Real-world evidence (RWE) is clinical evidence on a medical product’s safety and efficacy that is generated using real-world data (RWD) resulting from routine healthcare delivery. This study evaluates the clinical ef...Real-world evidence (RWE) is clinical evidence on a medical product’s safety and efficacy that is generated using real-world data (RWD) resulting from routine healthcare delivery. This study evaluates the clinical efficacy of amoxicillin + clavulanic acid in children with pharyngitis, acute otitis, or acute rhinosinusitis with suspected bacterial origin under normal office and home conditions. Methods: This was a real-life, prospective, observational, pharmacovigilance study. It included children of both sexes between 2 and 12 years old, with a diagnosis of Rhinopharyngitis (tonsillitis), Acute Otitis Media and Rhinosinusitis. The main effectiveness variable evaluated was reduction and time to resolution of symptoms. All patients received Amoxicillin/Clavulanic Acid suspension 600 mg/42.9 mg/5 mL at a dose of 90 mg/Kg/day in two doses, every 12 hours for 7 days. The evaluations were carried out at the beginning, at 72 hours (3rd day) and at 7 days. All patients underwent culture and antibiogram. Results: The majority of cultures were negative for pathogenic germs, suspecting unidentifiable germs, or viral etiology despite the rigorous selection of subjects following validated scores. The most frequently isolated germ was Staphylococcus aureus;growth of gram-negative bacteria was reported in 33.33% of the cultures. There was a significant improvement in symptoms in children with tonsillitis and rhinosinusitis from the first 72 hours of treatment, persisting until the 7 days. In the otitis media group, returning to normal by the tenth day. During the conduction of this investigation, no adverse effects associated with the prescribed therapy were reported.展开更多
Background:This study aimed to investigate the ventilation practice during cardiopulmonary resuscitation (CPR) and after return of spontaneous circulation (ROSC) in children.Methods:An online survey of CPR practices w...Background:This study aimed to investigate the ventilation practice during cardiopulmonary resuscitation (CPR) and after return of spontaneous circulation (ROSC) in children.Methods:An online survey of CPR practices was designed and sent to healthcare professionals treating children.Results:A total of 477 healthcare professionals from 46 countries responded to this survey;92.7% were physicians and 64.2% worked in pediatric intensive care units.Specific CPR guidelines were used by 97.7% of respondents.The respiratory rate most frequently used for children over 12 months was 13 to 20 respirations per minute (rpm) (46% in intubated and 41.8% in non-intubated).For infants under 12 months,the most frequently used respiratory rate was 21 to 30 rpm in intubated patients (37.3%):in non-intubated infants,13 to 20 rpm (26.5%) and 21 to 30 rpm (26.5%) were used with the same frequency.In North America,the respiratory rate most widely used was 7 to 12 rpm;higher rates (13 to 20 rpm and 21 to 30 rpm) were used in Europe and Latin America (P<0.001).After ROSC,no significant differences in the respiratory rates used were found between the continents.More than 40% of healthcare professionals had a target oxygen saturation below 94%;more than 10% used a target arterial PCO2 below 35 mmHg and more than 13% above 45 mmHg.Conclusion:There is considerable variation in the management of ventilation of children in cardiac arrest,and international recommendations are not being followed in a high percentage of cases.展开更多
文摘Real-world evidence (RWE) is clinical evidence on a medical product’s safety and efficacy that is generated using real-world data (RWD) resulting from routine healthcare delivery. This study evaluates the clinical efficacy of amoxicillin + clavulanic acid in children with pharyngitis, acute otitis, or acute rhinosinusitis with suspected bacterial origin under normal office and home conditions. Methods: This was a real-life, prospective, observational, pharmacovigilance study. It included children of both sexes between 2 and 12 years old, with a diagnosis of Rhinopharyngitis (tonsillitis), Acute Otitis Media and Rhinosinusitis. The main effectiveness variable evaluated was reduction and time to resolution of symptoms. All patients received Amoxicillin/Clavulanic Acid suspension 600 mg/42.9 mg/5 mL at a dose of 90 mg/Kg/day in two doses, every 12 hours for 7 days. The evaluations were carried out at the beginning, at 72 hours (3rd day) and at 7 days. All patients underwent culture and antibiogram. Results: The majority of cultures were negative for pathogenic germs, suspecting unidentifiable germs, or viral etiology despite the rigorous selection of subjects following validated scores. The most frequently isolated germ was Staphylococcus aureus;growth of gram-negative bacteria was reported in 33.33% of the cultures. There was a significant improvement in symptoms in children with tonsillitis and rhinosinusitis from the first 72 hours of treatment, persisting until the 7 days. In the otitis media group, returning to normal by the tenth day. During the conduction of this investigation, no adverse effects associated with the prescribed therapy were reported.
文摘Background:This study aimed to investigate the ventilation practice during cardiopulmonary resuscitation (CPR) and after return of spontaneous circulation (ROSC) in children.Methods:An online survey of CPR practices was designed and sent to healthcare professionals treating children.Results:A total of 477 healthcare professionals from 46 countries responded to this survey;92.7% were physicians and 64.2% worked in pediatric intensive care units.Specific CPR guidelines were used by 97.7% of respondents.The respiratory rate most frequently used for children over 12 months was 13 to 20 respirations per minute (rpm) (46% in intubated and 41.8% in non-intubated).For infants under 12 months,the most frequently used respiratory rate was 21 to 30 rpm in intubated patients (37.3%):in non-intubated infants,13 to 20 rpm (26.5%) and 21 to 30 rpm (26.5%) were used with the same frequency.In North America,the respiratory rate most widely used was 7 to 12 rpm;higher rates (13 to 20 rpm and 21 to 30 rpm) were used in Europe and Latin America (P<0.001).After ROSC,no significant differences in the respiratory rates used were found between the continents.More than 40% of healthcare professionals had a target oxygen saturation below 94%;more than 10% used a target arterial PCO2 below 35 mmHg and more than 13% above 45 mmHg.Conclusion:There is considerable variation in the management of ventilation of children in cardiac arrest,and international recommendations are not being followed in a high percentage of cases.
