary.It was characterized by EMI and EMII end-members that were formed by the metasomatism of the different components.展开更多
This study aimed at investigating the vitamin D status of pediatric patients with upper limb fractures and finding out the influences of age,gender,season and fracture sites.695 patients were admitted for upper limb f...This study aimed at investigating the vitamin D status of pediatric patients with upper limb fractures and finding out the influences of age,gender,season and fracture sites.695 patients were admitted for upper limb fractures between November 1st 2014 and October 31st 2015.224 healthy children were included during the same period.Serum 25(OH)D was measured at the time of visit and their demographic data were recorded.Generally fracture patients had significant lower vitamin D level than the healthy children.The average serum 25(OH)D of the patients was 24.5 ng/ml,compared to 28.1 ng/ml in healthy children.Vitamin D status worsened with the increase of age and adolescents had a deficiency rate of as high as 68.6%.Gender and fracture sites had no influence on vitamin D level.This study revealed high prevalence of vitamin D deficiency and insufficiency in pediatric patients with upper limb fractures.Adolescents had such high rate of vitamin D deficiency that called for vast attention.展开更多
Organs-on-a-chip is a microfluidic microphysiological system that uses microfluidic technology to analyze the structure and function of living human cells at the tissue and organ levels in vitro.Organs-on-a-chip techn...Organs-on-a-chip is a microfluidic microphysiological system that uses microfluidic technology to analyze the structure and function of living human cells at the tissue and organ levels in vitro.Organs-on-a-chip technology,as opposed to traditional two-dimensional cell culture and animal models,can more closely simulate pathologic and toxicologic interactions between different organs or tissues and reflect the collaborative response of multiple organs to drugs.Despite the fact that many organs-on-a-chip-related data have been published,none of the current databases have all of the following functions:searching,downloading,as well as analyzing data and results from the literature on organs-on-a-chip.Therefore,we created an organs-on-a-chip database(OOCDB)as a platform to integrate information about organs-on-a-chip from various sources,including literature,patents,raw data from microarray and transcriptome sequencing,several open-access datasets of organs-on-a-chip and organoids,and data generated in our laboratory.OOCDB contains dozens of sub-databases and analysis tools,and each sub-database contains various data associated with organs-on-a-chip,with the goal of providing researchers with a comprehensive,systematic,and convenient search engine.Furthermore,it offers a variety of other functions,such as mathematical modeling,three-dimensional modeling,and citation mapping,to meet the needs of organs-on-a-chip.展开更多
Background Refex seizures(RS)induced by micturition are extremely rare,and the clinical and electroencephalogram features of RS are not widely known among clinicians.In particular,the origin of the epileptic area is s...Background Refex seizures(RS)induced by micturition are extremely rare,and the clinical and electroencephalogram features of RS are not widely known among clinicians.In particular,the origin of the epileptic area is still unclear.Case presentation An 8-year-old girl who had generalized tonic-clonic seizures was diagnosed with RS induced by micturition based on the clinical manifestation and EEG recordings.We also reviewed the clinical and EEG characteristics of RS induced by micturition in literature by searching the databases of PubMed and MEDLINE using keywords“micturition refex seizure”,“refex seizure induced by micturition”,and“micturition induced seizure”by January 2022.We speculate that the mechanism of micturition-induced RS may involve excessive neuronal excitation in regions that participate in micturition.Conclusions The RS in this patient was considered to be induced by micturition.Awareness should be raised to this rare form of RS among practitioners.展开更多
Adakitic rocks are intermediate-acid magmatic rocks characterized by enrichment in light rare-earth elements,depletion in heavy rare-earth elements,positive to negligible Eu and Sr anomalies,and high La/Yb and Sr/Y ra...Adakitic rocks are intermediate-acid magmatic rocks characterized by enrichment in light rare-earth elements,depletion in heavy rare-earth elements,positive to negligible Eu and Sr anomalies,and high La/Yb and Sr/Y ratios.Cenozoic adakitic rocks generated by partial melting of subducted oceanic crust(slab)under eclogite-facies conditions(i.e.,the original definition of“adakite”)occur mainly in Pacific Rim volcanic arcs(intra-oceanic,continental,and continental-margin island arcs),whereas those generated by partial melting of thickened lower crust occur mainly in Tethyan Tibetan collisional orogens.In volcanic arcs,adakitic melts derived from the melting of subducted oceanic crust metasomatize the mantle wedge to form a unique rock suite comprising adakite-adakite-type high-Mg andesite-Piip-type high-Mg andesite-Nb-rich basalt-boninite.This suite differs from the basalt-andesite-dacite-rhyolite suite formed from mantle wedge metasomatized by fluids derived from subducted oceanic crust.Previously published data indicate that partial melting of mafic rocks can generate adakitic magmas under pressure,temperature,and hydrous conditions of 1.2-3.0 GPa,800-1000℃,and 1.5-6.0 wt.%H_(2)O,respectively,leaving residual minerals of garnet and rutile with little or no plagioclase.Cenozoic Au and Cu deposits occur proximally to adakitic rocks,with host rocks of some deposits actually being adakitic rocks.Adakitic rocks thus have important implications for both deep-Earth dynamics and Cu-Au mineralization/exploration.Although studies of Cenozoic adakitic rocks have made many important advances,there remain weaknesses in some important areas such as their tectonic settings,petrogenesis,magma sources,melt-mantle interactions of pre-Cenozoic adakitic rocks,and their relationship with the onset of plate tectonics and crustal growth.Future research directions are likely to involve(1)the generation of adakitic magmas by experimental simulations of partial melting of different types of rock(including intermediate-acid rocks)and magma fractional crystallization at different temperatures and pressures,(2)the relationship between magma reservoir evolution and the formation of adakitic rocks,(3)the tectonic setting and petrogenesis of pre-Cenozoic adakitic rocks and related geodynamic processes,(4)interactions between slab melts and the mantle wedge,(5)the formation of Archean adakitic tonalite-trondhjemite-granodiorite and its link to the onset of plate tectonics and crustal growth,and(6)the relationship between the formation of adakitic rocks and metal mineralization in different tectonic settings.展开更多
Whether arc magmatism occurs above oceanic subduction zones is the forefront of studies on convergent plate margins.The most important petrologic issue related to the evolution of arc systems is the origin of arc magm...Whether arc magmatism occurs above oceanic subduction zones is the forefront of studies on convergent plate margins.The most important petrologic issue related to the evolution of arc systems is the origin of arc magmatism,among which arc basalts are the most important one because they provide insights into mantle enrichment mechanism and crust-mantle interaction at oceanic subduction zones.Fluids or melts released either by dehydration or by melting of subducting oceanic slab infiltrate and metasomatize the overlying mantle wedge at varying depth,leading to the formation of source regions of arc basalts.Such processes make most of arc basalts commonly enriched in large ion lithosphile elements and light rare earth elements,but depleted in high-field strength elements and heavy rare earth elements.Small amounts of arc basalts are characterized by relatively high Nb contents or by Nb enrichment.Rare basalts with compositions similar to ocean island basalts or mid-ocean ridge basalt also occur in arc systems.For these peculiar rocks,it remains debated whether their source is affected by subduction-related components.During their ascent and before their eruption,arc basaltic magmas are subjected to crystal fractionation,mixing and crustal contamination.In addition to the contribution of subducting slab components to the mantle source of arc basalts,the materials above the subducting slab at forearc depths would have been transported either by drag or by subduction erosion into the subarc mantle and into the source of arc magmas.Heats and materials brought by corner flows also play important roles in the generation of arc basalts.Despite the important progresses made in recent studies of arc basalts,further efforts are needed to investigate subarc mantle metasomatism,material recycling,the formation of arc magma sources,geodynamic mechanism in generating arc basalts,and their implicationd s for the initiation of plate tectonics on Earth.展开更多
Sprouted potatoes are not allowed for healthy diet.A good knowledge of the sprouting stage of potatoes can help manage the storage conditions and guide market distribution,thus enabling the quality assurance of potato...Sprouted potatoes are not allowed for healthy diet.A good knowledge of the sprouting stage of potatoes can help manage the storage conditions and guide market distribution,thus enabling the quality assurance of potatoes on table.This article presented an intelligent method for precautionary analysis of potato eyes based on hyperspectral imaging technique.Potential potato eyes were classified into two categories according to the time gap to the sprouting date,i.e.by-sprouting and pre-sprouting potato eyes,representing eyes about to sprout and eyes that will take a while to sprout.Features used for classification were extracted by two methods,including successive projections algorithm(SPA)and a newly-developed sine fit algorithm(SFA).Then classifiers of fisher discriminant analysis(FDA)and least square support vector machine(LSSVM)were utilized for classification of potential sprouting potato eyes.Results showed that FDA was more effective than LSSVM in classifying pre-sprouting and by-sprouting potato eyes,and SFA performed well in FDA classifier with the recognition accuracy of 95.3%for prediction set.It is concluded that hyperspectral imaging has the potential for predicting the sprouting stages of potato eyes.展开更多
Biocompatible carbon-spheres-based nanocomposites exhibit great potential in biomedical and clinical applications. In this contribution we report the first green photochemical synthesis of carbon spheres through in-si...Biocompatible carbon-spheres-based nanocomposites exhibit great potential in biomedical and clinical applications. In this contribution we report the first green photochemical synthesis of carbon spheres through in-situ enwrapping around silver nanoparticles(CS–Ag NPs). Since mesoporous carbon spheres can provide the location for combining Ag NPs and other agents, one-step synthesis of glutathione-stabilized CS–Ag NPs could be readily realized by photoreduction. TEM characterization of CS–Ag NPs nanocomposites illustrates that Ag NPs were superbly wrapped inside the carbon spheres and also adhered to the surfaces of the carbon spheres. These porous CS–Ag NPs show excellent fluorescence and effective antibacterial efficiency, exhibiting ideal lengthened activities against Escherichia coli and Staphylococcus aureus compared with bare Ag NPs. The relevant rationale behind it could be attributed to the fact that CS–Ag NPs nanocomposites can provide some excellent niches for the durable and slow release of silver ions. This raises the possibility of promising applications of CS–Ag NPs nanocomposites as excellent antibacterial agents for the efficient monitoring of some disease-related bacteria.展开更多
基金the National Key R&D Program of China(No.2017YFA0700500)the National Natural Science Foundation of China(No.62172202)+1 种基金the Experiment Project of ChinaManned Space Program(No.HYZHXM01019)the Fundamental Research Funds for the Central Universities from Southeast University(No.3207032101C3).
文摘In modern terminology,“organoids”refer to cells that grow in a specific three-dimensional(3D)environment in vitro,sharing similar structures with their source organs or tissues.Observing themorphology or growth characteristics of organoids through a microscope is a commonly used method of organoid analysis.However,it is difficult,time-consuming,and inaccurate to screen and analyze organoids only manually,a problem which cannot be easily solved with traditional technology.Artificial intelligence(AI)technology has proven to be effective in many biological and medical research fields,especially in the analysis of single-cell or hematoxylin/eosin stained tissue slices.When used to analyze organoids,AI should also provide more efficient,quantitative,accurate,and fast solutions.In this review,we will first briefly outline the application areas of organoids and then discuss the shortcomings of traditional organoid measurement and analysis methods.Secondly,we will summarize the development from machine learning to deep learning and the advantages of the latter,and then describe how to utilize a convolutional neural network to solve the challenges in organoid observation and analysis.Finally,we will discuss the limitations of current AI used in organoid research,as well as opportunities and future research directions.
基金National Natural Science Foundation of China(Nos.52041001,21808024)Natural Science Foundation of Liaoning Province(No.2020-MS-126)Special Foundation for Key Fields of Colleges and Universities in Guangdong Province(No.2021ZDZX4094)。
文摘Efficient sterilization by a plasma photocatalytic system(PPS)requires strong synergy between plasma and photocatalyst to inactivate microorganisms while suppressing the formation of secondary pollutants.Here,we report that a PPS constructed from a needle array corona discharge and Au/TiO2plasmonic nanocatalyst could remarkably improve the sterilization of Escherichia coli(E.coli)and alleviate formation of the discharge pollutant O3.At 6 kV,the combination of corona discharge and Au/TiO2achieves sterilization efficiency of 100%within an exposure time of 5 min.At 5 kV and an exposure time of 8 min,the presence of Au/TiO2improves sterilization efficiency of the corona discharge from 73%to 91%and reduces the O3concentration from 0.38 to 0.04 ppm,whereas the presence of TiO2reduces the sterilization efficiency and O3concentration to 66%and 0.17 ppm,respectively.The Au/TiO2in the PPS enables a uniform corona discharge,enhances the interaction between plasma,E.coli and nanocatalysts,and suppresses the formation of O3.Further,the Au/TiO2can be excited by ultraviolet-visible light emitted from the plasma to generate electron-hole pairs,and thus contributes to the formation of reactive radicals and the oxidative inactivation of E.coli.The PPS constructed from a needle array corona discharge and Au-based plasmonic nanocatalyst provides a promising approach for developing high-efficiency sterilization techniques.
基金Supported by National Sugarcane Industry System Construction Project of China(CARS-20)Project of Science and Technology of Guangdong Province(2011B020415007)Project of Science and Technology of Zhanjiang City(2011D02)
文摘The weights of ten important traits of sugarcane, including the number of hair groups, plant height, defoliation capability, stalk diameter, ratooning property, stalk number of disease resistance, cane yield, sucrose content and sugar yield, were distributed with the Analytic Hierarchy Process （AHP） method. Ten Yuetang series of sugarcane lines were evaluated by Dynamic Technique for Order Preference by Similarity to Ideal Solution （DTOPSIS）. AHP results indicated that the weights of ten traits were 0. 013 4, 0.022 7, O. 030 2, 0.040 8, 0.065 3, 0.088 1, 0.116 2, 0. 160 6, 0.198 4 and 0.264 5, respectively, with random consistency ratio C.R. =0.098 1 〈0.1, suggesting that the distribution of the weights of evaluation indicators was reasonable. Comprehensive evaluation of 10 sugarcane lines by DTOPSLS method combining with the conclusion of AHP showed that the comprehensive performances of Yuetang 03-393 and Yuetang 03-373 were much better than other sugarcane lines, with relative approach degree Ci ranking the first and second, respectively, which was basically consistent with the practical survey, suggesting that Yuetang 03-393 and Yuetang 03-373 were suitable for large-scale popularization. The above results confirmed the feasibility of applying AHP and DTOPSIS in comprehensive evaluation of new crop varieties and provided reference for the breeding of new sugarcane lines.
基金supported by China Commerce Ministry (foreign-aid project (2007)420)China Geological Survey (Nos. DD20190443, DD20160109)。
文摘The voluminous Choke Shield basalts and flood basalts are distributed in the central Ethiopian Plateau.They are tholeiitic in composition and have OIB-like geochemical features.The ca.23 Ma Choke Shield basalts have SiO_(2)(47.1 wt.%-59.6 wt.%),MgO(1.01 wt.%-7.8 wt.%),Na_(2)O+K_(2)O(2.7 wt.%-8.4 wt.%),and display right inclined REE patterns((La/Yb)N=21.4-24.2) with enrichment of Nb,Ta,Zr,Hf and Pb in the primitive mantle-normalized trace element diagrams.They show low initial ^(87)Sr/^(86)Sr ratios(0.703 47-0.703 77) and high ε_(Nd)(t) values(+4.4 to+5.0).In comparison,the 24Ma high-Ti(HT1) flood basalts have SiO_(2)(38.9 wt.%-50.8 wt.%),MgO(3.9 wt.%-11.4 wt.%),Na_(2)O+K_(2)O(1.6 wt.%-5.8 wt.%), and display right inclined REE patterns((La/Yb)N=24-130.3) with enrichment of Nb,Ta,Zr,Hf,and Pb.They also show low initial ^(87)Sr/^(86)Sr ratios(0.703 30-0.704 44) and highε_(Nd)(t) values(+2.2 to+5.3).Both types of basalts were contaminated by minor crustal materials and underwent fractional crystallization of clinopyroxene,plagioclase,olivine,and minor Fe-Ti oxide.The Choke Shield basalts were generated by 1%-5% melting of garnet-spinel to phlogopite-bearing spinel lherzolite in a shallow zone of the mantle plume,while the flood basalts were formed by <20% melting of amphibole-bearing garnet to garnet-spinel lherzolite in a deeper zone of the same mantle plume.The mantle source beneath the central Ethiopian Plateau was significantly heterogeneous during the Tertiary.It was characterized by EMI and EMII end-members that were formed by the metasomatism of the different components.
基金This study was funded by National Natural Science Foundation of China,81700459.
文摘This study aimed at investigating the vitamin D status of pediatric patients with upper limb fractures and finding out the influences of age,gender,season and fracture sites.695 patients were admitted for upper limb fractures between November 1st 2014 and October 31st 2015.224 healthy children were included during the same period.Serum 25(OH)D was measured at the time of visit and their demographic data were recorded.Generally fracture patients had significant lower vitamin D level than the healthy children.The average serum 25(OH)D of the patients was 24.5 ng/ml,compared to 28.1 ng/ml in healthy children.Vitamin D status worsened with the increase of age and adolescents had a deficiency rate of as high as 68.6%.Gender and fracture sites had no influence on vitamin D level.This study revealed high prevalence of vitamin D deficiency and insufficiency in pediatric patients with upper limb fractures.Adolescents had such high rate of vitamin D deficiency that called for vast attention.
基金supported by the National Natural Science Foundation of China(Grant No.31871322)the National Key R&D Program of China(Grant No.2017YFA0700500)the Fundamental Research Funds for the Central Universities,China(Grant Nos.2242020 k10001 and 2242019 k10016).
文摘Organs-on-a-chip is a microfluidic microphysiological system that uses microfluidic technology to analyze the structure and function of living human cells at the tissue and organ levels in vitro.Organs-on-a-chip technology,as opposed to traditional two-dimensional cell culture and animal models,can more closely simulate pathologic and toxicologic interactions between different organs or tissues and reflect the collaborative response of multiple organs to drugs.Despite the fact that many organs-on-a-chip-related data have been published,none of the current databases have all of the following functions:searching,downloading,as well as analyzing data and results from the literature on organs-on-a-chip.Therefore,we created an organs-on-a-chip database(OOCDB)as a platform to integrate information about organs-on-a-chip from various sources,including literature,patents,raw data from microarray and transcriptome sequencing,several open-access datasets of organs-on-a-chip and organoids,and data generated in our laboratory.OOCDB contains dozens of sub-databases and analysis tools,and each sub-database contains various data associated with organs-on-a-chip,with the goal of providing researchers with a comprehensive,systematic,and convenient search engine.Furthermore,it offers a variety of other functions,such as mathematical modeling,three-dimensional modeling,and citation mapping,to meet the needs of organs-on-a-chip.
基金This work was supported by the Public Welfare Technology Research Program of Zhejiang Province(LGF20H090011)the Key Projects of Major Health Science and Technology Plan of Zhejiang Province(WKJ-ZJ-2129)the Educational Reform Project of Medical College of Zhejiang University(jgyb20202033).
文摘Background Refex seizures(RS)induced by micturition are extremely rare,and the clinical and electroencephalogram features of RS are not widely known among clinicians.In particular,the origin of the epileptic area is still unclear.Case presentation An 8-year-old girl who had generalized tonic-clonic seizures was diagnosed with RS induced by micturition based on the clinical manifestation and EEG recordings.We also reviewed the clinical and EEG characteristics of RS induced by micturition in literature by searching the databases of PubMed and MEDLINE using keywords“micturition refex seizure”,“refex seizure induced by micturition”,and“micturition induced seizure”by January 2022.We speculate that the mechanism of micturition-induced RS may involve excessive neuronal excitation in regions that participate in micturition.Conclusions The RS in this patient was considered to be induced by micturition.Awareness should be raised to this rare form of RS among practitioners.
基金the National Natural Science Foundation of China(Grant Nos.41630208 and 91855215)the Second Tibetan Plateau Scientific Expedition and Research Program(STEP)(Grant No.2019QZKK0702)+2 种基金the National Key R&D Program of China(Grant No.2016YFC0600407)the Strategic Priority Research Program(A)of the Chinese Academy of Sciences(Grant No.XDA2007030402),the Key Program of the Chinese Academy of Sciences(Grant No.QYZDJ-SSWDQC026)the Key Program of Guangzhou City(Grant No.201707020032).
文摘Adakitic rocks are intermediate-acid magmatic rocks characterized by enrichment in light rare-earth elements,depletion in heavy rare-earth elements,positive to negligible Eu and Sr anomalies,and high La/Yb and Sr/Y ratios.Cenozoic adakitic rocks generated by partial melting of subducted oceanic crust(slab)under eclogite-facies conditions(i.e.,the original definition of“adakite”)occur mainly in Pacific Rim volcanic arcs(intra-oceanic,continental,and continental-margin island arcs),whereas those generated by partial melting of thickened lower crust occur mainly in Tethyan Tibetan collisional orogens.In volcanic arcs,adakitic melts derived from the melting of subducted oceanic crust metasomatize the mantle wedge to form a unique rock suite comprising adakite-adakite-type high-Mg andesite-Piip-type high-Mg andesite-Nb-rich basalt-boninite.This suite differs from the basalt-andesite-dacite-rhyolite suite formed from mantle wedge metasomatized by fluids derived from subducted oceanic crust.Previously published data indicate that partial melting of mafic rocks can generate adakitic magmas under pressure,temperature,and hydrous conditions of 1.2-3.0 GPa,800-1000℃,and 1.5-6.0 wt.%H_(2)O,respectively,leaving residual minerals of garnet and rutile with little or no plagioclase.Cenozoic Au and Cu deposits occur proximally to adakitic rocks,with host rocks of some deposits actually being adakitic rocks.Adakitic rocks thus have important implications for both deep-Earth dynamics and Cu-Au mineralization/exploration.Although studies of Cenozoic adakitic rocks have made many important advances,there remain weaknesses in some important areas such as their tectonic settings,petrogenesis,magma sources,melt-mantle interactions of pre-Cenozoic adakitic rocks,and their relationship with the onset of plate tectonics and crustal growth.Future research directions are likely to involve(1)the generation of adakitic magmas by experimental simulations of partial melting of different types of rock(including intermediate-acid rocks)and magma fractional crystallization at different temperatures and pressures,(2)the relationship between magma reservoir evolution and the formation of adakitic rocks,(3)the tectonic setting and petrogenesis of pre-Cenozoic adakitic rocks and related geodynamic processes,(4)interactions between slab melts and the mantle wedge,(5)the formation of Archean adakitic tonalite-trondhjemite-granodiorite and its link to the onset of plate tectonics and crustal growth,and(6)the relationship between the formation of adakitic rocks and metal mineralization in different tectonic settings.
基金State Ocean Bureau International Collaboration Program(Grant No.GASI-GEOGE-02)the National Natural Science Foundation of China(Grant Nos.91855215,41630208)CAS Strategy Program B(Grant No.XDB18000000).
文摘Whether arc magmatism occurs above oceanic subduction zones is the forefront of studies on convergent plate margins.The most important petrologic issue related to the evolution of arc systems is the origin of arc magmatism,among which arc basalts are the most important one because they provide insights into mantle enrichment mechanism and crust-mantle interaction at oceanic subduction zones.Fluids or melts released either by dehydration or by melting of subducting oceanic slab infiltrate and metasomatize the overlying mantle wedge at varying depth,leading to the formation of source regions of arc basalts.Such processes make most of arc basalts commonly enriched in large ion lithosphile elements and light rare earth elements,but depleted in high-field strength elements and heavy rare earth elements.Small amounts of arc basalts are characterized by relatively high Nb contents or by Nb enrichment.Rare basalts with compositions similar to ocean island basalts or mid-ocean ridge basalt also occur in arc systems.For these peculiar rocks,it remains debated whether their source is affected by subduction-related components.During their ascent and before their eruption,arc basaltic magmas are subjected to crystal fractionation,mixing and crustal contamination.In addition to the contribution of subducting slab components to the mantle source of arc basalts,the materials above the subducting slab at forearc depths would have been transported either by drag or by subduction erosion into the subarc mantle and into the source of arc magmas.Heats and materials brought by corner flows also play important roles in the generation of arc basalts.Despite the important progresses made in recent studies of arc basalts,further efforts are needed to investigate subarc mantle metasomatism,material recycling,the formation of arc magma sources,geodynamic mechanism in generating arc basalts,and their implicationd s for the initiation of plate tectonics on Earth.
基金supported by the National Key Research and Development Plan of China(2016YFD0701603).
文摘Sprouted potatoes are not allowed for healthy diet.A good knowledge of the sprouting stage of potatoes can help manage the storage conditions and guide market distribution,thus enabling the quality assurance of potatoes on table.This article presented an intelligent method for precautionary analysis of potato eyes based on hyperspectral imaging technique.Potential potato eyes were classified into two categories according to the time gap to the sprouting date,i.e.by-sprouting and pre-sprouting potato eyes,representing eyes about to sprout and eyes that will take a while to sprout.Features used for classification were extracted by two methods,including successive projections algorithm(SPA)and a newly-developed sine fit algorithm(SFA).Then classifiers of fisher discriminant analysis(FDA)and least square support vector machine(LSSVM)were utilized for classification of potential sprouting potato eyes.Results showed that FDA was more effective than LSSVM in classifying pre-sprouting and by-sprouting potato eyes,and SFA performed well in FDA classifier with the recognition accuracy of 95.3%for prediction set.It is concluded that hyperspectral imaging has the potential for predicting the sprouting stages of potato eyes.
基金supported by the National Basic Research Program of China(2010CB732404)the National Natural Science Foundation of China(81325011,21327902,21175020)+1 种基金the National High Technology Research and Development Program of China(2012AA022703)the Suzhou Science&Technology Major Project(ZXY2012028)
文摘Biocompatible carbon-spheres-based nanocomposites exhibit great potential in biomedical and clinical applications. In this contribution we report the first green photochemical synthesis of carbon spheres through in-situ enwrapping around silver nanoparticles(CS–Ag NPs). Since mesoporous carbon spheres can provide the location for combining Ag NPs and other agents, one-step synthesis of glutathione-stabilized CS–Ag NPs could be readily realized by photoreduction. TEM characterization of CS–Ag NPs nanocomposites illustrates that Ag NPs were superbly wrapped inside the carbon spheres and also adhered to the surfaces of the carbon spheres. These porous CS–Ag NPs show excellent fluorescence and effective antibacterial efficiency, exhibiting ideal lengthened activities against Escherichia coli and Staphylococcus aureus compared with bare Ag NPs. The relevant rationale behind it could be attributed to the fact that CS–Ag NPs nanocomposites can provide some excellent niches for the durable and slow release of silver ions. This raises the possibility of promising applications of CS–Ag NPs nanocomposites as excellent antibacterial agents for the efficient monitoring of some disease-related bacteria.
