The>2000 km Indus-Yarlung Tsangpo suture zone(IYSZ)is composed of the Neo-tethys oceanic remnants,flysch units and related continental rocks,which has been regarded as the boundary between the Eurasian and Indian t...The>2000 km Indus-Yarlung Tsangpo suture zone(IYSZ)is composed of the Neo-tethys oceanic remnants,flysch units and related continental rocks,which has been regarded as the boundary between the Eurasian and Indian terranes.Among the ophiolitic complexes,the Purang ophiolite is the biggest massif in the IYSZ,and many studies have been conducted on this ophiolite.However,previous studies have mainly focused on harzburgite,clinopyroxenite and dunite.Field observations show that mafic dykes were emplaced within the Purang ophiolite.However,petrogenetic evolutions of those mafic dykes are poorly understood.In this study,we present new LA-ICP-MS zircon U-Pb dating results,whole-rock geochemistry and Sr-Nd-Hf isotope analyses for microgabbro,gabbro and dolerite dykes from the Purang ophiolite of the southwestern IYSZ,respectively.Three samples yielded zircon U-Pb ages of144.2±2.1 Ma.127.9±2.3 Ma and 126.5±0.42 Ma,suggesting two different phases of magmatic activities distinctly.Whole-rock geochemical results suggest that the gabbro samples show alkaline features marked by enrichments of light rare earth elements(LREE)and large-ion lithophile elements(LILE),as well as Nb-Ta elements,suggesting an oceanic island basalt-like(OIB-like)geochemical affinity.However,the dolerite and microgabbro samples demonstrate sub-alkaline characteristics with normal mid-oceanic ridge basalt-like(N-MORB-like)geochemical features.Three distinct mafic dykes show significant Rb element depletion.The geochemical data and Sr-Nd-Hf isotopic features suggest that the microgabbro and gabbro rocks were derived from a depleted mantle that had been metasomatized by partial melts of sediments and enriched slab-derived fluids.The dolerite was also originated from a depleted mantle marked by significantly depleted Sr-Nd-Hf compositions,which was not influenced by enriched slab-derived fluids and sediments contamination during subsequent evolution.The isotope and geochemical data and tectonic diagrams suggest a tectonic transition from a within-plate to a midoceanic ridge basalt-like(MORB-like)setting during the period from ca.144 Ma to 127 Ma.Combined with regional background and this study,we propose that these mafic dykes were formed in an oceanic back-arc basin setting.Additionally,integrated with previous studies,we suggest that the geodynamic evolution of the southwestern and central parts of the Neo-Tethys oceanic basin is comparable in Early Cretaceous.展开更多
DC motors are widely used in industry such as mechanics, robotics, and aerospace engineering. In this paper, we present a high performance control method for position control of DC motors. Fault-tolerant control model...DC motors are widely used in industry such as mechanics, robotics, and aerospace engineering. In this paper, we present a high performance control method for position control of DC motors. Fault-tolerant control model are also addressed to combine with neuro-robust control approach. It is shown that with the proposed control algorithms, external disturbances and coupled dynamics inherent in the system are effectively compensated using neural network unit in which no analytical estimation on the upper bound of the reconstruction error and uncertainties is needed. Simulations on various flight conditions also confirm the effectiveness of the proposed methods.展开更多
This study investigated the combinatorial expression of xanthine dehydrogenase(XDH)and chaperone XdhC from Acinetobacter baumannii and Rhodobacter capsulatus and their applications in decreasing purine content in the ...This study investigated the combinatorial expression of xanthine dehydrogenase(XDH)and chaperone XdhC from Acinetobacter baumannii and Rhodobacter capsulatus and their applications in decreasing purine content in the beer,beef and yeast.Naturally occurring xdhABC gene clusters of A.baumannii CICC 10254 and R.capsulatus CGMCC 1.3366 as well as two refactored clusters constructed by exchanging their xdhC genes were overexpressed in Escherichia coli and purified to near homogeneity.RcXDH chaperoned by AbXdhC showed nearly the same catalytic performance as that by RcXdhC,except for the decreased substrate affinity.While the AbXDH co-expressed with RcXdhC displayed enhanced acidic adaptation but weakened catalytic activity.All the XDHs degraded purines in beer,beef and yeast extract effectively,indicating potential applications in low-purine foods to prevent hyperuricemia and gout.The study also presents a method for exploiting the better chaperone XdhC and novel XDHs by functional complement activity using existing XdhCs such as RcXdhC.展开更多
The development of epigenetic maps, such as the ENCODE project in humans, provides resources for gene regulation studies and a reference for research of disease-related regulatory elements. However,epigenetic informat...The development of epigenetic maps, such as the ENCODE project in humans, provides resources for gene regulation studies and a reference for research of disease-related regulatory elements. However,epigenetic information, such as a bird-specific chromatin accessibility atlas, is currently lacking for the thousands of bird species currently described.The major genomic difference between birds and mammals is their shorter introns and intergenic distances, which seriously hinders the use of humans and mice as a reference for studying the function of important regulatory regions in birds. In this study, using chicken as a model bird species, we systematically compiled a chicken chromatin accessibility atlas using 53 Assay of Transposase Accessible Chromatin sequencing(ATAC-seq)samples across 11 tissues. An average of 50 ?796open chromatin regions were identified per sample,cumulatively accounting for 20.36% of the chicken genome. Tissue specificity was largely reflected by differences in intergenic and intronic peaks, with specific functional regulation achieved by two mechanisms: recruitment of several sequence-specific transcription factors and direct regulation of adjacent functional genes. By integrating data from genome-wide association studies, our results suggest that chicken body weight is driven by different regulatory variants active in growth-relevant tissues. We propose CAB39L(active in the duodenum), RCBTB1(muscle and liver), and novel long non-coding RNA ENSGALG00000053256(bone) as candidate genes regulating chicken body weight. Overall, this study demonstrates the value of epigenetic data in fine-mapping functional variants and provides a compendium of resources for further research on the epigenetics and evolution of birds and mammals.展开更多
Tree species diversity is vital for maintaining ecosystem functions,yet our ability to map the distribution of tree diversity is limited due to difficulties in traditional field-based approaches.Recent developments in...Tree species diversity is vital for maintaining ecosystem functions,yet our ability to map the distribution of tree diversity is limited due to difficulties in traditional field-based approaches.Recent developments in spaceborne remote sensing provide unprecedented opportunities to map and monitor tree diversity more efficiently.Here we built partial least squares regression models using the multispectral surface reflectance acquired by Sentinel-2 satellites and the inventory data from 74 subtropical forest plots to predict canopy tree diversity in a national natural reserve in eastern China.In particular,we evaluated the underappreciated roles of the practical definition of forest canopy and phenological variation in predicting tree diversity by testing three different definitions of canopy trees and comparing models built using satellite imagery of different seasons.Our best models explained 42%–63%variations in observed diversities in cross-validation tests,with higher explanation power for diversity indices that are more sensitive to abundant species.The models built using imageries from early spring and late autumn showed consistently better fits than those built using data from other seasons,highlighting the significant role of transitional phenology in remotely sensing plant diversity.Our results suggested that the cumulative diameter(60%–80%)of the biggest trees is a better way to define the canopy layer than using the subjective fixeddiameter-threshold(5–12 cm)or the cumulative basal area(90%–95%)of the biggest trees.Remarkably,these approaches resulted in contrasting diversity maps that call attention to canopy structure in remote sensing of tree diversity.This study demonstrates the potential of mapping and monitoring tree diversity using the Sentinal-2 data in species-rich forests.展开更多
Knowledge graph(KG)fact prediction aims to complete a KG by determining the truthfulness of predicted triples.Reinforcement learning(RL)-based approaches have been widely used for fact prediction.However,the existing ...Knowledge graph(KG)fact prediction aims to complete a KG by determining the truthfulness of predicted triples.Reinforcement learning(RL)-based approaches have been widely used for fact prediction.However,the existing approaches largely suffer from unreliable calculations on rule confidences owing to a limited number of obtained reasoning paths,thereby resulting in unreliable decisions on prediction triples.Hence,we propose a new RL-based approach named EvoPath in this study.EvoPath features a new reward mechanism based on entity heterogeneity,facilitating an agent to obtain effective reasoning paths during random walks.EvoPath also incorporates a new postwalking mechanism to leverage easily overlooked but valuable reasoning paths during RL.Both mechanisms provide sufficient reasoning paths to facilitate the reliable calculations of rule confidences,enabling EvoPath to make precise judgments about the truthfulness of prediction triples.Experiments demonstrate that EvoPath can achieve more accurate fact predictions than existing approaches.展开更多
High-dimensional quantum systems, such as qutrits(quantum three-level systems), have multiple accessible energy levels beyond the two-level qubits. Therefore, qutrits can offer a larger state space to improve the effi...High-dimensional quantum systems, such as qutrits(quantum three-level systems), have multiple accessible energy levels beyond the two-level qubits. Therefore, qutrits can offer a larger state space to improve the efficiency of quantum computation. Here, we demonstrate a high-fidelity iSWAP-like gate operation on a frequency-tunable superconducting qutrits system. The superconducting quantum system consists of two qutrits that are coupled via a resonator with fixed qutrit-resonator coupling strengths. Through designing the frequency pulse profile and optimizing the parameter values,the gate error can be suppressed below 1.5 × 10^(-3). To bear out the feasibility of the proposal, we have conducted our study with experimentally accessible parameters. As the resonator can mediate the interaction between the irrelevant qutrits, the presented approach can also be used to couple multiple qutrits together, providing a good platform for quantum information processing.展开更多
BACKGROUND Sclerosing odontogenic carcinoma is a rare primary intraosseous neoplasm that was featured recently as a single entity in the World Health Organization classification of Head and Neck Tumors 2017,with only ...BACKGROUND Sclerosing odontogenic carcinoma is a rare primary intraosseous neoplasm that was featured recently as a single entity in the World Health Organization classification of Head and Neck Tumors 2017,with only 14 cases published to date.The biological characteristics of sclerosing odontogenic carcinoma remain indistinct because of its rarity;however,it appears to be locally aggressive,with no regional or distant metastasis reported to date.CASE SUMMARY We reported a case of sclerosing odontogenic carcinoma of the maxilla in a 62-year-old woman,who presented with an indolent right palatal swelling,which progressively increased in size over 7 years.Right subtotal maxillectomy with surgical margins of approximately 1.5 cm was performed.The patient remained disease free for 4 years following the ablation surgery.Diagnostic workups,treatment,and therapeutic outcomes were discussed.CONCLUSION More cases are needed to further characterize this entity,understand its biological behavior,and justify the treatment protocols.Resection with wide margins of approximately 1.0 to 1.5 cm is proposed,while neck dissection,post-operative radiotherapy,or chemotherapy are deemed unnecessary.展开更多
BACKGROUND Malignant peripheral nerve sheath tumor(MPNST)is a rare and aggressive soft tissue sarcoma that poses a major diagnostic and therapeutic challenge.CASE SUMMARY We retrospectively reviewed patients with head...BACKGROUND Malignant peripheral nerve sheath tumor(MPNST)is a rare and aggressive soft tissue sarcoma that poses a major diagnostic and therapeutic challenge.CASE SUMMARY We retrospectively reviewed patients with head and neck MPNSTs treated in our hospital from 2000 to 2021.The clinical features,pathological manifestations,treatments,and prognoses were summarized.We also reviewed the literature,focusing on MPNST in the mandible and maxilla.The study population consisted of five women and five men aged 22–75 years(mean age,49 years).Of the 10 patients,7 were initial cases and 3 were recurrent cases.All lesions were sporadic.The most common site was the mandible.The most frequently encountered symptoms were a progressive mass and local swelling.Complete or partial loss of trimethylation at lysine 27 of histone H3(H3K27me3)was evident on staining in four of nine cases(one case was excluded due to lack of tissue for evaluation of loss of H3K27me3).The 2-and 5-year disease-specific survival rates were 86%a nd 43%,respectively.The average survival time was 64 mo.CONCLUSION MPNST is a highly malignant tumor with a poor prognosis,prone to a high risk of recurrence and distant metastasis.Complete surgical resection is the main treatment.展开更多
The gingiva is a key oral barrier that protects oral tissues from various stimuli.A loss of gingival tissue homeostasis causes periodontitis,one of the most prevalent inflammatory diseases in humans.The human gingiva ...The gingiva is a key oral barrier that protects oral tissues from various stimuli.A loss of gingival tissue homeostasis causes periodontitis,one of the most prevalent inflammatory diseases in humans.The human gingiva exists as a complex cell network comprising specialized structures.To understand the tissue-specific pathophysiology of the gingiva,we applied a recently developed spatial enhanced resolution omics-sequencing(Stereo-seq)technique to obtain a spatial transcriptome(ST)atlas of the gingiva in healthy individuals and periodontitis patients.By utilizing Stereo-seq,we identified the major cell types present in the gingiva,which included epithelial cells,fibroblasts,endothelial cells,and immune cells,as well as subgroups of epithelial cells and immune cells.We further observed that inflammation-related signalling pathways,such as the JAK-STAT and NF-κB signalling pathways,were significantly upregulated in the endothelial cells of the gingiva of periodontitis patients compared with those of healthy individuals.Additionally,we characterized the spatial distribution of periodontitis risk genes in the gingiva and found that the expression of IFI16 was significantly increased in endothelial cells of inflamed gingiva.In conclusion,our Stereo-seq findings may facilitate the development of innovative therapeutic strategies for periodontitis by mapping periodontitis-relevant genes and pathways and effector cells.展开更多
目的:探讨微小RNA-302c(miR-302c)在肺癌组织中的表达,以及对肺癌侵袭和迁移的影响和作用机制。方法:在线分析GEO数据库中GSE19945和GSE136043两组肺癌数据集中miR-302c的表达情况,通过Human Protein Atlas数据库研究CREB1表达情况;双...目的:探讨微小RNA-302c(miR-302c)在肺癌组织中的表达,以及对肺癌侵袭和迁移的影响和作用机制。方法:在线分析GEO数据库中GSE19945和GSE136043两组肺癌数据集中miR-302c的表达情况,通过Human Protein Atlas数据库研究CREB1表达情况;双荧光素酶实验证明miR-302c和CREB1的关系。正常组细胞不加任何药物,对照组细胞转染miR-302cmimic-NC,实验组细胞转染miR-302c-mimic。通过Transwell小室检测细胞的侵袭与迁移能力,通过小管形成检测细胞的血管生成能力,通过Western blot检测各组细胞中CREB1、p-P53、p-P21的表达水平。结果:生物信息分析显示,与正常组织相比,miR-302c在肺癌组织、肺癌淋巴转移组织中的表达明显降低,肺癌组织中CREB1的表达明显升高;双荧光素酶实验证明miR-302c靶向调控CREB1的表达;与正常组相比,实验组迁移和侵袭的细胞数量、小管生成的数量明显下降,实验组中CREB1的表达明显下降,p-P53、p-P21的表达明显升高(均P<0.05)。结论:miR-302c在肺癌组织表达降低,过表达miR-302c后能明显抑制肺癌细胞的侵袭与转移,这可能与抑制靶基因CREB1的表达,以及激活P53信号通路有关。展开更多
<strong>Objective: </strong>The quantum dots are the useful materials in microelectronics and biomedical research. However its toxicity has to be considered. We studied the effect of cell inhibition with Z...<strong>Objective: </strong>The quantum dots are the useful materials in microelectronics and biomedical research. However its toxicity has to be considered. We studied the effect of cell inhibition with ZnS core quantum dots and CdTe quantum dots modified with Thioglycolic acid or Cysteine functional group (TGA-CdTe, TGA-CdTe/ZnS, Cys-CdTe, Cys-CdTe/ZnS) on Caco-2 cell proliferation. <strong>Methods</strong>: We studied the effect of cell inhibition with ZnS core QDs and CdTe QDs modified with functional group on Caco-2 cell proliferation by MTT assay at 0, 12.5, 25, 50, 100 μg/ml and 6, 24, 48 h. <strong>Result:</strong> Our results showed that all QDs have inhibited cell proliferation and reached maximum 79.21%. The inhibition rate of Cys-modified QDs increased with the increase of concentration and reached maximum 66.72%. The inhibition rate of TGA-modified QDs increased with the increase of time. The ratios of Cys-modified to TGA-modified were less than 1 at all concentrations and three exposure times (P ≤ 0.01). The average ratios of Cys-CdTe/ZnS to Cys-CdTe reached 1.11 only for 48 h (P ≤ 0.05). The ratios of TGA-CdTe/ZnS to TGA-CdTe were closed to 1 at all concentrations and exposure times. <strong>Conclusion:</strong> The regularity of QDs modified with functional group is that inhibition of TGA-modified higher than Cys-modified. Inhibition exhibited dose-dependent for Cys-modified while exhibited time-dependent for TGA-modified. The regularity of CdTe-QDs with ZnS or not is that the inhibition of Cys-CdTe/ZnS was higher than Cys-CdTe while TGA-CdTe/ZnS and TGA-CdTe were consistent.展开更多
GeSe nanosheets were prepared by ultrasonic-assisted liquid<span><span><span style="font-family:;" "=""> </span></span></span><span><span><sp...GeSe nanosheets were prepared by ultrasonic-assisted liquid<span><span><span style="font-family:;" "=""> </span></span></span><span><span><span><span style="font-family:Verdana;">phase exfoliation (LPE), and the nonlinear saturated absorption performance was experimentally studied. The modulation depth and saturation intensity of the prepared GeSe saturable absorber (SA) were 15% and 1.44 MW/cm</span><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;">, respectively. Us</span><span style="font-family:Verdana;">ing the saturated absorption characteristics of GeSe SA, a passively Q-switched </span><span style="font-family:Verdana;">erbium-doped fiber laser was systematically demonstrated. As the pump</span><span style="font-family:Verdana;"> power increases, the pulse repetition frequency increases from 22.8 kHz to 77.59 </span><span style="font-family:Verdana;">kHz. The shortest pulse duration is 1.51 μs, and the corresponding pulse</span><span style="font-family:Verdana;"> energy is 46.14 nJ. Experimental results show that GeSe nanosheets can be used as high-efficiency SA in fiber lasers. Our results will provide a useful reference for demonstrating pulsed fiber lasers based on GeSe equipment.</span></span></span></span>展开更多
Hybrid precoding and combining have been considered as a promising technology, which can provide a compromise between hardware complexity and system performance in millimeter wave multiple-input multiple-output system...Hybrid precoding and combining have been considered as a promising technology, which can provide a compromise between hardware complexity and system performance in millimeter wave multiple-input multiple-output systems. However, most existing hybrid precoder and combiner designs generally assume that infinite resolution phase shifters(PSs) are used to produce the analog beamformers. In a practical scene, the design with accurate PSs can lead to high hardware cost and power consumption. In this paper, we investigate the hybrid precoder and combiner design with finite resolution PSs in millimeter wave systems. We employ alternate optimization as the main strategy to jointly design analog precoder and combiner. In addition, we propose a low complexity algorithm, where the analog beamformers are implemented only by finite resolution PSs to maximize spectral efficiency. Then, the digital precoder and combiner are designed based on the obtained analog beamformers to improve the spectral efficiency. Finally, simulation results and mathematical analysis show that the proposed algorithm with low-resolution PSs can achieve near-optimal performance and have low complexity.展开更多
基金supported by the Key Laboratory of Deep-Earth Dynamics of Ministry of Natural Resources (J1901-7,J1901-16)the Natural Foundation of Shandong Province (ZR2019QD002,ZR2017BD033)+6 种基金the Chinese Academy of Geological Sciences Fund (K1710)the National Key Research and Development Project of China (No.2016YFC0600310)the National Natural Science Foundation of China (NNSFCProject Nos.41672046,41641015,41703036,41720104009)the China Geological Survey (CGSProject No.DD20160023)the International Geological Correlation Programme (IGCP-649)
文摘The>2000 km Indus-Yarlung Tsangpo suture zone(IYSZ)is composed of the Neo-tethys oceanic remnants,flysch units and related continental rocks,which has been regarded as the boundary between the Eurasian and Indian terranes.Among the ophiolitic complexes,the Purang ophiolite is the biggest massif in the IYSZ,and many studies have been conducted on this ophiolite.However,previous studies have mainly focused on harzburgite,clinopyroxenite and dunite.Field observations show that mafic dykes were emplaced within the Purang ophiolite.However,petrogenetic evolutions of those mafic dykes are poorly understood.In this study,we present new LA-ICP-MS zircon U-Pb dating results,whole-rock geochemistry and Sr-Nd-Hf isotope analyses for microgabbro,gabbro and dolerite dykes from the Purang ophiolite of the southwestern IYSZ,respectively.Three samples yielded zircon U-Pb ages of144.2±2.1 Ma.127.9±2.3 Ma and 126.5±0.42 Ma,suggesting two different phases of magmatic activities distinctly.Whole-rock geochemical results suggest that the gabbro samples show alkaline features marked by enrichments of light rare earth elements(LREE)and large-ion lithophile elements(LILE),as well as Nb-Ta elements,suggesting an oceanic island basalt-like(OIB-like)geochemical affinity.However,the dolerite and microgabbro samples demonstrate sub-alkaline characteristics with normal mid-oceanic ridge basalt-like(N-MORB-like)geochemical features.Three distinct mafic dykes show significant Rb element depletion.The geochemical data and Sr-Nd-Hf isotopic features suggest that the microgabbro and gabbro rocks were derived from a depleted mantle that had been metasomatized by partial melts of sediments and enriched slab-derived fluids.The dolerite was also originated from a depleted mantle marked by significantly depleted Sr-Nd-Hf compositions,which was not influenced by enriched slab-derived fluids and sediments contamination during subsequent evolution.The isotope and geochemical data and tectonic diagrams suggest a tectonic transition from a within-plate to a midoceanic ridge basalt-like(MORB-like)setting during the period from ca.144 Ma to 127 Ma.Combined with regional background and this study,we propose that these mafic dykes were formed in an oceanic back-arc basin setting.Additionally,integrated with previous studies,we suggest that the geodynamic evolution of the southwestern and central parts of the Neo-Tethys oceanic basin is comparable in Early Cretaceous.
文摘DC motors are widely used in industry such as mechanics, robotics, and aerospace engineering. In this paper, we present a high performance control method for position control of DC motors. Fault-tolerant control model are also addressed to combine with neuro-robust control approach. It is shown that with the proposed control algorithms, external disturbances and coupled dynamics inherent in the system are effectively compensated using neural network unit in which no analytical estimation on the upper bound of the reconstruction error and uncertainties is needed. Simulations on various flight conditions also confirm the effectiveness of the proposed methods.
基金funded by the National Natural Science Foundation of China(21868003)the Guangxi Natural Science Foundation(2018AD19022,2017GXNSFAA198265)the Nanning Science and Technology Development Project(2017014).
文摘This study investigated the combinatorial expression of xanthine dehydrogenase(XDH)and chaperone XdhC from Acinetobacter baumannii and Rhodobacter capsulatus and their applications in decreasing purine content in the beer,beef and yeast.Naturally occurring xdhABC gene clusters of A.baumannii CICC 10254 and R.capsulatus CGMCC 1.3366 as well as two refactored clusters constructed by exchanging their xdhC genes were overexpressed in Escherichia coli and purified to near homogeneity.RcXDH chaperoned by AbXdhC showed nearly the same catalytic performance as that by RcXdhC,except for the decreased substrate affinity.While the AbXDH co-expressed with RcXdhC displayed enhanced acidic adaptation but weakened catalytic activity.All the XDHs degraded purines in beer,beef and yeast extract effectively,indicating potential applications in low-purine foods to prevent hyperuricemia and gout.The study also presents a method for exploiting the better chaperone XdhC and novel XDHs by functional complement activity using existing XdhCs such as RcXdhC.
基金supported by the National Natural Science Foundation of China(U2002205,32272862)。
文摘The development of epigenetic maps, such as the ENCODE project in humans, provides resources for gene regulation studies and a reference for research of disease-related regulatory elements. However,epigenetic information, such as a bird-specific chromatin accessibility atlas, is currently lacking for the thousands of bird species currently described.The major genomic difference between birds and mammals is their shorter introns and intergenic distances, which seriously hinders the use of humans and mice as a reference for studying the function of important regulatory regions in birds. In this study, using chicken as a model bird species, we systematically compiled a chicken chromatin accessibility atlas using 53 Assay of Transposase Accessible Chromatin sequencing(ATAC-seq)samples across 11 tissues. An average of 50 ?796open chromatin regions were identified per sample,cumulatively accounting for 20.36% of the chicken genome. Tissue specificity was largely reflected by differences in intergenic and intronic peaks, with specific functional regulation achieved by two mechanisms: recruitment of several sequence-specific transcription factors and direct regulation of adjacent functional genes. By integrating data from genome-wide association studies, our results suggest that chicken body weight is driven by different regulatory variants active in growth-relevant tissues. We propose CAB39L(active in the duodenum), RCBTB1(muscle and liver), and novel long non-coding RNA ENSGALG00000053256(bone) as candidate genes regulating chicken body weight. Overall, this study demonstrates the value of epigenetic data in fine-mapping functional variants and provides a compendium of resources for further research on the epigenetics and evolution of birds and mammals.
基金supported by the National Natural Science Foundation of China(No. 32101280)the Natural Science Foundation of Shanghai(No. 21ZR1420900)the Key R&D Project of Zhejiang(No. 2023C03138)
文摘Tree species diversity is vital for maintaining ecosystem functions,yet our ability to map the distribution of tree diversity is limited due to difficulties in traditional field-based approaches.Recent developments in spaceborne remote sensing provide unprecedented opportunities to map and monitor tree diversity more efficiently.Here we built partial least squares regression models using the multispectral surface reflectance acquired by Sentinel-2 satellites and the inventory data from 74 subtropical forest plots to predict canopy tree diversity in a national natural reserve in eastern China.In particular,we evaluated the underappreciated roles of the practical definition of forest canopy and phenological variation in predicting tree diversity by testing three different definitions of canopy trees and comparing models built using satellite imagery of different seasons.Our best models explained 42%–63%variations in observed diversities in cross-validation tests,with higher explanation power for diversity indices that are more sensitive to abundant species.The models built using imageries from early spring and late autumn showed consistently better fits than those built using data from other seasons,highlighting the significant role of transitional phenology in remotely sensing plant diversity.Our results suggested that the cumulative diameter(60%–80%)of the biggest trees is a better way to define the canopy layer than using the subjective fixeddiameter-threshold(5–12 cm)or the cumulative basal area(90%–95%)of the biggest trees.Remarkably,these approaches resulted in contrasting diversity maps that call attention to canopy structure in remote sensing of tree diversity.This study demonstrates the potential of mapping and monitoring tree diversity using the Sentinal-2 data in species-rich forests.
基金the National Natural Science Foundation of China,Nos.62272480 and 62072470and the National Science Foundation of Hunan Province,Nos.2021JJ30881 and 2020JJ4758.
文摘Knowledge graph(KG)fact prediction aims to complete a KG by determining the truthfulness of predicted triples.Reinforcement learning(RL)-based approaches have been widely used for fact prediction.However,the existing approaches largely suffer from unreliable calculations on rule confidences owing to a limited number of obtained reasoning paths,thereby resulting in unreliable decisions on prediction triples.Hence,we propose a new RL-based approach named EvoPath in this study.EvoPath features a new reward mechanism based on entity heterogeneity,facilitating an agent to obtain effective reasoning paths during random walks.EvoPath also incorporates a new postwalking mechanism to leverage easily overlooked but valuable reasoning paths during RL.Both mechanisms provide sufficient reasoning paths to facilitate the reliable calculations of rule confidences,enabling EvoPath to make precise judgments about the truthfulness of prediction triples.Experiments demonstrate that EvoPath can achieve more accurate fact predictions than existing approaches.
基金supported by the National Natural Science Foundation of China (Grant Nos. 12105146 and 12175104)supported by the National Natural Science Foundation of China (Grant No. 61871234)sponsored by NUPTSF (Grant No. NY220178)。
文摘High-dimensional quantum systems, such as qutrits(quantum three-level systems), have multiple accessible energy levels beyond the two-level qubits. Therefore, qutrits can offer a larger state space to improve the efficiency of quantum computation. Here, we demonstrate a high-fidelity iSWAP-like gate operation on a frequency-tunable superconducting qutrits system. The superconducting quantum system consists of two qutrits that are coupled via a resonator with fixed qutrit-resonator coupling strengths. Through designing the frequency pulse profile and optimizing the parameter values,the gate error can be suppressed below 1.5 × 10^(-3). To bear out the feasibility of the proposal, we have conducted our study with experimentally accessible parameters. As the resonator can mediate the interaction between the irrelevant qutrits, the presented approach can also be used to couple multiple qutrits together, providing a good platform for quantum information processing.
文摘BACKGROUND Sclerosing odontogenic carcinoma is a rare primary intraosseous neoplasm that was featured recently as a single entity in the World Health Organization classification of Head and Neck Tumors 2017,with only 14 cases published to date.The biological characteristics of sclerosing odontogenic carcinoma remain indistinct because of its rarity;however,it appears to be locally aggressive,with no regional or distant metastasis reported to date.CASE SUMMARY We reported a case of sclerosing odontogenic carcinoma of the maxilla in a 62-year-old woman,who presented with an indolent right palatal swelling,which progressively increased in size over 7 years.Right subtotal maxillectomy with surgical margins of approximately 1.5 cm was performed.The patient remained disease free for 4 years following the ablation surgery.Diagnostic workups,treatment,and therapeutic outcomes were discussed.CONCLUSION More cases are needed to further characterize this entity,understand its biological behavior,and justify the treatment protocols.Resection with wide margins of approximately 1.0 to 1.5 cm is proposed,while neck dissection,post-operative radiotherapy,or chemotherapy are deemed unnecessary.
文摘BACKGROUND Malignant peripheral nerve sheath tumor(MPNST)is a rare and aggressive soft tissue sarcoma that poses a major diagnostic and therapeutic challenge.CASE SUMMARY We retrospectively reviewed patients with head and neck MPNSTs treated in our hospital from 2000 to 2021.The clinical features,pathological manifestations,treatments,and prognoses were summarized.We also reviewed the literature,focusing on MPNST in the mandible and maxilla.The study population consisted of five women and five men aged 22–75 years(mean age,49 years).Of the 10 patients,7 were initial cases and 3 were recurrent cases.All lesions were sporadic.The most common site was the mandible.The most frequently encountered symptoms were a progressive mass and local swelling.Complete or partial loss of trimethylation at lysine 27 of histone H3(H3K27me3)was evident on staining in four of nine cases(one case was excluded due to lack of tissue for evaluation of loss of H3K27me3).The 2-and 5-year disease-specific survival rates were 86%a nd 43%,respectively.The average survival time was 64 mo.CONCLUSION MPNST is a highly malignant tumor with a poor prognosis,prone to a high risk of recurrence and distant metastasis.Complete surgical resection is the main treatment.
基金supported by the National Natural Science Foundation of China(82201011,82030031,92149301 and 82270945)the Beijing Municipal Government grant(Beijing Laboratory of Oral Health,PXM2021-014226-000041)+2 种基金the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M-5-038)the Science and Technology Project of Guangzhou,China(202206080009)the Postdoctoral Foundation of China(2021M703695 and 2021TQ0308)。
文摘The gingiva is a key oral barrier that protects oral tissues from various stimuli.A loss of gingival tissue homeostasis causes periodontitis,one of the most prevalent inflammatory diseases in humans.The human gingiva exists as a complex cell network comprising specialized structures.To understand the tissue-specific pathophysiology of the gingiva,we applied a recently developed spatial enhanced resolution omics-sequencing(Stereo-seq)technique to obtain a spatial transcriptome(ST)atlas of the gingiva in healthy individuals and periodontitis patients.By utilizing Stereo-seq,we identified the major cell types present in the gingiva,which included epithelial cells,fibroblasts,endothelial cells,and immune cells,as well as subgroups of epithelial cells and immune cells.We further observed that inflammation-related signalling pathways,such as the JAK-STAT and NF-κB signalling pathways,were significantly upregulated in the endothelial cells of the gingiva of periodontitis patients compared with those of healthy individuals.Additionally,we characterized the spatial distribution of periodontitis risk genes in the gingiva and found that the expression of IFI16 was significantly increased in endothelial cells of inflamed gingiva.In conclusion,our Stereo-seq findings may facilitate the development of innovative therapeutic strategies for periodontitis by mapping periodontitis-relevant genes and pathways and effector cells.
文摘目的:探讨微小RNA-302c(miR-302c)在肺癌组织中的表达,以及对肺癌侵袭和迁移的影响和作用机制。方法:在线分析GEO数据库中GSE19945和GSE136043两组肺癌数据集中miR-302c的表达情况,通过Human Protein Atlas数据库研究CREB1表达情况;双荧光素酶实验证明miR-302c和CREB1的关系。正常组细胞不加任何药物,对照组细胞转染miR-302cmimic-NC,实验组细胞转染miR-302c-mimic。通过Transwell小室检测细胞的侵袭与迁移能力,通过小管形成检测细胞的血管生成能力,通过Western blot检测各组细胞中CREB1、p-P53、p-P21的表达水平。结果:生物信息分析显示,与正常组织相比,miR-302c在肺癌组织、肺癌淋巴转移组织中的表达明显降低,肺癌组织中CREB1的表达明显升高;双荧光素酶实验证明miR-302c靶向调控CREB1的表达;与正常组相比,实验组迁移和侵袭的细胞数量、小管生成的数量明显下降,实验组中CREB1的表达明显下降,p-P53、p-P21的表达明显升高(均P<0.05)。结论:miR-302c在肺癌组织表达降低,过表达miR-302c后能明显抑制肺癌细胞的侵袭与转移,这可能与抑制靶基因CREB1的表达,以及激活P53信号通路有关。
文摘<strong>Objective: </strong>The quantum dots are the useful materials in microelectronics and biomedical research. However its toxicity has to be considered. We studied the effect of cell inhibition with ZnS core quantum dots and CdTe quantum dots modified with Thioglycolic acid or Cysteine functional group (TGA-CdTe, TGA-CdTe/ZnS, Cys-CdTe, Cys-CdTe/ZnS) on Caco-2 cell proliferation. <strong>Methods</strong>: We studied the effect of cell inhibition with ZnS core QDs and CdTe QDs modified with functional group on Caco-2 cell proliferation by MTT assay at 0, 12.5, 25, 50, 100 μg/ml and 6, 24, 48 h. <strong>Result:</strong> Our results showed that all QDs have inhibited cell proliferation and reached maximum 79.21%. The inhibition rate of Cys-modified QDs increased with the increase of concentration and reached maximum 66.72%. The inhibition rate of TGA-modified QDs increased with the increase of time. The ratios of Cys-modified to TGA-modified were less than 1 at all concentrations and three exposure times (P ≤ 0.01). The average ratios of Cys-CdTe/ZnS to Cys-CdTe reached 1.11 only for 48 h (P ≤ 0.05). The ratios of TGA-CdTe/ZnS to TGA-CdTe were closed to 1 at all concentrations and exposure times. <strong>Conclusion:</strong> The regularity of QDs modified with functional group is that inhibition of TGA-modified higher than Cys-modified. Inhibition exhibited dose-dependent for Cys-modified while exhibited time-dependent for TGA-modified. The regularity of CdTe-QDs with ZnS or not is that the inhibition of Cys-CdTe/ZnS was higher than Cys-CdTe while TGA-CdTe/ZnS and TGA-CdTe were consistent.
文摘GeSe nanosheets were prepared by ultrasonic-assisted liquid<span><span><span style="font-family:;" "=""> </span></span></span><span><span><span><span style="font-family:Verdana;">phase exfoliation (LPE), and the nonlinear saturated absorption performance was experimentally studied. The modulation depth and saturation intensity of the prepared GeSe saturable absorber (SA) were 15% and 1.44 MW/cm</span><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;">, respectively. Us</span><span style="font-family:Verdana;">ing the saturated absorption characteristics of GeSe SA, a passively Q-switched </span><span style="font-family:Verdana;">erbium-doped fiber laser was systematically demonstrated. As the pump</span><span style="font-family:Verdana;"> power increases, the pulse repetition frequency increases from 22.8 kHz to 77.59 </span><span style="font-family:Verdana;">kHz. The shortest pulse duration is 1.51 μs, and the corresponding pulse</span><span style="font-family:Verdana;"> energy is 46.14 nJ. Experimental results show that GeSe nanosheets can be used as high-efficiency SA in fiber lasers. Our results will provide a useful reference for demonstrating pulsed fiber lasers based on GeSe equipment.</span></span></span></span>
基金supported by NSFC (No. 61571055)fund of SKL of MMW (No. K201815)Important National Science & Technology Specific Projects (2017ZX03001028)
文摘Hybrid precoding and combining have been considered as a promising technology, which can provide a compromise between hardware complexity and system performance in millimeter wave multiple-input multiple-output systems. However, most existing hybrid precoder and combiner designs generally assume that infinite resolution phase shifters(PSs) are used to produce the analog beamformers. In a practical scene, the design with accurate PSs can lead to high hardware cost and power consumption. In this paper, we investigate the hybrid precoder and combiner design with finite resolution PSs in millimeter wave systems. We employ alternate optimization as the main strategy to jointly design analog precoder and combiner. In addition, we propose a low complexity algorithm, where the analog beamformers are implemented only by finite resolution PSs to maximize spectral efficiency. Then, the digital precoder and combiner are designed based on the obtained analog beamformers to improve the spectral efficiency. Finally, simulation results and mathematical analysis show that the proposed algorithm with low-resolution PSs can achieve near-optimal performance and have low complexity.
