The present study investigates Mg-SiO2 nanocomposites as biodegradable implants for orthopedic and maxillofacial applications.The effect of presence and progressive addition of hollow silica nanoparticles(0.5,1,and 1....The present study investigates Mg-SiO2 nanocomposites as biodegradable implants for orthopedic and maxillofacial applications.The effect of presence and progressive addition of hollow silica nanoparticles(0.5,1,and 1.5)vol.%on the microstructural,mechanical,degradation,and biocompatibility response of pure Mg were investigated.Results suggest that the increased addition of hollow silica nanoparticles resulted in a progressive increase in yield strength and ultimate compressive strength with Mg-1.5 vol.%SiO2 exhibiting superior enhancement.The response of Mg-SiO2 nanocomposites under the influence of Hanks’balanced salt solution revealed that the synthesized composites revealed lower corrosion rates,indicating rapid dynamic passivation when compared with pure Mg.Furthermore,cell adhesion and proliferation of osteoblast cells were noticeably higher than pure Mg with the addition of 1 vol.%SiO2 nanoparticle.The biocompatibility and the in vitro biodegradation of the Mg-SiO2 nanocomposites were influenced by the SiO2 content in pure Mg with Mg-0.5 vol.%SiO2 nanocomposite exhibiting the best corrosion resistance and biocompatibility when compared with other nanocomposites.Enhancement in mechanical,corrosion,and biocompatibility characteristics of Mg-SiO2 nanocomposites developed in this study are also compared with properties of other metallic biomaterials used in alloplastic mandibular reconstruction in a computational model.展开更多
Mesenchymal stem/stromal cells(MSCs)have demonstrated therapeutic efficacy for bone regeneration in animal and clinical studies.Although MSCs were initially thought to differentiate to various cell types to replace th...Mesenchymal stem/stromal cells(MSCs)have demonstrated therapeutic efficacy for bone regeneration in animal and clinical studies.Although MSCs were initially thought to differentiate to various cell types to replace the injured/diseased tissue,it is now accepted that these cells secrete factors to promote tissue repair.1 Among these factors,small extracellular vesicles(sEVs)of size 50–200 nm,which include the exosomes,have been identified as the principal agent mediating the wide-ranging therapeutic efficacy of MSCs.2 Several studies have also reported the therapeutic effects of MSC-sEVs to enhance bone repair in animal models,as recently reviewed.3 However,the cellular processes and mechanisms mediated by MSC-sEVs in bone regeneration remain to be fully elucidated.展开更多
基金This work was supported by the Singapore Ministry of Education Academic Research Funding grant number WBS#R-265-000-684-114.
文摘The present study investigates Mg-SiO2 nanocomposites as biodegradable implants for orthopedic and maxillofacial applications.The effect of presence and progressive addition of hollow silica nanoparticles(0.5,1,and 1.5)vol.%on the microstructural,mechanical,degradation,and biocompatibility response of pure Mg were investigated.Results suggest that the increased addition of hollow silica nanoparticles resulted in a progressive increase in yield strength and ultimate compressive strength with Mg-1.5 vol.%SiO2 exhibiting superior enhancement.The response of Mg-SiO2 nanocomposites under the influence of Hanks’balanced salt solution revealed that the synthesized composites revealed lower corrosion rates,indicating rapid dynamic passivation when compared with pure Mg.Furthermore,cell adhesion and proliferation of osteoblast cells were noticeably higher than pure Mg with the addition of 1 vol.%SiO2 nanoparticle.The biocompatibility and the in vitro biodegradation of the Mg-SiO2 nanocomposites were influenced by the SiO2 content in pure Mg with Mg-0.5 vol.%SiO2 nanocomposite exhibiting the best corrosion resistance and biocompatibility when compared with other nanocomposites.Enhancement in mechanical,corrosion,and biocompatibility characteristics of Mg-SiO2 nanocomposites developed in this study are also compared with properties of other metallic biomaterials used in alloplastic mandibular reconstruction in a computational model.
基金This work was funded by National University of Singapore(No.R221000114114,R221000134114)National Medical Research Council Singapore(No.R221000123213)SKL and WST are supported by the Agency for Science,Technology and Research under its Health and Biomedical Sciences Industry Alignment Fund Pre-Positioning(No.H19H6a0026).
文摘Mesenchymal stem/stromal cells(MSCs)have demonstrated therapeutic efficacy for bone regeneration in animal and clinical studies.Although MSCs were initially thought to differentiate to various cell types to replace the injured/diseased tissue,it is now accepted that these cells secrete factors to promote tissue repair.1 Among these factors,small extracellular vesicles(sEVs)of size 50–200 nm,which include the exosomes,have been identified as the principal agent mediating the wide-ranging therapeutic efficacy of MSCs.2 Several studies have also reported the therapeutic effects of MSC-sEVs to enhance bone repair in animal models,as recently reviewed.3 However,the cellular processes and mechanisms mediated by MSC-sEVs in bone regeneration remain to be fully elucidated.
