目的:探讨老年高血压患者不同脉压(PP)水平与脑卒中的关系。方法:收治老年高血压患者734例,分为脑卒中组(脑梗死组、脑出血组、腔隙性脑梗死组)和非脑卒中组。分析不同脉压水平与不同脑卒中事件的关系。结果:脑卒中组、脑出血组患者随...目的:探讨老年高血压患者不同脉压(PP)水平与脑卒中的关系。方法:收治老年高血压患者734例,分为脑卒中组(脑梗死组、脑出血组、腔隙性脑梗死组)和非脑卒中组。分析不同脉压水平与不同脑卒中事件的关系。结果:脑卒中组、脑出血组患者随脉压水平的增大,脑卒中发生的比例逐渐增高。腔隙性脑梗死组患者的PP>60 mm Hg的达7.66%。结论:随着脉压水平的增大,脑卒中发生的比例逐渐增高。PP>80 mm Hg的发生脑出血的比例明显增高,PP>60 mm Hg的发生腔隙性脑梗死的比例明显增高。展开更多
A new cell line, CSEC, has been successfully established from embryos at gastrula stage of a cultured marine fish, half smooth tongue sole （Cynoglossus sernilaevis）. CSEC cells grow actively and stably more than 50 ...A new cell line, CSEC, has been successfully established from embryos at gastrula stage of a cultured marine fish, half smooth tongue sole （Cynoglossus sernilaevis）. CSEC cells grow actively and stably more than 50 passages for over 200 d in DMEM medium supplemented with 15% FBS （fetal bovine serum）, 2.5 ng/cm^3 bFGF （basic fibroblast growth factor）, 1 ng/cm^3 LIF （leukemia inhibitory factor） and 50 mmol/dm^3 2-ME （2-mecaptoethanol）. The cells grew well in the temperature range of 24-30 ℃ and the optimal growth temperature was 24 ℃. FBS and bFGF concentrations are the two key components for CSEC cells proliferation. Chromosome analysis reveals that CSEC cells have a normal diploid karyotype with 2n=42t. The significant fluorescent signals were observed in CSEC after transfection with the GFP reporter gene, suggesting that the CSEC cell line can be used as a useful tool for transgenic and genetic manipulation studies. CSEC cells showed the cytopathic effect （CPE） after infection with lymphosystis disease virus （LCDV） in 2 d. Moreover, the LCDV particles can be observed in the cytoplasm of virus-infected cells by electron microscopy. It suggests that CSEC could be potentially used for the study of aquatic virus.展开更多
The deformation behavior of equal channel angular pressing(ECAP)was discussed by using plasticity method.The node mapping method is employed to realize the analysis of multi-pass ECAP by using three-dimensional FEM me...The deformation behavior of equal channel angular pressing(ECAP)was discussed by using plasticity method.The node mapping method is employed to realize the analysis of multi-pass ECAP by using three-dimensional FEM methods for pure aluminum.The single-pass ECAP is a non-uniform shear deformation process in the cross-section of the workpiece.The uniform deformation processing routes are obtained during multi-pass ECAP process.In addition,the density of dislocations and defects of crystal lattice are also largely changed for different processing routes.The grain microstructure is gradually refined with the increase of the pressing passes.The grains and their distribution obtained by route Bc are more useful for producing the material with high angle grain boundaries.The grain microstructure of the cross section of the pressed material decreases with the increase of strain,and some grains exhibit transformed grain boundary(PTB)fringes.The dislocation density in the grain decreases,and the grain boundary presents equiaxed distribution.展开更多
文摘目的:探讨老年高血压患者不同脉压(PP)水平与脑卒中的关系。方法:收治老年高血压患者734例,分为脑卒中组(脑梗死组、脑出血组、腔隙性脑梗死组)和非脑卒中组。分析不同脉压水平与不同脑卒中事件的关系。结果:脑卒中组、脑出血组患者随脉压水平的增大,脑卒中发生的比例逐渐增高。腔隙性脑梗死组患者的PP>60 mm Hg的达7.66%。结论:随着脉压水平的增大,脑卒中发生的比例逐渐增高。PP>80 mm Hg的发生脑出血的比例明显增高,PP>60 mm Hg的发生腔隙性脑梗死的比例明显增高。
基金The State "863" High-Technology Research and Development Project of China under contract Nos 2006AA09Z406 and 2006AA10A401the National Natural Science Foundation of China under contract No. 40376047the Taishan Scholar Project of Shandong Province and MOA for returned scientists from abroad
文摘A new cell line, CSEC, has been successfully established from embryos at gastrula stage of a cultured marine fish, half smooth tongue sole （Cynoglossus sernilaevis）. CSEC cells grow actively and stably more than 50 passages for over 200 d in DMEM medium supplemented with 15% FBS （fetal bovine serum）, 2.5 ng/cm^3 bFGF （basic fibroblast growth factor）, 1 ng/cm^3 LIF （leukemia inhibitory factor） and 50 mmol/dm^3 2-ME （2-mecaptoethanol）. The cells grew well in the temperature range of 24-30 ℃ and the optimal growth temperature was 24 ℃. FBS and bFGF concentrations are the two key components for CSEC cells proliferation. Chromosome analysis reveals that CSEC cells have a normal diploid karyotype with 2n=42t. The significant fluorescent signals were observed in CSEC after transfection with the GFP reporter gene, suggesting that the CSEC cell line can be used as a useful tool for transgenic and genetic manipulation studies. CSEC cells showed the cytopathic effect （CPE） after infection with lymphosystis disease virus （LCDV） in 2 d. Moreover, the LCDV particles can be observed in the cytoplasm of virus-infected cells by electron microscopy. It suggests that CSEC could be potentially used for the study of aquatic virus.
基金Funded by the National Natural Science Foundation of China(No.41305124)the Natural Science Foundation of Shandong Province,China(No.ZR2021ME182)State Key Laboratory of Materials Processing and Die&Mould Technology Foundation(P12)
文摘The deformation behavior of equal channel angular pressing(ECAP)was discussed by using plasticity method.The node mapping method is employed to realize the analysis of multi-pass ECAP by using three-dimensional FEM methods for pure aluminum.The single-pass ECAP is a non-uniform shear deformation process in the cross-section of the workpiece.The uniform deformation processing routes are obtained during multi-pass ECAP process.In addition,the density of dislocations and defects of crystal lattice are also largely changed for different processing routes.The grain microstructure is gradually refined with the increase of the pressing passes.The grains and their distribution obtained by route Bc are more useful for producing the material with high angle grain boundaries.The grain microstructure of the cross section of the pressed material decreases with the increase of strain,and some grains exhibit transformed grain boundary(PTB)fringes.The dislocation density in the grain decreases,and the grain boundary presents equiaxed distribution.
