Granular segregation is widely observed in nature and industry.Most research has focused on segregation caused by differences in the size and density of spherical grains.However,due to the fact that grains typically h...Granular segregation is widely observed in nature and industry.Most research has focused on segregation caused by differences in the size and density of spherical grains.However,due to the fact that grains typically have different shapes,the focus is shifting towards shape segregation.In this study,experiments are conducted by mixing cubic and spherical grains.The results indicate that spherical grains gather at the center and cubic grains are distributed around them,and the degree of segregation is low.Through experiments,a structured analysis of local regions is conducted to explain the inability to form stable segregation patterns with obviously different geometric shapes.Further,through simulations,the reasons for the central and peripheral distributions are explained by comparing velocities and the number of collisions of the grains in the flow layer.展开更多
Small RNAs in Penicillium digitatum were identified and analyzed via transcriptome sequencing on the BGISEQ-500 platform. A total of 15 predicted miRNAs and 10718 novel siRNAs were found. Their length distribution, se...Small RNAs in Penicillium digitatum were identified and analyzed via transcriptome sequencing on the BGISEQ-500 platform. A total of 15 predicted miRNAs and 10718 novel siRNAs were found. Their length distribution, sequence, predicted construction, base bias, expression levels and potential targets were determined as well. Through pathway and KEGG enrichment analysis, the miRNA target genes were mostly involved in carbohydrate metabolism, transport and catabolism, translation and amino acid metabolism. The target genes involved in aflatoxin biosynthesis and proteasome had a higher rich factor value. The results will provide a theoretical foundation for understanding the developmental and pathogenic mechanisms of P. digitatum at the transcriptional level.展开更多
Gas flow properties in nanopores are significantly determined by the flow patterns. Slug flow pattern is a potential water–gas two phase flow pattern, in which gas molecules flow in form of gas slugs and water molecu...Gas flow properties in nanopores are significantly determined by the flow patterns. Slug flow pattern is a potential water–gas two phase flow pattern, in which gas molecules flow in form of gas slugs and water molecules separate gas slugs. Considering water slippage, a portion of water molecules accumulates at the wall with lower mobility, while the remaining water molecules take the shape of a water bridge. Adopting foam apparent viscosity model to represent slug rheological behavior, how water bridge disturbs on gas flow capacity is estimated. The results are compared with the water–gas two phase flow model that assumes annular flow pattern as well as the single gas flow model without the consideration of water. The comparison illustrates that gas molecular movement is significantly hindered by flow space reduction and loss of gas slippage. The impact from water phase of slug flow pattern is more significant than that of annular flow pattern on gas flow capacity. It is discovered that larger nanopores improve gas flow capacity while maintaining bulk water layer thickness and increasing water bridge thickness tend to reduce gas transport ability. A better understanding of the structure and transport of water and gas molecules is conducive to figure out the specific gas–water flow behavior and predict shale gas production.展开更多
The velocity of a particle detector in granular flow can be regarded as the combination of rolling and sliding velocities.The study of the contribution of rolling velocity and sliding velocity provides a new explanati...The velocity of a particle detector in granular flow can be regarded as the combination of rolling and sliding velocities.The study of the contribution of rolling velocity and sliding velocity provides a new explanation to the relative motion between the detector and the local granular flow.In this study,a spherical detector using embedded inertial navigation technology is placed in the chute granular flow to study the movement of the detector relative to the granular flow.It is shown by particle image velocimetry(PIV)that the velocity of chute granular flow conforms to Silbert’s formula.And the velocity of the detector is greater than that of the granular flow around it.By decomposing the velocity into sliding and rolling velocity,it is indicated that the movement of the detector relative to the granular flow is mainly caused by rolling.The rolling detail shown by DEM simulation leads to two potential mechanisms based on the position and drive of the detector.展开更多
Objective: To investigate the research progress and new trend of acupuncture in the treatment of infertility from 2000 to 2021. Methods: The literature review was conducted on acupuncture and moxibustion treatment of ...Objective: To investigate the research progress and new trend of acupuncture in the treatment of infertility from 2000 to 2021. Methods: The literature review was conducted on acupuncture and moxibustion treatment of infertility from 2000 to 2021 from the Web of Science core collection and PubMed. CiteSpace and VOSviewer were used to analyze the annual number of articles, countries, institutions, authors, journals, references and keywords. Statistical Analysis Toolkit for Informetrics 3.2 (SATI) and IBM SPSS Modeler 18.0 were employed to draw the maps of core acupoints and acupuncture approaches. Results: A total of 316 articles were included. From 2000 to 2021 the number of publications has been ever increased with certain fluctuations. The United States was the most productive country. Heilongjiang University of Chinese Medicine was the most active institution. Stener-Victorin E was the highest cited author. Fertility and Sterility was the most prolific journal. Paulus We, 2002 was the highest co-citation literature. SP6 (Sanyinjiao) was the most commonly used acupoint. Manual acupuncture was the most commonly used method. Conclusions: The study of acupuncture in the treatment of infertility is characterized by multinational, multi-institutional participation and close regional cooperation. Acupuncture is a potentially effective therapy for infertility. Due to a lack of research quality and difficulties in performing double-blind, high-quality clinical evidence is urgently required. A complete acupuncture therapy system for infertility should be gradually constructed.展开更多
Brown rots of Red Fuji apples were observed in Hangzhou city (Zhengjiang Province, China). The causal agent was isolated and identified in both morphological and molecular genetic levels. The phenotype and phylogeneti...Brown rots of Red Fuji apples were observed in Hangzhou city (Zhengjiang Province, China). The causal agent was isolated and identified in both morphological and molecular genetic levels. The phenotype and phylogenetic analysis revealed that the isolate was </span><i><span style="font-family:Verdana;">Diaporthe phaseolorum</span></i><span style="font-family:Verdana;"> var. </span><i><span style="font-family:Verdana;">caulivora</span></i><span style="font-family:Verdana;">, and its pathogenicity on apple fruit was confirmed by re-inoculation experiment. To our knowledge, this is the first report of </span><i><span style="font-family:Verdana;">D. phaseolorum</span></i><span style="font-family:Verdana;"> var. </span><i><span style="font-family:Verdana;">caulivora</span></i><span style="font-family:Verdana;"> causing postharvest fruit rot on apple in China.展开更多
BACKGROUND Post-stroke epilepsy is a common and easily overlooked complication of acute cerebrovascular disease.Long-term seizures can seriously affect the prognosis and quality of life of patients.Electroencephalogra...BACKGROUND Post-stroke epilepsy is a common and easily overlooked complication of acute cerebrovascular disease.Long-term seizures can seriously affect the prognosis and quality of life of patients.Electroencephalogram(EEG)is the simplest way to diagnose epilepsy,and plays an important role in predicting seizures and guiding medication.AIM To explore the EEG characteristics of patients with post-stroke epilepsy and improve the detection rate of inter-seizure epileptiform discharges.METHODS From January 2017 to June 2020,10 patients with post-stroke epilepsy in our hospital were included.The clinical,imaging,and EEG characteristics were collected.The stroke location,seizure type,and ictal and interictal EEG manifestations of the patients with post-stroke epilepsy were then retrospectively analyzed.RESULTS In all 10 patients,epileptiform waves occurred in the side opposite to the stroke lesion during the interictal stage;these manifested as sharp wave,sharp-wave complex,or spike discharges in the anterior head lead of the side opposite to the lesion.CONCLUSION In EEG,epileptiform waves can occur in the side opposite to the stroke lesion in patients with post-stroke epilepsy.展开更多
Due to the impact of source-load prediction power errors and uncertainties,the actual operation of the park will have a wide range of fluctuations compared with the expected state,resulting in its inability to achieve...Due to the impact of source-load prediction power errors and uncertainties,the actual operation of the park will have a wide range of fluctuations compared with the expected state,resulting in its inability to achieve the expected economy.This paper constructs an operating simulation model of the park power grid operation considering demand response and proposes a multi-time scale operating simulation method that combines day-ahead optimization and model predictive control(MPC).In the day-ahead stage,an operating simulation plan that comprehensively considers the user’s side comfort and operating costs is proposed with a long-term time scale of 15 min.In order to cope with power fluctuations of photovoltaic,wind turbine and conventional load,MPC is used to track and roll correct the day-ahead operating simulation plan in the intra-day stage to meet the actual operating operation status of the park.Finally,the validity and economy of the operating simulation strategy are verified through the analysis of arithmetic examples.展开更多
The regional BeiDou Satellite System, or BDS2, broadcasts a differential correction as Equivalent Satellite Clock Correction to correct both orbit and satellite clock errors. For the global BDS, or BDS3, satellite orb...The regional BeiDou Satellite System, or BDS2, broadcasts a differential correction as Equivalent Satellite Clock Correction to correct both orbit and satellite clock errors. For the global BDS, or BDS3, satellite orbit and clock corrections conforming with RTCA standards will be broadcast to authorized users. The hybrid constellation and regional monitoring network pose challenges for the high precision separation of orbit and satellite clock corrections. Three correction models of kinematic,dynamic and Two-way Satellite Time Frequency Transfer(TWSTFT)-based dynamic were studied to estimate the satellite orbit and clock corrections. The correction accuracy of the three models is compared and analyzed based on the BDS observation data. Results show that the accuracies(root mean square, RMS) of dual-frequency real-time positioning for the three models are about 1.76 m, 1.78 m and 2.08 m respectively, which are comparable with the performance of WAAS and EGNOS. With dynamic corrections, the precision of Precise Point Positioning(PPP) experiments may reach about 23 cm after convergence.展开更多
Considering the complex coupling of multiple energies and the varying load forecasting errors for an integrated energy system(IES),this study proposes a dynamic time-scale scheduling strategy based on long short-term ...Considering the complex coupling of multiple energies and the varying load forecasting errors for an integrated energy system(IES),this study proposes a dynamic time-scale scheduling strategy based on long short-term memory(LSTM)and multiple load forecasting errors.This strategy dynamically selects a hybrid timescale which is suitable for a variety of energies for each month.This is obtained by combining the mean absolute percentage error(MAPE)curve of the load forecasting with the error restriction requirements of the dispatcher.Based on the day-ahead scheduling plan,the output of the partial equipment is selectively adjusted at each time-scale to realize multi-energy collaborative optimization and gives full play to the comprehensive advantages of the IES.This is achieved by considering the differences in the response speed for each piece of equipment within the intra-day scheduling.This study uses the IES as an example,and it dynamically determines the time scale of the energy monthly.In addition,this investigation presents a detailed analysis of the output plan of the key equipment to demonstrate the necessity and the advantages of the strategy.展开更多
Objective: To study the effect of trigonelline on the change of indicators of serum transaminase, lipoprotein and liver lipid of model rats with non-alcoholic fatty liver diseases and on the expression level of Bcl-2 ...Objective: To study the effect of trigonelline on the change of indicators of serum transaminase, lipoprotein and liver lipid of model rats with non-alcoholic fatty liver diseases and on the expression level of Bcl-2 and Bax proteins. Methods: A total of 45 SD rats were randomly divided into Fthe control group, model group and trigonelline intervention group. Rats in the control group were fed with the common diet, while rats in the model group and intervention group were fed with the high fat diet. 8 weeks later, the intervention group received the intragastric administration of trigonellin e(with the dosage of 40 mg/kg/d) for 8 weeks; while control group and model group received the intragastric administration of saline with the equal dosage. Blood was taken from the abdominal aorta of rats 8 weeks later, detecting the level of a series of indicators of ALT, AST, TG, TC, HDL-C and LDL-C in the serum. After the rats were sacrificed, detect the indicators of TG, TC, SOD and MDA in the liver tissue of rats, as well as the expression of Bcl-2 and Bax in the liver tissue. Results: Results of histopathologic examination showed that the damage degree of liver for rats in the trigonellineintervention group was smaller than the one in the model group, with significantly reduced hepatic steatosis and the partially visible hepatic lobule. The levels of ALT, AST, TC and LDL-C in the serum of rats in the trigonelline group were significantly reduced, while the change in the levels of TG and HDL-C was not significantly different. The levels of TG, TC and MDA in the liver tissues were significantly decreased, while the level of SOD significantly increased; the expression of Bcl-2 protein in the liver tissues of rats in the trigonelline intervention group was significantly increased, while the expression of Bax protein significantly decreased. Conclusions: The trigonelline contributes to the therapeutic effect of non-alcoholic fatty liver diseases. It can also increase the expression of Bcl-2 protein and decrease the expression of Bax protein in the liver tissues, which can protect the liver.展开更多
BACKGROUND Hypothyroidism is an endocrine disorder that has worldwide prevalence and can affect multiple organ systems.We report a case of hypothyroidism with elevated pancreatic amylase and trypsin without acute panc...BACKGROUND Hypothyroidism is an endocrine disorder that has worldwide prevalence and can affect multiple organ systems.We report a case of hypothyroidism with elevated pancreatic amylase and trypsin without acute pancreatitis.No such case has been previously reported.CASE SUMMARY A 29-year-old woman did not pay much attention to a fever 4 d prior.During this time,she experienced anorexia and only drank a small amount of water every day.She did not present with abdominal distension,postprandial nausea,vomiting,cough or expectoration.After physical and laboratory examinations,the patient was diagnosed with hypothyroidism.During the course of the disease,hypothyroidism was generally accompanied by constantly increased pancreatic amylase and trypsin.After admission,the possible etiology of the patient was excluded and the concentrations of pancreatic lipase and amylase in serum were>2000U/L(reference range 23-300 U/L)and 410 U/L(reference range 30-110 U/L),respectively.So we highly suspected that it may be acute pancreatitis.Interestingly,she never developed any complications associated with acute pancreatitis despite high levels of serum pancreatic amylase and trypsin,and she reported no symptoms of abdominal pain.Serum amylase and lipase decreased gradually after active thyroxine supplementation,and the patient was discharged from the hospital after active treatment.CONCLUSION This case suggests that clinicians should pay attention to hypothyroidism with elevated pancreatic amylase and trypsin,even if no complications of acute pancreatitis are reported.展开更多
The elliptical power-law model of the mass in a galaxy is widely used in strong gravitational lensing analyses.However,the distribution of mass in real galaxies is more complex.We quantify the biases due to this model...The elliptical power-law model of the mass in a galaxy is widely used in strong gravitational lensing analyses.However,the distribution of mass in real galaxies is more complex.We quantify the biases due to this model mismatch by simulating and then analyzing mock Hubble Space Telescope imaging of lenses with mass distributions inferred from SDSS-Ma NGA stellar dynamics data.We find accurate recovery of source galaxy morphology,except for a slight tendency to infer sources to be more compact than their true size.The Einstein radius of the lens is also robustly recovered with 0.1%accuracy,as is the global density slope,with 2.5%relative systematic error,compared to the 3.4%intrinsic dispersion.However,asymmetry in real lenses also leads to a spurious fitted"external shear"with typical strengthγext=0.015.Furthermore,time delays inferred from lens modeling without measurements of stellar dynamics are typically underestimated by~5%.Using such measurements from a sub-sample of 37 lenses would bias measurements of the Hubble constant H0 by~9%.Although this work is based on a particular set of Ma NGA galaxies,and the specific value of the detected biases may change for another set of strong lenses,our results strongly suggest the next generation cosmography needs to use more complex lens mass models.展开更多
基金Project supported by the National Natural Science Foundation of China (Grant Nos.12072200 and 12372384)。
文摘Granular segregation is widely observed in nature and industry.Most research has focused on segregation caused by differences in the size and density of spherical grains.However,due to the fact that grains typically have different shapes,the focus is shifting towards shape segregation.In this study,experiments are conducted by mixing cubic and spherical grains.The results indicate that spherical grains gather at the center and cubic grains are distributed around them,and the degree of segregation is low.Through experiments,a structured analysis of local regions is conducted to explain the inability to form stable segregation patterns with obviously different geometric shapes.Further,through simulations,the reasons for the central and peripheral distributions are explained by comparing velocities and the number of collisions of the grains in the flow layer.
文摘Small RNAs in Penicillium digitatum were identified and analyzed via transcriptome sequencing on the BGISEQ-500 platform. A total of 15 predicted miRNAs and 10718 novel siRNAs were found. Their length distribution, sequence, predicted construction, base bias, expression levels and potential targets were determined as well. Through pathway and KEGG enrichment analysis, the miRNA target genes were mostly involved in carbohydrate metabolism, transport and catabolism, translation and amino acid metabolism. The target genes involved in aflatoxin biosynthesis and proteasome had a higher rich factor value. The results will provide a theoretical foundation for understanding the developmental and pathogenic mechanisms of P. digitatum at the transcriptional level.
基金the Science Foundation of China University of Petroleum,Beijing(No.2462018YJRC033)Beijing Natural Science Foundation(2204093)for providing research funding.
文摘Gas flow properties in nanopores are significantly determined by the flow patterns. Slug flow pattern is a potential water–gas two phase flow pattern, in which gas molecules flow in form of gas slugs and water molecules separate gas slugs. Considering water slippage, a portion of water molecules accumulates at the wall with lower mobility, while the remaining water molecules take the shape of a water bridge. Adopting foam apparent viscosity model to represent slug rheological behavior, how water bridge disturbs on gas flow capacity is estimated. The results are compared with the water–gas two phase flow model that assumes annular flow pattern as well as the single gas flow model without the consideration of water. The comparison illustrates that gas molecular movement is significantly hindered by flow space reduction and loss of gas slippage. The impact from water phase of slug flow pattern is more significant than that of annular flow pattern on gas flow capacity. It is discovered that larger nanopores improve gas flow capacity while maintaining bulk water layer thickness and increasing water bridge thickness tend to reduce gas transport ability. A better understanding of the structure and transport of water and gas molecules is conducive to figure out the specific gas–water flow behavior and predict shale gas production.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11972212,12072200,and 12002213)。
文摘The velocity of a particle detector in granular flow can be regarded as the combination of rolling and sliding velocities.The study of the contribution of rolling velocity and sliding velocity provides a new explanation to the relative motion between the detector and the local granular flow.In this study,a spherical detector using embedded inertial navigation technology is placed in the chute granular flow to study the movement of the detector relative to the granular flow.It is shown by particle image velocimetry(PIV)that the velocity of chute granular flow conforms to Silbert’s formula.And the velocity of the detector is greater than that of the granular flow around it.By decomposing the velocity into sliding and rolling velocity,it is indicated that the movement of the detector relative to the granular flow is mainly caused by rolling.The rolling detail shown by DEM simulation leads to two potential mechanisms based on the position and drive of the detector.
文摘Objective: To investigate the research progress and new trend of acupuncture in the treatment of infertility from 2000 to 2021. Methods: The literature review was conducted on acupuncture and moxibustion treatment of infertility from 2000 to 2021 from the Web of Science core collection and PubMed. CiteSpace and VOSviewer were used to analyze the annual number of articles, countries, institutions, authors, journals, references and keywords. Statistical Analysis Toolkit for Informetrics 3.2 (SATI) and IBM SPSS Modeler 18.0 were employed to draw the maps of core acupoints and acupuncture approaches. Results: A total of 316 articles were included. From 2000 to 2021 the number of publications has been ever increased with certain fluctuations. The United States was the most productive country. Heilongjiang University of Chinese Medicine was the most active institution. Stener-Victorin E was the highest cited author. Fertility and Sterility was the most prolific journal. Paulus We, 2002 was the highest co-citation literature. SP6 (Sanyinjiao) was the most commonly used acupoint. Manual acupuncture was the most commonly used method. Conclusions: The study of acupuncture in the treatment of infertility is characterized by multinational, multi-institutional participation and close regional cooperation. Acupuncture is a potentially effective therapy for infertility. Due to a lack of research quality and difficulties in performing double-blind, high-quality clinical evidence is urgently required. A complete acupuncture therapy system for infertility should be gradually constructed.
文摘Brown rots of Red Fuji apples were observed in Hangzhou city (Zhengjiang Province, China). The causal agent was isolated and identified in both morphological and molecular genetic levels. The phenotype and phylogenetic analysis revealed that the isolate was </span><i><span style="font-family:Verdana;">Diaporthe phaseolorum</span></i><span style="font-family:Verdana;"> var. </span><i><span style="font-family:Verdana;">caulivora</span></i><span style="font-family:Verdana;">, and its pathogenicity on apple fruit was confirmed by re-inoculation experiment. To our knowledge, this is the first report of </span><i><span style="font-family:Verdana;">D. phaseolorum</span></i><span style="font-family:Verdana;"> var. </span><i><span style="font-family:Verdana;">caulivora</span></i><span style="font-family:Verdana;"> causing postharvest fruit rot on apple in China.
基金Research Fund for Lin He’s Academician Workstation of New Medicine and Clinical Translation in Jining Medical University,No.JYHL2019FMS25and The Key Research and Development Program of Jining,No.2022YXNS028.
文摘BACKGROUND Post-stroke epilepsy is a common and easily overlooked complication of acute cerebrovascular disease.Long-term seizures can seriously affect the prognosis and quality of life of patients.Electroencephalogram(EEG)is the simplest way to diagnose epilepsy,and plays an important role in predicting seizures and guiding medication.AIM To explore the EEG characteristics of patients with post-stroke epilepsy and improve the detection rate of inter-seizure epileptiform discharges.METHODS From January 2017 to June 2020,10 patients with post-stroke epilepsy in our hospital were included.The clinical,imaging,and EEG characteristics were collected.The stroke location,seizure type,and ictal and interictal EEG manifestations of the patients with post-stroke epilepsy were then retrospectively analyzed.RESULTS In all 10 patients,epileptiform waves occurred in the side opposite to the stroke lesion during the interictal stage;these manifested as sharp wave,sharp-wave complex,or spike discharges in the anterior head lead of the side opposite to the lesion.CONCLUSION In EEG,epileptiform waves can occur in the side opposite to the stroke lesion in patients with post-stroke epilepsy.
基金supported by the Science and Technology Project of State Grid Shanxi Electric Power Research Institute:Research on Data-Driven New Power System Operation Simulation and Multi Agent Control Strategy(52053022000F).
文摘Due to the impact of source-load prediction power errors and uncertainties,the actual operation of the park will have a wide range of fluctuations compared with the expected state,resulting in its inability to achieve the expected economy.This paper constructs an operating simulation model of the park power grid operation considering demand response and proposes a multi-time scale operating simulation method that combines day-ahead optimization and model predictive control(MPC).In the day-ahead stage,an operating simulation plan that comprehensively considers the user’s side comfort and operating costs is proposed with a long-term time scale of 15 min.In order to cope with power fluctuations of photovoltaic,wind turbine and conventional load,MPC is used to track and roll correct the day-ahead operating simulation plan in the intra-day stage to meet the actual operating operation status of the park.Finally,the validity and economy of the operating simulation strategy are verified through the analysis of arithmetic examples.
基金supported by the National Key Research Program of China as the“Collaborative Precision Positioning Project”(No.2016YFB0501900)the National Natural Science Foundation of China(Grant Nos.41674041,41574029 and 11203059)+2 种基金the Youth Innovation Promotion Association CAS(Grant No.2016242)Shanghai Science and Technology Committee Foundation(Grant No.16511103003)the Shanghai Key Laboratory of Space Navigation and Position Techniques(Grant No.12DZ2273300,ZZXT201701)
文摘The regional BeiDou Satellite System, or BDS2, broadcasts a differential correction as Equivalent Satellite Clock Correction to correct both orbit and satellite clock errors. For the global BDS, or BDS3, satellite orbit and clock corrections conforming with RTCA standards will be broadcast to authorized users. The hybrid constellation and regional monitoring network pose challenges for the high precision separation of orbit and satellite clock corrections. Three correction models of kinematic,dynamic and Two-way Satellite Time Frequency Transfer(TWSTFT)-based dynamic were studied to estimate the satellite orbit and clock corrections. The correction accuracy of the three models is compared and analyzed based on the BDS observation data. Results show that the accuracies(root mean square, RMS) of dual-frequency real-time positioning for the three models are about 1.76 m, 1.78 m and 2.08 m respectively, which are comparable with the performance of WAAS and EGNOS. With dynamic corrections, the precision of Precise Point Positioning(PPP) experiments may reach about 23 cm after convergence.
基金supported by the Fundamental Research Funds for the Central Universities(No.2017MS093)
文摘Considering the complex coupling of multiple energies and the varying load forecasting errors for an integrated energy system(IES),this study proposes a dynamic time-scale scheduling strategy based on long short-term memory(LSTM)and multiple load forecasting errors.This strategy dynamically selects a hybrid timescale which is suitable for a variety of energies for each month.This is obtained by combining the mean absolute percentage error(MAPE)curve of the load forecasting with the error restriction requirements of the dispatcher.Based on the day-ahead scheduling plan,the output of the partial equipment is selectively adjusted at each time-scale to realize multi-energy collaborative optimization and gives full play to the comprehensive advantages of the IES.This is achieved by considering the differences in the response speed for each piece of equipment within the intra-day scheduling.This study uses the IES as an example,and it dynamically determines the time scale of the energy monthly.In addition,this investigation presents a detailed analysis of the output plan of the key equipment to demonstrate the necessity and the advantages of the strategy.
基金supported by Natural Science Fund of Shandong Province(No.:ZR2009CL018)
文摘Objective: To study the effect of trigonelline on the change of indicators of serum transaminase, lipoprotein and liver lipid of model rats with non-alcoholic fatty liver diseases and on the expression level of Bcl-2 and Bax proteins. Methods: A total of 45 SD rats were randomly divided into Fthe control group, model group and trigonelline intervention group. Rats in the control group were fed with the common diet, while rats in the model group and intervention group were fed with the high fat diet. 8 weeks later, the intervention group received the intragastric administration of trigonellin e(with the dosage of 40 mg/kg/d) for 8 weeks; while control group and model group received the intragastric administration of saline with the equal dosage. Blood was taken from the abdominal aorta of rats 8 weeks later, detecting the level of a series of indicators of ALT, AST, TG, TC, HDL-C and LDL-C in the serum. After the rats were sacrificed, detect the indicators of TG, TC, SOD and MDA in the liver tissue of rats, as well as the expression of Bcl-2 and Bax in the liver tissue. Results: Results of histopathologic examination showed that the damage degree of liver for rats in the trigonellineintervention group was smaller than the one in the model group, with significantly reduced hepatic steatosis and the partially visible hepatic lobule. The levels of ALT, AST, TC and LDL-C in the serum of rats in the trigonelline group were significantly reduced, while the change in the levels of TG and HDL-C was not significantly different. The levels of TG, TC and MDA in the liver tissues were significantly decreased, while the level of SOD significantly increased; the expression of Bcl-2 protein in the liver tissues of rats in the trigonelline intervention group was significantly increased, while the expression of Bax protein significantly decreased. Conclusions: The trigonelline contributes to the therapeutic effect of non-alcoholic fatty liver diseases. It can also increase the expression of Bcl-2 protein and decrease the expression of Bax protein in the liver tissues, which can protect the liver.
基金Supported by Shanghai Shenkang Hospital Development Center,No.SHDC12016109.
文摘BACKGROUND Hypothyroidism is an endocrine disorder that has worldwide prevalence and can affect multiple organ systems.We report a case of hypothyroidism with elevated pancreatic amylase and trypsin without acute pancreatitis.No such case has been previously reported.CASE SUMMARY A 29-year-old woman did not pay much attention to a fever 4 d prior.During this time,she experienced anorexia and only drank a small amount of water every day.She did not present with abdominal distension,postprandial nausea,vomiting,cough or expectoration.After physical and laboratory examinations,the patient was diagnosed with hypothyroidism.During the course of the disease,hypothyroidism was generally accompanied by constantly increased pancreatic amylase and trypsin.After admission,the possible etiology of the patient was excluded and the concentrations of pancreatic lipase and amylase in serum were>2000U/L(reference range 23-300 U/L)and 410 U/L(reference range 30-110 U/L),respectively.So we highly suspected that it may be acute pancreatitis.Interestingly,she never developed any complications associated with acute pancreatitis despite high levels of serum pancreatic amylase and trypsin,and she reported no symptoms of abdominal pain.Serum amylase and lipase decreased gradually after active thyroxine supplementation,and the patient was discharged from the hospital after active treatment.CONCLUSION This case suggests that clinicians should pay attention to hypothyroidism with elevated pancreatic amylase and trypsin,even if no complications of acute pancreatitis are reported.
基金the support of the National Natural Science Foundation of China(Nos.11988101,11773032,12022306)the science research grants from the China Manned Space Project(Nos.CMS-CSST-2021-B01,CMS-CSST-2021-A01)+5 种基金the support from K.C.Wong Education Foundationfunding from the UK Space Agency through award ST/W002612/1from STFC through award ST/T002565/1support by the European Research Council(ERC)through Advanced Investigator grant to CSF,DMIDAS(GA 786910)supported by the European Research Council Horizon 2020 grant“EWC”(award AMD-776247-6)supported by an STFC/UKRI Ernest Rutherford Fellowship,Project Reference:ST/S004998/1。
文摘The elliptical power-law model of the mass in a galaxy is widely used in strong gravitational lensing analyses.However,the distribution of mass in real galaxies is more complex.We quantify the biases due to this model mismatch by simulating and then analyzing mock Hubble Space Telescope imaging of lenses with mass distributions inferred from SDSS-Ma NGA stellar dynamics data.We find accurate recovery of source galaxy morphology,except for a slight tendency to infer sources to be more compact than their true size.The Einstein radius of the lens is also robustly recovered with 0.1%accuracy,as is the global density slope,with 2.5%relative systematic error,compared to the 3.4%intrinsic dispersion.However,asymmetry in real lenses also leads to a spurious fitted"external shear"with typical strengthγext=0.015.Furthermore,time delays inferred from lens modeling without measurements of stellar dynamics are typically underestimated by~5%.Using such measurements from a sub-sample of 37 lenses would bias measurements of the Hubble constant H0 by~9%.Although this work is based on a particular set of Ma NGA galaxies,and the specific value of the detected biases may change for another set of strong lenses,our results strongly suggest the next generation cosmography needs to use more complex lens mass models.
