综合征监测作为公共医疗卫生政策的主要检测指标,拥有充足且及时的监测信息至关重要。传统流行病学指标监测的滞后和误导会影响病情严重地区的医疗实施方案。使用谷歌趋势搜索量、谷歌移动、电信运营商、英国国家医疗服务体系(National ...综合征监测作为公共医疗卫生政策的主要检测指标,拥有充足且及时的监测信息至关重要。传统流行病学指标监测的滞后和误导会影响病情严重地区的医疗实施方案。使用谷歌趋势搜索量、谷歌移动、电信运营商、英国国家医疗服务体系(National Health Service,NHS)电话119和线上新冠检测请求网站的空间数据,提出一种局部范围内SARS-CoV-2传播和临床风险的早期指标建模方法。利用浅层学习算法作为基准方法训练局部空间神经网络,提出空间集成长短期记忆(Spatio-Integrated Long Short-Term Memory,SI-LSTM)算法和空间集成卷积神经网络长短期记忆(Spatio-Integrated Convolutional Neural Network Long Short-Term Memory,SI-CNN-LSTM)算法。在规定的评估时间周期内,两种算法均能准确识别出疫情感染高风险区域。此外,在基本公共卫生服务项目中,该模型还原了2020年底阿尔法变体、2021年4月德尔塔变体和2021年11月奥密克戎变体在英国境内的局部增长指数,其空间分散性和增长指数得到了临床数据的证实。展开更多
网络流量监控与分析(Network Traffic Monitoring and Analysis,NTMA)作为网络管理技术的关键组成部分,能够有效提高互联网等大型网络的健壮性。然而随着互联网业务的复杂性和通信量不断增加,如何设计具有高可扩展性、实时性和高安全性...网络流量监控与分析(Network Traffic Monitoring and Analysis,NTMA)作为网络管理技术的关键组成部分,能够有效提高互联网等大型网络的健壮性。然而随着互联网业务的复杂性和通信量不断增加,如何设计具有高可扩展性、实时性和高安全性的NTMA应用是一个极其重要且严峻的挑战。将大数据处理技术引入NTMA应用,能够有效提升数据传输过程中的信息量、传输速率、多样性以及准确性。为了进一步研究面向大数据的NTMA算法,首先介绍NTMA算法的背景技术,包括现有的大数据技术和NTMA应用框架;其次,介绍NTMA应用的数据管理技术,并详细阐述数据管理的主要流程和关键技术;最后,概述基于大数据的NTMA框架的最新研究方法。展开更多
Twenty prenylated flavonoids 1-20 were synthesized by glycoside hydrolysis, dehydrogenation, selective O-methylation, O-prenylation and Claisen rearrangement reaction, from abundant and inexpensive natural flavonoids ...Twenty prenylated flavonoids 1-20 were synthesized by glycoside hydrolysis, dehydrogenation, selective O-methylation, O-prenylation and Claisen rearrangement reaction, from abundant and inexpensive natural flavonoids naringin, hespiredin, quercetin and myricetin. Among them, 1-7, 10-15 and 17-20 are novel compounds, the natural product 3,3',4',7-tetramethoxy-8-prenyl-5-hydroxy flavonoid(16) was synthesized in a high yield. Their antiprolirative activities were evaluated in vitro on a panel of three human cancer cell lines(HeLa, HCC1954 and SK-OV-3). The results show that most of the target compounds displayed moderate to potent antiprolirative activities against the three cancer cells with half maximal inhibitory concentration(ICs0) values from 0.49 μmol/L to 95.07 μmol/L. Among them, 3′,4′,7-trimethoxyl-5-hydroxyl-8-prenyl flavonoid(12) exhibited the strongest antiprolirative activity against the three cancer cells mentioned above with IC50 values of 0.91-7.08 μmol/L. 3′,7-Dimethoxy-5-O- prenyl flavone(6) and 3′,4′,7-trimethoxy-5-O-prenyl flavone(10) showed selective antiproliferative activity against HCC1954 cells with TC50 value of 0 49 and 5 .32μmol/L, respectively.展开更多
文摘综合征监测作为公共医疗卫生政策的主要检测指标,拥有充足且及时的监测信息至关重要。传统流行病学指标监测的滞后和误导会影响病情严重地区的医疗实施方案。使用谷歌趋势搜索量、谷歌移动、电信运营商、英国国家医疗服务体系(National Health Service,NHS)电话119和线上新冠检测请求网站的空间数据,提出一种局部范围内SARS-CoV-2传播和临床风险的早期指标建模方法。利用浅层学习算法作为基准方法训练局部空间神经网络,提出空间集成长短期记忆(Spatio-Integrated Long Short-Term Memory,SI-LSTM)算法和空间集成卷积神经网络长短期记忆(Spatio-Integrated Convolutional Neural Network Long Short-Term Memory,SI-CNN-LSTM)算法。在规定的评估时间周期内,两种算法均能准确识别出疫情感染高风险区域。此外,在基本公共卫生服务项目中,该模型还原了2020年底阿尔法变体、2021年4月德尔塔变体和2021年11月奥密克戎变体在英国境内的局部增长指数,其空间分散性和增长指数得到了临床数据的证实。
文摘网络流量监控与分析(Network Traffic Monitoring and Analysis,NTMA)作为网络管理技术的关键组成部分,能够有效提高互联网等大型网络的健壮性。然而随着互联网业务的复杂性和通信量不断增加,如何设计具有高可扩展性、实时性和高安全性的NTMA应用是一个极其重要且严峻的挑战。将大数据处理技术引入NTMA应用,能够有效提升数据传输过程中的信息量、传输速率、多样性以及准确性。为了进一步研究面向大数据的NTMA算法,首先介绍NTMA算法的背景技术,包括现有的大数据技术和NTMA应用框架;其次,介绍NTMA应用的数据管理技术,并详细阐述数据管理的主要流程和关键技术;最后,概述基于大数据的NTMA框架的最新研究方法。
基金Supported by the National Natural Science Foundation of China(Nos.J1210040, 21173074).
文摘Twenty prenylated flavonoids 1-20 were synthesized by glycoside hydrolysis, dehydrogenation, selective O-methylation, O-prenylation and Claisen rearrangement reaction, from abundant and inexpensive natural flavonoids naringin, hespiredin, quercetin and myricetin. Among them, 1-7, 10-15 and 17-20 are novel compounds, the natural product 3,3',4',7-tetramethoxy-8-prenyl-5-hydroxy flavonoid(16) was synthesized in a high yield. Their antiprolirative activities were evaluated in vitro on a panel of three human cancer cell lines(HeLa, HCC1954 and SK-OV-3). The results show that most of the target compounds displayed moderate to potent antiprolirative activities against the three cancer cells with half maximal inhibitory concentration(ICs0) values from 0.49 μmol/L to 95.07 μmol/L. Among them, 3′,4′,7-trimethoxyl-5-hydroxyl-8-prenyl flavonoid(12) exhibited the strongest antiprolirative activity against the three cancer cells mentioned above with IC50 values of 0.91-7.08 μmol/L. 3′,7-Dimethoxy-5-O- prenyl flavone(6) and 3′,4′,7-trimethoxy-5-O-prenyl flavone(10) showed selective antiproliferative activity against HCC1954 cells with TC50 value of 0 49 and 5 .32μmol/L, respectively.