The use of polymer based composites in the treatment of skin tissue damages,has got huge attention in clinical demand,which enforced the scientists to improve the methods of biopolymer designing in order to obtain hig...The use of polymer based composites in the treatment of skin tissue damages,has got huge attention in clinical demand,which enforced the scientists to improve the methods of biopolymer designing in order to obtain highly efficient system for complete restoration of damaged tissue.In last few decades,chitosan-based biomaterials have major applications in skin tissue engineering due to its biocompatible,hemostatic,antimicrobial and biodegradable capabilities.This article overviewed the promising biological properties of chitosan and further discussed the various preparation methods involved in chitosan-based biomaterials.In addition,this review also gave a comprehensive discussion of different forms of chitosan-based biomaterials including membrane,sponge,nanofiber and hydrogel that were extensively employed in skin tissue engineering.This review will help to form a base for the advanced applications of chitosan-based biomaterials in treatment of skin tissue damages.展开更多
This study involves mathematical simulation model such as in vitro-in vivo correlation(IVIVC) development for various extended release formulations of nimesulide loaded hydroxypropylmethylcellulose(HPMC) microparticle...This study involves mathematical simulation model such as in vitro-in vivo correlation(IVIVC) development for various extended release formulations of nimesulide loaded hydroxypropylmethylcellulose(HPMC) microparticles(M1,M2 and M3 containing 1,2,and 3 g HPMC,respectively and 1 g drug in each) having variable release characteristics.In vitro dissolution data of these formulations were correlated to their relevant in vivo absorption profiles followed by predictability worth analysis of these Level A IVIVC.Nimaran was used as control formulation to validate developed formulations and their respective models.The regression coefficients of IVIVC plots for M1,M2,M3 and Nimaran were 0.834 9,0.831 2,0.927 2 and 0.898 1,respectively.The internal prediction error for all formulations was within limits,i.e.,<10%.A good IVIVC was found for controlled release nimesulide loaded HPMC floating M3 microparticles.In other words,this mathematical simulation model is best fit for biowaiver studies which involves study parameters as those adopted for M3 because the value of its IVIVC regression coefficient is the closest to 1 as compared to M1 and M2.展开更多
文摘The use of polymer based composites in the treatment of skin tissue damages,has got huge attention in clinical demand,which enforced the scientists to improve the methods of biopolymer designing in order to obtain highly efficient system for complete restoration of damaged tissue.In last few decades,chitosan-based biomaterials have major applications in skin tissue engineering due to its biocompatible,hemostatic,antimicrobial and biodegradable capabilities.This article overviewed the promising biological properties of chitosan and further discussed the various preparation methods involved in chitosan-based biomaterials.In addition,this review also gave a comprehensive discussion of different forms of chitosan-based biomaterials including membrane,sponge,nanofiber and hydrogel that were extensively employed in skin tissue engineering.This review will help to form a base for the advanced applications of chitosan-based biomaterials in treatment of skin tissue damages.
基金Higher Education Commission of Pakistan for proving financial support for research.
文摘This study involves mathematical simulation model such as in vitro-in vivo correlation(IVIVC) development for various extended release formulations of nimesulide loaded hydroxypropylmethylcellulose(HPMC) microparticles(M1,M2 and M3 containing 1,2,and 3 g HPMC,respectively and 1 g drug in each) having variable release characteristics.In vitro dissolution data of these formulations were correlated to their relevant in vivo absorption profiles followed by predictability worth analysis of these Level A IVIVC.Nimaran was used as control formulation to validate developed formulations and their respective models.The regression coefficients of IVIVC plots for M1,M2,M3 and Nimaran were 0.834 9,0.831 2,0.927 2 and 0.898 1,respectively.The internal prediction error for all formulations was within limits,i.e.,<10%.A good IVIVC was found for controlled release nimesulide loaded HPMC floating M3 microparticles.In other words,this mathematical simulation model is best fit for biowaiver studies which involves study parameters as those adopted for M3 because the value of its IVIVC regression coefficient is the closest to 1 as compared to M1 and M2.
